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The map label for this gene is groEL [H]

Identifier: 124022360

GI number: 124022360

Start: 612102

End: 613796

Strand: Reverse

Name: groEL [H]

Synonym: P9303_06501

Alternate gene names: 124022360

Gene position: 613796-612102 (Counterclockwise)

Preceding gene: 124022362

Following gene: 124022358

Centisome position: 22.88

GC content: 55.75

Gene sequence:

>1695_bases
ATGGCCAAACTCCTCAGTTTTTCAGATGACTCCCGCAGTGCGCTTGAGCGCGGTGTCAATTCCCTAGCCGATGCCGTGCG
CGTCACCATCGGCCCCCGTGGCCGCAACGTGGTGCTTGAGAAAAAATTTGGCGCCCCAGACATCGTTAATGACGGCGTCA
CCATCGCCAAAGAGATCGAACTTGACGATCCATTTGAAAACCTTGGTGCCAAGCTGATTCAACAGGTCGCATCCAAGACA
AAAGACAAGGCAGGGGATGGCACCACAACCGCCACCGTGCTTGCCCAAGCGATGGTGCATGAAGGCTTACGCAATGTGGC
CGCTGGCGCGAGTCCAATCGAACTGCGTCGTGGCATGGAAAAGGCCGTGGCCCAATTGGTAGAAGAGCTTGCCCAGCTCA
GTCAAGCTGTTGGAGGTAATGCCATCCATCAGGTCGCCACTGTTAGCTCAGGGGGAGACCAGGAAGTGGGCCGGATGGTG
TCTGAAGCCATGGACAAAGTAAGCGCCGATGGTGTGATCACCGTTGAGGAATCCAAATCTCTCGCCACTGAACTAGAAGT
CACTGAAGGCATGGCCTTCGACCGCGGTTACAGCTCCCCTTACTTTGTTACCGATGCAGACCGTCAGATCTGCGAATTTG
AGAATGCCCTGCTGTTGCTCACAGACCGCAAGATCAGTTCAGTTTCCGATCTTGTGCCCATCTTGGAAAGCCTGCAGAAA
AGTGGCTCCCCTCTCGTCATCATTGCTGAGGAGGTAGAGGGTGAGGCCCTTGCCACCCTGGTCGTCAACAAAAACAGAGG
TGTCTTGCAGGTAGCAGCTGTTCGTGCACCATCCTTCGGAGATCGCCGCAAAGCTGCCCTGGCCGACATCGCAGTTCTAA
CTGGTGGAACTGTCATTAGTGAAGACCGCGCCATGACCCTTGAGAAAGTCAGCCAAGACGATCTAGGGCAGGTCCGACGA
ATCACAATCAGCAAAGACAACACCACTATTGTCGCCAAGGATGAGAACCGCGATGCCGTGAATGCCCGCGTGGCCTCTAT
CAAAAGAGAATTAGATGAAACTGACTCCGAATACGACCGCGAGAAACTCAATGAACGCATTGCCAAGCTGGCCGGTGGTG
TAGCCGTCATCAAGGTTGGGGCCCCTACCGAAACGGAACTCAAAAACCGCAAGCTGCGCATTGAGGATGCGCTCAACGCC
ACCCGTGCTGCAGTTGAAGAGGGGATTGTGGCAGGTGGTGGCACCACGCTCCTGCGATTAAGCAAAGGGCTGAGAAAACT
GGCCGAACAGCAGCTCAACGGCGATCAACGCACCGGCGTAGAAATTGTGCAGCGAGCACTCTCCGCACCTGCACGCCAGA
TTGCCATCAATGCTGGCGAGAATGGTGATGTAGTGATCTCTGAGATGCAACGCCTTAACAAGGGCTTTAACGCCATCTCC
AGCACCTACGAAGACCTTTTGGGAGCAGGCATTCTCGATGCCACCAAGGTGGTGCGCCTGGCACTTCAGGACGCAGTCTC
AATCGCTTCGATGATGGTGACCACAGAGCTCGTGATTGCAGACAAACCCGAGCCTCCTGCTCCCGCCGGCGATGGCGGTG
GTGACCCGATGGGTGGCATGGGTGGCATGGGTGGCATGGGTGGAATGGGTGGCATGGGTGGAATGGGTGGAATGGGAATG
CCAGGCATGATGTAG

Upstream 100 bases:

>100_bases
AAGCACACCCATAACAGCAAGGATTCGGCTTTCCCCACTTATGCCCCCTCGCCCGCAGTGAACGTCCTATGGGACATTGA
CGGACGGGTACCAGCAGACC

Downstream 100 bases:

>100_bases
TCCGGCCCCAAAGCTTTTCCTAGGGCTAGAAAAAGAACGCCGCCACAACGCATGGACAAGTCTCATGCGTTGTGCATCTG
CATCTGCCTGGACAAGTCAC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MAKLLSFSDDSRSALERGVNSLADAVRVTIGPRGRNVVLEKKFGAPDIVNDGVTIAKEIELDDPFENLGAKLIQQVASKT
KDKAGDGTTTATVLAQAMVHEGLRNVAAGASPIELRRGMEKAVAQLVEELAQLSQAVGGNAIHQVATVSSGGDQEVGRMV
SEAMDKVSADGVITVEESKSLATELEVTEGMAFDRGYSSPYFVTDADRQICEFENALLLLTDRKISSVSDLVPILESLQK
SGSPLVIIAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGDRRKAALADIAVLTGGTVISEDRAMTLEKVSQDDLGQVRR
ITISKDNTTIVAKDENRDAVNARVASIKRELDETDSEYDREKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNA
TRAAVEEGIVAGGGTTLLRLSKGLRKLAEQQLNGDQRTGVEIVQRALSAPARQIAINAGENGDVVISEMQRLNKGFNAIS
STYEDLLGAGILDATKVVRLALQDAVSIASMMVTTELVIADKPEPPAPAGDGGGDPMGGMGGMGGMGGMGGMGGMGGMGM
PGMM

Sequences:

>Translated_564_residues
MAKLLSFSDDSRSALERGVNSLADAVRVTIGPRGRNVVLEKKFGAPDIVNDGVTIAKEIELDDPFENLGAKLIQQVASKT
KDKAGDGTTTATVLAQAMVHEGLRNVAAGASPIELRRGMEKAVAQLVEELAQLSQAVGGNAIHQVATVSSGGDQEVGRMV
SEAMDKVSADGVITVEESKSLATELEVTEGMAFDRGYSSPYFVTDADRQICEFENALLLLTDRKISSVSDLVPILESLQK
SGSPLVIIAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGDRRKAALADIAVLTGGTVISEDRAMTLEKVSQDDLGQVRR
ITISKDNTTIVAKDENRDAVNARVASIKRELDETDSEYDREKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNA
TRAAVEEGIVAGGGTTLLRLSKGLRKLAEQQLNGDQRTGVEIVQRALSAPARQIAINAGENGDVVISEMQRLNKGFNAIS
STYEDLLGAGILDATKVVRLALQDAVSIASMMVTTELVIADKPEPPAPAGDGGGDPMGGMGGMGGMGGMGGMGGMGGMGM
PGMM
>Mature_563_residues
AKLLSFSDDSRSALERGVNSLADAVRVTIGPRGRNVVLEKKFGAPDIVNDGVTIAKEIELDDPFENLGAKLIQQVASKTK
DKAGDGTTTATVLAQAMVHEGLRNVAAGASPIELRRGMEKAVAQLVEELAQLSQAVGGNAIHQVATVSSGGDQEVGRMVS
EAMDKVSADGVITVEESKSLATELEVTEGMAFDRGYSSPYFVTDADRQICEFENALLLLTDRKISSVSDLVPILESLQKS
GSPLVIIAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGDRRKAALADIAVLTGGTVISEDRAMTLEKVSQDDLGQVRRI
TISKDNTTIVAKDENRDAVNARVASIKRELDETDSEYDREKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNAT
RAAVEEGIVAGGGTTLLRLSKGLRKLAEQQLNGDQRTGVEIVQRALSAPARQIAINAGENGDVVISEMQRLNKGFNAISS
TYEDLLGAGILDATKVVRLALQDAVSIASMMVTTELVIADKPEPPAPAGDGGGDPMGGMGGMGGMGGMGGMGGMGGMGMP
GMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=47.3484848484849, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=47.3484848484849, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI24307939, Length=358, Percent_Identity=24.0223463687151, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=55.5765595463138, Blast_Score=572, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17555558, Length=532, Percent_Identity=47.9323308270677, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=42.9245283018868, Blast_Score=166, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=49.6197718631179, Blast_Score=495, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6322524, Length=112, Percent_Identity=34.8214285714286, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=50, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=50, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=47.438330170778, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=47.438330170778, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=47.438330170778, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17864606, Length=527, Percent_Identity=43.8330170777989, Blast_Score=407, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24584129, Length=531, Percent_Identity=35.0282485875706, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI19921262, Length=531, Percent_Identity=35.0282485875706, Blast_Score=285, Evalue=5e-77,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 59233; Mature: 59102

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLLSFSDDSRSALERGVNSLADAVRVTIGPRGRNVVLEKKFGAPDIVNDGVTIAKEIE
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCEEEEECC
LDDPFENLGAKLIQQVASKTKDKAGDGTTTATVLAQAMVHEGLRNVAAGASPIELRRGME
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVAQLVEELAQLSQAVGGNAIHQVATVSSGGDQEVGRMVSEAMDKVSADGVITVEESKS
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCH
LATELEVTEGMAFDRGYSSPYFVTDADRQICEFENALLLLTDRKISSVSDLVPILESLQK
HHHHHHHHCCCEECCCCCCCEEEECCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
SGSPLVIIAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGDRRKAALADIAVLTGGTVIS
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEC
EDRAMTLEKVSQDDLGQVRRITISKDNTTIVAKDENRDAVNARVASIKRELDETDSEYDR
CCHHHHHHHCCCCHHCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHH
EKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNATRAAVEEGIVAGGGTTLLRL
HHHHHHHHHHHCCEEEEEECCCCHHHHHCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHH
SKGLRKLAEQQLNGDQRTGVEIVQRALSAPARQIAINAGENGDVVISEMQRLNKGFNAIS
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
STYEDLLGAGILDATKVVRLALQDAVSIASMMVTTELVIADKPEPPAPAGDGGGDPMGGM
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCC
GGMGGMGGMGGMGGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKLLSFSDDSRSALERGVNSLADAVRVTIGPRGRNVVLEKKFGAPDIVNDGVTIAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCEEEEECC
LDDPFENLGAKLIQQVASKTKDKAGDGTTTATVLAQAMVHEGLRNVAAGASPIELRRGME
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVAQLVEELAQLSQAVGGNAIHQVATVSSGGDQEVGRMVSEAMDKVSADGVITVEESKS
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCH
LATELEVTEGMAFDRGYSSPYFVTDADRQICEFENALLLLTDRKISSVSDLVPILESLQK
HHHHHHHHCCCEECCCCCCCEEEECCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
SGSPLVIIAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGDRRKAALADIAVLTGGTVIS
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEC
EDRAMTLEKVSQDDLGQVRRITISKDNTTIVAKDENRDAVNARVASIKRELDETDSEYDR
CCHHHHHHHCCCCHHCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHH
EKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNATRAAVEEGIVAGGGTTLLRL
HHHHHHHHHHHCCEEEEEECCCCHHHHHCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHH
SKGLRKLAEQQLNGDQRTGVEIVQRALSAPARQIAINAGENGDVVISEMQRLNKGFNAIS
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
STYEDLLGAGILDATKVVRLALQDAVSIASMMVTTELVIADKPEPPAPAGDGGGDPMGGM
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCC
GGMGGMGGMGGMGGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]