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The map label for this gene is msrA [H]

Identifier: 124023477

GI number: 124023477

Start: 1553247

End: 1553966

Strand: Direct

Name: msrA [H]

Synonym: P9303_17771

Alternate gene names: 124023477

Gene position: 1553247-1553966 (Clockwise)

Preceding gene: 124023476

Following gene: 124023479

Centisome position: 57.9

GC content: 48.47

Gene sequence:

>720_bases
ATGTTCCCATCCTGGTTAACCCCAAAGGCTTCAAAAGAGGCTCCAATTCCCTCAGAAACTGAGCAGCACGCCGTTCTAGG
TACAGGGCTCCATGACCCGCTAACCACAGATCATGAAGATGCTCTGTTTGCTTGTGGCTGCTTTTGGGGAGCCGAAAAGG
GTTTCTGGAAATTGCCTGGGATCATCACCACGGCAGTGGGTTACGCCGGTGGCCATCAAGAGCAACCGACCTATCAAGAG
GTCTGCTCAGGACGTACCGGACACACTGAAATCGTACGGGTGGTGTGGAATAAATCCGTCATTGACTTCAGCGACCTCCT
CAAATTGTTCTGGGAATGCCATGACCCCACGCAAGGAAATCGCCAGGGTAATGATCGAGGGAGTCAATATCGATCGGCGA
TTTACACCACCACAATTCAGCAGATGGAGCTTGCGCAGGCCAGTCGAGACAGCTTTCAACAACTCTTAAGTAAGGGTGGT
TTTGGAGCAATTACGACTGAAATCAAAGCCGATCAACAATTCCATTATGCCGAGTCCTATCACCAGCAATACCTAGCAAA
ACCCGGAAGTAGACCATACTGCTCTGCAATGCCTACTCAGGTTGCTCTAAATGATTTCCCAGGAGCAAACTTTAAATTAC
CAGTCAGTGTCTGGCAAGAATATGATTGGTCAGTTAGTCATTGCGTTCTAAGATCTGGCAATGAAATAATCAAGCTCTAG

Upstream 100 bases:

>100_bases
GCCTAGCCCCCTCCTGTTGAGCTTCTTGACAGGGCTCCATAACCACCTGCATCTAAAGCCAAAAGAAGTTGCCTATGGTT
AGCAATCTTGCCTGAATTTG

Downstream 100 bases:

>100_bases
CGAATAGCATGCTTAAAAGGTAAATTCTCACACTAAGTTAATTCAAGACATACAACCAAAGCTTCAACAATATACGAAAG
GAGGTGTCAGGCTGGGCAAA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MFPSWLTPKASKEAPIPSETEQHAVLGTGLHDPLTTDHEDALFACGCFWGAEKGFWKLPGIITTAVGYAGGHQEQPTYQE
VCSGRTGHTEIVRVVWNKSVIDFSDLLKLFWECHDPTQGNRQGNDRGSQYRSAIYTTTIQQMELAQASRDSFQQLLSKGG
FGAITTEIKADQQFHYAESYHQQYLAKPGSRPYCSAMPTQVALNDFPGANFKLPVSVWQEYDWSVSHCVLRSGNEIIKL

Sequences:

>Translated_239_residues
MFPSWLTPKASKEAPIPSETEQHAVLGTGLHDPLTTDHEDALFACGCFWGAEKGFWKLPGIITTAVGYAGGHQEQPTYQE
VCSGRTGHTEIVRVVWNKSVIDFSDLLKLFWECHDPTQGNRQGNDRGSQYRSAIYTTTIQQMELAQASRDSFQQLLSKGG
FGAITTEIKADQQFHYAESYHQQYLAKPGSRPYCSAMPTQVALNDFPGANFKLPVSVWQEYDWSVSHCVLRSGNEIIKL
>Mature_239_residues
MFPSWLTPKASKEAPIPSETEQHAVLGTGLHDPLTTDHEDALFACGCFWGAEKGFWKLPGIITTAVGYAGGHQEQPTYQE
VCSGRTGHTEIVRVVWNKSVIDFSDLLKLFWECHDPTQGNRQGNDRGSQYRSAIYTTTIQQMELAQASRDSFQQLLSKGG
FGAITTEIKADQQFHYAESYHQQYLAKPGSRPYCSAMPTQVALNDFPGANFKLPVSVWQEYDWSVSHCVLRSGNEIIKL

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=200, Percent_Identity=49.5, Blast_Score=204, Evalue=4e-53,
Organism=Homo sapiens, GI208609995, Length=181, Percent_Identity=53.0386740331492, Blast_Score=201, Evalue=3e-52,
Organism=Homo sapiens, GI208609993, Length=103, Percent_Identity=60.1941747572816, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1790665, Length=177, Percent_Identity=51.9774011299435, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17533973, Length=166, Percent_Identity=35.5421686746988, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=35.5421686746988, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24664627, Length=164, Percent_Identity=35.9756097560976, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=38.1294964028777, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=37.5, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 26707; Mature: 26707

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPSWLTPKASKEAPIPSETEQHAVLGTGLHDPLTTDHEDALFACGCFWGAEKGFWKLPG
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEHHHHCCCCCCEECCH
IITTAVGYAGGHQEQPTYQEVCSGRTGHTEIVRVVWNKSVIDFSDLLKLFWECHDPTQGN
HHHHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
RQGNDRGSQYRSAIYTTTIQQMELAQASRDSFQQLLSKGGFGAITTEIKADQQFHYAESY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
HQQYLAKPGSRPYCSAMPTQVALNDFPGANFKLPVSVWQEYDWSVSHCVLRSGNEIIKL
HHHHHHCCCCCCCCCCCCCHHHHCCCCCCCEEEHHHHHHCCCCCHHHHHHHCCCCEECC
>Mature Secondary Structure
MFPSWLTPKASKEAPIPSETEQHAVLGTGLHDPLTTDHEDALFACGCFWGAEKGFWKLPG
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEHHHHCCCCCCEECCH
IITTAVGYAGGHQEQPTYQEVCSGRTGHTEIVRVVWNKSVIDFSDLLKLFWECHDPTQGN
HHHHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
RQGNDRGSQYRSAIYTTTIQQMELAQASRDSFQQLLSKGGFGAITTEIKADQQFHYAESY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
HQQYLAKPGSRPYCSAMPTQVALNDFPGANFKLPVSVWQEYDWSVSHCVLRSGNEIIKL
HHHHHHCCCCCCCCCCCCCHHHHCCCCCCCEEEHHHHHHCCCCCHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA