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The map label for this gene is dxs

Identifier: 124023239

GI number: 124023239

Start: 1338911

End: 1340845

Strand: Reverse

Name: dxs

Synonym: P9303_15371

Alternate gene names: 124023239

Gene position: 1340845-1338911 (Counterclockwise)

Preceding gene: 124023243

Following gene: 124023238

Centisome position: 49.98

GC content: 52.51

Gene sequence:

>1935_bases
ATGCGTCTGAGCGAGTTAACCCATCCGAATCAGCTTCATGGCTTGAGCATTGCCGAGCTTGAGGATGTAGCACGTCAGAT
ACGGGAACGCCATCTTGAGGTGGTGTCCACCAGTGGAGGTCATTTGGGGCCTGGGCTCGGTGTTGTTGAACTCACCCTTG
CTCTTTATCAAACTCTTGATCTAGATCATGATCGAGTTGTATGGGACGTTGGCCATCAGGCTTATCCACACAAGCTGATT
ACTGGCCGATATGGCGACTTCAATACCTTGCGTCAGCAGGGTGGTGTCGCTGGCTATCTGAAGCGTTGTGAAAGTTCTTT
CGATCATTTTGGTGCCGGCCATGCCAGCACCTCGATATCAGCAGCACTGGGCATGGCCGTTGCTCGTGAGCGTCGTGGTG
AATCGTTCAAATGCGTAGCTGTAATTGGTGATGGGGCTCTTACTGGCGGCATAGCACTAGAAGCGATTAATCATGCCGGC
CATATGCCCAACACACCTTTTCTGGTTGTTCTCAACGACAACGACATGTCGATTTCTCCGCCAGTAGGAGCGTTGTCGAC
TCATCTAAATCGCATGCGCCACAGTGCGCCTGTGCAGTTCATCTCGGATAGCGTCGAGGAGAGGGTCAAGAGTCTGCCTT
TCATGGGAGGGGAACTGCCTGCCGAACTCGACCTGCTCAAGGGCAGTATGCGCCGATTATCCGTGCCGAAGGTAGGGGCT
GTTTTTGAGGAGCTTGGCTTCACCTACATGGGCCCTATTGATGGCCATGACATTGAACGCATGGTTCGAACCTTTGAGAC
GGCTCACAAGGTTGGTGGCCCTGTACTCGTTCATGTGGTTACGACCAAAGGCAAGGGCTATCCCTATGCCGAAGCAGATC
AAGTTGGCTATCACGCCCAATCAGCGTTTGATCTAATTACTGGTAAAGCTCTTCCCTCAAAAGGAAAGAAACCACCGAGT
TACAGCAAGGTGTTTGGCGAGACGCTCATTAAGCTTTGTCAGCAGGACAGCACTGTCGTTGGAATCACAGCCGCGATGGC
CACAGGTACTGGCCTTGACCTCCTGCAAAAGGCTGTTCCTGAGCAATACATCGATGTAGGTATCGCTGAACAGCATGCTG
TAACTCTTGCTGCTGGGATGGCTTGTGAGGGGCTCAAGCCTGTGCTGGCGATTTACAGCACATTCCTGCAGCGCGCCTTC
GACCAATTGATCCACGACGTGGGAATTCAGAACCTGCCAGTGACCTTTGTGATGGATCGCGCAGGCATTGTTGGCGCTGA
TGGACCGACCCATCAGGGTCAGTACGACATCAGTTATTTCCGCGCTATTCCTAATTTCACCGTGATGGCGCCCAAGGATG
AGGCTGAACTTCAACGCATGTTGGTGACATGTCTTCAGCATCAAGGCCCTGCAGCTCTCCGTATTCCAAGAGGATCAGGC
GAGGGAGTACCTCTGCTTGATGAAGGCTGGGAGCCTTTAGCAATTGGTCGAGGCGAAGTGCTTTGTGAAGGTGATGATCT
ATTAATCGTTGCTTATGGAGTAATGGTGCCTGCTGCCATGATCACAGCTCAGCTGTTGCAGGAAGCAGGTGTCAAGGCCA
CTGTGATCAATGCTCGCTTCCTAAGACCACTTGATCAAGCCTTGATTCATCCGTTAGCCCGTCGTATCGGTCGTGTCGTC
ACGATGGAGGAGGGTGCTCTTGCGGGTGGTTTTGGTGCAGCTGTGGTTGAGTCCCTTAGTGATCAAGATGTCTTGGTGCC
AACGTTCCGAATTGGAATCCCTGATCAATTGGTAGACCATGCCAGTCCCCAACAGAGCCGGGAAGCACTGGGGCTCACAC
CAACACAGATGTCTGAACGAATTCAAGAACACTTTTGCTTGAATTCGCAGCCTTCTCTTGTAGGGCAGGAAGCACCGCAG
GCCCTGTCAACCTGA

Upstream 100 bases:

>100_bases
ATTCAGATCCGGCAACTGTTTGCACTTGCCAGGGTTGCTTTCGCCGTTCTATAGCTGAGAAGACCTAGATTGAATGGGTT
GGAGTGGGACAGGAACGCGA

Downstream 100 bases:

>100_bases
TCAATTGACTGTTTTGGTAGCAGGTGCAGGGCCAGCAGGAGCCCGGCTTGCACAACGACTTGCTAGCCAGGGGATTGCGG
TAACTCTTGTTGAACGCCTA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MRLSELTHPNQLHGLSIAELEDVARQIRERHLEVVSTSGGHLGPGLGVVELTLALYQTLDLDHDRVVWDVGHQAYPHKLI
TGRYGDFNTLRQQGGVAGYLKRCESSFDHFGAGHASTSISAALGMAVARERRGESFKCVAVIGDGALTGGIALEAINHAG
HMPNTPFLVVLNDNDMSISPPVGALSTHLNRMRHSAPVQFISDSVEERVKSLPFMGGELPAELDLLKGSMRRLSVPKVGA
VFEELGFTYMGPIDGHDIERMVRTFETAHKVGGPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLITGKALPSKGKKPPS
YSKVFGETLIKLCQQDSTVVGITAAMATGTGLDLLQKAVPEQYIDVGIAEQHAVTLAAGMACEGLKPVLAIYSTFLQRAF
DQLIHDVGIQNLPVTFVMDRAGIVGADGPTHQGQYDISYFRAIPNFTVMAPKDEAELQRMLVTCLQHQGPAALRIPRGSG
EGVPLLDEGWEPLAIGRGEVLCEGDDLLIVAYGVMVPAAMITAQLLQEAGVKATVINARFLRPLDQALIHPLARRIGRVV
TMEEGALAGGFGAAVVESLSDQDVLVPTFRIGIPDQLVDHASPQQSREALGLTPTQMSERIQEHFCLNSQPSLVGQEAPQ
ALST

Sequences:

>Translated_644_residues
MRLSELTHPNQLHGLSIAELEDVARQIRERHLEVVSTSGGHLGPGLGVVELTLALYQTLDLDHDRVVWDVGHQAYPHKLI
TGRYGDFNTLRQQGGVAGYLKRCESSFDHFGAGHASTSISAALGMAVARERRGESFKCVAVIGDGALTGGIALEAINHAG
HMPNTPFLVVLNDNDMSISPPVGALSTHLNRMRHSAPVQFISDSVEERVKSLPFMGGELPAELDLLKGSMRRLSVPKVGA
VFEELGFTYMGPIDGHDIERMVRTFETAHKVGGPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLITGKALPSKGKKPPS
YSKVFGETLIKLCQQDSTVVGITAAMATGTGLDLLQKAVPEQYIDVGIAEQHAVTLAAGMACEGLKPVLAIYSTFLQRAF
DQLIHDVGIQNLPVTFVMDRAGIVGADGPTHQGQYDISYFRAIPNFTVMAPKDEAELQRMLVTCLQHQGPAALRIPRGSG
EGVPLLDEGWEPLAIGRGEVLCEGDDLLIVAYGVMVPAAMITAQLLQEAGVKATVINARFLRPLDQALIHPLARRIGRVV
TMEEGALAGGFGAAVVESLSDQDVLVPTFRIGIPDQLVDHASPQQSREALGLTPTQMSERIQEHFCLNSQPSLVGQEAPQ
ALST
>Mature_644_residues
MRLSELTHPNQLHGLSIAELEDVARQIRERHLEVVSTSGGHLGPGLGVVELTLALYQTLDLDHDRVVWDVGHQAYPHKLI
TGRYGDFNTLRQQGGVAGYLKRCESSFDHFGAGHASTSISAALGMAVARERRGESFKCVAVIGDGALTGGIALEAINHAG
HMPNTPFLVVLNDNDMSISPPVGALSTHLNRMRHSAPVQFISDSVEERVKSLPFMGGELPAELDLLKGSMRRLSVPKVGA
VFEELGFTYMGPIDGHDIERMVRTFETAHKVGGPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLITGKALPSKGKKPPS
YSKVFGETLIKLCQQDSTVVGITAAMATGTGLDLLQKAVPEQYIDVGIAEQHAVTLAAGMACEGLKPVLAIYSTFLQRAF
DQLIHDVGIQNLPVTFVMDRAGIVGADGPTHQGQYDISYFRAIPNFTVMAPKDEAELQRMLVTCLQHQGPAALRIPRGSG
EGVPLLDEGWEPLAIGRGEVLCEGDDLLIVAYGVMVPAAMITAQLLQEAGVKATVINARFLRPLDQALIHPLARRIGRVV
TMEEGALAGGFGAAVVESLSDQDVLVPTFRIGIPDQLVDHASPQQSREALGLTPTQMSERIQEHFCLNSQPSLVGQEAPQ
ALST

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=618, Percent_Identity=22.4919093851133, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI4507521, Length=618, Percent_Identity=22.4919093851133, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI225637459, Length=535, Percent_Identity=25.2336448598131, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI225637461, Length=535, Percent_Identity=25.2336448598131, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI225637463, Length=535, Percent_Identity=25.2336448598131, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI133778974, Length=638, Percent_Identity=23.9811912225705, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4557353, Length=248, Percent_Identity=24.5967741935484, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI34101272, Length=248, Percent_Identity=24.5967741935484, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1786622, Length=616, Percent_Identity=44.4805194805195, Blast_Score=498, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17539652, Length=412, Percent_Identity=29.126213592233, Blast_Score=135, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17538422, Length=244, Percent_Identity=26.2295081967213, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=245, Percent_Identity=25.7142857142857, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551847, Length=651, Percent_Identity=24.8847926267281, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI45550715, Length=651, Percent_Identity=24.8847926267281, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24645119, Length=607, Percent_Identity=25.3706754530478, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24666278, Length=632, Percent_Identity=25.3164556962025, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21358145, Length=255, Percent_Identity=27.4509803921569, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24650940, Length=255, Percent_Identity=27.4509803921569, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_PROM3 (A2C9X1)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001017546.1
- ProteinModelPortal:   A2C9X1
- SMR:   A2C9X1
- STRING:   A2C9X1
- GeneID:   4777418
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_15371
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   VSNTGGH
- ProtClustDB:   PRK05444
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69181; Mature: 69181

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSELTHPNQLHGLSIAELEDVARQIRERHLEVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHC
LDHDRVVWDVGHQAYPHKLITGRYGDFNTLRQQGGVAGYLKRCESSFDHFGAGHASTSIS
CCCCEEEEECCCCCCCCCEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHH
AALGMAVARERRGESFKCVAVIGDGALTGGIALEAINHAGHMPNTPFLVVLNDNDMSISP
HHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSTHLNRMRHSAPVQFISDSVEERVKSLPFMGGELPAELDLLKGSMRRLSVPKVGA
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
VFEELGFTYMGPIDGHDIERMVRTFETAHKVGGPVLVHVVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHCCCHHH
SAFDLITGKALPSKGKKPPSYSKVFGETLIKLCQQDSTVVGITAAMATGTGLDLLQKAVP
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCHHHHHHHCC
EQYIDVGIAEQHAVTLAAGMACEGLKPVLAIYSTFLQRAFDQLIHDVGIQNLPVTFVMDR
HHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
AGIVGADGPTHQGQYDISYFRAIPNFTVMAPKDEAELQRMLVTCLQHQGPAALRIPRGSG
CCEECCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCC
EGVPLLDEGWEPLAIGRGEVLCEGDDLLIVAYGVMVPAAMITAQLLQEAGVKATVINARF
CCCCCCCCCCCCEEECCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECHHH
LRPLDQALIHPLARRIGRVVTMEEGALAGGFGAAVVESLSDQDVLVPTFRIGIPDQLVDH
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHC
ASPQQSREALGLTPTQMSERIQEHFCLNSQPSLVGQEAPQALST
CCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCC
>Mature Secondary Structure
MRLSELTHPNQLHGLSIAELEDVARQIRERHLEVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHC
LDHDRVVWDVGHQAYPHKLITGRYGDFNTLRQQGGVAGYLKRCESSFDHFGAGHASTSIS
CCCCEEEEECCCCCCCCCEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHH
AALGMAVARERRGESFKCVAVIGDGALTGGIALEAINHAGHMPNTPFLVVLNDNDMSISP
HHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSTHLNRMRHSAPVQFISDSVEERVKSLPFMGGELPAELDLLKGSMRRLSVPKVGA
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
VFEELGFTYMGPIDGHDIERMVRTFETAHKVGGPVLVHVVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHCCCHHH
SAFDLITGKALPSKGKKPPSYSKVFGETLIKLCQQDSTVVGITAAMATGTGLDLLQKAVP
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCHHHHHHHCC
EQYIDVGIAEQHAVTLAAGMACEGLKPVLAIYSTFLQRAFDQLIHDVGIQNLPVTFVMDR
HHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
AGIVGADGPTHQGQYDISYFRAIPNFTVMAPKDEAELQRMLVTCLQHQGPAALRIPRGSG
CCEECCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCC
EGVPLLDEGWEPLAIGRGEVLCEGDDLLIVAYGVMVPAAMITAQLLQEAGVKATVINARF
CCCCCCCCCCCCEEECCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECHHH
LRPLDQALIHPLARRIGRVVTMEEGALAGGFGAAVVESLSDQDVLVPTFRIGIPDQLVDH
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHC
ASPQQSREALGLTPTQMSERIQEHFCLNSQPSLVGQEAPQALST
CCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA