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The map label for this gene is ribH

Identifier: 124021805

GI number: 124021805

Start: 91967

End: 92464

Strand: Direct

Name: ribH

Synonym: P9303_00901

Alternate gene names: 124021805

Gene position: 91967-92464 (Clockwise)

Preceding gene: 124021804

Following gene: 124021807

Centisome position: 3.43

GC content: 51.41

Gene sequence:

>498_bases
ATGATGGCCACATATGAAGGGCGTTATACCGATGCACAAGCTCTGCGTATAGCTGTTGTTGTTGCCAGGTTTAACGACTT
GGTGACTGGCAAGCTTTTAAGTGGCTGTCTTGATTGTTTGGCTCGTCATGGTGTCGACACATCGTCCAACAGCGATCAAC
TCGATGTGGCATGGGTACCTGGAGCCTTTGAGTTGCCGATCGTGACTCAGACACTTGCACTCAGTGGTCAATATGAAGTG
GTGATCACTCTTGGTGCGGTCATTCGTGGTGACACGCCCCATTTTGATGTGGTGGTTGCTGAGGCCAGTAAGGGCATTGC
ATCAGTTTCAAGGGAGACAGGTGTGCCGGTGATTTTTGGTGTTTTAACAACCGACACGATGCAGCAGGCGCTTGAACGGG
CTGGCATCAAGAGCAATTTGGGTTGGAGTTATGGGCTACAGGCTTTAGAAATGGGCTCGCTGATGGGAGTGCTTCGCTCA
GCCACTTCCGCCAGCTGA

Upstream 100 bases:

>100_bases
TTCCATCTTGTTTTGCTCAACGGAGCAATAAGCTTTTTGGTGGTTTGAACCAATCACTCACTTGCTGTGATGAGAGCATG
TGGGCAGTTTCTGCCACTGA

Downstream 100 bases:

>100_bases
TTGATTGGAATTGACCAGTTCCCCTTCGGTGGTGCATGCTGTCTTTGTCCAAGGGGAGACATCCCTAAGGCATGTATTGC
GGATGTAGCTCAGTGGTAGA

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MMATYEGRYTDAQALRIAVVVARFNDLVTGKLLSGCLDCLARHGVDTSSNSDQLDVAWVPGAFELPIVTQTLALSGQYEV
VITLGAVIRGDTPHFDVVVAEASKGIASVSRETGVPVIFGVLTTDTMQQALERAGIKSNLGWSYGLQALEMGSLMGVLRS
ATSAS

Sequences:

>Translated_165_residues
MMATYEGRYTDAQALRIAVVVARFNDLVTGKLLSGCLDCLARHGVDTSSNSDQLDVAWVPGAFELPIVTQTLALSGQYEV
VITLGAVIRGDTPHFDVVVAEASKGIASVSRETGVPVIFGVLTTDTMQQALERAGIKSNLGWSYGLQALEMGSLMGVLRS
ATSAS
>Mature_165_residues
MMATYEGRYTDAQALRIAVVVARFNDLVTGKLLSGCLDCLARHGVDTSSNSDQLDVAWVPGAFELPIVTQTLALSGQYEV
VITLGAVIRGDTPHFDVVVAEASKGIASVSRETGVPVIFGVLTTDTMQQALERAGIKSNLGWSYGLQALEMGSLMGVLRS
ATSAS

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=146, Percent_Identity=44.5205479452055, Blast_Score=134, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324429, Length=156, Percent_Identity=31.4102564102564, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_PROM3 (A2C5T7)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016112.1
- ProteinModelPortal:   A2C5T7
- SMR:   A2C5T7
- STRING:   A2C5T7
- GeneID:   4778769
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_00901
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- ProtClustDB:   PRK00061
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 17408; Mature: 17408

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMATYEGRYTDAQALRIAVVVARFNDLVTGKLLSGCLDCLARHGVDTSSNSDQLDVAWVP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
GAFELPIVTQTLALSGQYEVVITLGAVIRGDTPHFDVVVAEASKGIASVSRETGVPVIFG
CCEECCHHHHHHHCCCCEEEEEEEEHEEECCCCCEEEEEECCCCCHHHHHHHCCCCEEEE
VLTTDTMQQALERAGIKSNLGWSYGLQALEMGSLMGVLRSATSAS
EHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMATYEGRYTDAQALRIAVVVARFNDLVTGKLLSGCLDCLARHGVDTSSNSDQLDVAWVP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
GAFELPIVTQTLALSGQYEVVITLGAVIRGDTPHFDVVVAEASKGIASVSRETGVPVIFG
CCEECCHHHHHHHCCCCEEEEEEEEHEEECCCCCEEEEEECCCCCHHHHHHHCCCCEEEE
VLTTDTMQQALERAGIKSNLGWSYGLQALEMGSLMGVLRSATSAS
EHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA