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The map label for this gene is pepP [H]

Identifier: 124022205

GI number: 124022205

Start: 489138

End: 490415

Strand: Direct

Name: pepP [H]

Synonym: P9303_04951

Alternate gene names: 124022205

Gene position: 489138-490415 (Clockwise)

Preceding gene: 124022201

Following gene: 124022206

Centisome position: 18.23

GC content: 55.87

Gene sequence:

>1278_bases
ATGGCGCAATTGGGGGGAGTGGCAGCGGTAATTCCAGCGGCTTCGTTCGTGACGCATCACGCCGATTGCGAGTATCCGTT
TCGTCAAAACAGTGACTTCTGGTATCTCACGGGTCTGGATGAGCCTGATGCGGTGGCTTTGCTTTTGCCCTACCGGCCCG
AAGGAGAGCGTTTTGTGCTGTTTGTGCAACCCAAAGAGCCAACGACCGAGGTATGGAATGGCTTTCGTTGGGGTGTCGAG
GGAGCAGTGGCGCAGTTCGGTGCTGATCGTGCTCATCCAATAGCTGAATTGCCTCAGCTGTTGGGCGATTACCTCAAAGA
CGCCGAAGCGATTGGCTTCAGGGTGGGGAAGCACCCAAAGGTGGAGTCGCTGGTTCTTGAGGCCTGGGCTAAGCAACTCG
ATCAGGCCCCACGCAGCGGCGTATCGGCGCTTGGTCTTGTCGCCCCTTGCCCTTTCATCCATCAGTTGAGGTTGCGCAAG
GGAGCAGAGGAAATCGAGCGCATGCGTGAGACGGCTCGGATTTCTGCGCAAGCTCATCAGCTGGTTCGGAATACGGCGCG
TCCGGGCATGAATGAGCGACAGTTGCAGGCTGTAATCGAGCAGCATTTTCTTGAGCAAGGCGCGCGCGGCCCTGCCTATG
GATCGATCGTGGCCGGCGGCGATAACGCCTGCGTGTTGCATTACACCGCTAACAATGCTCCGCTTGTTGATGGCGAGCTG
GTGCTGATCGATGCAGGCTGTTCGCTCGTTGATTACTACAACGGAGATATCACTAGGACATTCCCTGTTAACGGACGCTT
TAGCGCAGAGCAACGCGCTCTGTATGAGCTGGTTTTAGCAGCGCAGCAGGCAGCGATCGCTGAGGTAAGACCGGGTGGCA
CTGCTGATCGCGTGCATGATCTTGCGGTGCGGGTGCTCGTTGAAGGGCTTGTGGAGTTGGGTTTATTGCTTGGCAGTGTT
GATGGACTGATTGAACAAGGGGCCTACCGACACCTTTATATGCATCGCACTGGCCATTGGCTGGGCCTTGATGTTCATGA
TGTAGGCGCCTATCGCCTTGGTGAGCATCCGGTGGATCTTGAGCCCGGCATGGTGTTAACAGTGGAACCGGGTTTGTATG
TCAGTGACCGTTTGCCAGTGCCGGATGGGCAGCCTGCGATTGCTGATCGTTGGAAGGGGATCGGCATTCGTATTGAAGAT
GATGTGTTGGTAAGTGAGCAGGGAAATGAGGTGCTCACATCGTTAGCGGAGAAAAGTGTTGAAGCAATGCAGCGATAA

Upstream 100 bases:

>100_bases
CCCCCTGCATGGTGTTCTGCTGCCATCCTGACGTCCAAATGCTGTTGTGTCTCTTGCCGTGATCGATCTGTGTATCTTCC
ATCAGCGTCGCGCTTGCTTG

Downstream 100 bases:

>100_bases
GGGAATCACTTAACTCCAAAATCTTCGACTGGTCTATGCATATTAAGAAGCGACCCTGTAATCAATGTCAGAAGAACAAC
TCAAGGCATTCATCGCCAAA

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MAQLGGVAAVIPAASFVTHHADCEYPFRQNSDFWYLTGLDEPDAVALLLPYRPEGERFVLFVQPKEPTTEVWNGFRWGVE
GAVAQFGADRAHPIAELPQLLGDYLKDAEAIGFRVGKHPKVESLVLEAWAKQLDQAPRSGVSALGLVAPCPFIHQLRLRK
GAEEIERMRETARISAQAHQLVRNTARPGMNERQLQAVIEQHFLEQGARGPAYGSIVAGGDNACVLHYTANNAPLVDGEL
VLIDAGCSLVDYYNGDITRTFPVNGRFSAEQRALYELVLAAQQAAIAEVRPGGTADRVHDLAVRVLVEGLVELGLLLGSV
DGLIEQGAYRHLYMHRTGHWLGLDVHDVGAYRLGEHPVDLEPGMVLTVEPGLYVSDRLPVPDGQPAIADRWKGIGIRIED
DVLVSEQGNEVLTSLAEKSVEAMQR

Sequences:

>Translated_425_residues
MAQLGGVAAVIPAASFVTHHADCEYPFRQNSDFWYLTGLDEPDAVALLLPYRPEGERFVLFVQPKEPTTEVWNGFRWGVE
GAVAQFGADRAHPIAELPQLLGDYLKDAEAIGFRVGKHPKVESLVLEAWAKQLDQAPRSGVSALGLVAPCPFIHQLRLRK
GAEEIERMRETARISAQAHQLVRNTARPGMNERQLQAVIEQHFLEQGARGPAYGSIVAGGDNACVLHYTANNAPLVDGEL
VLIDAGCSLVDYYNGDITRTFPVNGRFSAEQRALYELVLAAQQAAIAEVRPGGTADRVHDLAVRVLVEGLVELGLLLGSV
DGLIEQGAYRHLYMHRTGHWLGLDVHDVGAYRLGEHPVDLEPGMVLTVEPGLYVSDRLPVPDGQPAIADRWKGIGIRIED
DVLVSEQGNEVLTSLAEKSVEAMQR
>Mature_424_residues
AQLGGVAAVIPAASFVTHHADCEYPFRQNSDFWYLTGLDEPDAVALLLPYRPEGERFVLFVQPKEPTTEVWNGFRWGVEG
AVAQFGADRAHPIAELPQLLGDYLKDAEAIGFRVGKHPKVESLVLEAWAKQLDQAPRSGVSALGLVAPCPFIHQLRLRKG
AEEIERMRETARISAQAHQLVRNTARPGMNERQLQAVIEQHFLEQGARGPAYGSIVAGGDNACVLHYTANNAPLVDGELV
LIDAGCSLVDYYNGDITRTFPVNGRFSAEQRALYELVLAAQQAAIAEVRPGGTADRVHDLAVRVLVEGLVELGLLLGSVD
GLIEQGAYRHLYMHRTGHWLGLDVHDVGAYRLGEHPVDLEPGMVLTVEPGLYVSDRLPVPDGQPAIADRWKGIGIRIEDD
VLVSEQGNEVLTSLAEKSVEAMQR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=416, Percent_Identity=33.1730769230769, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI149589008, Length=428, Percent_Identity=32.4766355140187, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI260593665, Length=303, Percent_Identity=36.6336633663366, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI260593663, Length=246, Percent_Identity=37.8048780487805, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1789275, Length=420, Percent_Identity=44.047619047619, Blast_Score=337, Evalue=7e-94,
Organism=Escherichia coli, GI1788728, Length=274, Percent_Identity=35.7664233576642, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790282, Length=294, Percent_Identity=29.9319727891156, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508215, Length=428, Percent_Identity=29.6728971962617, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71989583, Length=282, Percent_Identity=32.9787234042553, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320922, Length=411, Percent_Identity=32.1167883211679, Blast_Score=182, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6321118, Length=425, Percent_Identity=30.1176470588235, Blast_Score=172, Evalue=7e-44,
Organism=Drosophila melanogaster, GI19920384, Length=425, Percent_Identity=38.3529411764706, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI21357079, Length=444, Percent_Identity=31.7567567567568, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 46474; Mature: 46343

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLGGVAAVIPAASFVTHHADCEYPFRQNSDFWYLTGLDEPDAVALLLPYRPEGERFVL
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEE
FVQPKEPTTEVWNGFRWGVEGAVAQFGADRAHPIAELPQLLGDYLKDAEAIGFRVGKHPK
EEECCCCHHHHHCCEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCC
VESLVLEAWAKQLDQAPRSGVSALGLVAPCPFIHQLRLRKGAEEIERMRETARISAQAHQ
HHHHHHHHHHHHHHHCHHCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LVRNTARPGMNERQLQAVIEQHFLEQGARGPAYGSIVAGGDNACVLHYTANNAPLVDGEL
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCEECCEE
VLIDAGCSLVDYYNGDITRTFPVNGRFSAEQRALYELVLAAQQAAIAEVRPGGTADRVHD
EEEECCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LAVRVLVEGLVELGLLLGSVDGLIEQGAYRHLYMHRTGHWLGLDVHDVGAYRLGEHPVDL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHHHCCCEECCCCCCCC
EPGMVLTVEPGLYVSDRLPVPDGQPAIADRWKGIGIRIEDDVLVSEQGNEVLTSLAEKSV
CCCEEEEECCCEEEECCCCCCCCCCHHHHHCCCCCEEEECCEEECCCCHHHHHHHHHHHH
EAMQR
HHHCC
>Mature Secondary Structure 
AQLGGVAAVIPAASFVTHHADCEYPFRQNSDFWYLTGLDEPDAVALLLPYRPEGERFVL
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEE
FVQPKEPTTEVWNGFRWGVEGAVAQFGADRAHPIAELPQLLGDYLKDAEAIGFRVGKHPK
EEECCCCHHHHHCCEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCC
VESLVLEAWAKQLDQAPRSGVSALGLVAPCPFIHQLRLRKGAEEIERMRETARISAQAHQ
HHHHHHHHHHHHHHHCHHCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LVRNTARPGMNERQLQAVIEQHFLEQGARGPAYGSIVAGGDNACVLHYTANNAPLVDGEL
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCEECCEE
VLIDAGCSLVDYYNGDITRTFPVNGRFSAEQRALYELVLAAQQAAIAEVRPGGTADRVHD
EEEECCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LAVRVLVEGLVELGLLLGSVDGLIEQGAYRHLYMHRTGHWLGLDVHDVGAYRLGEHPVDL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHHHCCCEECCCCCCCC
EPGMVLTVEPGLYVSDRLPVPDGQPAIADRWKGIGIRIEDDVLVSEQGNEVLTSLAEKSV
CCCEEEEECCCEEEECCCCCCCCCCHHHHHCCCCCEEEECCEEECCCCHHHHHHHHHHHH
EAMQR
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]