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The map label for this gene is ilvD

Identifier: 124023394

GI number: 124023394

Start: 1480038

End: 1481708

Strand: Reverse

Name: ilvD

Synonym: P9303_16921

Alternate gene names: 124023394

Gene position: 1481708-1480038 (Counterclockwise)

Preceding gene: 124023395

Following gene: 124023391

Centisome position: 55.23

GC content: 54.28

Gene sequence:

>1671_bases
ATGCTCAGATCTGCAGCCATCACAAAGGGAACTCAACGCTCTCCCAACCGAGCCATGCTTCGCGCAGTGGGCTTTGGCGA
CGAAGATTTCAATAAACCAATCATCGGTATAGCCAACGGCTACAGCACGATCACTCCTTGCAACATCGGTCTTAATGACC
TGGCGCGACGTTCAGAAGAAGCAGCCCGCCAGGCCGGTGCAATGCCCCAGATGTTCGGCACCATCACCGTCAGTGATGGC
ATCTCTATGGGCACCGAAGGGATGAAATATTCCCTGGTAAGCCGCGAGGTGATTGCTGATTCGATCGAGACAGCCTGCAA
CGCCCAAAGCATGGATGGCGTCCTAGCAATCGGTGGCTGTGACAAAAACATGCCTGGAGCCATGATCGCCCTGGCGCGAA
TGAACATCCCAGGTGTCTTTGTCTATGGCGGAACGATCAAACCAGGGAAATTGGCTGACCGCGACCTCACGGTAGTCAGC
GCCTTTGAAGCTGTTGGCCAGCATGCCAGCGGCAAGATTAACGAGGAGCAACTCACCGCTATCGAGAAGAACGCATGCCC
AGGAGCAGGAAGTTGCGGTGGCATGTTCACAGCCAACACGATGTCAGCCGCGATTGAAACATTGGGATTGAGTTTGCCTT
ACAGCTCAACGATGGCTGCAGAGGATGAGGAAAAAGCAAATAGCGCAGCCCGTAGTGCTGAAGTGCTTGTGGATGCCATT
AAGGCAAATATCTGTCCCCTCGATCTACTCACCAAGAACGCATTTGAAAACGCGATTAGCGTTGTCATGGCAGTGGGCGG
CTCCACCAATGCAGTTCTGCATCTGCTTGCGATTGCCCGTAGCGCAGGCGTAGACCTTTGCATCGACGACTTTGAGCGCA
TCCGCCAGCGTGTACCAGTGATTTGTGATCTAAAACCCAGCGGCCGTTACGTGACTGTTGATTTGCATAAAGCTGGCGGC
ATTCCCCAAGTCATGAAACAGTTGCTCGATGCAGGCTTACTCCATGGAGACTGCTGCAATGTGGAAGGTAAAACCTTGAG
AGAACTGCTCAAGGATGTGCCATCCGAGCCTTCAGCAGAGCAAGACGTCATTCATCCCCTCTCGAAACCGGTCTATGCCA
AGGGGCACCTGGCGATCCTTAAAGGCAATCTGGCCAGTGAAGGATGCGTGGCCAAGATCAGCGGGATCAAAACTCCTGTA
CTTACCGGACCTGCAAGGGTTTTTGAAAGCGAGGAGGCCTGCCTTGCTGCCATTCTCAACAACAAGGTGAAGGCGGGAGA
TGTCGTCGTCATACGTAACGAAGGCCCGGTTGGCGGGCCTGGAATGCGAGAGATGCTTGCTCCTACATCCGCCATCGTCG
GTGCAGACCTTGGCGACAAGGTGGCCCTGATCACAGATGGACGCTTCAGCGGAGGTACCTATGGTTTAGTTGTGGGTCAC
GTGGCACCTGAAGCAGCGGTAGGCGGCATGATTGGCCTTGTGCATGAAGGCGACAGCATCACCATCGATGCCGATCAACT
GCTGATCCAACTCAATATCGAGAACGATGAGTTGGAGCGTCGCTCCAGCGCATGGAAAAAACCACAGCCGCGTTATCAAA
CAGGAGTGCTCGGTAAATATGCCCGAATGGTGAGTAGCTCCAGCAAGGGTGCTGTCACCGACCAGCCCTGA

Upstream 100 bases:

>100_bases
CTCAATGCCGCCATTGCAGATGTGCGCAGACAGCTTGAAGATCTAGGAGCGAGGACCTGAGTGGTCGTTAGGTTGGCGAC
TGAGTGCCCCAGTTGTCACC

Downstream 100 bases:

>100_bases
CCTCTGATCAACTAGCTCTGCTCAGGCAATACCAGCAATGCTCTCAACCTACGAGCAAACGATTCCATTGGCGCTCCGTC
CTCAGGCGGCTGACAGCGTT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MLRSAAITKGTQRSPNRAMLRAVGFGDEDFNKPIIGIANGYSTITPCNIGLNDLARRSEEAARQAGAMPQMFGTITVSDG
ISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGCDKNMPGAMIALARMNIPGVFVYGGTIKPGKLADRDLTVVS
AFEAVGQHASGKINEEQLTAIEKNACPGAGSCGGMFTANTMSAAIETLGLSLPYSSTMAAEDEEKANSAARSAEVLVDAI
KANICPLDLLTKNAFENAISVVMAVGGSTNAVLHLLAIARSAGVDLCIDDFERIRQRVPVICDLKPSGRYVTVDLHKAGG
IPQVMKQLLDAGLLHGDCCNVEGKTLRELLKDVPSEPSAEQDVIHPLSKPVYAKGHLAILKGNLASEGCVAKISGIKTPV
LTGPARVFESEEACLAAILNNKVKAGDVVVIRNEGPVGGPGMREMLAPTSAIVGADLGDKVALITDGRFSGGTYGLVVGH
VAPEAAVGGMIGLVHEGDSITIDADQLLIQLNIENDELERRSSAWKKPQPRYQTGVLGKYARMVSSSSKGAVTDQP

Sequences:

>Translated_556_residues
MLRSAAITKGTQRSPNRAMLRAVGFGDEDFNKPIIGIANGYSTITPCNIGLNDLARRSEEAARQAGAMPQMFGTITVSDG
ISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGCDKNMPGAMIALARMNIPGVFVYGGTIKPGKLADRDLTVVS
AFEAVGQHASGKINEEQLTAIEKNACPGAGSCGGMFTANTMSAAIETLGLSLPYSSTMAAEDEEKANSAARSAEVLVDAI
KANICPLDLLTKNAFENAISVVMAVGGSTNAVLHLLAIARSAGVDLCIDDFERIRQRVPVICDLKPSGRYVTVDLHKAGG
IPQVMKQLLDAGLLHGDCCNVEGKTLRELLKDVPSEPSAEQDVIHPLSKPVYAKGHLAILKGNLASEGCVAKISGIKTPV
LTGPARVFESEEACLAAILNNKVKAGDVVVIRNEGPVGGPGMREMLAPTSAIVGADLGDKVALITDGRFSGGTYGLVVGH
VAPEAAVGGMIGLVHEGDSITIDADQLLIQLNIENDELERRSSAWKKPQPRYQTGVLGKYARMVSSSSKGAVTDQP
>Mature_556_residues
MLRSAAITKGTQRSPNRAMLRAVGFGDEDFNKPIIGIANGYSTITPCNIGLNDLARRSEEAARQAGAMPQMFGTITVSDG
ISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGCDKNMPGAMIALARMNIPGVFVYGGTIKPGKLADRDLTVVS
AFEAVGQHASGKINEEQLTAIEKNACPGAGSCGGMFTANTMSAAIETLGLSLPYSSTMAAEDEEKANSAARSAEVLVDAI
KANICPLDLLTKNAFENAISVVMAVGGSTNAVLHLLAIARSAGVDLCIDDFERIRQRVPVICDLKPSGRYVTVDLHKAGG
IPQVMKQLLDAGLLHGDCCNVEGKTLRELLKDVPSEPSAEQDVIHPLSKPVYAKGHLAILKGNLASEGCVAKISGIKTPV
LTGPARVFESEEACLAAILNNKVKAGDVVVIRNEGPVGGPGMREMLAPTSAIVGADLGDKVALITDGRFSGGTYGLVVGH
VAPEAAVGGMIGLVHEGDSITIDADQLLIQLNIENDELERRSSAWKKPQPRYQTGVLGKYARMVSSSSKGAVTDQP

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=607, Percent_Identity=40.5271828665568, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI2367371, Length=484, Percent_Identity=34.504132231405, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1788157, Length=507, Percent_Identity=31.163708086785, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1786464, Length=510, Percent_Identity=33.921568627451, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322476, Length=559, Percent_Identity=49.5527728085868, Blast_Score=532, Evalue=1e-152,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_PROM3 (A2CAC6)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001017701.1
- ProteinModelPortal:   A2CAC6
- SMR:   A2CAC6
- STRING:   A2CAC6
- GeneID:   4778566
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_16921
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   NMPGAMI
- ProtClustDB:   PRK00911
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 58127; Mature: 58127

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSAAITKGTQRSPNRAMLRAVGFGDEDFNKPIIGIANGYSTITPCNIGLNDLARRSEE
CCCCCCCCCCCCCCCCHHHHEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
AARQAGAMPQMFGTITVSDGISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGC
HHHHHCCCCHHHEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
DKNMPGAMIALARMNIPGVFVYGGTIKPGKLADRDLTVVSAFEAVGQHASGKINEEQLTA
CCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
IEKNACPGAGSCGGMFTANTMSAAIETLGLSLPYSSTMAAEDEEKANSAARSAEVLVDAI
HHHCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KANICPLDLLTKNAFENAISVVMAVGGSTNAVLHLLAIARSAGVDLCIDDFERIRQRVPV
HCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCE
ICDLKPSGRYVTVDLHKAGGIPQVMKQLLDAGLLHGDCCNVEGKTLRELLKDVPSEPSAE
EEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
QDVIHPLSKPVYAKGHLAILKGNLASEGCVAKISGIKTPVLTGPARVFESEEACLAAILN
HHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHHHHC
NKVKAGDVVVIRNEGPVGGPGMREMLAPTSAIVGADLGDKVALITDGRFSGGTYGLVVGH
CCCCCCCEEEEECCCCCCCCCHHHHHCCCHHHCCCCCCCEEEEEECCCCCCCEEEEEEEC
VAPEAAVGGMIGLVHEGDSITIDADQLLIQLNIENDELERRSSAWKKPQPRYQTGVLGKY
CCCHHHHCCEEEEEECCCEEEEECCEEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHH
ARMVSSSSKGAVTDQP
HHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLRSAAITKGTQRSPNRAMLRAVGFGDEDFNKPIIGIANGYSTITPCNIGLNDLARRSEE
CCCCCCCCCCCCCCCCHHHHEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
AARQAGAMPQMFGTITVSDGISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGC
HHHHHCCCCHHHEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
DKNMPGAMIALARMNIPGVFVYGGTIKPGKLADRDLTVVSAFEAVGQHASGKINEEQLTA
CCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
IEKNACPGAGSCGGMFTANTMSAAIETLGLSLPYSSTMAAEDEEKANSAARSAEVLVDAI
HHHCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KANICPLDLLTKNAFENAISVVMAVGGSTNAVLHLLAIARSAGVDLCIDDFERIRQRVPV
HCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCE
ICDLKPSGRYVTVDLHKAGGIPQVMKQLLDAGLLHGDCCNVEGKTLRELLKDVPSEPSAE
EEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
QDVIHPLSKPVYAKGHLAILKGNLASEGCVAKISGIKTPVLTGPARVFESEEACLAAILN
HHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHHHHC
NKVKAGDVVVIRNEGPVGGPGMREMLAPTSAIVGADLGDKVALITDGRFSGGTYGLVVGH
CCCCCCCEEEEECCCCCCCCCHHHHHCCCHHHCCCCCCCEEEEEECCCCCCCEEEEEEEC
VAPEAAVGGMIGLVHEGDSITIDADQLLIQLNIENDELERRSSAWKKPQPRYQTGVLGKY
CCCHHHHCCEEEEEECCCEEEEECCEEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHH
ARMVSSSSKGAVTDQP
HHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA