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The map label for this gene is gltP [H]

Identifier: 124022940

GI number: 124022940

Start: 1071435

End: 1073648

Strand: Direct

Name: gltP [H]

Synonym: P9303_12331

Alternate gene names: 124022940

Gene position: 1071435-1073648 (Clockwise)

Preceding gene: 124022939

Following gene: 124022941

Centisome position: 39.94

GC content: 48.28

Gene sequence:

>2214_bases
ATGGTTGCCGGACTGCGATGGCTTCTTTGGCCACTGAGCCGCTTTCTGCGTCAGAGCCTATCGATGCAGATCCTTGAAGG
TTTGCTGGCAGGGGTTATTGCTGGGCTGATGCTTCCCGTAGCCATGGTGAGCCTGCTTGCACCAATAGGGGAAGGCTTCC
TTCGCCTGTTCCAGATGCCAGTTGTGCCGTTTTTGAGCATTTCGCTCGTGGCTGGAGTGGGACGCCTTGAACTTGCTCAA
GCAAGTCGGCTGCTCAGCCGAGCAGCGATTGTGCTGATGGGGTTCTGGGTGGTCGTGCTCGGGGCAGTGCTTTTGATTCC
CCTTGGCTTTCCAGATTGGCGGGAAGCATCGTTCTTCCGGCCAAGCCTCTTAGAGGCTGCTCAGCCGATGAACCTCATCG
AACTGTTTATTCCCGTCAATCCATTCGCAGCATTTGCAGACACTCAAATTCCAGCAGTGGTGCTGTTTTCTATTGCGCTC
GGCATCGCTTTGATTTCAGTTCCAAAAAGGCAGGGCCTGATCGAGGTGTTGGACCGGGTTCAATCAGCGCTGTTGAAGAT
CTCTGCATACATCGCAAGGTATACACCACTTGGAGTGTTTGCGATCCTCGCAAGCACGACGTCTCAAGTTTCACCATCAG
AGATCCCTCGACTCGCCATCTACATTGTTTTGCAGGGCGGAGTTGCAGTTGTCCTTACATTTCTCTTCCTTCCCTACCTC
GTTCAAGCAGTAATCCCTATCAAGGCAGGGGAACTGATCAAGTCTTTCCGTACACCGCTTGTGATTGCGTTCTCAACAGC
AAATTTACTGGTGGTACTTCCATTACTAATCAATCAAGGCAAACAGCTCTTGATTGAGGGGATGGCAAGACAACGTTCCC
TTGGCTTAGAAGATCGTGAAAGCCGTAAAAAGTTAGCTCAGTCGATCGAATTACCGGTTGAGGTGCTAACGCCTCTTGCG
CTGGTCTTTCCTGATATGGGCCGAGTGTTGTCGCTAGCTTTCGTCCCTTTTGCAGGTTGGCTCACAGGCAATCCGTTAAC
AGTCGAACAAATGCCCAGCTTCCTCATCACAGGTCTGGCAAGCACCTTCCTTGAAGGAGTGCTTGCGATGACATTCCTGC
TGAGCAAGATGGGCTTACCTACAGACATGGTGAATCTCTACATTGCCCTTGATCAGTTGGCTGTAGCACGTCTTGGCACG
CTGCTCGCATGCATGAGTGTGATCAGCCTTGTACTTGTTGGTACATGGATCAGCCTTGAGGGATTTCGATACAGATTATC
GAAACTTTTACCGGTTGCCATTTCAATGCTAATCATACCAATATTCATCAGTGTGAGTCGGTTTATCCTCAATCAAATTC
CGCAACCAAGTAATCCATACCGAAGTCAACTCGAGACTCAAGGCTTTGTTCTGGCCAAAGAAAAAGCAGAGCTAATCGAG
GAACCCAAGCCACTCGAAGAAGCCGGCATCTGGCCGTCAATGCAGGCTAGAGGAGCAATCCGTTACTGCATCCATAGGCA
GGATTATCCAATGGCTTATCGCAATGCAAAACAAGAGTTGGTTGGTGCTGATGTAGAAACTGGGCTCTTATTTGCAGAAG
ATATGGGCATGAAAGCCAGCTTTATTCAAATCGATCACTTGGGTAATCCAAATAAGGTTAGACCAAATGGACTAGAGGCA
CTGAAGAATGGATTATGTGACCTAAAACTATCCAGTGATATCATTGTACCTCAGGAGTCTGCTGAGGTGTTGTACACTTC
AACCAATCAAAGCTATGGCATAGGATTGCTGTTAAAGGGGAGTCGATTCAGTAGCAAATATAGATGGAAAGAGATCAAGT
CTATAAAAGGTTTTCGAGTTGGCCTCGAAGCTCATTCCCCATACAGTATCAATTGGGTGCAACGATTGCTTCCGCACGCT
ATCTTGAACACATCGAAAGGAACGGCCGAGCTACTCAAGGAACTCAAAAATGATAACCTTGATGCAGTCATCATTTCGGC
CCAGAAGGGTGCTGCTTGGAATGTACTCGAACCAAGCCTCGCATTACTCGTACCAAAACCTACAAAAAGCCTGCCGACCG
CAAGACAAGTTCCTGAAGATGCGCTTGAGCTTTCGAGGGTTTGGAATCATTGGCTAAAGCTGCAGGGGTTTGACGGAACT
AAAAATAAAGTTTATCAACACTGGGTTGAAGGAATTGCAGATGAGGAAAAATAA

Upstream 100 bases:

>100_bases
TTGAGTGACAGGTTCTCAACTCTGTGCTTGCCTTTAATGGCTAACCGTGAGAAATCGTTTTACTGACGTGAAACGCCCTC
CGGGACATGGAGTTGCCGAG

Downstream 100 bases:

>100_bases
TGACACCATCAATATCAACCGATTAACAGACAAGACTTGATAGTTGCCTAATCTTTTCAAGATCGATACCCTGGAAATAT
GTATGTCAGTGATAGTGCTC

Product: DAACS family glutamate/aspartate/dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 737; Mature: 737

Protein sequence:

>737_residues
MVAGLRWLLWPLSRFLRQSLSMQILEGLLAGVIAGLMLPVAMVSLLAPIGEGFLRLFQMPVVPFLSISLVAGVGRLELAQ
ASRLLSRAAIVLMGFWVVVLGAVLLIPLGFPDWREASFFRPSLLEAAQPMNLIELFIPVNPFAAFADTQIPAVVLFSIAL
GIALISVPKRQGLIEVLDRVQSALLKISAYIARYTPLGVFAILASTTSQVSPSEIPRLAIYIVLQGGVAVVLTFLFLPYL
VQAVIPIKAGELIKSFRTPLVIAFSTANLLVVLPLLINQGKQLLIEGMARQRSLGLEDRESRKKLAQSIELPVEVLTPLA
LVFPDMGRVLSLAFVPFAGWLTGNPLTVEQMPSFLITGLASTFLEGVLAMTFLLSKMGLPTDMVNLYIALDQLAVARLGT
LLACMSVISLVLVGTWISLEGFRYRLSKLLPVAISMLIIPIFISVSRFILNQIPQPSNPYRSQLETQGFVLAKEKAELIE
EPKPLEEAGIWPSMQARGAIRYCIHRQDYPMAYRNAKQELVGADVETGLLFAEDMGMKASFIQIDHLGNPNKVRPNGLEA
LKNGLCDLKLSSDIIVPQESAEVLYTSTNQSYGIGLLLKGSRFSSKYRWKEIKSIKGFRVGLEAHSPYSINWVQRLLPHA
ILNTSKGTAELLKELKNDNLDAVIISAQKGAAWNVLEPSLALLVPKPTKSLPTARQVPEDALELSRVWNHWLKLQGFDGT
KNKVYQHWVEGIADEEK

Sequences:

>Translated_737_residues
MVAGLRWLLWPLSRFLRQSLSMQILEGLLAGVIAGLMLPVAMVSLLAPIGEGFLRLFQMPVVPFLSISLVAGVGRLELAQ
ASRLLSRAAIVLMGFWVVVLGAVLLIPLGFPDWREASFFRPSLLEAAQPMNLIELFIPVNPFAAFADTQIPAVVLFSIAL
GIALISVPKRQGLIEVLDRVQSALLKISAYIARYTPLGVFAILASTTSQVSPSEIPRLAIYIVLQGGVAVVLTFLFLPYL
VQAVIPIKAGELIKSFRTPLVIAFSTANLLVVLPLLINQGKQLLIEGMARQRSLGLEDRESRKKLAQSIELPVEVLTPLA
LVFPDMGRVLSLAFVPFAGWLTGNPLTVEQMPSFLITGLASTFLEGVLAMTFLLSKMGLPTDMVNLYIALDQLAVARLGT
LLACMSVISLVLVGTWISLEGFRYRLSKLLPVAISMLIIPIFISVSRFILNQIPQPSNPYRSQLETQGFVLAKEKAELIE
EPKPLEEAGIWPSMQARGAIRYCIHRQDYPMAYRNAKQELVGADVETGLLFAEDMGMKASFIQIDHLGNPNKVRPNGLEA
LKNGLCDLKLSSDIIVPQESAEVLYTSTNQSYGIGLLLKGSRFSSKYRWKEIKSIKGFRVGLEAHSPYSINWVQRLLPHA
ILNTSKGTAELLKELKNDNLDAVIISAQKGAAWNVLEPSLALLVPKPTKSLPTARQVPEDALELSRVWNHWLKLQGFDGT
KNKVYQHWVEGIADEEK
>Mature_737_residues
MVAGLRWLLWPLSRFLRQSLSMQILEGLLAGVIAGLMLPVAMVSLLAPIGEGFLRLFQMPVVPFLSISLVAGVGRLELAQ
ASRLLSRAAIVLMGFWVVVLGAVLLIPLGFPDWREASFFRPSLLEAAQPMNLIELFIPVNPFAAFADTQIPAVVLFSIAL
GIALISVPKRQGLIEVLDRVQSALLKISAYIARYTPLGVFAILASTTSQVSPSEIPRLAIYIVLQGGVAVVLTFLFLPYL
VQAVIPIKAGELIKSFRTPLVIAFSTANLLVVLPLLINQGKQLLIEGMARQRSLGLEDRESRKKLAQSIELPVEVLTPLA
LVFPDMGRVLSLAFVPFAGWLTGNPLTVEQMPSFLITGLASTFLEGVLAMTFLLSKMGLPTDMVNLYIALDQLAVARLGT
LLACMSVISLVLVGTWISLEGFRYRLSKLLPVAISMLIIPIFISVSRFILNQIPQPSNPYRSQLETQGFVLAKEKAELIE
EPKPLEEAGIWPSMQARGAIRYCIHRQDYPMAYRNAKQELVGADVETGLLFAEDMGMKASFIQIDHLGNPNKVRPNGLEA
LKNGLCDLKLSSDIIVPQESAEVLYTSTNQSYGIGLLLKGSRFSSKYRWKEIKSIKGFRVGLEAHSPYSINWVQRLLPHA
ILNTSKGTAELLKELKNDNLDAVIISAQKGAAWNVLEPSLALLVPKPTKSLPTARQVPEDALELSRVWNHWLKLQGFDGT
KNKVYQHWVEGIADEEK

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1790514, Length=301, Percent_Identity=27.5747508305648, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 81075; Mature: 81075

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAGLRWLLWPLSRFLRQSLSMQILEGLLAGVIAGLMLPVAMVSLLAPIGEGFLRLFQMP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VVPFLSISLVAGVGRLELAQASRLLSRAAIVLMGFWVVVLGAVLLIPLGFPDWREASFFR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PSLLEAAQPMNLIELFIPVNPFAAFADTQIPAVVLFSIALGIALISVPKRQGLIEVLDRV
HHHHHHCCCCCHHHEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QSALLKISAYIARYTPLGVFAILASTTSQVSPSEIPRLAIYIVLQGGVAVVLTFLFLPYL
HHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHCCEEEEEEEECCCHHHHHHHHHHHHH
VQAVIPIKAGELIKSFRTPLVIAFSTANLLVVLPLLINQGKQLLIEGMARQRSLGLEDRE
HHHHHCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHH
SRKKLAQSIELPVEVLTPLALVFPDMGRVLSLAFVPFAGWLTGNPLTVEQMPSFLITGLA
HHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHH
STFLEGVLAMTFLLSKMGLPTDMVNLYIALDQLAVARLGTLLACMSVISLVLVGTWISLE
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFRYRLSKLLPVAISMLIIPIFISVSRFILNQIPQPSNPYRSQLETQGFVLAKEKAELIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEHHHHHHHC
EPKPLEEAGIWPSMQARGAIRYCIHRQDYPMAYRNAKQELVGADVETGLLFAEDMGMKAS
CCCCHHHCCCCCCHHHCHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHCEEEECCCCCCEE
FIQIDHLGNPNKVRPNGLEALKNGLCDLKLSSDIIVPQESAEVLYTSTNQSYGIGLLLKG
EEEEECCCCCCCCCCCHHHHHHCCCCEEEECCCEECCCCCCCEEEEECCCCCCEEEEEEC
SRFSSKYRWKEIKSIKGFRVGLEAHSPYSINWVQRLLPHAILNTSKGTAELLKELKNDNL
CCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
DAVIISAQKGAAWNVLEPSLALLVPKPTKSLPTARQVPEDALELSRVWNHWLKLQGFDGT
CEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHEECCCCCC
KNKVYQHWVEGIADEEK
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVAGLRWLLWPLSRFLRQSLSMQILEGLLAGVIAGLMLPVAMVSLLAPIGEGFLRLFQMP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VVPFLSISLVAGVGRLELAQASRLLSRAAIVLMGFWVVVLGAVLLIPLGFPDWREASFFR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PSLLEAAQPMNLIELFIPVNPFAAFADTQIPAVVLFSIALGIALISVPKRQGLIEVLDRV
HHHHHHCCCCCHHHEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QSALLKISAYIARYTPLGVFAILASTTSQVSPSEIPRLAIYIVLQGGVAVVLTFLFLPYL
HHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHCCEEEEEEEECCCHHHHHHHHHHHHH
VQAVIPIKAGELIKSFRTPLVIAFSTANLLVVLPLLINQGKQLLIEGMARQRSLGLEDRE
HHHHHCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHH
SRKKLAQSIELPVEVLTPLALVFPDMGRVLSLAFVPFAGWLTGNPLTVEQMPSFLITGLA
HHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHH
STFLEGVLAMTFLLSKMGLPTDMVNLYIALDQLAVARLGTLLACMSVISLVLVGTWISLE
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFRYRLSKLLPVAISMLIIPIFISVSRFILNQIPQPSNPYRSQLETQGFVLAKEKAELIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEHHHHHHHC
EPKPLEEAGIWPSMQARGAIRYCIHRQDYPMAYRNAKQELVGADVETGLLFAEDMGMKAS
CCCCHHHCCCCCCHHHCHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHCEEEECCCCCCEE
FIQIDHLGNPNKVRPNGLEALKNGLCDLKLSSDIIVPQESAEVLYTSTNQSYGIGLLLKG
EEEEECCCCCCCCCCCHHHHHHCCCCEEEECCCEECCCCCCCEEEEECCCCCCEEEEEEC
SRFSSKYRWKEIKSIKGFRVGLEAHSPYSINWVQRLLPHAILNTSKGTAELLKELKNDNL
CCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
DAVIISAQKGAAWNVLEPSLALLVPKPTKSLPTARQVPEDALELSRVWNHWLKLQGFDGT
CEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHEECCCCCC
KNKVYQHWVEGIADEEK
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]