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The map label for this gene is pphA [C]

Identifier: 124022667

GI number: 124022667

Start: 864114

End: 865142

Strand: Direct

Name: pphA [C]

Synonym: P9303_09581

Alternate gene names: 124022667

Gene position: 864114-865142 (Clockwise)

Preceding gene: 124022665

Following gene: 124022668

Centisome position: 32.21

GC content: 52.58

Gene sequence:

>1029_bases
ATGGTAATCAGGGCCTCTTTCTCCTTCCACCAGATCCAGTCACGGATTGGTGGTGTGGTCATCAAATCTTCCCGGGTGAG
ACCAAGCTCAAGCTGGGCTGCCGCACCTAGAAGGACGTCAATCATGGAGTCTGCATCCTTGCAACGCGCCAAAGCTTCAT
TGGTGCGTTCAGCACCATTGAGGGCTTTAACGAGTAAGTCCACTCGTTTCAGAACCGGCAACGTGCGTGGATCCAAATCA
ACCACTTCAAGACTGTTCACCGTACGCAGTAGCGATGACATATGGCTACTGCCTAGTCAGAATCTTGAAGAGAATGCTGC
TCCGATTGTGAAGTCACCCCGCGAATGTCACTGGGTGATTGGGGATGTCCATGGCTGTTATCAATCCTTGTTGGAGTTAA
TCGCCTTGCTCCCCAGCTCAGACCAGCTCGTGTTTTGTGGAGATGTGATCAATCGAGGGCCGGCTATTGAGGCCACCATG
TTGCTTGCCTGGGAAATGGTCTGTAGCGGTCGTGCTCATTGGTTGCGTGGTAACCATGAACAACACCTGATCGACTGTCT
GGAGCTCGATCCTCAAGATAGCCAGGCTGCTTTGCTGGCGATTGACACTTACCGGCAATTGGGTGATCGACAGGCTCGTG
AGTGGTTAAGCCGCTTGAAAGGGCTTCCTCTTGTTTATAAAGCCAAGGGATGGATTGCGACTCACGCTGGCTTTGGCCTC
GATGGCAATCCTGATTTGAGCATTCGTAAGCGATTCTGGGAGGATTACGACGGTCGCTATGGACGCGTGATCGTTGCTCA
TACCCCTCGTCCCCAGGTGGAGCGCCATCGCCATATTGTGATGATTGATACGGGAGCTTGCTACGGGGGCTTGCTGAGCG
CCTATTGCCCTGAACGCGATGCTGTTGTTCAGGTCTGCGGTGACCGCAAGTTGAATCAGCATCTTGCATGCGATGTCGAC
AAGCTCAAAGAGGTGTTAACTCGAGAGATGACTACCTCATCATCCCTGGTTTCTGCTAAGCCTTGCTGA

Upstream 100 bases:

>100_bases
GAACAATCAGAATCTGAACAACCCTAGAAAGGTGCGACGTCCAGTCGAATTCTCTGCGGAGGCTCGATCGTCCTGTTTGT
AACGGGGCTTGGTTTCACCG

Downstream 100 bases:

>100_bases
CGATCTACCGCAGCAACAGAGCGGAGTGGTTAGCTCGAGTGTTGGCGGAGCAGCTGCGTCTGGCACCACCAGGTCTATTT
GACTCAGTGGATGTCGTGGT

Product: serine/threonine specific protein phosphatase

Products: A Protein; Orthophosphate. [C]

Alternate protein names: Serine/Threonine Specific Protein Phosphatase; Serine/Threonine Protein Phosphatase; Phosphatase; Serine-Threonine Phosphatase

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MVIRASFSFHQIQSRIGGVVIKSSRVRPSSSWAAAPRRTSIMESASLQRAKASLVRSAPLRALTSKSTRFRTGNVRGSKS
TTSRLFTVRSSDDIWLLPSQNLEENAAPIVKSPRECHWVIGDVHGCYQSLLELIALLPSSDQLVFCGDVINRGPAIEATM
LLAWEMVCSGRAHWLRGNHEQHLIDCLELDPQDSQAALLAIDTYRQLGDRQAREWLSRLKGLPLVYKAKGWIATHAGFGL
DGNPDLSIRKRFWEDYDGRYGRVIVAHTPRPQVERHRHIVMIDTGACYGGLLSAYCPERDAVVQVCGDRKLNQHLACDVD
KLKEVLTREMTTSSSLVSAKPC

Sequences:

>Translated_342_residues
MVIRASFSFHQIQSRIGGVVIKSSRVRPSSSWAAAPRRTSIMESASLQRAKASLVRSAPLRALTSKSTRFRTGNVRGSKS
TTSRLFTVRSSDDIWLLPSQNLEENAAPIVKSPRECHWVIGDVHGCYQSLLELIALLPSSDQLVFCGDVINRGPAIEATM
LLAWEMVCSGRAHWLRGNHEQHLIDCLELDPQDSQAALLAIDTYRQLGDRQAREWLSRLKGLPLVYKAKGWIATHAGFGL
DGNPDLSIRKRFWEDYDGRYGRVIVAHTPRPQVERHRHIVMIDTGACYGGLLSAYCPERDAVVQVCGDRKLNQHLACDVD
KLKEVLTREMTTSSSLVSAKPC
>Mature_342_residues
MVIRASFSFHQIQSRIGGVVIKSSRVRPSSSWAAAPRRTSIMESASLQRAKASLVRSAPLRALTSKSTRFRTGNVRGSKS
TTSRLFTVRSSDDIWLLPSQNLEENAAPIVKSPRECHWVIGDVHGCYQSLLELIALLPSSDQLVFCGDVINRGPAIEATM
LLAWEMVCSGRAHWLRGNHEQHLIDCLELDPQDSQAALLAIDTYRQLGDRQAREWLSRLKGLPLVYKAKGWIATHAGFGL
DGNPDLSIRKRFWEDYDGRYGRVIVAHTPRPQVERHRHIVMIDTGACYGGLLSAYCPERDAVVQVCGDRKLNQHLACDVD
KLKEVLTREMTTSSSLVSAKPC

Specific function: Plays A Key Role In Signaling Protein Misfolding Via The Cpxr/Cpxa Transducing System. It Also Modulates The Phosphorylated Status Of Many Phosphoproteins In E. coli, Some Of Which Acting As Major Chaperones. Has Been Shown, In Vitro, To Act On Ser, Thr A

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.3.16 [C]

Molecular weight: Translated: 38128; Mature: 38128

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIRASFSFHQIQSRIGGVVIKSSRVRPSSSWAAAPRRTSIMESASLQRAKASLVRSAPL
CEEECCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
RALTSKSTRFRTGNVRGSKSTTSRLFTVRSSDDIWLLPSQNLEENAAPIVKSPRECHWVI
HHHHCCCCEEEECCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEEE
GDVHGCYQSLLELIALLPSSDQLVFCGDVINRGPAIEATMLLAWEMVCSGRAHWLRGNHE
ECHHHHHHHHHHHHHHCCCCCCEEEECHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCCCH
QHLIDCLELDPQDSQAALLAIDTYRQLGDRQAREWLSRLKGLPLVYKAKGWIATHAGFGL
HHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCC
DGNPDLSIRKRFWEDYDGRYGRVIVAHTPRPQVERHRHIVMIDTGACYGGLLSAYCPERD
CCCCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCEEEEEECCCHHHHHHHHHCCCCH
AVVQVCGDRKLNQHLACDVDKLKEVLTREMTTSSSLVSAKPC
HHHEECCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MVIRASFSFHQIQSRIGGVVIKSSRVRPSSSWAAAPRRTSIMESASLQRAKASLVRSAPL
CEEECCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
RALTSKSTRFRTGNVRGSKSTTSRLFTVRSSDDIWLLPSQNLEENAAPIVKSPRECHWVI
HHHHCCCCEEEECCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEEE
GDVHGCYQSLLELIALLPSSDQLVFCGDVINRGPAIEATMLLAWEMVCSGRAHWLRGNHE
ECHHHHHHHHHHHHHHCCCCCCEEEECHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCCCH
QHLIDCLELDPQDSQAALLAIDTYRQLGDRQAREWLSRLKGLPLVYKAKGWIATHAGFGL
HHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCC
DGNPDLSIRKRFWEDYDGRYGRVIVAHTPRPQVERHRHIVMIDTGACYGGLLSAYCPERD
CCCCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCEEEEEECCCHHHHHHHHHCCCCH
AVVQVCGDRKLNQHLACDVDKLKEVLTREMTTSSSLVSAKPC
HHHEECCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Phosphoprotein; H2O [C]

Specific reaction: A Phosphoprotein + H2O = A Protein + Orthophosphate. [C]

General reaction: Phosphoric ester hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA