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The map label for this gene is mas1 [H]

Identifier: 124023409

GI number: 124023409

Start: 1491987

End: 1492697

Strand: Direct

Name: mas1 [H]

Synonym: P9303_17071

Alternate gene names: 124023409

Gene position: 1491987-1492697 (Clockwise)

Preceding gene: 124023408

Following gene: 124023410

Centisome position: 55.62

GC content: 51.48

Gene sequence:

>711_bases
ATGATGCGCACGATCTTGATCAGTGGTGCCAGTCGAGGTATAGGCCGAGCAATTGCCGAACGAATGTTGGCTGATGGCCA
TCGTCTTAGCCTTGGCCTACGGGACCCCAAATGCCTAATTGGTAGCTCACTTGACCCGGCAATCGCTGGTTCTGAACAAG
TGTTCCTACATCCCTATGAAGCCCAGGACGTTAACGCTGCCGAAAGCTGGGTATCTGCAAGCCTGGCTCATTTCAGTGGC
TTCGATAGTTTGATTCACTGTGCAGGCGTATTTCATCGCACGCCAATACGGTTTAATGATAACCAGCAGCATGAGATTGA
TCAGCTCTGGCAGGTGAATGTAATGGGCCCATGGTTGCTCAGCCGCGCTGCTTGGTCTCAGCTTGAATGCCATGATGAGG
CGCGCATCATTGTGTTGGTCTCAATGAGTGGCAAGCGCTCCAAGGGCCGTTTGGCTGGCTACACAGTTAGTAAGTTTGCG
CTGATGGGCCTTTGTCAGACCATGCGTAACGAAGGATGGGAGCAAGGCATCCGCGTGACAGCGATTTGTCCAGGTTGGGT
CAATACCGATATGGCTGCCAGGGTTAAGTCTTTGCCCAAAGAGGCGATGACTCAGCCTGATGACATCGCCTCTTTGAGCT
CTCATTTGTTACAGCTACCTAACAGTTGTGTACCGTTTGAACTGAGCATGAATTGCACACATGAGATCTGA

Upstream 100 bases:

>100_bases
GTGGAGCGGGATTTCATCAAAAGGTTTTCAGATTCTGCAGAGTCATGAGCATCACGAGAACTACCAGCAATAGTGTTTTT
GGATTTGCGACCATTCAGGA

Downstream 100 bases:

>100_bases
ACCCTTAGTTGAGTTGATGGGACTTTGTTATTGGCAAAGAAATGACGAGCAAAACTTTCCAAACCTCTTCAATAACATGG
ATTCTTCGCGATAAAAATCG

Product: Short-chain dehydrogenase/reductase (SDR) superfamily

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MMRTILISGASRGIGRAIAERMLADGHRLSLGLRDPKCLIGSSLDPAIAGSEQVFLHPYEAQDVNAAESWVSASLAHFSG
FDSLIHCAGVFHRTPIRFNDNQQHEIDQLWQVNVMGPWLLSRAAWSQLECHDEARIIVLVSMSGKRSKGRLAGYTVSKFA
LMGLCQTMRNEGWEQGIRVTAICPGWVNTDMAARVKSLPKEAMTQPDDIASLSSHLLQLPNSCVPFELSMNCTHEI

Sequences:

>Translated_236_residues
MMRTILISGASRGIGRAIAERMLADGHRLSLGLRDPKCLIGSSLDPAIAGSEQVFLHPYEAQDVNAAESWVSASLAHFSG
FDSLIHCAGVFHRTPIRFNDNQQHEIDQLWQVNVMGPWLLSRAAWSQLECHDEARIIVLVSMSGKRSKGRLAGYTVSKFA
LMGLCQTMRNEGWEQGIRVTAICPGWVNTDMAARVKSLPKEAMTQPDDIASLSSHLLQLPNSCVPFELSMNCTHEI
>Mature_236_residues
MMRTILISGASRGIGRAIAERMLADGHRLSLGLRDPKCLIGSSLDPAIAGSEQVFLHPYEAQDVNAAESWVSASLAHFSG
FDSLIHCAGVFHRTPIRFNDNQQHEIDQLWQVNVMGPWLLSRAAWSQLECHDEARIIVLVSMSGKRSKGRLAGYTVSKFA
LMGLCQTMRNEGWEQGIRVTAICPGWVNTDMAARVKSLPKEAMTQPDDIASLSSHLLQLPNSCVPFELSMNCTHEI

Specific function: Reduces deoxy-fructosyl-glutamine to mannopine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI33667109, Length=204, Percent_Identity=30.3921568627451, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI5031737, Length=200, Percent_Identity=30.5, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI40254992, Length=226, Percent_Identity=24.3362831858407, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=187, Percent_Identity=28.8770053475936, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87082100, Length=241, Percent_Identity=25.3112033195021, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=192, Percent_Identity=28.6458333333333, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571387, Length=234, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358495, Length=198, Percent_Identity=24.7474747474747, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR013078
- InterPro:   IPR015845
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short; PF00300 PGAM [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26028; Mature: 26028

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRTILISGASRGIGRAIAERMLADGHRLSLGLRDPKCLIGSSLDPAIAGSEQVFLHPYE
CCEEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCCCCCCCCEEEEECCC
AQDVNAAESWVSASLAHFSGFDSLIHCAGVFHRTPIRFNDNQQHEIDQLWQVNVMGPWLL
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHEEECCCHHHH
SRAAWSQLECHDEARIIVLVSMSGKRSKGRLAGYTVSKFALMGLCQTMRNEGWEQGIRVT
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCEEE
AICPGWVNTDMAARVKSLPKEAMTQPDDIASLSSHLLQLPNSCVPFELSMNCTHEI
EECCCCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MMRTILISGASRGIGRAIAERMLADGHRLSLGLRDPKCLIGSSLDPAIAGSEQVFLHPYE
CCEEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCCCCCCCCEEEEECCC
AQDVNAAESWVSASLAHFSGFDSLIHCAGVFHRTPIRFNDNQQHEIDQLWQVNVMGPWLL
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHEEECCCHHHH
SRAAWSQLECHDEARIIVLVSMSGKRSKGRLAGYTVSKFALMGLCQTMRNEGWEQGIRVT
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCEEE
AICPGWVNTDMAARVKSLPKEAMTQPDDIASLSSHLLQLPNSCVPFELSMNCTHEI
EECCCCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1909028 [H]