Click here to switch to the map view.

The map label for this gene is hisG

Identifier: 124022532

GI number: 124022532

Start: 748007

End: 748660

Strand: Direct

Name: hisG

Synonym: P9303_08231

Alternate gene names: 124022532

Gene position: 748007-748660 (Clockwise)

Preceding gene: 124022530

Following gene: 124022533

Centisome position: 27.88

GC content: 52.75

Gene sequence:

>654_bases
ATGATCACTGTCGCGCTTGCAAAAGGAGCTTTGCTGAATGATTCGGTTGCTCGTTTTCAATCTGCTGGGTTGGATTTTTC
AGCTGTACTTGATCCAGGCAATCGTCAGTTAATGGTGCCTTCCCATTGTGGCCGGGCCCGGGCACTGTTGGTGCGCAACG
GGGATGTGCCCGTTTATGTTGCCTATGGTCAGGCCCAGTTGGGAGTTGTTGGTTACGACGTGCTGCGGGAGCATCAGATG
CCCGTTGCCCAGTTGGTTGATCTTGGCTTCGGGGGCTGCCGTATGGCTGTGGCAGTGAAGGCCAGTAGTGGCTATCAGCA
CGCAGCTGATCTGCCTCCCCATTGTCGAGTTGCTAGCAAGTTTACCCATTGTGCTCGAGAATTTTTCGATGCTCTCGATC
TGCCTGTAGAGCTTGTTCACCTGACCGGTTCGGTAGAACTTGGCCCTTTAACAGGCATTGCTGAAGCGATAGTCGATCTG
GTCGCGACAGGCCGTACCCTTCGCGACAATGGATTAGTGGCCATTGAGGAGCTATTTCAGTCTTCGGCTCGCTTGATCGG
TCATCCATTGGCCTTGAGGTTGGACCGTGGAGATCTTCAGTTGATTGTGGAGGCTATGCGCATTCAGGAATCATTACCTA
AAAATCCAGCTTGA

Upstream 100 bases:

>100_bases
TGAAGAACAGGAAGGGCATGGATCGATGAACGTTGTTTATCGCTAGTCGCAGCTGTTGAGGTTGCCTCCATCGTTAAAGT
CCAGGTCGACGCATCGCTCC

Downstream 100 bases:

>100_bases
TGGCTGTTACTGATTTTCAGCGGGTTCGGCGTCTGGGGCGTTATCTCCGTGAGGACCGTCGGCGTTTATGGATCGTCCTG
TCTCTCTTGGTGCCGCTAGC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MITVALAKGALLNDSVARFQSAGLDFSAVLDPGNRQLMVPSHCGRARALLVRNGDVPVYVAYGQAQLGVVGYDVLREHQM
PVAQLVDLGFGGCRMAVAVKASSGYQHAADLPPHCRVASKFTHCAREFFDALDLPVELVHLTGSVELGPLTGIAEAIVDL
VATGRTLRDNGLVAIEELFQSSARLIGHPLALRLDRGDLQLIVEAMRIQESLPKNPA

Sequences:

>Translated_217_residues
MITVALAKGALLNDSVARFQSAGLDFSAVLDPGNRQLMVPSHCGRARALLVRNGDVPVYVAYGQAQLGVVGYDVLREHQM
PVAQLVDLGFGGCRMAVAVKASSGYQHAADLPPHCRVASKFTHCAREFFDALDLPVELVHLTGSVELGPLTGIAEAIVDL
VATGRTLRDNGLVAIEELFQSSARLIGHPLALRLDRGDLQLIVEAMRIQESLPKNPA
>Mature_217_residues
MITVALAKGALLNDSVARFQSAGLDFSAVLDPGNRQLMVPSHCGRARALLVRNGDVPVYVAYGQAQLGVVGYDVLREHQM
PVAQLVDLGFGGCRMAVAVKASSGYQHAADLPPHCRVASKFTHCAREFFDALDLPVELVHLTGSVELGPLTGIAEAIVDL
VATGRTLRDNGLVAIEELFQSSARLIGHPLALRLDRGDLQLIVEAMRIQESLPKNPA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=147, Percent_Identity=34.6938775510204, Blast_Score=83, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320896, Length=138, Percent_Identity=35.5072463768116, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_PROMM (Q7V6G9)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895023.1
- ProteinModelPortal:   Q7V6G9
- SMR:   Q7V6G9
- STRING:   Q7V6G9
- GeneID:   1728986
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT1193
- NMPDR:   fig|74547.1.peg.1190
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   PMAR74547:PMT1193-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23198; Mature: 23198

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR; PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVALAKGALLNDSVARFQSAGLDFSAVLDPGNRQLMVPSHCGRARALLVRNGDVPVYV
CEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCEEEEEEECCCEEEEE
AYGQAQLGVVGYDVLREHQMPVAQLVDLGFGGCRMAVAVKASSGYQHAADLPPHCRVASK
EECCEEECHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHH
FTHCAREFFDALDLPVELVHLTGSVELGPLTGIAEAIVDLVATGRTLRDNGLVAIEELFQ
HHHHHHHHHHHHCCCEEEEEEECCEEECCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHH
SSARLIGHPLALRLDRGDLQLIVEAMRIQESLPKNPA
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MITVALAKGALLNDSVARFQSAGLDFSAVLDPGNRQLMVPSHCGRARALLVRNGDVPVYV
CEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCEEEEEEECCCEEEEE
AYGQAQLGVVGYDVLREHQMPVAQLVDLGFGGCRMAVAVKASSGYQHAADLPPHCRVASK
EECCEEECHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHH
FTHCAREFFDALDLPVELVHLTGSVELGPLTGIAEAIVDLVATGRTLRDNGLVAIEELFQ
HHHHHHHHHHHHCCCEEEEEEECCEEECCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHH
SSARLIGHPLALRLDRGDLQLIVEAMRIQESLPKNPA
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642