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The map label for this gene is hisI [H]

Identifier: 124023529

GI number: 124023529

Start: 1587391

End: 1588059

Strand: Reverse

Name: hisI [H]

Synonym: P9303_18291

Alternate gene names: 124023529

Gene position: 1588059-1587391 (Counterclockwise)

Preceding gene: 124023530

Following gene: 124023526

Centisome position: 59.2

GC content: 50.52

Gene sequence:

>669_bases
ATGCAACCCCTCAGCCCCGCCTTCATCGACCAACTTTGTTTTGACGATATTGGTTTAATTCCAGCGATCTCCCAAGACTG
GCTTGATGGAGCCGTTCTGATGATGGCCTGGATGAATCGCACTGCCCTAGAGCAGACATTAAAGAGTGGCCAAGTTCATT
ACTGGAGCCGCTCGCGTCAGGAGCTTTGGCATAAAGGTGCCACTAGCGGTCATACGCAGACCCTTAAGGGAATTCGTTAT
GACTGCGATGCTGATGTGCTTTTACTCAGTATCGAACAAACCGGTTTGGTCAGTTGTCATACCGGAGCTCGAAGCTGTTT
CTTCGCAGAGGTAAACCAGCATTCGCAGGGAGACTCACTGACGCTCCCACCTCCGATGGATGCCTGCAGTGAACTTTTTC
GGGTGATTGATCAACGCCACACCACACCCGAAGCCAACAGTTACACAAACAAGCTTTTAGAAGGTGGTGACAATCGCATC
CTCAAGAAAATTGGTGAGGAGAGTGCGGAATTTGTGATGGCTTGCAAAGACGACGATGCGAAGGCAATTGCTAATGAAGC
AGCTGATCTTCTCTTTCATCTGCAAGTCGCTCTTGCCCACCACGGTGTGAACTGGAGAGAAGTGCTTGAGGTGCTCGCTA
ATAGACGTGGAGCACCGCGTCGAAACTGA

Upstream 100 bases:

>100_bases
AGACCTCAGGAGGGGCGGATCATGCGAGAGCGAAGCAGTTGATGACTCGTTTGGTGCTGAGGGATGATTGCACGGCAGCA
CCTGCGCTCCTTGAGGACGA

Downstream 100 bases:

>100_bases
ATGCTGAACTGTGGCTTACTGAGTGATTCTTTTTAGTGAAACCCCCATCAATGTGGTTGCCCAAAGTTGGTGGATTGTGA
ACGGATCCACTCAAGTGTGA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MQPLSPAFIDQLCFDDIGLIPAISQDWLDGAVLMMAWMNRTALEQTLKSGQVHYWSRSRQELWHKGATSGHTQTLKGIRY
DCDADVLLLSIEQTGLVSCHTGARSCFFAEVNQHSQGDSLTLPPPMDACSELFRVIDQRHTTPEANSYTNKLLEGGDNRI
LKKIGEESAEFVMACKDDDAKAIANEAADLLFHLQVALAHHGVNWREVLEVLANRRGAPRRN

Sequences:

>Translated_222_residues
MQPLSPAFIDQLCFDDIGLIPAISQDWLDGAVLMMAWMNRTALEQTLKSGQVHYWSRSRQELWHKGATSGHTQTLKGIRY
DCDADVLLLSIEQTGLVSCHTGARSCFFAEVNQHSQGDSLTLPPPMDACSELFRVIDQRHTTPEANSYTNKLLEGGDNRI
LKKIGEESAEFVMACKDDDAKAIANEAADLLFHLQVALAHHGVNWREVLEVLANRRGAPRRN
>Mature_222_residues
MQPLSPAFIDQLCFDDIGLIPAISQDWLDGAVLMMAWMNRTALEQTLKSGQVHYWSRSRQELWHKGATSGHTQTLKGIRY
DCDADVLLLSIEQTGLVSCHTGARSCFFAEVNQHSQGDSLTLPPPMDACSELFRVIDQRHTTPEANSYTNKLLEGGDNRI
LKKIGEESAEFVMACKDDDAKAIANEAADLLFHLQVALAHHGVNWREVLEVLANRRGAPRRN

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=198, Percent_Identity=37.3737373737374, Blast_Score=127, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6319819, Length=177, Percent_Identity=31.0734463276836, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 24771; Mature: 24771

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLSPAFIDQLCFDDIGLIPAISQDWLDGAVLMMAWMNRTALEQTLKSGQVHYWSRSRQ
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHH
ELWHKGATSGHTQTLKGIRYDCDADVLLLSIEQTGLVSCHTGARSCFFAEVNQHSQGDSL
HHHHCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCEEEECCCCCCEEHHHHHCCCCCCCC
TLPPPMDACSELFRVIDQRHTTPEANSYTNKLLEGGDNRILKKIGEESAEFVMACKDDDA
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHCCHHHHEEEEECCCCH
KAIANEAADLLFHLQVALAHHGVNWREVLEVLANRRGAPRRN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQPLSPAFIDQLCFDDIGLIPAISQDWLDGAVLMMAWMNRTALEQTLKSGQVHYWSRSRQ
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHH
ELWHKGATSGHTQTLKGIRYDCDADVLLLSIEQTGLVSCHTGARSCFFAEVNQHSQGDSL
HHHHCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCEEEECCCCCCEEHHHHHCCCCCCCC
TLPPPMDACSELFRVIDQRHTTPEANSYTNKLLEGGDNRILKKIGEESAEFVMACKDDDA
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHCCHHHHEEEEECCCCH
KAIANEAADLLFHLQVALAHHGVNWREVLEVLANRRGAPRRN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]