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The map label for this gene is acrA [H]

Identifier: 124022579

GI number: 124022579

Start: 790398

End: 791576

Strand: Reverse

Name: acrA [H]

Synonym: P9303_08701

Alternate gene names: 124022579

Gene position: 791576-790398 (Counterclockwise)

Preceding gene: 124022582

Following gene: 124022578

Centisome position: 29.51

GC content: 56.32

Gene sequence:

>1179_bases
ATGGCCAGTACAAAGGCCCCGCCCATATCGGCACATCAGGAGCAGGGATTGGTCCATCTCACACAACTCAAAGGTGCTAA
ACGCCGCCGCAAACTCTGGATAGGCCTCAGTGCAGCTGTCGTGCTGATCACTGCAGGCAGCGTGGCGTGGAGGTTCAGCC
CCCAGCAGCGCTTGGGTCGCGATCTCAGCGACTACACCGTAGAAACCGAGAGGGGCTCACTTCCCGGGATCGTGAGCGCC
AATGGCGAATTGCAGGCGAAGCGGAGCGTGAATGTCAGTCCCAAAAAAGCAGGTTTGCTGGAAGAGCTCTATGTCGATCA
AGGCGACACGGTCAAGAAGGGAGAGGTGCTGGCTCGCATGGATAGTGGCGACTACAACGACCGCTTAGATGAAGCGAAGG
CCCTTGAAAGAAAAGAGCAAGCTGAATACCAAACGAGAAAAGCAGACCATGAGCGGCGCGACAACCTCTACCAACAAGGA
GCCATCTCAGCCGACGACGCGAGCAAATATCGCCGCCTCTACCTGACCAGCCGCGCCAACCTTGCCGCAGCCCAAGAGCG
TGTTCAACAACGCATTACTGAAGGGAGGGAACTTCTGATCAGAGCACCCTTCAGTGGTGTGATCACAGCCCGTTATGCGG
AGCCAGGAGCCTTTGTGACCCCAACAACAGCAGCCTCTGCAACTGCCGGAGCCAGCAGCTCCTCCCTTGTTGAGCTCTCA
GAAGGAATGGAGGTCAACGCCAAAGTGCCCGAAAGTGACATCGGCCGCATCCGCATCGGCCAAAATGCCAGTGTGCGTGT
TGACGCCTTCCCAGAACAACGTTTTATGGCCCGGGTCAGCGAAATCGCTCCCAGGGCAGCAAAAACTGAGAATGTCATCT
CTTTCGCAGTCAAGCTCAACCTGATCAAGCGTTCCCCCCAACTGCTGATAGGCATGTCCGCAGACGTGGATTTTCAAACG
GGCAAGACTGCACCCAGCACGTTGGTTCCCACCGTGGCGATTGTGACTGAAAAGGGCAAACCTGGAGTGCTTCTGGTGGG
CCAAAAAAATCAACCACGCTTTCAAGCGGTGGAACTAGGCACCAGTAGTGGCAGCAAAACAGCCATCCTGAGCGGGCTCA
ATCCCGGCACGCGAATTTTTATCGATCTGCCCCCATGGGCCAAACCAAAACGCGACTGA

Upstream 100 bases:

>100_bases
CCGCAAAACAACGCTAAAGACACTTAGCAGTTACGTGATCGTGCCTTGCTGCAGTCAGGCACGCTGACCAGCGAGACTGC
TGGACATCGTTGGTGGGTTG

Downstream 100 bases:

>100_bases
TGCCAACCCCCATCAATCCGCCCCATGCCTGAGGCTGCTAACAAGCCACTGTTGCTGCTGGTGGATGGCCACTCGCTGGC
CTTCCGCAGCTTTTATGCCT

Product: membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MASTKAPPISAHQEQGLVHLTQLKGAKRRRKLWIGLSAAVVLITAGSVAWRFSPQQRLGRDLSDYTVETERGSLPGIVSA
NGELQAKRSVNVSPKKAGLLEELYVDQGDTVKKGEVLARMDSGDYNDRLDEAKALERKEQAEYQTRKADHERRDNLYQQG
AISADDASKYRRLYLTSRANLAAAQERVQQRITEGRELLIRAPFSGVITARYAEPGAFVTPTTAASATAGASSSSLVELS
EGMEVNAKVPESDIGRIRIGQNASVRVDAFPEQRFMARVSEIAPRAAKTENVISFAVKLNLIKRSPQLLIGMSADVDFQT
GKTAPSTLVPTVAIVTEKGKPGVLLVGQKNQPRFQAVELGTSSGSKTAILSGLNPGTRIFIDLPPWAKPKRD

Sequences:

>Translated_392_residues
MASTKAPPISAHQEQGLVHLTQLKGAKRRRKLWIGLSAAVVLITAGSVAWRFSPQQRLGRDLSDYTVETERGSLPGIVSA
NGELQAKRSVNVSPKKAGLLEELYVDQGDTVKKGEVLARMDSGDYNDRLDEAKALERKEQAEYQTRKADHERRDNLYQQG
AISADDASKYRRLYLTSRANLAAAQERVQQRITEGRELLIRAPFSGVITARYAEPGAFVTPTTAASATAGASSSSLVELS
EGMEVNAKVPESDIGRIRIGQNASVRVDAFPEQRFMARVSEIAPRAAKTENVISFAVKLNLIKRSPQLLIGMSADVDFQT
GKTAPSTLVPTVAIVTEKGKPGVLLVGQKNQPRFQAVELGTSSGSKTAILSGLNPGTRIFIDLPPWAKPKRD
>Mature_391_residues
ASTKAPPISAHQEQGLVHLTQLKGAKRRRKLWIGLSAAVVLITAGSVAWRFSPQQRLGRDLSDYTVETERGSLPGIVSAN
GELQAKRSVNVSPKKAGLLEELYVDQGDTVKKGEVLARMDSGDYNDRLDEAKALERKEQAEYQTRKADHERRDNLYQQGA
ISADDASKYRRLYLTSRANLAAAQERVQQRITEGRELLIRAPFSGVITARYAEPGAFVTPTTAASATAGASSSSLVELSE
GMEVNAKVPESDIGRIRIGQNASVRVDAFPEQRFMARVSEIAPRAAKTENVISFAVKLNLIKRSPQLLIGMSADVDFQTG
KTAPSTLVPTVAIVTEKGKPGVLLVGQKNQPRFQAVELGTSSGSKTAILSGLNPGTRIFIDLPPWAKPKRD

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=374, Percent_Identity=23.7967914438503, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42558; Mature: 42427

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTKAPPISAHQEQGLVHLTQLKGAKRRRKLWIGLSAAVVLITAGSVAWRFSPQQRLGR
CCCCCCCCCCCHHHCCCEEEEHHCCCHHHHEEEEEHEEEEEEEECCCEEEEECCHHHHCC
DLSDYTVETERGSLPGIVSANGELQAKRSVNVSPKKAGLLEELYVDQGDTVKKGEVLARM
CHHHCEEECCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEE
DSGDYNDRLDEAKALERKEQAEYQTRKADHERRDNLYQQGAISADDASKYRRLYLTSRAN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCH
LAAAQERVQQRITEGRELLIRAPFSGVITARYAEPGAFVTPTTAASATAGASSSSLVELS
HHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCEEECC
EGMEVNAKVPESDIGRIRIGQNASVRVDAFPEQRFMARVSEIAPRAAKTENVISFAVKLN
CCCEEECCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHEEEEEEEE
LIKRSPQLLIGMSADVDFQTGKTAPSTLVPTVAIVTEKGKPGVLLVGQKNQPRFQAVELG
EHHCCCCEEEEECCCCCCCCCCCCCCHHCCEEEEEEECCCCCEEEEECCCCCCEEEEEEC
TSSGSKTAILSGLNPGTRIFIDLPPWAKPKRD
CCCCCCEEEEECCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
ASTKAPPISAHQEQGLVHLTQLKGAKRRRKLWIGLSAAVVLITAGSVAWRFSPQQRLGR
CCCCCCCCCCHHHCCCEEEEHHCCCHHHHEEEEEHEEEEEEEECCCEEEEECCHHHHCC
DLSDYTVETERGSLPGIVSANGELQAKRSVNVSPKKAGLLEELYVDQGDTVKKGEVLARM
CHHHCEEECCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEE
DSGDYNDRLDEAKALERKEQAEYQTRKADHERRDNLYQQGAISADDASKYRRLYLTSRAN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCH
LAAAQERVQQRITEGRELLIRAPFSGVITARYAEPGAFVTPTTAASATAGASSSSLVELS
HHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCEEECC
EGMEVNAKVPESDIGRIRIGQNASVRVDAFPEQRFMARVSEIAPRAAKTENVISFAVKLN
CCCEEECCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHEEEEEEEE
LIKRSPQLLIGMSADVDFQTGKTAPSTLVPTVAIVTEKGKPGVLLVGQKNQPRFQAVELG
EHHCCCCEEEEECCCCCCCCCCCCCCHHCCEEEEEEECCCCCEEEEECCCCCCEEEEEEC
TSSGSKTAILSGLNPGTRIFIDLPPWAKPKRD
CCCCCCEEEEECCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]