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The map label for this gene is hit [C]

Identifier: 124022025

GI number: 124022025

Start: 327031

End: 327471

Strand: Direct

Name: hit [C]

Synonym: P9303_03141

Alternate gene names: 124022025

Gene position: 327031-327471 (Clockwise)

Preceding gene: 124022023

Following gene: 124022026

Centisome position: 12.19

GC content: 55.56

Gene sequence:

>441_bases
ATGCCATGCAGAGAACCACTCAGGCAACGTGCCAGCATTTGTAATCAGACGGTGCATGGATTTCATGCCCCAGCCGTCCC
ATCCTCAGACTGTGACTCAATGGCTGGTGACACCATTTTTGGCCAGATGCTTCGCGGTGAGATTCCTTGTGATGAGGTTT
ATCGCGATGAGAGATGTCTGGCCTTTCGCGATATTCAGCCTCAGGCCCCGGTTCATGTGCTGGTGATCCCCCGCAAACCG
CTGGAAAGTCTGCGGGCCGCTGATTCCACGGACTCGGAGTTGCTGGGGCATTTGCTGCTGGTGGCAGCCAGGGTTGCCAA
GCAGGAGGGCCTTGATGACTTTCGCACCGTGATCAATAGTGGTCTTGAAGCAGGGCAAACCGTTTTTCATCTTCATGTTC
ATGTGATAGGTGGCCGTCCGCTGGCTTGGCCTCCCGGTTGA

Upstream 100 bases:

>100_bases
CTCACGAGACTCCTGTATGGCGGCGTCGGGTAGCCCTACCAGTTGCAGCCCTGGCAGCCCAGGCACTAGATCCACTTCCA
CAGTGACGGCTAGGGCTTCA

Downstream 100 bases:

>100_bases
GGCTTGAACTGGCAAGAATGACTCCATGACAACCACTACCAGGAGACAGGCTCTTCAGGGCCTGTCTAATCAGCTCGGCA
AGTTCCGGAGGCTTGCTCAG

Product: HIT (histidine triad) family protein

Products: NA

Alternate protein names: ORF 1 [H]

Number of amino acids: Translated: 146; Mature: 145

Protein sequence:

>146_residues
MPCREPLRQRASICNQTVHGFHAPAVPSSDCDSMAGDTIFGQMLRGEIPCDEVYRDERCLAFRDIQPQAPVHVLVIPRKP
LESLRAADSTDSELLGHLLLVAARVAKQEGLDDFRTVINSGLEAGQTVFHLHVHVIGGRPLAWPPG

Sequences:

>Translated_146_residues
MPCREPLRQRASICNQTVHGFHAPAVPSSDCDSMAGDTIFGQMLRGEIPCDEVYRDERCLAFRDIQPQAPVHVLVIPRKP
LESLRAADSTDSELLGHLLLVAARVAKQEGLDDFRTVINSGLEAGQTVFHLHVHVIGGRPLAWPPG
>Mature_145_residues
PCREPLRQRASICNQTVHGFHAPAVPSSDCDSMAGDTIFGQMLRGEIPCDEVYRDERCLAFRDIQPQAPVHVLVIPRKPL
ESLRAADSTDSELLGHLLLVAARVAKQEGLDDFRTVINSGLEAGQTVFHLHVHVIGGRPLAWPPG

Specific function: Unknown

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Homo sapiens, GI14211923, Length=113, Percent_Identity=55.7522123893805, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI4885413, Length=113, Percent_Identity=50.4424778761062, Blast_Score=132, Evalue=1e-31,
Organism=Escherichia coli, GI1787346, Length=111, Percent_Identity=44.1441441441441, Blast_Score=100, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17506713, Length=118, Percent_Identity=47.4576271186441, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28574010, Length=125, Percent_Identity=52, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24581222, Length=125, Percent_Identity=52, Blast_Score=143, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR019808
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: NA

Molecular weight: Translated: 16011; Mature: 15879

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00892 HIT_1 ; PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCREPLRQRASICNQTVHGFHAPAVPSSDCDSMAGDTIFGQMLRGEIPCDEVYRDERCL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCHHHHHCCCHHH
AFRDIQPQAPVHVLVIPRKPLESLRAADSTDSELLGHLLLVAARVAKQEGLDDFRTVINS
HEECCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GLEAGQTVFHLHVHVIGGRPLAWPPG
CHHCCCEEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
PCREPLRQRASICNQTVHGFHAPAVPSSDCDSMAGDTIFGQMLRGEIPCDEVYRDERCL
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCHHHHHCCCHHH
AFRDIQPQAPVHVLVIPRKPLESLRAADSTDSELLGHLLLVAARVAKQEGLDDFRTVINS
HEECCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GLEAGQTVFHLHVHVIGGRPLAWPPG
CHHCCCEEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2108129; 1472710 [H]