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The map label for this gene is gadB [H]

Identifier: 124023351

GI number: 124023351

Start: 1440015

End: 1441427

Strand: Direct

Name: gadB [H]

Synonym: P9303_16491

Alternate gene names: 124023351

Gene position: 1440015-1441427 (Clockwise)

Preceding gene: 124023349

Following gene: 124023357

Centisome position: 53.68

GC content: 54.78

Gene sequence:

>1413_bases
TTGGCTGGCACTCCCCAGATAAGGCCGACTGCGACCTTGGCGCCCTTTGCCAAGCCTGACCGTTTCGATCCAGAACTGCA
GACTTTTCTGGAGCAGGCCAGTGCTCGACTTTGTCAGTGGTTCGCAACAGCAAGCAATCGAGGCCCCTTACCAGCGCTGA
GTGCTTTGCCTGATGTGGCGCCGCCGCCTCAAGGTCTTTCAGTTGATGCCTTGCTGGACGATTTGCAGTTGGTGATGGAA
GGGGCCTATCAGCCTTCCCATCCAGGTGCTTTGGCTCATCTCGATCCGCCTCCTCTAACGGCATCCATCGCTGCCGATTT
GATCTGCGCAGGACTAAACAACAATCTTTTGGCCGAGGAGTTGTCACCAAGTCTTTCGCGTTTAGAGCGAGAGATGTGCC
GCTGGTTTGCTGAGCGCTTGGGACTGCCGTTGTCGGCTGGTGGTGTGGCAGCCAGTGGTGGCAGCCTCAGCAACCTGATG
GCGATGGTGATAGCTCGCCAACAGGCAGATCTTCAAGATGATCCCAGGGCGGTGGTGATTGCAAGTGTCGACGCTCATGT
GTCGCTCGCTAAGGCCATTCGAGTCATGGGATTGGCTAGCGATGCCTTGCAGACGGTGCCTGTCGATCAAGAGGGCTGCA
TGAATCTCGATGCCCTAGAGCATCAACTGAAGGCTCTCCGCGCAGAAGGGAGACCATGCTTAGCCGTTGTGGCGACAGCA
GGTACGACTGTCCAGGGAGCTGTAGATCCCTTGGTAGCGGTAGCAGAGCTATGCAGGCGCGAGCGGGTCTGGTTGCATAT
CGATGCAGCTATTGGAGGGGTCTTTGCTCTAGCAGCAGCCACTGCTTCTGTGGTTGAAGGAATCTCTCTAGCCGATTCGA
TCACAGTGAATCCTCAAAAGTTGCTTGGGATCACTAAGACATCATCCCTATTGCTAGTCGCGAACCAATCCCATCTTGCT
TCAGCCTTCTCGACTGGCTTGCCCTATATGGAACCAGCCTGGGGAGACGGTCATGGAAGTGAAATTGGCCTTCAAGGAAC
TCGGCCAGCAGAGGTGCTCAAGCTTTGGTTGGGTCTGCGTCAGCTCGGGGAGCAGGGAATTCAGAGCTTGCTGGAGGGGG
CAATTCAGCGTCGTCAATCTCTCGCGCGTCAACTCGATGCATCCAGGTTCATTCTTCTCAGCGGACCATTGCATCTCATT
GCCTGTACCCCTAAAAACGCCGATGCAGATCAAGCCTCAGTCTGGTCATTAGCAACTCGGCAAAGCTTGCTGGAACAACA
GTTGATGGTGTCAAGACCCTTGCATCATGGTCGTCATTTCCTCAAGGTGGTCTTGGGCAACCCCCATACGCAATCGATTC
ATCTCAATCGGTTGGCAACTCTGATGAATCAATCTTTGCTGGGTTTGCGCTAA

Upstream 100 bases:

>100_bases
TGGTTAGTTCAACAGGTTTCGCTAAAGGCACCGCTAAGTGGCAGCTCCTGATCAAACAATGCCATCAGGAGGGAGAATGG
AACTTGTATGACGAGCGTTT

Downstream 100 bases:

>100_bases
TGGCTTCATCACCCCCGCGAGGTCGCTGGGTGGCGATTATCACGACTGTTTTATCAGTAGCGATTGGATTGTTCTACCTG
GCTTTGATCACAGTTCTGGA

Product: pyridoxal-dependent decarboxylase family protein

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MAGTPQIRPTATLAPFAKPDRFDPELQTFLEQASARLCQWFATASNRGPLPALSALPDVAPPPQGLSVDALLDDLQLVME
GAYQPSHPGALAHLDPPPLTASIAADLICAGLNNNLLAEELSPSLSRLEREMCRWFAERLGLPLSAGGVAASGGSLSNLM
AMVIARQQADLQDDPRAVVIASVDAHVSLAKAIRVMGLASDALQTVPVDQEGCMNLDALEHQLKALRAEGRPCLAVVATA
GTTVQGAVDPLVAVAELCRRERVWLHIDAAIGGVFALAAATASVVEGISLADSITVNPQKLLGITKTSSLLLVANQSHLA
SAFSTGLPYMEPAWGDGHGSEIGLQGTRPAEVLKLWLGLRQLGEQGIQSLLEGAIQRRQSLARQLDASRFILLSGPLHLI
ACTPKNADADQASVWSLATRQSLLEQQLMVSRPLHHGRHFLKVVLGNPHTQSIHLNRLATLMNQSLLGLR

Sequences:

>Translated_470_residues
MAGTPQIRPTATLAPFAKPDRFDPELQTFLEQASARLCQWFATASNRGPLPALSALPDVAPPPQGLSVDALLDDLQLVME
GAYQPSHPGALAHLDPPPLTASIAADLICAGLNNNLLAEELSPSLSRLEREMCRWFAERLGLPLSAGGVAASGGSLSNLM
AMVIARQQADLQDDPRAVVIASVDAHVSLAKAIRVMGLASDALQTVPVDQEGCMNLDALEHQLKALRAEGRPCLAVVATA
GTTVQGAVDPLVAVAELCRRERVWLHIDAAIGGVFALAAATASVVEGISLADSITVNPQKLLGITKTSSLLLVANQSHLA
SAFSTGLPYMEPAWGDGHGSEIGLQGTRPAEVLKLWLGLRQLGEQGIQSLLEGAIQRRQSLARQLDASRFILLSGPLHLI
ACTPKNADADQASVWSLATRQSLLEQQLMVSRPLHHGRHFLKVVLGNPHTQSIHLNRLATLMNQSLLGLR
>Mature_469_residues
AGTPQIRPTATLAPFAKPDRFDPELQTFLEQASARLCQWFATASNRGPLPALSALPDVAPPPQGLSVDALLDDLQLVMEG
AYQPSHPGALAHLDPPPLTASIAADLICAGLNNNLLAEELSPSLSRLEREMCRWFAERLGLPLSAGGVAASGGSLSNLMA
MVIARQQADLQDDPRAVVIASVDAHVSLAKAIRVMGLASDALQTVPVDQEGCMNLDALEHQLKALRAEGRPCLAVVATAG
TTVQGAVDPLVAVAELCRRERVWLHIDAAIGGVFALAAATASVVEGISLADSITVNPQKLLGITKTSSLLLVANQSHLAS
AFSTGLPYMEPAWGDGHGSEIGLQGTRPAEVLKLWLGLRQLGEQGIQSLLEGAIQRRQSLARQLDASRFILLSGPLHLIA
CTPKNADADQASVWSLATRQSLLEQQLMVSRPLHHGRHFLKVVLGNPHTQSIHLNRLATLMNQSLLGLR

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=423, Percent_Identity=26.7139479905437, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI4503875, Length=423, Percent_Identity=26.7139479905437, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI194294551, Length=443, Percent_Identity=28.6681715575621, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI197383062, Length=385, Percent_Identity=27.5324675324675, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI58331246, Length=351, Percent_Identity=23.6467236467236, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI92110055, Length=367, Percent_Identity=28.8828337874659, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI4503281, Length=358, Percent_Identity=25.9776536312849, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI132814448, Length=358, Percent_Identity=25.9776536312849, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI31982936, Length=393, Percent_Identity=23.4096692111959, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17555682, Length=368, Percent_Identity=27.9891304347826, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71993058, Length=353, Percent_Identity=28.328611898017, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71993062, Length=334, Percent_Identity=29.0419161676647, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17534819, Length=416, Percent_Identity=23.3173076923077, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17534817, Length=416, Percent_Identity=23.3173076923077, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71981211, Length=488, Percent_Identity=23.9754098360656, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71981217, Length=500, Percent_Identity=24, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI133931025, Length=360, Percent_Identity=25.8333333333333, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17136594, Length=365, Percent_Identity=29.041095890411, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24657193, Length=399, Percent_Identity=27.5689223057644, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24657185, Length=399, Percent_Identity=27.5689223057644, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24657188, Length=399, Percent_Identity=27.5689223057644, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21356415, Length=322, Percent_Identity=29.8136645962733, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI28573972, Length=390, Percent_Identity=26.6666666666667, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17136190, Length=446, Percent_Identity=23.542600896861, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585135, Length=439, Percent_Identity=23.6902050113895, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24586044, Length=370, Percent_Identity=25.4054054054054, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24652373, Length=372, Percent_Identity=24.4623655913978, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585139, Length=414, Percent_Identity=24.1545893719807, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221476190, Length=393, Percent_Identity=23.9185750636132, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585143, Length=393, Percent_Identity=23.9185750636132, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 49874; Mature: 49743

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGTPQIRPTATLAPFAKPDRFDPELQTFLEQASARLCQWFATASNRGPLPALSALPDVA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC
PPPQGLSVDALLDDLQLVMEGAYQPSHPGALAHLDPPPLTASIAADLICAGLNNNLLAEE
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHH
LSPSLSRLEREMCRWFAERLGLPLSAGGVAASGGSLSNLMAMVIARQQADLQDDPRAVVI
HCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEE
ASVDAHVSLAKAIRVMGLASDALQTVPVDQEGCMNLDALEHQLKALRAEGRPCLAVVATA
EECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHCCCCEEEEEEEC
GTTVQGAVDPLVAVAELCRRERVWLHIDAAIGGVFALAAATASVVEGISLADSITVNPQK
CCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LLGITKTSSLLLVANQSHLASAFSTGLPYMEPAWGDGHGSEIGLQGTRPAEVLKLWLGLR
HEEEECCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
QLGEQGIQSLLEGAIQRRQSLARQLDASRFILLSGPLHLIACTPKNADADQASVWSLATR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCCCCHHHHHHHHHH
QSLLEQQLMVSRPLHHGRHFLKVVLGNPHTQSIHLNRLATLMNQSLLGLR
HHHHHHHHHHHCCHHHHHHEEEEEECCCCCCEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AGTPQIRPTATLAPFAKPDRFDPELQTFLEQASARLCQWFATASNRGPLPALSALPDVA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC
PPPQGLSVDALLDDLQLVMEGAYQPSHPGALAHLDPPPLTASIAADLICAGLNNNLLAEE
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHH
LSPSLSRLEREMCRWFAERLGLPLSAGGVAASGGSLSNLMAMVIARQQADLQDDPRAVVI
HCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEE
ASVDAHVSLAKAIRVMGLASDALQTVPVDQEGCMNLDALEHQLKALRAEGRPCLAVVATA
EECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHCCCCEEEEEEEC
GTTVQGAVDPLVAVAELCRRERVWLHIDAAIGGVFALAAATASVVEGISLADSITVNPQK
CCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LLGITKTSSLLLVANQSHLASAFSTGLPYMEPAWGDGHGSEIGLQGTRPAEVLKLWLGLR
HEEEECCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
QLGEQGIQSLLEGAIQRRQSLARQLDASRFILLSGPLHLIACTPKNADADQASVWSLATR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCCCCHHHHHHHHHH
QSLLEQQLMVSRPLHHGRHFLKVVLGNPHTQSIHLNRLATLMNQSLLGLR
HHHHHHHHHHHCCHHHHHHEEEEEECCCCCCEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]