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The map label for this gene is cobK [H]

Identifier: 124022447

GI number: 124022447

Start: 680734

End: 681555

Strand: Direct

Name: cobK [H]

Synonym: P9303_07381

Alternate gene names: 124022447

Gene position: 680734-681555 (Clockwise)

Preceding gene: 124022445

Following gene: 124022449

Centisome position: 25.38

GC content: 57.79

Gene sequence:

>822_bases
ATGCAAGCTTGCAGGAATGACCAGCGGCATGTCTGGTTGCTATCTGGGACTGGTGAAGGGCCTGTTTTGGTGGCCGCTTT
GGTGGCTCAGGGATGGCGAGTCAGTGTCAGTGTCGTCAGTGCTAGCGCCGCAGGGGCCTACGCAGGTCTGTCCTTGGAAG
ATCTTTGGACGGGTCCCCTCGACGGAGTGGAAGGAATTCTTGGGGTGCTTGATCAGGCTCGTGATCGCCATCAAGGCTTT
GATTGGGTGGTGGATGCGACCCATCCCTTTGCGGTGAAGATCAGTACGGATCTGCAGCGTGCCTGTCAGGAATTTGCTCA
GCCTTTGTTGCGCTTTGAGCGTCCCATGGAGGGTTGTGGAGAAGCATCCCTGATCGGGAGCTCGGCTGATTTGGCAAGGC
AAACATTGCAAGGAAGTCGATTGTTGATGGCTCTTGGGGCAAGGCATCTTGGCCAGGCTGTTAGGGCAGCTCGTCAGGCT
GGAGCTCAAGTGTTTGCCCGTGTGCTTCCTTCGCCGGAAAGTCTTCGACATGCGTTGGCGAGTGGCTTGCCAGAGCACCA
TCTGGCTGTGGTGCGTCCGCTGCAGGGGCAATCTCATGGCGAATTGGAGTCAGCCTTGTGCCGGCGCTGGTCGATTACAG
CAGTGGTTTGCAGGCAGTCGGGGGGGGTGACGGAGCAGCTCTGGCACAAGATCTGTCGGCAGCAGGGTCTTGGCCTTTGG
TTGATCTCCCGGCCACAGCCCTGCGTTGCAGTAGAAGCCATCGGTAGCGTTAAGAGCCTGCTCAATCGGCTCTCAACCAA
TCCATTAGCTCCACTTTGCTGA

Upstream 100 bases:

>100_bases
GTTTGGTTGTCTTGGGTATAACGAATGGTTGGTGCCTGGATCACTTCCACTTCAAGTACGCAGTGGTTCATGTCCTTCCC
TTGGAGTGAAAGTCATTTTG

Downstream 100 bases:

>100_bases
CGTTCTTCGCAAAGGTCTTCATGGTTGATCGAGGATCCTCATCGACATTGGTTTTGGTGTTGACCACAGAGGCAAACACA
AAGCTGGCCGAGGGATTGGC

Product: precorrin-6X reductase

Products: Precorrin 6A; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MQACRNDQRHVWLLSGTGEGPVLVAALVAQGWRVSVSVVSASAAGAYAGLSLEDLWTGPLDGVEGILGVLDQARDRHQGF
DWVVDATHPFAVKISTDLQRACQEFAQPLLRFERPMEGCGEASLIGSSADLARQTLQGSRLLMALGARHLGQAVRAARQA
GAQVFARVLPSPESLRHALASGLPEHHLAVVRPLQGQSHGELESALCRRWSITAVVCRQSGGVTEQLWHKICRQQGLGLW
LISRPQPCVAVEAIGSVKSLLNRLSTNPLAPLC

Sequences:

>Translated_273_residues
MQACRNDQRHVWLLSGTGEGPVLVAALVAQGWRVSVSVVSASAAGAYAGLSLEDLWTGPLDGVEGILGVLDQARDRHQGF
DWVVDATHPFAVKISTDLQRACQEFAQPLLRFERPMEGCGEASLIGSSADLARQTLQGSRLLMALGARHLGQAVRAARQA
GAQVFARVLPSPESLRHALASGLPEHHLAVVRPLQGQSHGELESALCRRWSITAVVCRQSGGVTEQLWHKICRQQGLGLW
LISRPQPCVAVEAIGSVKSLLNRLSTNPLAPLC
>Mature_273_residues
MQACRNDQRHVWLLSGTGEGPVLVAALVAQGWRVSVSVVSASAAGAYAGLSLEDLWTGPLDGVEGILGVLDQARDRHQGF
DWVVDATHPFAVKISTDLQRACQEFAQPLLRFERPMEGCGEASLIGSSADLARQTLQGSRLLMALGARHLGQAVRAARQA
GAQVFARVLPSPESLRHALASGLPEHHLAVVRPLQGQSHGELESALCRRWSITAVVCRQSGGVTEQLWHKICRQQGLGLW
LISRPQPCVAVEAIGSVKSLLNRLSTNPLAPLC

Specific function: Catalyzes the reduction of the macrocycle of cobalt- precorrin-6X into cobalt-precorrin-6Y [H]

COG id: COG2099

COG function: function code H; Precorrin-6x reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin-6x reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003723 [H]

Pfam domain/function: PF02571 CbiJ [H]

EC number: 1.3.1.54

Molecular weight: Translated: 29288; Mature: 29288

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS51014 COBK_CBIJ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQACRNDQRHVWLLSGTGEGPVLVAALVAQGWRVSVSVVSASAAGAYAGLSLEDLWTGPL
CCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCCHHCCCCHHHHCCCCC
DGVEGILGVLDQARDRHQGFDWVVDATHPFAVKISTDLQRACQEFAQPLLRFERPMEGCG
HHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCHHCCC
EASLIGSSADLARQTLQGSRLLMALGARHLGQAVRAARQAGAQVFARVLPSPESLRHALA
CCHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SGLPEHHLAVVRPLQGQSHGELESALCRRWSITAVVCRQSGGVTEQLWHKICRQQGLGLW
HCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHCCCCEE
LISRPQPCVAVEAIGSVKSLLNRLSTNPLAPLC
EECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQACRNDQRHVWLLSGTGEGPVLVAALVAQGWRVSVSVVSASAAGAYAGLSLEDLWTGPL
CCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCCHHCCCCHHHHCCCCC
DGVEGILGVLDQARDRHQGFDWVVDATHPFAVKISTDLQRACQEFAQPLLRFERPMEGCG
HHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCHHCCC
EASLIGSSADLARQTLQGSRLLMALGARHLGQAVRAARQAGAQVFARVLPSPESLRHALA
CCHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SGLPEHHLAVVRPLQGQSHGELESALCRRWSITAVVCRQSGGVTEQLWHKICRQQGLGLW
HCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHCCCCEE
LISRPQPCVAVEAIGSVKSLLNRLSTNPLAPLC
EECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 6B; NADP+

Specific reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]