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The map label for this gene is ubiB [C]

Identifier: 124022692

GI number: 124022692

Start: 894820

End: 896514

Strand: Reverse

Name: ubiB [C]

Synonym: P9303_09851

Alternate gene names: 124022692

Gene position: 896514-894820 (Counterclockwise)

Preceding gene: 124022695

Following gene: 124022690

Centisome position: 33.42

GC content: 50.44

Gene sequence:

>1695_bases
TTGAACACCTCCAATCCATCGTCAGCTTCAGCATCCCGCAAAGCCCCGATGCGTTACGACGCGAATCAGGATCTGCTCTG
GTTGCTAGCCAGGCCCTGGGTGTGGATACCTCGATTCATTCATGTGCTCACCTCACTGCTCACATTGGCGGTGAGAGTGC
TGTCTCAGGGCTCTAACAACGACGAAGAGGCACAAAAAAGGCTCGCAAAAAGACTGCTCATCACCCTCACCAACCTCGGG
CCTTGCTTTATCAAGGTGGGCCAAGCCCTTTCCACCCGACCAGACCTAATCAAGCGTGAATGGCTCGAGGAACTCACCAG
CCTTCAAGACAATCTGCCCTCCTTCAACCATGCCACGGCCCTCGCCACATTGGCAGACGATCTTGGGGCTCCAGCTAGTC
AACTCTTTGAAGAGTTTCCTAGCCAACCAATTGCTGCAGCCAGCCTTGGCCAGGTCTACAAAGCTCGCCTACACGGCAAT
CAATGGGTAGCCGTGAAAGTACAACGTCCTCAACTGGCGTTCATCTTGCGCCGCGACCTCGTCATCATCCGCCTTCTCGG
CGTGCTGTCAGCACCAGTGCTCCCACTCAACCTGGGCTTTGGACTAGGCAACATCATTGATGAATTCGGTCGCAGCCTAT
TTGAGGAGATTAATTACGAACAAGAAGCTAACAATGCTGAACGATTTGCGGCTCTTTTCGCCAAAGACCCAACGGTGACG
GTCCCGAGGGTGGAGCGATTGCTGTCATCCCGCCGTGTACTAACCACAAGCTGGATCGAGGGCACGAAGCTACGAGACCG
CAAGGAGTTACAAGCCCAACTTCTTAATCCAACAGCACTGATCAGGACGGCCGTCATCAGCGGTCTTCAGCAACTTTTTG
AGTTCGGCTATTTCCATGCTGATCCTCACCCAGGCAACATTTTTGCCCTCAGTGGTCAAAGTAAAAGGATGGGTCATCTT
GCCTACTGCGATTTCGGCATGATGGATTCAATTAGTGATGACGATCGTCTCACTCTTACTGGAGCAGTAGTTCACCTAAT
CAACAACGATTTCAATGCTCTAGCTAAAGACTTTCAAAAGCTGGGATTCCTTAGTCTAACAAGTGATCTAACGTCAATCA
TACCGGCACTAGAAGAAGTACTTGGTGGCTCTCTTGGTGAATCGGTGGAGTCCTTCAACTTCAAGGCAATCACCGATCGC
TTCTCAGAACTGATGTTCGATTACCCCTTCAGAGTCCCGGCGAGATTTGCCTTGATCATCCGAGCTGTTGTTAGTCAAGA
AGGTCTTGCATTAAGGCTAGATCCAGAGTTCAAGATTATTGGAATTGCCTACCCATATGTGGCCAAACGTCTACTGGCAG
GAGACTCAATGGAGATGCGCGAGAAGCTGATGGAGGTGATTTTCGATAATAATGGGCACCTGCGTCTGGAGCGAATTGAA
AGTTTGCTGAAAGTGATAAACCAAGACGCTGTAGCACCAGATGCAGAACTAATCCCTGTAGCAGGAGCAGGTCTAAAACT
GCTACTTGGCCCAGATGGATCCACTTTGCGTAGTCGTCTACTGATGACATTGATCAAAGATGAGCGTTTAAGCGCATCTG
ATATCAAGGCCTTAATGAGCCTGCTACGGCGAACCTTCAGTCCTCGCAAGGTCGCAAATGGCATGTTGCAAACCCTTACT
CCAAGGACCACCTAA

Upstream 100 bases:

>100_bases
TGCAAGCTGCGACCACGGTCGCGAGTCAACAGGGGAAGAAAGCCCATGAAGGTGAATCGCCGTTTCTAAAGTCTGATGAT
CAACGTGCCCAGGCGGTCTG

Downstream 100 bases:

>100_bases
ACATCGGCACAAAGGATAACAATCGCCAGAGGGAAAGAAGCTACTCCAAGTTACAAGTCTCTGCCATTCATCAATGGTCT
AATTCCACAATAGCTATCTA

Product: kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MNTSNPSSASASRKAPMRYDANQDLLWLLARPWVWIPRFIHVLTSLLTLAVRVLSQGSNNDEEAQKRLAKRLLITLTNLG
PCFIKVGQALSTRPDLIKREWLEELTSLQDNLPSFNHATALATLADDLGAPASQLFEEFPSQPIAAASLGQVYKARLHGN
QWVAVKVQRPQLAFILRRDLVIIRLLGVLSAPVLPLNLGFGLGNIIDEFGRSLFEEINYEQEANNAERFAALFAKDPTVT
VPRVERLLSSRRVLTTSWIEGTKLRDRKELQAQLLNPTALIRTAVISGLQQLFEFGYFHADPHPGNIFALSGQSKRMGHL
AYCDFGMMDSISDDDRLTLTGAVVHLINNDFNALAKDFQKLGFLSLTSDLTSIIPALEEVLGGSLGESVESFNFKAITDR
FSELMFDYPFRVPARFALIIRAVVSQEGLALRLDPEFKIIGIAYPYVAKRLLAGDSMEMREKLMEVIFDNNGHLRLERIE
SLLKVINQDAVAPDAELIPVAGAGLKLLLGPDGSTLRSRLLMTLIKDERLSASDIKALMSLLRRTFSPRKVANGMLQTLT
PRTT

Sequences:

>Translated_564_residues
MNTSNPSSASASRKAPMRYDANQDLLWLLARPWVWIPRFIHVLTSLLTLAVRVLSQGSNNDEEAQKRLAKRLLITLTNLG
PCFIKVGQALSTRPDLIKREWLEELTSLQDNLPSFNHATALATLADDLGAPASQLFEEFPSQPIAAASLGQVYKARLHGN
QWVAVKVQRPQLAFILRRDLVIIRLLGVLSAPVLPLNLGFGLGNIIDEFGRSLFEEINYEQEANNAERFAALFAKDPTVT
VPRVERLLSSRRVLTTSWIEGTKLRDRKELQAQLLNPTALIRTAVISGLQQLFEFGYFHADPHPGNIFALSGQSKRMGHL
AYCDFGMMDSISDDDRLTLTGAVVHLINNDFNALAKDFQKLGFLSLTSDLTSIIPALEEVLGGSLGESVESFNFKAITDR
FSELMFDYPFRVPARFALIIRAVVSQEGLALRLDPEFKIIGIAYPYVAKRLLAGDSMEMREKLMEVIFDNNGHLRLERIE
SLLKVINQDAVAPDAELIPVAGAGLKLLLGPDGSTLRSRLLMTLIKDERLSASDIKALMSLLRRTFSPRKVANGMLQTLT
PRTT
>Mature_564_residues
MNTSNPSSASASRKAPMRYDANQDLLWLLARPWVWIPRFIHVLTSLLTLAVRVLSQGSNNDEEAQKRLAKRLLITLTNLG
PCFIKVGQALSTRPDLIKREWLEELTSLQDNLPSFNHATALATLADDLGAPASQLFEEFPSQPIAAASLGQVYKARLHGN
QWVAVKVQRPQLAFILRRDLVIIRLLGVLSAPVLPLNLGFGLGNIIDEFGRSLFEEINYEQEANNAERFAALFAKDPTVT
VPRVERLLSSRRVLTTSWIEGTKLRDRKELQAQLLNPTALIRTAVISGLQQLFEFGYFHADPHPGNIFALSGQSKRMGHL
AYCDFGMMDSISDDDRLTLTGAVVHLINNDFNALAKDFQKLGFLSLTSDLTSIIPALEEVLGGSLGESVESFNFKAITDR
FSELMFDYPFRVPARFALIIRAVVSQEGLALRLDPEFKIIGIAYPYVAKRLLAGDSMEMREKLMEVIFDNNGHLRLERIE
SLLKVINQDAVAPDAELIPVAGAGLKLLLGPDGSTLRSRLLMTLIKDERLSASDIKALMSLLRRTFSPRKVANGMLQTLT
PRTT

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=277, Percent_Identity=32.4909747292419, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI40254938, Length=297, Percent_Identity=28.2828282828283, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI217035081, Length=279, Percent_Identity=25.8064516129032, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI34147522, Length=262, Percent_Identity=31.6793893129771, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI27363457, Length=245, Percent_Identity=29.7959183673469, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI217416386, Length=206, Percent_Identity=29.6116504854369, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI2367309, Length=389, Percent_Identity=25.706940874036, Blast_Score=138, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17559152, Length=331, Percent_Identity=29.0030211480363, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI32565180, Length=361, Percent_Identity=28.5318559556787, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323282, Length=276, Percent_Identity=29.7101449275362, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=326, Percent_Identity=27.9141104294479, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325148, Length=429, Percent_Identity=22.8438228438228, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24662575, Length=306, Percent_Identity=32.3529411764706, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI22024280, Length=314, Percent_Identity=25.796178343949, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18859849, Length=265, Percent_Identity=32.0754716981132, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62727; Mature: 62727

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSNPSSASASRKAPMRYDANQDLLWLLARPWVWIPRFIHVLTSLLTLAVRVLSQGSNN
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DEEAQKRLAKRLLITLTNLGPCFIKVGQALSTRPDLIKREWLEELTSLQDNLPSFNHATA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
LATLADDLGAPASQLFEEFPSQPIAAASLGQVYKARLHGNQWVAVKVQRPQLAFILRRDL
HHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHH
VIIRLLGVLSAPVLPLNLGFGLGNIIDEFGRSLFEEINYEQEANNAERFAALFAKDPTVT
HHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHCCCCCC
VPRVERLLSSRRVLTTSWIEGTKLRDRKELQAQLLNPTALIRTAVISGLQQLFEFGYFHA
HHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
DPHPGNIFALSGQSKRMGHLAYCDFGMMDSISDDDRLTLTGAVVHLINNDFNALAKDFQK
CCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHHHHHH
LGFLSLTSDLTSIIPALEEVLGGSLGESVESFNFKAITDRFSELMFDYPFRVPARFALII
HCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
RAVVSQEGLALRLDPEFKIIGIAYPYVAKRLLAGDSMEMREKLMEVIFDNNGHLRLERIE
HHHHCCCCCEEEECCCEEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEHHHHH
SLLKVINQDAVAPDAELIPVAGAGLKLLLGPDGSTLRSRLLMTLIKDERLSASDIKALMS
HHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
LLRRTFSPRKVANGMLQTLTPRTT
HHHHCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNTSNPSSASASRKAPMRYDANQDLLWLLARPWVWIPRFIHVLTSLLTLAVRVLSQGSNN
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DEEAQKRLAKRLLITLTNLGPCFIKVGQALSTRPDLIKREWLEELTSLQDNLPSFNHATA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
LATLADDLGAPASQLFEEFPSQPIAAASLGQVYKARLHGNQWVAVKVQRPQLAFILRRDL
HHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHH
VIIRLLGVLSAPVLPLNLGFGLGNIIDEFGRSLFEEINYEQEANNAERFAALFAKDPTVT
HHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHCCCCCC
VPRVERLLSSRRVLTTSWIEGTKLRDRKELQAQLLNPTALIRTAVISGLQQLFEFGYFHA
HHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
DPHPGNIFALSGQSKRMGHLAYCDFGMMDSISDDDRLTLTGAVVHLINNDFNALAKDFQK
CCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHHHHHH
LGFLSLTSDLTSIIPALEEVLGGSLGESVESFNFKAITDRFSELMFDYPFRVPARFALII
HCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
RAVVSQEGLALRLDPEFKIIGIAYPYVAKRLLAGDSMEMREKLMEVIFDNNGHLRLERIE
HHHHCCCCCEEEECCCEEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEHHHHH
SLLKVINQDAVAPDAELIPVAGAGLKLLLGPDGSTLRSRLLMTLIKDERLSASDIKALMS
HHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
LLRRTFSPRKVANGMLQTLTPRTT
HHHHCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]