Click here to switch to the map view.

The map label for this gene is rnr [C]

Identifier: 124023181

GI number: 124023181

Start: 1272073

End: 1274124

Strand: Reverse

Name: rnr [C]

Synonym: P9303_14771

Alternate gene names: 124023181

Gene position: 1274124-1272073 (Counterclockwise)

Preceding gene: 124023182

Following gene: 124023179

Centisome position: 47.49

GC content: 48.2

Gene sequence:

>2052_bases
TTGACGCCTTCTCTACAGCAAGGTGATTTAGTTGGCTTTGTTTTAAAAGGTCAACCACAAATTGGCCTGCTAACTTCCTT
GAAGGGCAGCCGAGCAATCGTAAGCGTTGCAGGAACACGGCGAGAACAACAGCTGGCCAGTCGAGAGCTGTCCGTTCTAA
AGCAAAAACACAACATGGTAGAGGTGGAGACATCTCTACCCACAATGAGTGAGGTCCGTAACCTTAGTCTTAATTCACGC
GATTTAATTGCTGGTTGGCGATTGCTCGAAGGCGAAAGGCGTAAAAGTAAGACTTCACCAACAGCACTCAAAATTACAGA
ACTAGCTGATTTACTCCTTAATAAAGATGATCCTATCCATCTCGCAGCATTGTGGTTTTGGCTTAATAGCGACCAACCTT
TATTTCGAGTTCGACGTGACCACCATGTTGAAGCACGTCAACTTATTGATCTGCGCCGCATCCGCCAGCTGCGCCGCAAG
CAACAATCTCGAGTGCAGCAACGCCTAGATTCTCTTGCATTGCTGATAGCAGATACACCTCTGAGCAAAGATCAGTGGCA
GGATTTACCCTCGGATCTTCAGTTAACTATCAACCGTTTAATCGAGTTGGCTGACGGTCCAGAGGATGCTTTTTTAACAG
ATGAGCAAGCTCTTGAGCTGATTAAAGATTTAAAGTTGGGTCGATCGCTGAGCGACCTCCGTTATTGGTTGATCAAGAAA
GGCTGGCGCGATCCACACGATCTAACAACTCTCAAAGGCAGTATCTGGACAAAAAGCTTTGAAGGGAGTGTACAAGCTCA
AGCGGACCAATTACTCAATAAGTTTGAGCAACTATCGTTCGCAAGCGATGATAGTCGTCTTGATTTGAGTGATTTAAGAA
CCTACACCCTCGACGATCATCAAACTCAGGAAATTGATGATGCAATCTCTTTGCAGTCTGTTGATCAAGACAGCTGGGTT
TGGATCCATATCGCCGATCCGGCAAGACTTATTCCTGTTGACAGCCCCTTAGATCTTGAGGCTCGTGCAAGAGCAACCAG
CCTCTACTTGGCTGATGGCCTAAGACCAATGCTGCCATTGAGTGTTGCCGCTGAAGTTCTCAGTCTTAGAGCTGGCCGTC
GCTGTGCAGCGTTGAGTGTTGCTGTGGTTCTAGATGAATCAGGATGTATAGCCGACACTCGTGTTTGTCGCACTTGGATT
CGCCCCTGCTATCGACTCACTTATGAGGATGGGGATGAATTGATTGAGCTTGCGCCTCCTGGCGATGAAGATCTTTCAAC
ACTCGCAAGCCTGCTCAAAAAACGTCAATTATGGCGTGAGCGACAAGGTGCACTGCTGCTTGAACAATCTGAAGGGCGAT
TCAAAGTCAAGGATGATCAGCCTGAGCTTCATGTTGTTGAGTCAACTCCAGCCAGACGGTTAGTAAGCGAAGCCATGATC
CTGATGGGTACTGTTATTGCTGAATTTGGAAAGCGTCAAAACCTTGCTCTGCCCTATCGCAGCCAGCCTCCAACTCAACT
ACCCAGTGCAACTGACTTATCACAGTTGATTGAAGGACCTGTCCGACATGCCGCGATCAAGCGTTGCCTTAGCCGAGGTG
TCCTTGGTACTCGTCCGATGGCTCATTTCAGTCTTGGCCTCTCTGCCTACGTACAAGCCAGTTCGCCGATCCGTCGCTAT
GCAGATTTACTTGCCCATCGACAGGTGGTGGCTCACTTAGGAGGCTCAGTTCCATTAAGCGAGCACGCTCTCATGGTGCA
GTTGGATGCACTTGAAGACCCTCTTCGCCAAGCACAGCAAATCCAACGCGAAGACCAGCGACACTGGCAAAAGGTGTGGT
TTTTAAAACATCGCCATGAACAATGGCCAGCCCTATTTCTGCGCTGGTTGAGACCACAAGATCAGATTGCACTTGTGCAT
GTGGAATGCCTGGCTATGGATCTTGCCTGCAAGCTAAACGGTTTGATCGACCCTATTCCAGGTCTTGCATTGATCATGAC
AGTTCTTGCAATTGATCCATTGACTGATCAAATTGAGTTGGTCGCCAAGTAG

Upstream 100 bases:

>100_bases
TAACGTCTAAGCAACAACGTGACCTTACTAATGCTGTAAAACGTGCACGTATTATTGCACTTTTGCCATTTGTTAATCCA
GAAGGCTGATTGCAACAGCT

Downstream 100 bases:

>100_bases
CTTCTCAAAGCAAAGAAACAAAAAACAAACTACCAAAAGCTGCTATTAATCTAAAATGCGAATCAACCTCAGCCATGGTC
CCCATGGATTGGCAACTGCT

Product: ribonuclease II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 683; Mature: 682

Protein sequence:

>683_residues
MTPSLQQGDLVGFVLKGQPQIGLLTSLKGSRAIVSVAGTRREQQLASRELSVLKQKHNMVEVETSLPTMSEVRNLSLNSR
DLIAGWRLLEGERRKSKTSPTALKITELADLLLNKDDPIHLAALWFWLNSDQPLFRVRRDHHVEARQLIDLRRIRQLRRK
QQSRVQQRLDSLALLIADTPLSKDQWQDLPSDLQLTINRLIELADGPEDAFLTDEQALELIKDLKLGRSLSDLRYWLIKK
GWRDPHDLTTLKGSIWTKSFEGSVQAQADQLLNKFEQLSFASDDSRLDLSDLRTYTLDDHQTQEIDDAISLQSVDQDSWV
WIHIADPARLIPVDSPLDLEARARATSLYLADGLRPMLPLSVAAEVLSLRAGRRCAALSVAVVLDESGCIADTRVCRTWI
RPCYRLTYEDGDELIELAPPGDEDLSTLASLLKKRQLWRERQGALLLEQSEGRFKVKDDQPELHVVESTPARRLVSEAMI
LMGTVIAEFGKRQNLALPYRSQPPTQLPSATDLSQLIEGPVRHAAIKRCLSRGVLGTRPMAHFSLGLSAYVQASSPIRRY
ADLLAHRQVVAHLGGSVPLSEHALMVQLDALEDPLRQAQQIQREDQRHWQKVWFLKHRHEQWPALFLRWLRPQDQIALVH
VECLAMDLACKLNGLIDPIPGLALIMTVLAIDPLTDQIELVAK

Sequences:

>Translated_683_residues
MTPSLQQGDLVGFVLKGQPQIGLLTSLKGSRAIVSVAGTRREQQLASRELSVLKQKHNMVEVETSLPTMSEVRNLSLNSR
DLIAGWRLLEGERRKSKTSPTALKITELADLLLNKDDPIHLAALWFWLNSDQPLFRVRRDHHVEARQLIDLRRIRQLRRK
QQSRVQQRLDSLALLIADTPLSKDQWQDLPSDLQLTINRLIELADGPEDAFLTDEQALELIKDLKLGRSLSDLRYWLIKK
GWRDPHDLTTLKGSIWTKSFEGSVQAQADQLLNKFEQLSFASDDSRLDLSDLRTYTLDDHQTQEIDDAISLQSVDQDSWV
WIHIADPARLIPVDSPLDLEARARATSLYLADGLRPMLPLSVAAEVLSLRAGRRCAALSVAVVLDESGCIADTRVCRTWI
RPCYRLTYEDGDELIELAPPGDEDLSTLASLLKKRQLWRERQGALLLEQSEGRFKVKDDQPELHVVESTPARRLVSEAMI
LMGTVIAEFGKRQNLALPYRSQPPTQLPSATDLSQLIEGPVRHAAIKRCLSRGVLGTRPMAHFSLGLSAYVQASSPIRRY
ADLLAHRQVVAHLGGSVPLSEHALMVQLDALEDPLRQAQQIQREDQRHWQKVWFLKHRHEQWPALFLRWLRPQDQIALVH
VECLAMDLACKLNGLIDPIPGLALIMTVLAIDPLTDQIELVAK
>Mature_682_residues
TPSLQQGDLVGFVLKGQPQIGLLTSLKGSRAIVSVAGTRREQQLASRELSVLKQKHNMVEVETSLPTMSEVRNLSLNSRD
LIAGWRLLEGERRKSKTSPTALKITELADLLLNKDDPIHLAALWFWLNSDQPLFRVRRDHHVEARQLIDLRRIRQLRRKQ
QSRVQQRLDSLALLIADTPLSKDQWQDLPSDLQLTINRLIELADGPEDAFLTDEQALELIKDLKLGRSLSDLRYWLIKKG
WRDPHDLTTLKGSIWTKSFEGSVQAQADQLLNKFEQLSFASDDSRLDLSDLRTYTLDDHQTQEIDDAISLQSVDQDSWVW
IHIADPARLIPVDSPLDLEARARATSLYLADGLRPMLPLSVAAEVLSLRAGRRCAALSVAVVLDESGCIADTRVCRTWIR
PCYRLTYEDGDELIELAPPGDEDLSTLASLLKKRQLWRERQGALLLEQSEGRFKVKDDQPELHVVESTPARRLVSEAMIL
MGTVIAEFGKRQNLALPYRSQPPTQLPSATDLSQLIEGPVRHAAIKRCLSRGVLGTRPMAHFSLGLSAYVQASSPIRRYA
DLLAHRQVVAHLGGSVPLSEHALMVQLDALEDPLRQAQQIQREDQRHWQKVWFLKHRHEQWPALFLRWLRPQDQIALVHV
ECLAMDLACKLNGLIDPIPGLALIMTVLAIDPLTDQIELVAK

Specific function: 3'-5'Exoribonuclease That Participates In An Essential Cell Function. Acts Nonspecifically On Poly(A), Poly(U) And Ribosomal RNAs. Required For The Expression Of VIrulence Genes In Enteroinvasive Strains Of E.Coli. [C]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonuclease II (RNB) family [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=353, Percent_Identity=28.8951841359773, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI19115966, Length=391, Percent_Identity=24.5524296675192, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI219521928, Length=391, Percent_Identity=24.5524296675192, Blast_Score=90, Evalue=9e-18,
Organism=Homo sapiens, GI190014623, Length=378, Percent_Identity=24.8677248677249, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI190014625, Length=378, Percent_Identity=24.8677248677249, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI156105695, Length=166, Percent_Identity=31.3253012048193, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI156105693, Length=166, Percent_Identity=31.3253012048193, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI87082383, Length=347, Percent_Identity=26.2247838616715, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1787542, Length=376, Percent_Identity=26.063829787234, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI212645896, Length=334, Percent_Identity=26.9461077844311, Blast_Score=96, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323943, Length=384, Percent_Identity=26.5625, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324552, Length=341, Percent_Identity=26.3929618768328, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24649634, Length=336, Percent_Identity=27.6785714285714, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19922976, Length=359, Percent_Identity=26.4623955431755, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24654597, Length=359, Percent_Identity=26.4623955431755, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24654592, Length=359, Percent_Identity=26.4623955431755, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001900
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00773 RNB [H]

EC number: 3.1.13.1

Molecular weight: Translated: 77221; Mature: 77090

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSLQQGDLVGFVLKGQPQIGLLTSLKGSRAIVSVAGTRREQQLASRELSVLKQKHNMV
CCCCCCCCCEEEEEEECCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCEE
EVETSLPTMSEVRNLSLNSRDLIAGWRLLEGERRKSKTSPTALKITELADLLLNKDDPIH
EEECCCCCHHHHHHCCCCCCHHHHHHHHHCCHHHCCCCCCCEEEHHHHHHHHHCCCCCEE
LAALWFWLNSDQPLFRVRRDHHVEARQLIDLRRIRQLRRKQQSRVQQRLDSLALLIADTP
EEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHEECCC
LSKDQWQDLPSDLQLTINRLIELADGPEDAFLTDEQALELIKDLKLGRSLSDLRYWLIKK
CCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHC
GWRDPHDLTTLKGSIWTKSFEGSVQAQADQLLNKFEQLSFASDDSRLDLSDLRTYTLDDH
CCCCCCHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCEEECCCC
QTQEIDDAISLQSVDQDSWVWIHIADPARLIPVDSPLDLEARARATSLYLADGLRPMLPL
CHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHH
SVAAEVLSLRAGRRCAALSVAVVLDESGCIADTRVCRTWIRPCYRLTYEDGDELIELAPP
HHHHHHHHHHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCCCEEEECCC
GDEDLSTLASLLKKRQLWRERQGALLLEQSEGRFKVKDDQPELHVVESTPARRLVSEAMI
CCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCEEEECCCHHHHHHHHHHH
LMGTVIAEFGKRQNLALPYRSQPPTQLPSATDLSQLIEGPVRHAAIKRCLSRGVLGTRPM
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AHFSLGLSAYVQASSPIRRYADLLAHRQVVAHLGGSVPLSEHALMVQLDALEDPLRQAQQ
HHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHH
IQREDQRHWQKVWFLKHRHEQWPALFLRWLRPQDQIALVHVECLAMDLACKLNGLIDPIP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCC
GLALIMTVLAIDPLTDQIELVAK
HHHHHHHHHHCCCCCCCHHEECC
>Mature Secondary Structure 
TPSLQQGDLVGFVLKGQPQIGLLTSLKGSRAIVSVAGTRREQQLASRELSVLKQKHNMV
CCCCCCCCEEEEEEECCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCEE
EVETSLPTMSEVRNLSLNSRDLIAGWRLLEGERRKSKTSPTALKITELADLLLNKDDPIH
EEECCCCCHHHHHHCCCCCCHHHHHHHHHCCHHHCCCCCCCEEEHHHHHHHHHCCCCCEE
LAALWFWLNSDQPLFRVRRDHHVEARQLIDLRRIRQLRRKQQSRVQQRLDSLALLIADTP
EEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHEECCC
LSKDQWQDLPSDLQLTINRLIELADGPEDAFLTDEQALELIKDLKLGRSLSDLRYWLIKK
CCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHC
GWRDPHDLTTLKGSIWTKSFEGSVQAQADQLLNKFEQLSFASDDSRLDLSDLRTYTLDDH
CCCCCCHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCEEECCCC
QTQEIDDAISLQSVDQDSWVWIHIADPARLIPVDSPLDLEARARATSLYLADGLRPMLPL
CHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHH
SVAAEVLSLRAGRRCAALSVAVVLDESGCIADTRVCRTWIRPCYRLTYEDGDELIELAPP
HHHHHHHHHHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCCCEEEECCC
GDEDLSTLASLLKKRQLWRERQGALLLEQSEGRFKVKDDQPELHVVESTPARRLVSEAMI
CCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCEEEECCCHHHHHHHHHHH
LMGTVIAEFGKRQNLALPYRSQPPTQLPSATDLSQLIEGPVRHAAIKRCLSRGVLGTRPM
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AHFSLGLSAYVQASSPIRRYADLLAHRQVVAHLGGSVPLSEHALMVQLDALEDPLRQAQQ
HHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHH
IQREDQRHWQKVWFLKHRHEQWPALFLRWLRPQDQIALVHVECLAMDLACKLNGLIDPIP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCC
GLALIMTVLAIDPLTDQIELVAK
HHHHHHHHHHCCCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]