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The map label for this gene is ppiA [C]

Identifier: 124022555

GI number: 124022555

Start: 767631

End: 768335

Strand: Direct

Name: ppiA [C]

Synonym: P9303_08461

Alternate gene names: 124022555

Gene position: 767631-768335 (Clockwise)

Preceding gene: 124022554

Following gene: 124022558

Centisome position: 28.61

GC content: 51.49

Gene sequence:

>705_bases
GTGTTGCTCTCATCTCTTGCGCGTTTGATTCGGCGTCAAGACATCTGGGGAATTCTGCTTTGTGTGCCCTTATTGGTTGG
CTGCAGCAAGTCCACTACGGCATCGATCAAGGCGGTTTGTTCCTCGCTGACTAGCCCCTGCTTGCAGGGCAAAGCAAATG
TGCTGATGAGTACGAATCGAGGCGCAATCACCCTTGAGGTGGATGGTGATGCTGCTCCTGTTACCGCAGGTAATTTTGTC
GATCTTGTTAAACGTGGTGTCTATAACGGCACCGTTTTTCATCGGGTCGTGAAAGAGCCCGTTTCCTTTGTTGTTCAGGG
TGGTGATCCTGCTTCAAAGGACCCTAAGACGCTCAAGACCAATTACGGGAAGGGTAGTTTCATCGATCCCGCCAGTGCTC
AGGCCCGCTTCATTCCCTTTGAAGTGAAGTTGAAAACAGATGACCAGCCTCGCTATGGAAAGTTGATCACCAACCCCAGA
GAGTTGCTGCAATTGCAATTGACTCATAAGAAAGGGGCCCTGGCTATGGCTCGTTCTCCGGCGCCGGATTCAGCCAGTGC
TCAGTTTTACATTGCTTTGCGCCCTTTGCCCGAACTTGATGGCCGTTATGCCGTTTTCGGCAGGGTGATCAAGGGGTTGG
AGGTGGTGGATGCGATTCAGCAGGGTGATCGTATTTTTAAGGCCAGCCTGCTAATGGCGAAATAA

Upstream 100 bases:

>100_bases
TCTTACCCGCGTCGGTCAGCCTCTCCCCCTCGCACAGTTAGAACAGGATGGTGCTGAGCTAGCGCGTTTTCTTGACGTGA
ATCTTGAAGGGCTCTGAATT

Downstream 100 bases:

>100_bases
AAACCCTTAATGCATTGCCAATCACTTAGGCCGGTATTCGGCTGCCGCTGGGAGAGACCTTTAAGAGTTCGGTGTTTACC
CCTGAGGCCCTTTCCAGAGC

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase sll0227; Rotamase sll0227 [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MLLSSLARLIRRQDIWGILLCVPLLVGCSKSTTASIKAVCSSLTSPCLQGKANVLMSTNRGAITLEVDGDAAPVTAGNFV
DLVKRGVYNGTVFHRVVKEPVSFVVQGGDPASKDPKTLKTNYGKGSFIDPASAQARFIPFEVKLKTDDQPRYGKLITNPR
ELLQLQLTHKKGALAMARSPAPDSASAQFYIALRPLPELDGRYAVFGRVIKGLEVVDAIQQGDRIFKASLLMAK

Sequences:

>Translated_234_residues
MLLSSLARLIRRQDIWGILLCVPLLVGCSKSTTASIKAVCSSLTSPCLQGKANVLMSTNRGAITLEVDGDAAPVTAGNFV
DLVKRGVYNGTVFHRVVKEPVSFVVQGGDPASKDPKTLKTNYGKGSFIDPASAQARFIPFEVKLKTDDQPRYGKLITNPR
ELLQLQLTHKKGALAMARSPAPDSASAQFYIALRPLPELDGRYAVFGRVIKGLEVVDAIQQGDRIFKASLLMAK
>Mature_234_residues
MLLSSLARLIRRQDIWGILLCVPLLVGCSKSTTASIKAVCSSLTSPCLQGKANVLMSTNRGAITLEVDGDAAPVTAGNFV
DLVKRGVYNGTVFHRVVKEPVSFVVQGGDPASKDPKTLKTNYGKGSFIDPASAQARFIPFEVKLKTDDQPRYGKLITNPR
ELLQLQLTHKKGALAMARSPAPDSASAQFYIALRPLPELDGRYAVFGRVIKGLEVVDAIQQGDRIFKASLLMAK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=167, Percent_Identity=35.9281437125749, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1789763, Length=201, Percent_Identity=33.8308457711443, Blast_Score=88, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 25270; Mature: 25270

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSSLARLIRRQDIWGILLCVPLLVGCSKSTTASIKAVCSSLTSPCLQGKANVLMSTNR
CCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
GAITLEVDGDAAPVTAGNFVDLVKRGVYNGTVFHRVVKEPVSFVVQGGDPASKDPKTLKT
CEEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCEEC
NYGKGSFIDPASAQARFIPFEVKLKTDDQPRYGKLITNPRELLQLQLTHKKGALAMARSP
CCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHEEHCCCCCCCEEEECCC
APDSASAQFYIALRPLPELDGRYAVFGRVIKGLEVVDAIQQGDRIFKASLLMAK
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MLLSSLARLIRRQDIWGILLCVPLLVGCSKSTTASIKAVCSSLTSPCLQGKANVLMSTNR
CCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
GAITLEVDGDAAPVTAGNFVDLVKRGVYNGTVFHRVVKEPVSFVVQGGDPASKDPKTLKT
CEEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCEEC
NYGKGSFIDPASAQARFIPFEVKLKTDDQPRYGKLITNPRELLQLQLTHKKGALAMARSP
CCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHEEHCCCCCCCEEEECCC
APDSASAQFYIALRPLPELDGRYAVFGRVIKGLEVVDAIQQGDRIFKASLLMAK
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]