Click here to switch to the map view.

The map label for this gene is pyrG [H]

Identifier: 123969431

GI number: 123969431

Start: 1635109

End: 1636719

Strand: Direct

Name: pyrG [H]

Synonym: A9601_18991

Alternate gene names: 123969431

Gene position: 1635109-1636719 (Clockwise)

Preceding gene: 123969430

Following gene: 123969432

Centisome position: 97.92

GC content: 34.14

Gene sequence:

>1611_bases
ATGTCAAAATTTGTATTTGTCACTGGAGGAGTAGTTTCTAGCATTGGTAAAGGGATTGTAGCTGCAAGCTTAGGAAGATT
ATTAAAATCTAGAGGATATAGTGTTTCAATATTAAAACTAGATCCATATCTAAATGTTGATCCAGGAACAATGAGCCCTT
TTCAACATGGAGAAGTATTTGTAACCGAAGATGGGGCTGAAACCGATCTAGATTTAGGTCACTACGAAAGATTTACTGAT
ACTGCAATGACTAGGTTAAATAGTGTGACTACTGGATCTATTTATCAAGCAGTTATTAATAAAGAAAGAAGAGGCAATTA
TAACGGTGGAACTGTGCAAGTAATACCTCACATAACGGGAGAAATTAGAGAAAGGATTCATAGAGTAGCCGCTAACAGCA
ATGCAGATATTATTATTACTGAAATTGGTGGAACAGTTGGTGATATTGAATCTCTACCTTTTTTAGAGGCAATAAGAGAA
TTCAAAAATGATGTCAATAGGAACGATGTTGCATACATACACGTAACATTACTTCCTTACATCAAAACCTCTGGCGAAAT
AAAAACTAAACCAACACAACATTCAGTGAAAGAATTAAGATCAATTGGAATTCAGCCAGATTTACTTGTATGCCGAAGTG
ATAAATCTATCAATGAAGCTCTTAAAAAAAAGCTTAGTGGTTTTTGCGGTGTCAATATCAACTCTGTAATTGAAGCTTTA
GACGCAGACAGTATATATTCTGTACCTCTTTCTTTAAAAAAAGAAGGTTTATGCAAAGAAACCTTGAAGTATTTAGACCT
TGAAGATAAAAAATGTGATTTGAAAAATTGGGAGCAACTAATACACAACCTAAGAAATCCTGGAGATCCAATAAAAGTTG
CACTTGTAGGCAAATATATTGAACTTGGAGATGCATATTTATCCGTTGTTGAAGCTTTAAGACATGCATGCATTGAACAA
AGGGCTTTATTAGATTTACATTGGGTAAGTGCTGAAATGATAGAAAACAATTCAGCAGAAACTTACTTAAATGAAGTTGA
TGCAATTGTTGTACCCGGGGGATTTGGTAATAGAGGAGTAAATGGAAAAATTTCGGCTATAAAATTCGCAAGAGAAAATA
AAATTCCCTTTTTAGGTTTGTGCCTTGGCATGCAATGTGCAGTTATTGAATGGGCCAGGAATGTAGCTAATCTTCCAGAT
GCATCTAGTTCAGAACTAGACCCAAACACTCCAAATCCAGTGATACATTTATTACCAGAACAGGAAGATGTAGTTGATTT
AGGTGGGACAATGAGACTTGGAGTTTATCCATGTAGACTGACAAAAAATACAACTGGAAAAAACTTATATGATGAGGATG
TTATTTATGAGAGACATCGGCATAGATACGAATTTAATAATTACTACAAACAAAGTTTTTTAGATTCTGGATACAAAATT
AGTGGTACATCACCAGATGGCAGATTAGTTGAGTTAATTGAGTTAGAAAATCATCCATACTTCTTAGCCTGTCAATATCA
TCCTGAGTTTTTATCAAGACCTGGCAAACCTCATCCTTTATTTAAAGGATTAATAAAAGCCTCTCAAGATAAGTTAACTC
AATCAAATTAA

Upstream 100 bases:

>100_bases
TATTGAAATAACAATTGATGAATAAGAATATATATGGATGTTCTAAAAGTTTTTTGTTTAAATAAAATATAAGGAGGCTG
TGCTTAATTAAAAATATTTA

Downstream 100 bases:

>100_bases
TATTCTTTATTTTTTTGAATGAAAATGACAAATTTTTTACCCTTAGTCGAACAATTTCATTCATTACAAGGTGAAGGTTA
TCACGCTGGAAAAAGTGCTT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTD
TAMTRLNSVTTGSIYQAVINKERRGNYNGGTVQVIPHITGEIRERIHRVAANSNADIIITEIGGTVGDIESLPFLEAIRE
FKNDVNRNDVAYIHVTLLPYIKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKSINEALKKKLSGFCGVNINSVIEAL
DADSIYSVPLSLKKEGLCKETLKYLDLEDKKCDLKNWEQLIHNLRNPGDPIKVALVGKYIELGDAYLSVVEALRHACIEQ
RALLDLHWVSAEMIENNSAETYLNEVDAIVVPGGFGNRGVNGKISAIKFARENKIPFLGLCLGMQCAVIEWARNVANLPD
ASSSELDPNTPNPVIHLLPEQEDVVDLGGTMRLGVYPCRLTKNTTGKNLYDEDVIYERHRHRYEFNNYYKQSFLDSGYKI
SGTSPDGRLVELIELENHPYFLACQYHPEFLSRPGKPHPLFKGLIKASQDKLTQSN

Sequences:

>Translated_536_residues
MSKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTD
TAMTRLNSVTTGSIYQAVINKERRGNYNGGTVQVIPHITGEIRERIHRVAANSNADIIITEIGGTVGDIESLPFLEAIRE
FKNDVNRNDVAYIHVTLLPYIKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKSINEALKKKLSGFCGVNINSVIEAL
DADSIYSVPLSLKKEGLCKETLKYLDLEDKKCDLKNWEQLIHNLRNPGDPIKVALVGKYIELGDAYLSVVEALRHACIEQ
RALLDLHWVSAEMIENNSAETYLNEVDAIVVPGGFGNRGVNGKISAIKFARENKIPFLGLCLGMQCAVIEWARNVANLPD
ASSSELDPNTPNPVIHLLPEQEDVVDLGGTMRLGVYPCRLTKNTTGKNLYDEDVIYERHRHRYEFNNYYKQSFLDSGYKI
SGTSPDGRLVELIELENHPYFLACQYHPEFLSRPGKPHPLFKGLIKASQDKLTQSN
>Mature_535_residues
SKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTDT
AMTRLNSVTTGSIYQAVINKERRGNYNGGTVQVIPHITGEIRERIHRVAANSNADIIITEIGGTVGDIESLPFLEAIREF
KNDVNRNDVAYIHVTLLPYIKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKSINEALKKKLSGFCGVNINSVIEALD
ADSIYSVPLSLKKEGLCKETLKYLDLEDKKCDLKNWEQLIHNLRNPGDPIKVALVGKYIELGDAYLSVVEALRHACIEQR
ALLDLHWVSAEMIENNSAETYLNEVDAIVVPGGFGNRGVNGKISAIKFARENKIPFLGLCLGMQCAVIEWARNVANLPDA
SSSELDPNTPNPVIHLLPEQEDVVDLGGTMRLGVYPCRLTKNTTGKNLYDEDVIYERHRHRYEFNNYYKQSFLDSGYKIS
GTSPDGRLVELIELENHPYFLACQYHPEFLSRPGKPHPLFKGLIKASQDKLTQSN

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=553, Percent_Identity=46.1121157323689, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI28559085, Length=552, Percent_Identity=46.5579710144928, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI28559083, Length=552, Percent_Identity=46.5579710144928, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI221316689, Length=552, Percent_Identity=46.5579710144928, Blast_Score=475, Evalue=1e-134,
Organism=Escherichia coli, GI1789142, Length=539, Percent_Identity=52.8756957328386, Blast_Score=574, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI25148299, Length=605, Percent_Identity=38.6776859504132, Blast_Score=428, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=44.6996466431095, Blast_Score=465, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319432, Length=558, Percent_Identity=42.831541218638, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24664469, Length=556, Percent_Identity=46.9424460431655, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI21357815, Length=501, Percent_Identity=45.9081836327345, Blast_Score=421, Evalue=1e-118,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59591; Mature: 59459

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVF
CCCEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFTDTAMTRLNSVTTGSIYQAVINKERRGNYNGGTVQVIPHITG
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHH
EIRERIHRVAANSNADIIITEIGGTVGDIESLPFLEAIREFKNDVNRNDVAYIHVTLLPY
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEE
IKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKSINEALKKKLSGFCGVNINSVIEAL
ECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHH
DADSIYSVPLSLKKEGLCKETLKYLDLEDKKCDLKNWEQLIHNLRNPGDPIKVALVGKYI
CCCCEEECCCHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHH
ELGDAYLSVVEALRHACIEQRALLDLHWVSAEMIENNSAETYLNEVDAIVVPGGFGNRGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCCC
NGKISAIKFARENKIPFLGLCLGMQCAVIEWARNVANLPDASSSELDPNTPNPVIHLLPE
CCCEEEEEEECCCCCCEEEHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCC
QEDVVDLGGTMRLGVYPCRLTKNTTGKNLYDEDVIYERHRHRYEFNNYYKQSFLDSGYKI
CCCHHHCCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEE
SGTSPDGRLVELIELENHPYFLACQYHPEFLSRPGKPHPLFKGLIKASQDKLTQSN
ECCCCCCCEEEEEEECCCCEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVF
CCEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFTDTAMTRLNSVTTGSIYQAVINKERRGNYNGGTVQVIPHITG
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHH
EIRERIHRVAANSNADIIITEIGGTVGDIESLPFLEAIREFKNDVNRNDVAYIHVTLLPY
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEE
IKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKSINEALKKKLSGFCGVNINSVIEAL
ECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHH
DADSIYSVPLSLKKEGLCKETLKYLDLEDKKCDLKNWEQLIHNLRNPGDPIKVALVGKYI
CCCCEEECCCHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHH
ELGDAYLSVVEALRHACIEQRALLDLHWVSAEMIENNSAETYLNEVDAIVVPGGFGNRGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCCC
NGKISAIKFARENKIPFLGLCLGMQCAVIEWARNVANLPDASSSELDPNTPNPVIHLLPE
CCCEEEEEEECCCCCCEEEHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCC
QEDVVDLGGTMRLGVYPCRLTKNTTGKNLYDEDVIYERHRHRYEFNNYYKQSFLDSGYKI
CCCHHHCCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEE
SGTSPDGRLVELIELENHPYFLACQYHPEFLSRPGKPHPLFKGLIKASQDKLTQSN
ECCCCCCCEEEEEEECCCCEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA