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The map label for this gene is tig [H]

Identifier: 123969396

GI number: 123969396

Start: 1598024

End: 1599448

Strand: Direct

Name: tig [H]

Synonym: A9601_18641

Alternate gene names: 123969396

Gene position: 1598024-1599448 (Clockwise)

Preceding gene: 123969392

Following gene: 123969397

Centisome position: 95.7

GC content: 31.02

Gene sequence:

>1425_bases
ATGGCTAAAGATGCACTAATAGTCAAAACAACTCCTCTGCCTCAAAGTAGAATTTCATTCGAATTAGAAATACCATCTGA
GACATGCAAAACGTGTGTAAATGAAACAATCAATTCTATCAGTCGTTCAGCTAAAATTCCGGGATTTAGACTTGGTAAGA
TTCCTAAACAAGTCTTAATCCAAAGAATTGGCATCACACAATTACATGCTTCTGCTCTGGAAAAAATTATTGATAAATCA
TGGCAAGAAGCGTTAAAAATAAAATCTATAGAGCCACTAAGTGAGCCAGAATTGGTGGATGGATTTGAATCTTTACTTGC
AAAGTTTAGTCCTGAAAAATCACTTAAGGTTACTCTTCAAACTGATGTTGCCCCAGAATTAAAACTTAAAAAATCCAAAG
GACTTAGTGTTGAAATATCAAAGACAAAGTTTGATCCTAAGTCAATAGATGAAGCGCTAGAAAAATCTAGAAATCAGTTT
GCAAACATTATTCCAGTTACCAATAGAGCAGCAAAATTAGGAGATATTGCTGTAGTTAGTTTCAAAGGAAAATATAAAGA
TTCTGGTAAAGAGATTGATGGTGGAACAAGTGAATCAATGGATCTTGAGTTAGAAAAGAACAAAATGATTCCCGGTTTCG
TTGAGGGAATCGTAAAGATGAAAATTGGTGATACTAAAACACTTAACCTTAAATTTCCTGATGATTATTCTCATGAGGAT
TCAAGAGGCAAAGAAGCAATTTTTGAAGTAAATCTTAAGGATCTTAAGGAAAAAGAATTGCCTGAACTTAATGACGATTT
TGCAAAACAGTCTGGCAACAAAGAATCATTAAAAGAGTTAAAGAAAGATATTGAAAAGCAACTTAAAGACAATTTTGAAA
AAACTCAAAAAGATATCAAAATTGAAGCTTTATTAGATGCCTTAACAAACGAATTGGTTGCTGAAATTCCAAAATCTATG
ATTGATATAGAAGTGAGGAATAATATTGAACAAACCGCTCAAAGATTCGCTCAACAAGGTCTTGATGTTAAATCTACTTT
CACTCCAGAATTAGTTAAGTCATTAGCAGATTCCACAAGGCCTCAAGCTGAAAAAAATGTTCAAAGAAATTTAGCTTTAA
AAGCATTAGCTGAAACTGAAAACATAAAAGTTGAGCAAGATGAAATTGATTCAAAAATGAAAGATTATGAAGATGCAATC
TCTCAATCTTCAAAACAAATAGATATTAAAAAACTAACAGAAGTATTAACTAACGATTTACTCAAAGAAAAATTAATCAT
TTGGCTTGAAGAAAATTCTGAAGTAAAAGAAAAAACTACAAAAACTTCTAAAGCTACAAAAACCTCAAAAACAACAAAAG
CCACAAAAACTGCGTCAAAAACTACAAAAACTACAAAAACTCAAAATAAAAAAGAAAAAAAATAA

Upstream 100 bases:

>100_bases
GATTGACTATTTTTTTTACTTTATCAAAAAATTAACTTTCAAGGAAATCACATAATGTGAAATAATTAAGATTCGGTTCA
AAGTAATAACTTAGAAAAAC

Downstream 100 bases:

>100_bases
TTTATGAAATTTCCTACTAATTAGACAAAAACCCCTTAAATTATTTATAAGACGAAAACTATTTTGTGAACTCAGAAAAA
AAACATTTAATCCAAAGCTC

Product: trigger factor

Products: peptidylproline (w =0) [C]

Alternate protein names: TF [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MAKDALIVKTTPLPQSRISFELEIPSETCKTCVNETINSISRSAKIPGFRLGKIPKQVLIQRIGITQLHASALEKIIDKS
WQEALKIKSIEPLSEPELVDGFESLLAKFSPEKSLKVTLQTDVAPELKLKKSKGLSVEISKTKFDPKSIDEALEKSRNQF
ANIIPVTNRAAKLGDIAVVSFKGKYKDSGKEIDGGTSESMDLELEKNKMIPGFVEGIVKMKIGDTKTLNLKFPDDYSHED
SRGKEAIFEVNLKDLKEKELPELNDDFAKQSGNKESLKELKKDIEKQLKDNFEKTQKDIKIEALLDALTNELVAEIPKSM
IDIEVRNNIEQTAQRFAQQGLDVKSTFTPELVKSLADSTRPQAEKNVQRNLALKALAETENIKVEQDEIDSKMKDYEDAI
SQSSKQIDIKKLTEVLTNDLLKEKLIIWLEENSEVKEKTTKTSKATKTSKTTKATKTASKTTKTTKTQNKKEKK

Sequences:

>Translated_474_residues
MAKDALIVKTTPLPQSRISFELEIPSETCKTCVNETINSISRSAKIPGFRLGKIPKQVLIQRIGITQLHASALEKIIDKS
WQEALKIKSIEPLSEPELVDGFESLLAKFSPEKSLKVTLQTDVAPELKLKKSKGLSVEISKTKFDPKSIDEALEKSRNQF
ANIIPVTNRAAKLGDIAVVSFKGKYKDSGKEIDGGTSESMDLELEKNKMIPGFVEGIVKMKIGDTKTLNLKFPDDYSHED
SRGKEAIFEVNLKDLKEKELPELNDDFAKQSGNKESLKELKKDIEKQLKDNFEKTQKDIKIEALLDALTNELVAEIPKSM
IDIEVRNNIEQTAQRFAQQGLDVKSTFTPELVKSLADSTRPQAEKNVQRNLALKALAETENIKVEQDEIDSKMKDYEDAI
SQSSKQIDIKKLTEVLTNDLLKEKLIIWLEENSEVKEKTTKTSKATKTSKTTKATKTASKTTKTTKTQNKKEKK
>Mature_473_residues
AKDALIVKTTPLPQSRISFELEIPSETCKTCVNETINSISRSAKIPGFRLGKIPKQVLIQRIGITQLHASALEKIIDKSW
QEALKIKSIEPLSEPELVDGFESLLAKFSPEKSLKVTLQTDVAPELKLKKSKGLSVEISKTKFDPKSIDEALEKSRNQFA
NIIPVTNRAAKLGDIAVVSFKGKYKDSGKEIDGGTSESMDLELEKNKMIPGFVEGIVKMKIGDTKTLNLKFPDDYSHEDS
RGKEAIFEVNLKDLKEKELPELNDDFAKQSGNKESLKELKKDIEKQLKDNFEKTQKDIKIEALLDALTNELVAEIPKSMI
DIEVRNNIEQTAQRFAQQGLDVKSTFTPELVKSLADSTRPQAEKNVQRNLALKALAETENIKVEQDEIDSKMKDYEDAIS
QSSKQIDIKKLTEVLTNDLLKEKLIIWLEENSEVKEKTTKTSKATKTSKTTKATKTASKTTKTTKTQNKKEKK

Specific function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation [H]

COG id: COG0544

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786640, Length=442, Percent_Identity=27.3755656108597, Blast_Score=139, Evalue=6e-34,

Paralogues:

None

Copy number: 1070 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 500 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 340 Molecules/Cell In: Growth-Phase, Mini

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR005215
- InterPro:   IPR008880
- InterPro:   IPR008881 [H]

Pfam domain/function: PF00254 FKBP_C; PF05698 Trigger_C; PF05697 Trigger_N [H]

EC number: NA

Molecular weight: Translated: 53197; Mature: 53065

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDALIVKTTPLPQSRISFELEIPSETCKTCVNETINSISRSAKIPGFRLGKIPKQVLI
CCCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHH
QRIGITQLHASALEKIIDKSWQEALKIKSIEPLSEPELVDGFESLLAKFSPEKSLKVTLQ
HHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
TDVAPELKLKKSKGLSVEISKTKFDPKSIDEALEKSRNQFANIIPVTNRAAKLGDIAVVS
CCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEE
FKGKYKDSGKEIDGGTSESMDLELEKNKMIPGFVEGIVKMKIGDTKTLNLKFPDDYSHED
ECCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHEEECCCEEEEEECCCCCCCCC
SRGKEAIFEVNLKDLKEKELPELNDDFAKQSGNKESLKELKKDIEKQLKDNFEKTQKDIK
CCCCCEEEECCHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEALLDALTNELVAEIPKSMIDIEVRNNIEQTAQRFAQQGLDVKSTFTPELVKSLADSTR
HHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
PQAEKNVQRNLALKALAETENIKVEQDEIDSKMKDYEDAISQSSKQIDIKKLTEVLTNDL
CHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LKEKLIIWLEENSEVKEKTTKTSKATKTSKTTKATKTASKTTKTTKTQNKKEKK
HHHHEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AKDALIVKTTPLPQSRISFELEIPSETCKTCVNETINSISRSAKIPGFRLGKIPKQVLI
CCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHH
QRIGITQLHASALEKIIDKSWQEALKIKSIEPLSEPELVDGFESLLAKFSPEKSLKVTLQ
HHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
TDVAPELKLKKSKGLSVEISKTKFDPKSIDEALEKSRNQFANIIPVTNRAAKLGDIAVVS
CCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEE
FKGKYKDSGKEIDGGTSESMDLELEKNKMIPGFVEGIVKMKIGDTKTLNLKFPDDYSHED
ECCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHEEECCCEEEEEECCCCCCCCC
SRGKEAIFEVNLKDLKEKELPELNDDFAKQSGNKESLKELKKDIEKQLKDNFEKTQKDIK
CCCCCEEEECCHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEALLDALTNELVAEIPKSMIDIEVRNNIEQTAQRFAQQGLDVKSTFTPELVKSLADSTR
HHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
PQAEKNVQRNLALKALAETENIKVEQDEIDSKMKDYEDAISQSSKQIDIKKLTEVLTNDL
CHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LKEKLIIWLEENSEVKEKTTKTSKATKTSKTTKATKTASKTTKTTKTQNKKEKK
HHHHEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: peptidylproline (w =180) [C]

Specific reaction: peptidylproline (w =180) = peptidylproline (w =0) [C]

General reaction: Isomerases; cis-trans-Isomerases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA