Click here to switch to the map view.

The map label for this gene is yciC [H]

Identifier: 124022823

GI number: 124022823

Start: 998400

End: 999773

Strand: Direct

Name: yciC [H]

Synonym: P9303_11161

Alternate gene names: 124022823

Gene position: 998400-999773 (Clockwise)

Preceding gene: 124022822

Following gene: 124022824

Centisome position: 37.22

GC content: 43.6

Gene sequence:

>1374_bases
ATGACTGTTGACCAAAAAGTGCCAGTAACGATCCTTACCGGATTCCTGGGCTCTGGTAAGACAACGTTGCTGAACCGAAT
TCTCAGCGAAAAGCACGGTAAACGAATCGCTGTGATTGAGAATGAATATGGAGAGGTTGGTATTGATCAGGGCCTTGTCA
TCAATGCTGATGAAGAGGTTTTTGAGATGTCTAATGGCTGCATATGTTGCACAGTGAGAGGAGATTTGATACGCGTACTG
GGAAATCTGATGAAACGTCGAGACAAATTTGACTACGTCTTAGTTGAAACAACAGGCCTAGCAGACCCTGGACCTGTTGC
TCAGACATTTTTTATGGATGATGAAATTCGCGATGAATTCTCTCTTGATGGAATTGTAACACTTGTCGATGCAGCCCATA
TTCAGCAACAACTTGGTCGTAGTCGGGAAAGTTCAGAGCAAGTCGCTTTTGCAGATGTTCTTATTCTGAATAAAACAGAT
CTCGTTAGTCACGACAGTCTTGATGTCCTTGAATCTCGGCTGCGAGACATGAATAGGATGGCCCGTATTGTGAGAAGTGA
AGAAGCTGATGTACCTGTAGATACAGTCTTGAATCTCAGTGCTTTTGACTTGGATCAAGTATTGGCACATCGGCCAACTT
TTCTAGAGCCAGAGTATCCATTCGAATGGACGGGCGTCTTTGATCTTGAGGAAGGTACTTATCATCTCAGTCTCGAAGAA
GGTCCAGATCCCACGATGTCTATTGTTGTTCTCCCGAATCAAGCTACAGATGAGAGATCATTTAGAGAGGGAGCTGAACA
GTGCGTGCGCTTATATGCTCAACCAGCCATCGATTTGGAGCCTGGGCAAACAATCCCTGTTTGTCAGCACGTGAATCTTC
AACTACAAGCTGAGGGTCAAAAGATTTTTCGATTAGAGATCAACCGAACTTGTCAATTAGGGCTATTTACCCAGCATACT
GCCGATGAGTTTGACATTAAAGTTAAGAAGTTTTTACCTGCCTTTAATGATTCTTCTGATCCAATTCCATATCTATCAAC
TACATCCGAACGTGTATGGGTCGCTGAACATGAACACGATGATGAGGTTGGCTCCATTGCGATAGAATGTTCAGGAAATG
TCGATCCTGAAAAGCTCAATCAGTGGATGGGTAAGCTGTTAGTAGAGAAAGGTGTTGATATTTTTAGAACGAAAGGTTTT
ATTAGTTATGAGGGTGATTCGCGTAGGATTGTTTTTCAGGGAGTCCATATGCTGTTCACGGCTCAACCTGATCGTGAATG
GGGGGATGAGCCTCGCCATAATCAACTTGTATTCATTGGGCGAAAACTGGACGAAGAGTCCATGCGTGAGGGATTTGAGC
ATTGTCTAATCTAA

Upstream 100 bases:

>100_bases
CTGAACAAAACGGCTTGGCGCTAACCAGGAATTCTTAAGAATGATAATCATTCTCACGCCTTTGCGTCAAAGGGATTAAG
TTTAGTTTTTATTTTTATGC

Downstream 100 bases:

>100_bases
AAGTTTTCAAGCCTCAAGGAATGCTCCACGAAGGCTGGAGTGCGCAGGTTGATGATTACGCTATGGCCTGTGGCTGGGTT
CATAATGGTGAAGCTTTGTT

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTVDQKVPVTILTGFLGSGKTTLLNRILSEKHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDDEIRDEFSLDGIVTLVDAAHIQQQLGRSRESSEQVAFADVLILNKTD
LVSHDSLDVLESRLRDMNRMARIVRSEEADVPVDTVLNLSAFDLDQVLAHRPTFLEPEYPFEWTGVFDLEEGTYHLSLEE
GPDPTMSIVVLPNQATDERSFREGAEQCVRLYAQPAIDLEPGQTIPVCQHVNLQLQAEGQKIFRLEINRTCQLGLFTQHT
ADEFDIKVKKFLPAFNDSSDPIPYLSTTSERVWVAEHEHDDEVGSIAIECSGNVDPEKLNQWMGKLLVEKGVDIFRTKGF
ISYEGDSRRIVFQGVHMLFTAQPDREWGDEPRHNQLVFIGRKLDEESMREGFEHCLI

Sequences:

>Translated_457_residues
MTVDQKVPVTILTGFLGSGKTTLLNRILSEKHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDDEIRDEFSLDGIVTLVDAAHIQQQLGRSRESSEQVAFADVLILNKTD
LVSHDSLDVLESRLRDMNRMARIVRSEEADVPVDTVLNLSAFDLDQVLAHRPTFLEPEYPFEWTGVFDLEEGTYHLSLEE
GPDPTMSIVVLPNQATDERSFREGAEQCVRLYAQPAIDLEPGQTIPVCQHVNLQLQAEGQKIFRLEINRTCQLGLFTQHT
ADEFDIKVKKFLPAFNDSSDPIPYLSTTSERVWVAEHEHDDEVGSIAIECSGNVDPEKLNQWMGKLLVEKGVDIFRTKGF
ISYEGDSRRIVFQGVHMLFTAQPDREWGDEPRHNQLVFIGRKLDEESMREGFEHCLI
>Mature_456_residues
TVDQKVPVTILTGFLGSGKTTLLNRILSEKHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVLG
NLMKRRDKFDYVLVETTGLADPGPVAQTFFMDDEIRDEFSLDGIVTLVDAAHIQQQLGRSRESSEQVAFADVLILNKTDL
VSHDSLDVLESRLRDMNRMARIVRSEEADVPVDTVLNLSAFDLDQVLAHRPTFLEPEYPFEWTGVFDLEEGTYHLSLEEG
PDPTMSIVVLPNQATDERSFREGAEQCVRLYAQPAIDLEPGQTIPVCQHVNLQLQAEGQKIFRLEINRTCQLGLFTQHTA
DEFDIKVKKFLPAFNDSSDPIPYLSTTSERVWVAEHEHDDEVGSIAIECSGNVDPEKLNQWMGKLLVEKGVDIFRTKGFI
SYEGDSRRIVFQGVHMLFTAQPDREWGDEPRHNQLVFIGRKLDEESMREGFEHCLI

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=224, Percent_Identity=43.3035714285714, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI126722884, Length=224, Percent_Identity=43.75, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI146231952, Length=224, Percent_Identity=43.75, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI148727351, Length=224, Percent_Identity=43.3035714285714, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI223941779, Length=197, Percent_Identity=44.1624365482233, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI223941776, Length=213, Percent_Identity=42.2535211267606, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI119120938, Length=133, Percent_Identity=50.3759398496241, Blast_Score=143, Evalue=4e-34,
Organism=Escherichia coli, GI87082430, Length=213, Percent_Identity=39.906103286385, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788499, Length=185, Percent_Identity=30.8108108108108, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6324356, Length=224, Percent_Identity=33.0357142857143, Blast_Score=142, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 51647; Mature: 51516

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDQKVPVTILTGFLGSGKTTLLNRILSEKHGKRIAVIENEYGEVGIDQGLVINADEEV
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDDEIRDEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHHH
SLDGIVTLVDAAHIQQQLGRSRESSEQVAFADVLILNKTDLVSHDSLDVLESRLRDMNRM
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
ARIVRSEEADVPVDTVLNLSAFDLDQVLAHRPTFLEPEYPFEWTGVFDLEEGTYHLSLEE
HHHHHCCCCCCCHHHHCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEEEECCCEEEEEECC
GPDPTMSIVVLPNQATDERSFREGAEQCVRLYAQPAIDLEPGQTIPVCQHVNLQLQAEGQ
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEECCC
KIFRLEINRTCQLGLFTQHTADEFDIKVKKFLPAFNDSSDPIPYLSTTSERVWVAEHEHD
EEEEEEECCEEEEEEEECCCCCCCCEEHHHHCCCCCCCCCCCCCEECCCCEEEEECCCCC
DEVGSIAIECSGNVDPEKLNQWMGKLLVEKGVDIFRTKGFISYEGDSRRIVFQGVHMLFT
CCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCCEEEEECEEEEEE
AQPDREWGDEPRHNQLVFIGRKLDEESMREGFEHCLI
ECCCHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TVDQKVPVTILTGFLGSGKTTLLNRILSEKHGKRIAVIENEYGEVGIDQGLVINADEEV
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDDEIRDEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHHH
SLDGIVTLVDAAHIQQQLGRSRESSEQVAFADVLILNKTDLVSHDSLDVLESRLRDMNRM
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
ARIVRSEEADVPVDTVLNLSAFDLDQVLAHRPTFLEPEYPFEWTGVFDLEEGTYHLSLEE
HHHHHCCCCCCCHHHHCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEEEECCCEEEEEECC
GPDPTMSIVVLPNQATDERSFREGAEQCVRLYAQPAIDLEPGQTIPVCQHVNLQLQAEGQ
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEECCC
KIFRLEINRTCQLGLFTQHTADEFDIKVKKFLPAFNDSSDPIPYLSTTSERVWVAEHEHD
EEEEEEECCEEEEEEEECCCCCCCCEEHHHHCCCCCCCCCCCCCEECCCCEEEEECCCCC
DEVGSIAIECSGNVDPEKLNQWMGKLLVEKGVDIFRTKGFISYEGDSRRIVFQGVHMLFT
CCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCCEEEEECEEEEEE
AQPDREWGDEPRHNQLVFIGRKLDEESMREGFEHCLI
ECCCHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]