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The map label for this gene is uvrB [H]

Identifier: 123969390

GI number: 123969390

Start: 1589962

End: 1592001

Strand: Reverse

Name: uvrB [H]

Synonym: A9601_18581

Alternate gene names: 123969390

Gene position: 1592001-1589962 (Counterclockwise)

Preceding gene: 123969391

Following gene: 123969387

Centisome position: 95.34

GC content: 33.82

Gene sequence:

>2040_bases
ATGAACAACTATAAGCTTCAAGCTCCTTACGAACCAAATGGAGATCAACCAGAAGCTATTAAAAAATTAGTTAAAGGCGT
AAATAATGGTAAACAGTTTCAGACTCTTTTAGGAGCTACTGGAACTGGAAAAACATTTACCATTGCCAATGTAATTCAAC
AAACAGGAAGGCCAGCACTTGTTTTAGCCCATAACAAAACGTTGGCTGCACAACTATGTAATGAATTAAGGGAATTTTTC
CCAAAAAATGCTGTTGAGTACTTCATTTCTTACTACGATTATTATCAACCTGAAGCTTATGTACCTGTAAGTGATACTTA
CATAGCCAAAACTGCTTCAATCAATGAAGAAATAGATATGCTTAGGCATTCTGCAACACGCTCATTATTTGAAAGAAAAG
ATGTAATTGTTGTAGCCTCAATAAGTTGTATTTATGGTCTTGGTATACCGAGTGAGTATTTAAAAGCTGCAGTTAAATTT
GAAGTGGGAAAATCAATAAATCTACGTTCTTCTTTGAGGTCTCTGGTTGAAAATCAATATACTAGAAATGATATTGAAAT
TACTAGAGGTAGATTCAGAATTAAAGGTGATGTTTTAGAAATCGGTCCAGCTTATGAAGATAGATTAATAAGAATTGAGT
TATTTGGTGATGAAGTCGAGGCTATTAGATATGTTGACCCTACTACAGGAGAAATACTTGAAAGCTTGGAACAAGTTAGC
GTTTACCCAGCGAAGCATTTTGTAACTCCAAAAGAAAGACTTGAGAGTGCAATAAGTGCAATTAGAAGTGAATTAAAAAC
TCAACTAGATAAATTTACATACGAAGGAAAATTATTAGAGGCTCAACGTCTAGAACAACGTACAAAATATGATTTAGAAA
TGCTTAAAGAGGTTGGTTATTGTAATGGAGTTGAGAATTATGCTCGTCATTTATCAGGTAGGGAGGAAGGTTCACCGCCA
GAATGTTTAATAGATTACTTTCCCAAAGATTGGTTGTTGGTAGTTGATGAGAGTCATGTAACATGTCCTCAACTTCATGC
GATGTACAACGGTGATCAATCTAGAAAAAAAGTTTTAATAGATCATGGTTTTAGATTGCCAAGTGCTGCAGATAATAGAC
CTTTAAAATGTGAAGAGTTTTGGGAAAAATCAAAACAGACATTATTTATAAGTGCAACCCCCGGTCAATGGGAATTAGAT
CAATGTGATGGTGAATTTATTGAGCAAGTTATAAGACCAACTGGGGTATTAGACCCGGTAATTGATGTAAGACCTAGTGA
AGGCCAAATAGAAGATCTGTTATCTGAAATAAGAATTCGAGCTGAAAAGAATCAAAGAGTGCTTGTGACAACACTTACTA
AGAGAATGGCTGAAGATCTAACTGATTTTTTATCTGAAAATAAAGTAAGAGTTAGATATTTGCATTCCGAAATCCATTCA
ATTGAAAGAATTGAAATTATTCAAGACCTCAGAATGGGCGAATATGATGTTTTGGTAGGAGTTAATTTATTAAGAGAGGG
ACTAGATCTTCCAGAAGTATCCTTAGTCGCCATTTTAGATGCTGATAAAGAAGGTTTTCTGAGGGCAGAAAGGTCATTGA
TTCAAACAATAGGAAGAGCTGCCAGACATGTTGAAGGTGTTGCCTTGCTTTATGCGGATAACTTCACAGATTCAATGAAA
AGAGCAATATCTGAAACTGATAGAAGAAGAACTATTCAAAAAAAATATAACCAAGTCAATGGTATTACTCCAAAACCTGC
AGGCAAAAAAATAGAAAATTCAATATTATCTTTTCTAGAACTTTCCAGAAAACTTGATGCTGGTGGTTTATCTAAAGATT
TAATAAATATAGTTAATAACAAAACTGACGCAATTCTCAGTTCCAGTGATAATCAATGTTTGCTCGAAGAATTGCCTGAC
TTAATAGAAAAGTTAGAAATTAAAATGAAAGACGCTGCAAAAGAGTTAAATTTTGAAGAAGCAGCAAATTTGAGGGATAG
AATCAAAAAATTAAGGCAAAAATTGGCAAGAAATAATTAA

Upstream 100 bases:

>100_bases
CAATGATTGCGGTTGTTAGGGCCTTAAAAGAATCTTTGAAAAATTCAATCATTGGAGAAAAAATTTCTTAGTATAGCAAT
ATCCTTTAGCTACTAGCTTG

Downstream 100 bases:

>100_bases
AAAGAACTTATTTTTCTAATTCGAAATGATTATGAATCGCATTAACTGCTTTGTCACAATCTTTTTCTAAGACAATACAT
GAAGTCCTAATTTCACTAGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MNNYKLQAPYEPNGDQPEAIKKLVKGVNNGKQFQTLLGATGTGKTFTIANVIQQTGRPALVLAHNKTLAAQLCNELREFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
EVGKSINLRSSLRSLVENQYTRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQVS
VYPAKHFVTPKERLESAISAIRSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGYCNGVENYARHLSGREEGSPP
ECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCDGEFIEQVIRPTGVLDPVIDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTDSMK
RAISETDRRRTIQKKYNQVNGITPKPAGKKIENSILSFLELSRKLDAGGLSKDLINIVNNKTDAILSSSDNQCLLEELPD
LIEKLEIKMKDAAKELNFEEAANLRDRIKKLRQKLARNN

Sequences:

>Translated_679_residues
MNNYKLQAPYEPNGDQPEAIKKLVKGVNNGKQFQTLLGATGTGKTFTIANVIQQTGRPALVLAHNKTLAAQLCNELREFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
EVGKSINLRSSLRSLVENQYTRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQVS
VYPAKHFVTPKERLESAISAIRSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGYCNGVENYARHLSGREEGSPP
ECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCDGEFIEQVIRPTGVLDPVIDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTDSMK
RAISETDRRRTIQKKYNQVNGITPKPAGKKIENSILSFLELSRKLDAGGLSKDLINIVNNKTDAILSSSDNQCLLEELPD
LIEKLEIKMKDAAKELNFEEAANLRDRIKKLRQKLARNN
>Mature_679_residues
MNNYKLQAPYEPNGDQPEAIKKLVKGVNNGKQFQTLLGATGTGKTFTIANVIQQTGRPALVLAHNKTLAAQLCNELREFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
EVGKSINLRSSLRSLVENQYTRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQVS
VYPAKHFVTPKERLESAISAIRSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGYCNGVENYARHLSGREEGSPP
ECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCDGEFIEQVIRPTGVLDPVIDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTDSMK
RAISETDRRRTIQKKYNQVNGITPKPAGKKIENSILSFLELSRKLDAGGLSKDLINIVNNKTDAILSSSDNQCLLEELPD
LIEKLEIKMKDAAKELNFEEAANLRDRIKKLRQKLARNN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=56.4828614008942, Blast_Score=750, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77270; Mature: 77270

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNYKLQAPYEPNGDQPEAIKKLVKGVNNGKQFQTLLGATGTGKTFTIANVIQQTGRPAL
CCCCEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEE
VLAHNKTLAAQLCNELREFFPKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDM
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCHHHHHH
LRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKFEVGKSINLRSSLRSLVENQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
TRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQVS
CCCCCEEECCEEEEECCEEECCCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
VYPAKHFVTPKERLESAISAIRSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGY
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
CNGVENYARHLSGREEGSPPECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLI
CCCHHHHHHHCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHEEEH
DHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELDQCDGEFIEQVIRPTGVLDPV
HCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHCCHHHHHHHHCCCCCCCCC
IDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
CCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVEGVALLYADNFTDSMKRAISETDRRRTIQKKYNQVNGITPKPAGKKIENSILSFLE
HHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LSRKLDAGGLSKDLINIVNNKTDAILSSSDNQCLLEELPDLIEKLEIKMKDAAKELNFEE
HHHHCCCCCCHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
AANLRDRIKKLRQKLARNN
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNYKLQAPYEPNGDQPEAIKKLVKGVNNGKQFQTLLGATGTGKTFTIANVIQQTGRPAL
CCCCEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEE
VLAHNKTLAAQLCNELREFFPKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDM
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCHHHHHH
LRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKFEVGKSINLRSSLRSLVENQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
TRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQVS
CCCCCEEECCEEEEECCEEECCCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
VYPAKHFVTPKERLESAISAIRSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGY
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
CNGVENYARHLSGREEGSPPECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLI
CCCHHHHHHHCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHEEEH
DHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELDQCDGEFIEQVIRPTGVLDPV
HCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHCCHHHHHHHHCCCCCCCCC
IDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
CCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVEGVALLYADNFTDSMKRAISETDRRRTIQKKYNQVNGITPKPAGKKIENSILSFLE
HHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LSRKLDAGGLSKDLINIVNNKTDAILSSSDNQCLLEELPDLIEKLEIKMKDAAKELNFEE
HHHHCCCCCCHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
AANLRDRIKKLRQKLARNN
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA