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The map label for this gene is serS

Identifier: 124022316

GI number: 124022316

Start: 572208

End: 573485

Strand: Reverse

Name: serS

Synonym: P9303_06061

Alternate gene names: 124022316

Gene position: 573485-572208 (Counterclockwise)

Preceding gene: 124022317

Following gene: 124022315

Centisome position: 21.38

GC content: 55.79

Gene sequence:

>1278_bases
GTGCTTGACCAGCGCCTGGTGCGGGACAACCCCGACCTGATTGCCAACGAACTGGGCCGAAGGGGCATGACGTTAGATCT
AACGGGCCTACAACTGATCGCCCAGCAGCAAAGAAATCTCGAGGAACAGCGCAGCAGCCTCCAGGCAGAAGGAAATCGGA
TCGGCAAGGAAGTCGGTCAACGTATCCAGCAGGGAAGCGACCCAAAAGCCAGCGACGTGGCAGAACTACGACATCAAGGC
AACCTAATCAAGCAAAAGGTGGCCGTTTTAGAAGACGAGGAGAAACAACTATCAGCCCGATTGCGAGAGCAACTGCTGAG
CTTGCCAAACCTGCCCTCCCCTGATTGTCCTGAAGGACGCGACGAGAACGACAACCAGGAAAGACACTGTTGGGGCAAGC
CACGTGAAGGGAAAGACCTTCTGGAGCACTGGTCAATTGCCGAGCGGCTCAACCTTTTCGAAACAGAACGCTCTGTACGG
ATTGCCCAAAGTCGCTTCGTCACCCTGATGGGTCAGGGTGCGCGACTGGAACGAGCACTCATCAACTTCATGCTCGACCT
CCACACCTCAAAGGGATATCGAGAAGTGATGCCTCCCGTACTGGTGAATACCGCCAGCCTTACGGGCTCTGGCCAGCTAC
CAAAATTCGCCGAAGAAAGCTTCCGCTGCGCTGAAGACGACCTCTGGCTAACACCAACTGCAGAGGTGCCGGTGACATCT
CTGCACCGCGATGAAATCATCCCCGCTGACCAACTGCCACTGCGATACGCCGCTTACAGTCCATGCTTTCGCCGCGAAGC
TGGCAGCTATGGACGAGACACCCGTGGCCTGATCCGGCTGCATCAATTCAACAAGGTGGAGCTCTATTGGTTCGTCCATC
CAGACCATTCGCAGGCTGCCCACGCTCAGATCACAGCCGATGCCGAAGCCGTGCTGCAGGCCTTGGAATTGCCCTACCGC
GTCATTGAACTTTGCACAGGTGATCTAGGGTTTTCTTCCTCACGCACCTACGACCTCGAAGTCTGGCTACCAGGAGCAGG
CGCCTTCAGAGAAATTTCAAGTTGCAGTATCTGTGGAGACTTCCAAGCACGGCGATCTGCTATTCGCACCAAAGACCAAA
AAGGTACCCGACTCATCCACACCCTCAATGGCAGTGGCCTGGCGGTAGGACGCACCATGGCTGCCCTTCTCGAAACAGGC
CAACAATCTGATGGGAGTGTCCTCCTCCCCAAGGCACTTGTGCCTTATTTCGGCAAAGATCGACTAGAGCCAGAATGA

Upstream 100 bases:

>100_bases
CTGTTGCTTCCAATCTCGCAAGCTGAATAGGAGTAACCAAACAGGATTCATTTGCAGGGCCAACAACACTTAGGCTGCCC
GCGCTTACTTCAAAACCCTC

Downstream 100 bases:

>100_bases
ACCAATTACTAGAAGCTGAATGAACGTTTTTGCGGCGCTGACGGTTCTAGCCCTGCTGATCATCATTCATGAAGCTGGGC
ACTTTCTGGCTGCCACTGCT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDQRLVRDNPDLIANELGRRGMTLDLTGLQLIAQQQRNLEEQRSSLQAEGNRIGKEVGQRIQQGSDPKASDVAELRHQG
NLIKQKVAVLEDEEKQLSARLREQLLSLPNLPSPDCPEGRDENDNQERHCWGKPREGKDLLEHWSIAERLNLFETERSVR
IAQSRFVTLMGQGARLERALINFMLDLHTSKGYREVMPPVLVNTASLTGSGQLPKFAEESFRCAEDDLWLTPTAEVPVTS
LHRDEIIPADQLPLRYAAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFVHPDHSQAAHAQITADAEAVLQALELPYR
VIELCTGDLGFSSSRTYDLEVWLPGAGAFREISSCSICGDFQARRSAIRTKDQKGTRLIHTLNGSGLAVGRTMAALLETG
QQSDGSVLLPKALVPYFGKDRLEPE

Sequences:

>Translated_425_residues
MLDQRLVRDNPDLIANELGRRGMTLDLTGLQLIAQQQRNLEEQRSSLQAEGNRIGKEVGQRIQQGSDPKASDVAELRHQG
NLIKQKVAVLEDEEKQLSARLREQLLSLPNLPSPDCPEGRDENDNQERHCWGKPREGKDLLEHWSIAERLNLFETERSVR
IAQSRFVTLMGQGARLERALINFMLDLHTSKGYREVMPPVLVNTASLTGSGQLPKFAEESFRCAEDDLWLTPTAEVPVTS
LHRDEIIPADQLPLRYAAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFVHPDHSQAAHAQITADAEAVLQALELPYR
VIELCTGDLGFSSSRTYDLEVWLPGAGAFREISSCSICGDFQARRSAIRTKDQKGTRLIHTLNGSGLAVGRTMAALLETG
QQSDGSVLLPKALVPYFGKDRLEPE
>Mature_425_residues
MLDQRLVRDNPDLIANELGRRGMTLDLTGLQLIAQQQRNLEEQRSSLQAEGNRIGKEVGQRIQQGSDPKASDVAELRHQG
NLIKQKVAVLEDEEKQLSARLREQLLSLPNLPSPDCPEGRDENDNQERHCWGKPREGKDLLEHWSIAERLNLFETERSVR
IAQSRFVTLMGQGARLERALINFMLDLHTSKGYREVMPPVLVNTASLTGSGQLPKFAEESFRCAEDDLWLTPTAEVPVTS
LHRDEIIPADQLPLRYAAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFVHPDHSQAAHAQITADAEAVLQALELPYR
VIELCTGDLGFSSSRTYDLEVWLPGAGAFREISSCSICGDFQARRSAIRTKDQKGTRLIHTLNGSGLAVGRTMAALLETG
QQSDGSVLLPKALVPYFGKDRLEPE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=363, Percent_Identity=33.8842975206612, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI8923421, Length=413, Percent_Identity=33.4140435835351, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI225579074, Length=417, Percent_Identity=32.8537170263789, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=47.4299065420561, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17539260, Length=406, Percent_Identity=31.0344827586207, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17542084, Length=322, Percent_Identity=31.055900621118, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=445, Percent_Identity=29.438202247191, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=412, Percent_Identity=28.8834951456311, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24581334, Length=463, Percent_Identity=30.4535637149028, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17737985, Length=358, Percent_Identity=27.6536312849162, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24649556, Length=421, Percent_Identity=23.2779097387173, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_PROM3 (A2C798)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016623.1
- ProteinModelPortal:   A2C798
- SMR:   A2C798
- STRING:   A2C798
- GeneID:   4777123
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_06061
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47685; Mature: 47685

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 287-287 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDQRLVRDNPDLIANELGRRGMTLDLTGLQLIAQQQRNLEEQRSSLQAEGNRIGKEVGQ
CCCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIQQGSDPKASDVAELRHQGNLIKQKVAVLEDEEKQLSARLREQLLSLPNLPSPDCPEGR
HHHCCCCCCHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DENDNQERHCWGKPREGKDLLEHWSIAERLNLFETERSVRIAQSRFVTLMGQGARLERAL
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
INFMLDLHTSKGYREVMPPVLVNTASLTGSGQLPKFAEESFRCAEDDLWLTPTAEVPVTS
HHHHHHHHCCCCHHHHCCHHHEECCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCCCHH
LHRDEIIPADQLPLRYAAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFVHPDHSQAA
CCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCCCHHHHEEEECCEEEEEEEECCCCCCCC
HAQITADAEAVLQALELPYRVIELCTGDLGFSSSRTYDLEVWLPGAGAFREISSCSICGD
CEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHCCCCCCCC
FQARRSAIRTKDQKGTRLIHTLNGSGLAVGRTMAALLETGQQSDGSVLLPKALVPYFGKD
HHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECHHHHCCCCCCC
RLEPE
CCCCC
>Mature Secondary Structure
MLDQRLVRDNPDLIANELGRRGMTLDLTGLQLIAQQQRNLEEQRSSLQAEGNRIGKEVGQ
CCCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIQQGSDPKASDVAELRHQGNLIKQKVAVLEDEEKQLSARLREQLLSLPNLPSPDCPEGR
HHHCCCCCCHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DENDNQERHCWGKPREGKDLLEHWSIAERLNLFETERSVRIAQSRFVTLMGQGARLERAL
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
INFMLDLHTSKGYREVMPPVLVNTASLTGSGQLPKFAEESFRCAEDDLWLTPTAEVPVTS
HHHHHHHHCCCCHHHHCCHHHEECCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCCCHH
LHRDEIIPADQLPLRYAAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFVHPDHSQAA
CCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCCCHHHHEEEECCEEEEEEEECCCCCCCC
HAQITADAEAVLQALELPYRVIELCTGDLGFSSSRTYDLEVWLPGAGAFREISSCSICGD
CEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHCCCCCCCC
FQARRSAIRTKDQKGTRLIHTLNGSGLAVGRTMAALLETGQQSDGSVLLPKALVPYFGKD
HHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECHHHHCCCCCCC
RLEPE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA