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The map label for this gene is envZ [H]

Identifier: 124023110

GI number: 124023110

Start: 1199688

End: 1201022

Strand: Direct

Name: envZ [H]

Synonym: P9303_14051

Alternate gene names: 124023110

Gene position: 1199688-1201022 (Clockwise)

Preceding gene: 124023109

Following gene: 124023111

Centisome position: 44.72

GC content: 51.69

Gene sequence:

>1335_bases
ATGACGCGGACACAACGCAAGTCGGCGATCGTGTTCACTTCTTTGGGCTGGAGTGGTGTTGTTCTTGGCAGTTGGGCGCT
TTGTTTATTGGTTTTGCAGGTGCTCTTTGGCCGACAGTTAGAGATGCTTCAGACCGTTCAACTTGGTCGTGATCTATCAC
TCAACGTTCGTCTTACTGAGTTAGCTCTTGAGCGGTATCCGCCTGGTTTGGTTTCTGAGCTAACAGGGCTGGATCTAGCA
GTGATCGATCGACCACCAGATCCGCTTCGATTTGATCATGCTCTTCAGCGGCAAACAGATGCGCTTCAGAGGCAGCTATG
TCAACGACTCTCCCATTGTCCAATTTTTGTTCCTTTCTCGGCTGAAGGTGCGCAACGTGGAGCTTGGATTGAACTTATTT
CCCCTTTAGAGCCCGTTTGGCTCCGAGTTGGACTGCGTTCCGCGTTTGCTTGGCCACCGGAGCCAATCATGTTTGGGCTG
GCTTTGGTTGGTGCCGTGGTGATTTGTGGTGGTCTTTTTCTTCTCTTTCAGGTTGATCGACCGTTGAGGGGTCTGGAAAG
GGCTCTCGCTCGTGTTGGTGATGGTATTGATCCTGAGGCTGTAGCAGAAGTGGGAGCTCCTGAAGTTCAACGCCTCACAC
AACGTTTCAACGCCATGCTTTTACGCTTATCGGCCAACCGCCGTGAAAGGGCAACGATGCTTGCAGGCATCGCCCATGAT
CTGAGAGCCCCCATAACTCGACTCAGTTTTCGGCTGTCTTTGCCATCCCTCAGTGCTAATGATCGTGAGCAATGTTCAAG
GGATTTAGAGTCTCTTGAGCGAATTACTGGCCAGTTTCTTCTTTTTGCCGGTGGTGGTGATAGCGAAGCCTTGGTGGAGC
TGCCTCTAGATGCGTGGATGGCTGAGGTCTGCGCTACTCATTCTGCCGATTTGCTGAGGCTTGATCTTCAACCTCTTATG
GCCAAGGTGAGGCCTGTTGCCTTGGGACGAGCAGTAGTCAATCTCATCGATAATGCATTTACCTACGGTTTAGCCCCCGT
GACTGTGTCGCTGCGTGGCTTTGAACACAGCTATCGCATCGAAGTTTGGGACCAGGGAAAAGGCATGCCAATGGATCAGT
GGGAGCGAGCCTTGCAACCTTTTCAACGCTTGGATGAATCACGCCGCGAACAGGGGCATAGCGGCCTCGGGTTGGCGATC
GTTGCTCATGTTGTTAGTCGACATGCAGGCCAACTTAGCTTTGTTGCTTCTGATCGAACCAGTGAAGATCAACCTGGTCG
CTTTGCGGTAAGGCTTCAATTACCTTTTGACCCTCCTGAAAAGTCGTTGCAGTAA

Upstream 100 bases:

>100_bases
GAAGGTTGGTCGAACCCGATTCCAGTCGACCTCGCTATATCCAGACGGTATGGGGCTATGGATATGTTTTTGTCCCTGAT
GGTGAGCCCAGGTCTCGCTG

Downstream 100 bases:

>100_bases
AACGTCGTTGATATTCTCAATTCTTTTTGTAAGATTGCTCAAGGATTGAGAAAGCTTGATTCATGGTTTCTTTTTGTCAC
TTTAGGAGGCAATATAGGGT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTRTQRKSAIVFTSLGWSGVVLGSWALCLLVLQVLFGRQLEMLQTVQLGRDLSLNVRLTELALERYPPGLVSELTGLDLA
VIDRPPDPLRFDHALQRQTDALQRQLCQRLSHCPIFVPFSAEGAQRGAWIELISPLEPVWLRVGLRSAFAWPPEPIMFGL
ALVGAVVICGGLFLLFQVDRPLRGLERALARVGDGIDPEAVAEVGAPEVQRLTQRFNAMLLRLSANRRERATMLAGIAHD
LRAPITRLSFRLSLPSLSANDREQCSRDLESLERITGQFLLFAGGGDSEALVELPLDAWMAEVCATHSADLLRLDLQPLM
AKVRPVALGRAVVNLIDNAFTYGLAPVTVSLRGFEHSYRIEVWDQGKGMPMDQWERALQPFQRLDESRREQGHSGLGLAI
VAHVVSRHAGQLSFVASDRTSEDQPGRFAVRLQLPFDPPEKSLQ

Sequences:

>Translated_444_residues
MTRTQRKSAIVFTSLGWSGVVLGSWALCLLVLQVLFGRQLEMLQTVQLGRDLSLNVRLTELALERYPPGLVSELTGLDLA
VIDRPPDPLRFDHALQRQTDALQRQLCQRLSHCPIFVPFSAEGAQRGAWIELISPLEPVWLRVGLRSAFAWPPEPIMFGL
ALVGAVVICGGLFLLFQVDRPLRGLERALARVGDGIDPEAVAEVGAPEVQRLTQRFNAMLLRLSANRRERATMLAGIAHD
LRAPITRLSFRLSLPSLSANDREQCSRDLESLERITGQFLLFAGGGDSEALVELPLDAWMAEVCATHSADLLRLDLQPLM
AKVRPVALGRAVVNLIDNAFTYGLAPVTVSLRGFEHSYRIEVWDQGKGMPMDQWERALQPFQRLDESRREQGHSGLGLAI
VAHVVSRHAGQLSFVASDRTSEDQPGRFAVRLQLPFDPPEKSLQ
>Mature_443_residues
TRTQRKSAIVFTSLGWSGVVLGSWALCLLVLQVLFGRQLEMLQTVQLGRDLSLNVRLTELALERYPPGLVSELTGLDLAV
IDRPPDPLRFDHALQRQTDALQRQLCQRLSHCPIFVPFSAEGAQRGAWIELISPLEPVWLRVGLRSAFAWPPEPIMFGLA
LVGAVVICGGLFLLFQVDRPLRGLERALARVGDGIDPEAVAEVGAPEVQRLTQRFNAMLLRLSANRRERATMLAGIAHDL
RAPITRLSFRLSLPSLSANDREQCSRDLESLERITGQFLLFAGGGDSEALVELPLDAWMAEVCATHSADLLRLDLQPLMA
KVRPVALGRAVVNLIDNAFTYGLAPVTVSLRGFEHSYRIEVWDQGKGMPMDQWERALQPFQRLDESRREQGHSGLGLAIV
AHVVSRHAGQLSFVASDRTSEDQPGRFAVRLQLPFDPPEKSLQ

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=348, Percent_Identity=31.3218390804598, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1787894, Length=303, Percent_Identity=29.3729372937294, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790346, Length=249, Percent_Identity=28.9156626506024, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786783, Length=296, Percent_Identity=23.9864864864865, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49261; Mature: 49129

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTQRKSAIVFTSLGWSGVVLGSWALCLLVLQVLFGRQLEMLQTVQLGRDLSLNVRLTE
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEHHH
LALERYPPGLVSELTGLDLAVIDRPPDPLRFDHALQRQTDALQRQLCQRLSHCPIFVPFS
HHHHHCCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
AEGAQRGAWIELISPLEPVWLRVGLRSAFAWPPEPIMFGLALVGAVVICGGLFLLFQVDR
CCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLRGLERALARVGDGIDPEAVAEVGAPEVQRLTQRFNAMLLRLSANRRERATMLAGIAHD
HHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LRAPITRLSFRLSLPSLSANDREQCSRDLESLERITGQFLLFAGGGDSEALVELPLDAWM
HHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECCHHHHH
AEVCATHSADLLRLDLQPLMAKVRPVALGRAVVNLIDNAFTYGLAPVTVSLRGFEHSYRI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEE
EVWDQGKGMPMDQWERALQPFQRLDESRREQGHSGLGLAIVAHVVSRHAGQLSFVASDRT
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
SEDQPGRFAVRLQLPFDPPEKSLQ
CCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TRTQRKSAIVFTSLGWSGVVLGSWALCLLVLQVLFGRQLEMLQTVQLGRDLSLNVRLTE
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEHHH
LALERYPPGLVSELTGLDLAVIDRPPDPLRFDHALQRQTDALQRQLCQRLSHCPIFVPFS
HHHHHCCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
AEGAQRGAWIELISPLEPVWLRVGLRSAFAWPPEPIMFGLALVGAVVICGGLFLLFQVDR
CCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLRGLERALARVGDGIDPEAVAEVGAPEVQRLTQRFNAMLLRLSANRRERATMLAGIAHD
HHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LRAPITRLSFRLSLPSLSANDREQCSRDLESLERITGQFLLFAGGGDSEALVELPLDAWM
HHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECCHHHHH
AEVCATHSADLLRLDLQPLMAKVRPVALGRAVVNLIDNAFTYGLAPVTVSLRGFEHSYRI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEE
EVWDQGKGMPMDQWERALQPFQRLDESRREQGHSGLGLAIVAHVVSRHAGQLSFVASDRT
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
SEDQPGRFAVRLQLPFDPPEKSLQ
CCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]