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The map label for this gene is aroE

Identifier: 123969447

GI number: 123969447

Start: 1655401

End: 1656261

Strand: Direct

Name: aroE

Synonym: A9601_19151

Alternate gene names: 123969447

Gene position: 1655401-1656261 (Clockwise)

Preceding gene: 123969445

Following gene: 123969448

Centisome position: 99.13

GC content: 31.01

Gene sequence:

>861_bases
ATGATTTCAAGTAAGACATCTTTCATCGCATTAATTGGCAATCCAGTAAGCCATTCTTTGTCTCCAATTATGCAAAATGC
TGCCCTTCAATATTTAGGCTTAGATTTAATCTATATTGCTGTACCCTGCAAAGATGAAGATCTAGAATTAGTTCTTAATT
CTTTTAAAAAGATTAATTGCAAAGGTTTAAACATTACAATTCCACACAAAGAAAAAGTATTAACCCTTTGTAGTGAAATC
TCCCCTATTGCTAACAAACTTAAAGCAATTAATACCCTGAAATTAAATTCTGAAAAAAAATGGAGCGCAACTAATACCGA
TGTAGAGGGATTTATTTATCCATTAAAAAATTTAAACTTAGCAAAGAAAAAATCAATAGTTCTTGGCTCCGGGGGTGCAG
CAAGATCTGTTATTCAAGGTTTAATAAATTTAAATCTTTCAACAATTTCAGTAATATCACGTAACAAATCATCACTGGAT
GAATTAATTAAAAACTTTGGTAATGAAATTCAACTACAGGGTTTATTGAATAGTGATGATCAAGCCCAAGTTTTAATTCG
GGAAGCAGATTTGATTGTAAATACAACACCAGCAGGGATGAAAACAACTAAATATAAAAATAATGTAATGCCATATGGCG
AAACATTTTGGAGATCTCTTAACTCGCAAACAATTGTTTACGATTTAATATACAATCCTGCTCCAACTACTTTATTGAAA
TTTAGTGCTAGAAAAGGATGCAAGACTATAGATGGTTTGGAAATGCTTGTTGCCCAAGGAATAAAATCATTATCATTTTG
GACAGATGGTTTAGAAGTACCTTTTCATGTAATGAATGACGCACTAAAAAAATATCTTTAA

Upstream 100 bases:

>100_bases
TTGTTACTCTCCATAATCGGTCATTGACGTCATTATTGTTACTCAAAGACGAGGTGTGGTTCCCGAACAGACTATTAATT
TTAAGGTTAAAATTCTAAAT

Downstream 100 bases:

>100_bases
AAAAATGATCCTACTTGTCAAGAAATTGCCTATCGTAATGTATGGTAAGTAATGAACAGACGCTCATTACATCAATTGAT
GAGCCAAAGACCTTGTCTGA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MISSKTSFIALIGNPVSHSLSPIMQNAALQYLGLDLIYIAVPCKDEDLELVLNSFKKINCKGLNITIPHKEKVLTLCSEI
SPIANKLKAINTLKLNSEKKWSATNTDVEGFIYPLKNLNLAKKKSIVLGSGGAARSVIQGLINLNLSTISVISRNKSSLD
ELIKNFGNEIQLQGLLNSDDQAQVLIREADLIVNTTPAGMKTTKYKNNVMPYGETFWRSLNSQTIVYDLIYNPAPTTLLK
FSARKGCKTIDGLEMLVAQGIKSLSFWTDGLEVPFHVMNDALKKYL

Sequences:

>Translated_286_residues
MISSKTSFIALIGNPVSHSLSPIMQNAALQYLGLDLIYIAVPCKDEDLELVLNSFKKINCKGLNITIPHKEKVLTLCSEI
SPIANKLKAINTLKLNSEKKWSATNTDVEGFIYPLKNLNLAKKKSIVLGSGGAARSVIQGLINLNLSTISVISRNKSSLD
ELIKNFGNEIQLQGLLNSDDQAQVLIREADLIVNTTPAGMKTTKYKNNVMPYGETFWRSLNSQTIVYDLIYNPAPTTLLK
FSARKGCKTIDGLEMLVAQGIKSLSFWTDGLEVPFHVMNDALKKYL
>Mature_286_residues
MISSKTSFIALIGNPVSHSLSPIMQNAALQYLGLDLIYIAVPCKDEDLELVLNSFKKINCKGLNITIPHKEKVLTLCSEI
SPIANKLKAINTLKLNSEKKWSATNTDVEGFIYPLKNLNLAKKKSIVLGSGGAARSVIQGLINLNLSTISVISRNKSSLD
ELIKNFGNEIQLQGLLNSDDQAQVLIREADLIVNTTPAGMKTTKYKNNVMPYGETFWRSLNSQTIVYDLIYNPAPTTLLK
FSARKGCKTIDGLEMLVAQGIKSLSFWTDGLEVPFHVMNDALKKYL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=291, Percent_Identity=28.8659793814433, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1789675, Length=261, Percent_Identity=29.1187739463602, Blast_Score=105, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320332, Length=284, Percent_Identity=27.112676056338, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_PROMS (A2BTT7)

Other databases:

- EMBL:   CP000551
- RefSeq:   YP_001010305.1
- ProteinModelPortal:   A2BTT7
- SMR:   A2BTT7
- STRING:   A2BTT7
- GeneID:   4718654
- GenomeReviews:   CP000551_GR
- KEGG:   pmb:A9601_19151
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   CALRSIN
- PhylomeDB:   A2BTT7
- ProtClustDB:   PRK00258
- BioCyc:   PMAR146891:A9601_19151-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31548; Mature: 31548

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISSKTSFIALIGNPVSHSLSPIMQNAALQYLGLDLIYIAVPCKDEDLELVLNSFKKINC
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCC
KGLNITIPHKEKVLTLCSEISPIANKLKAINTLKLNSEKKWSATNTDVEGFIYPLKNLNL
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEEECCCCCC
AKKKSIVLGSGGAARSVIQGLINLNLSTISVISRNKSSLDELIKNFGNEIQLQGLLNSDD
CHHCEEEEECCCHHHHHHHHHHHCCHHEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCC
QAQVLIREADLIVNTTPAGMKTTKYKNNVMPYGETFWRSLNSQTIVYDLIYNPAPTTLLK
CCEEEEEECCEEEECCCCCCEECCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCHHEE
FSARKGCKTIDGLEMLVAQGIKSLSFWTDGLEVPFHVMNDALKKYL
EHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MISSKTSFIALIGNPVSHSLSPIMQNAALQYLGLDLIYIAVPCKDEDLELVLNSFKKINC
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCC
KGLNITIPHKEKVLTLCSEISPIANKLKAINTLKLNSEKKWSATNTDVEGFIYPLKNLNL
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEEECCCCCC
AKKKSIVLGSGGAARSVIQGLINLNLSTISVISRNKSSLDELIKNFGNEIQLQGLLNSDD
CHHCEEEEECCCHHHHHHHHHHHCCHHEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCC
QAQVLIREADLIVNTTPAGMKTTKYKNNVMPYGETFWRSLNSQTIVYDLIYNPAPTTLLK
CCEEEEEECCEEEECCCCCCEECCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCHHEE
FSARKGCKTIDGLEMLVAQGIKSLSFWTDGLEVPFHVMNDALKKYL
EHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA