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The map label for this gene is lysC [H]

Identifier: 123969389

GI number: 123969389

Start: 1588194

End: 1589954

Strand: Direct

Name: lysC [H]

Synonym: A9601_18571

Alternate gene names: 123969389

Gene position: 1588194-1589954 (Clockwise)

Preceding gene: 123969388

Following gene: 123969392

Centisome position: 95.11

GC content: 35.04

Gene sequence:

>1761_bases
ATGGCTTTACTAGTAAAAAAATTTGGCGGTACTTCTATCGGTGATATAAAAAAAATTAAAAATATTGCAAGTAGCATTTG
TCAAAGTAAAGAAGCAGGTAATGAAATTGTCGTAGTTGTCTCTGCGATGGGGCAAACTACAGATGATTTAAATTGTTTAG
CGGAATCAATTAGTAAAAATCCTAATCGAAGAGAATTGGATATGCTTCTCTCAACTGGAGAGCAAGTAACCATAGCTCTT
CTATCAATGGCATTAAACGAATGCGGAATACCTGCAATTTCAATGACTGGTAGCCAGGTTGGAATTATTACTGAATCAAT
TCATGGGAAAGCGAGAATTCTGGATATTAAAACAGAAAGGATCCAAAATTATTTAAATCAGGGTTTTGTAGTTGTAGTGG
CTGGATTTCAAGGAACAACATTAAGCCATACGGGTTCAATGGAAATTACAACTTTGGGTAGAGGTGGTTCAGATACTTCC
GCGGTAGCTTTATCAACAGCTTTAGGAGCTGAGACTTGCGAAATTTATACAGACGTTCCAGGGGTTCTTACTACTGATCC
ACGGATTGTTCCTAATGCAAAACTCTTAGATGAAATTAGCTGTGAGGAAATGCTTGAACTTGCAAGCGTCGGTGCTTCAG
TTCTCCATCCAAGAGCAGTAGAAATTGCTCGCAATTATGGAATTAAATTGTGTGTCAAATCAAGCCAAAGTGACTCCAGT
GGGACTCTCCTAGAAAGTCAAATCCAACCTCTCCCACTAAAAAGAGGAAGCTTAGAATTAACAAAAACAGTCAATAGTCT
TGAAGTATTAGAAAACCAAGCAGTATTCAGTCTCTCAAATATACCTGATAGGCCTGGGATTGCTGCGCAAATATTTGAAA
AACTTTCAGAAGCAAGTATTAACGTAGATTTAATAATACAAGCGACAAATGATGGAAATAAAAACGATATTACATTTACT
GTTGGTGAATTAGAAGTACAAAAAACTGCAGAACAATGTGAACTTATAACTAGTCAATTAGGGGGAGAATTTAACTTAAA
AACCAACATGACAAAATTAAGTATTCAAGGAGCAGGCATTATGGGCAGACCTAGTGTTTCAGCTGATTTATTTGACACTT
TATCTCAAGCGAATATAAACGTTAGGTTAATAGCTACTAGTGAAATTAAAGTCAGCTGTGTAATTGAAGTTAATAATATA
CCAAAAGCTATTAGATTTGTTGCTGAGAAATTTAAGTTATCAGAAACACAAATATTTGTTAATCCAATCAATGAAAAACA
AGATCAACCTGAAGTAAGAGGAATTGCATTAGATAGAAACCAAGTTCAGGTAAGCTTTCGAAAACTGCCTGATCGTCCAG
GTGTAGCAGCATCGATATGTTTAGCATTAGCTGAAAATAATTTACTTATCGATACTATTGTTCAGTCTGAAAGAATTTCC
ACTTTAAAAACTAAGGATATTAGTCTTACAATGAATAAACAAGATAGAGATAAAGCTAACTTAGTTTTTGAGGCCTTAAC
AAAAAAATTACCCGGATCATACGTTGAAGATGGCCCTGCTATAGCAAAAGTAAGTACTGTAGGAGCGGGAATGGCATTTA
AGGTTGGAACCGCTGGAAAAATATTTAGAGCATTGGCTGACCAAAATATCAATATTGAAATGATTGCCACTAGTGAAATT
AGGACTTCATGTATTGTCTTAGAAAAAGATTGTGACAAAGCAGTTAATGCGATTCATAATCATTTCGAATTAGAAAAATA
A

Upstream 100 bases:

>100_bases
ACTAAAACAAGGTAATAATCCTATAAATGTTTTTACAGAGAAATTAATTAATTTAAGTTAACCAAATTATAAGTTTAAGA
ATTTACATTATCATTTAAAT

Downstream 100 bases:

>100_bases
GTTCTTTTTAATTATTTCTTGCCAATTTTTGCCTTAATTTTTTGATTCTATCCCTCAAATTTGCTGCTTCTTCAAAATTT
AACTCTTTTGCAGCGTCTTT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase; ASK [H]

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MALLVKKFGGTSIGDIKKIKNIASSICQSKEAGNEIVVVVSAMGQTTDDLNCLAESISKNPNRRELDMLLSTGEQVTIAL
LSMALNECGIPAISMTGSQVGIITESIHGKARILDIKTERIQNYLNQGFVVVVAGFQGTTLSHTGSMEITTLGRGGSDTS
AVALSTALGAETCEIYTDVPGVLTTDPRIVPNAKLLDEISCEEMLELASVGASVLHPRAVEIARNYGIKLCVKSSQSDSS
GTLLESQIQPLPLKRGSLELTKTVNSLEVLENQAVFSLSNIPDRPGIAAQIFEKLSEASINVDLIIQATNDGNKNDITFT
VGELEVQKTAEQCELITSQLGGEFNLKTNMTKLSIQGAGIMGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIEVNNI
PKAIRFVAEKFKLSETQIFVNPINEKQDQPEVRGIALDRNQVQVSFRKLPDRPGVAASICLALAENNLLIDTIVQSERIS
TLKTKDISLTMNKQDRDKANLVFEALTKKLPGSYVEDGPAIAKVSTVGAGMAFKVGTAGKIFRALADQNINIEMIATSEI
RTSCIVLEKDCDKAVNAIHNHFELEK

Sequences:

>Translated_586_residues
MALLVKKFGGTSIGDIKKIKNIASSICQSKEAGNEIVVVVSAMGQTTDDLNCLAESISKNPNRRELDMLLSTGEQVTIAL
LSMALNECGIPAISMTGSQVGIITESIHGKARILDIKTERIQNYLNQGFVVVVAGFQGTTLSHTGSMEITTLGRGGSDTS
AVALSTALGAETCEIYTDVPGVLTTDPRIVPNAKLLDEISCEEMLELASVGASVLHPRAVEIARNYGIKLCVKSSQSDSS
GTLLESQIQPLPLKRGSLELTKTVNSLEVLENQAVFSLSNIPDRPGIAAQIFEKLSEASINVDLIIQATNDGNKNDITFT
VGELEVQKTAEQCELITSQLGGEFNLKTNMTKLSIQGAGIMGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIEVNNI
PKAIRFVAEKFKLSETQIFVNPINEKQDQPEVRGIALDRNQVQVSFRKLPDRPGVAASICLALAENNLLIDTIVQSERIS
TLKTKDISLTMNKQDRDKANLVFEALTKKLPGSYVEDGPAIAKVSTVGAGMAFKVGTAGKIFRALADQNINIEMIATSEI
RTSCIVLEKDCDKAVNAIHNHFELEK
>Mature_585_residues
ALLVKKFGGTSIGDIKKIKNIASSICQSKEAGNEIVVVVSAMGQTTDDLNCLAESISKNPNRRELDMLLSTGEQVTIALL
SMALNECGIPAISMTGSQVGIITESIHGKARILDIKTERIQNYLNQGFVVVVAGFQGTTLSHTGSMEITTLGRGGSDTSA
VALSTALGAETCEIYTDVPGVLTTDPRIVPNAKLLDEISCEEMLELASVGASVLHPRAVEIARNYGIKLCVKSSQSDSSG
TLLESQIQPLPLKRGSLELTKTVNSLEVLENQAVFSLSNIPDRPGIAAQIFEKLSEASINVDLIIQATNDGNKNDITFTV
GELEVQKTAEQCELITSQLGGEFNLKTNMTKLSIQGAGIMGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIEVNNIP
KAIRFVAEKFKLSETQIFVNPINEKQDQPEVRGIALDRNQVQVSFRKLPDRPGVAASICLALAENNLLIDTIVQSERIST
LKTKDISLTMNKQDRDKANLVFEALTKKLPGSYVEDGPAIAKVSTVGAGMAFKVGTAGKIFRALADQNINIEMIATSEIR
TSCIVLEKDCDKAVNAIHNHFELEK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=375, Percent_Identity=31.2, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790455, Length=359, Percent_Identity=30.6406685236769, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1790376, Length=289, Percent_Identity=25.9515570934256, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320893, Length=416, Percent_Identity=25.9615384615385, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 63017; Mature: 62886

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLVKKFGGTSIGDIKKIKNIASSICQSKEAGNEIVVVVSAMGQTTDDLNCLAESISKN
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHCC
PNRRELDMLLSTGEQVTIALLSMALNECGIPAISMTGSQVGIITESIHGKARILDIKTER
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCEEEEEEEHHH
IQNYLNQGFVVVVAGFQGTTLSHTGSMEITTLGRGGSDTSAVALSTALGAETCEIYTDVP
HHHHHCCCEEEEEECCCCCEEECCCCEEEEEECCCCCCCHHEEEHHHCCCCEEEEEECCC
GVLTTDPRIVPNAKLLDEISCEEMLELASVGASVLHPRAVEIARNYGIKLCVKSSQSDSS
CCEECCCCCCCCHHHHHHCCHHHHHHHHHCCHHHCCCHHHHHHHCCCEEEEEECCCCCCC
GTLLESQIQPLPLKRGSLELTKTVNSLEVLENQAVFSLSNIPDRPGIAAQIFEKLSEASI
CCEEHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCC
NVDLIIQATNDGNKNDITFTVGELEVQKTAEQCELITSQLGGEFNLKTNMTKLSIQGAGI
CEEEEEEECCCCCCCEEEEEEECEEHHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCC
MGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIEVNNIPKAIRFVAEKFKLSETQIFV
CCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEE
NPINEKQDQPEVRGIALDRNQVQVSFRKLPDRPGVAASICLALAENNLLIDTIVQSERIS
ECCCCCCCCCCCCEEEECCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHC
TLKTKDISLTMNKQDRDKANLVFEALTKKLPGSYVEDGPAIAKVSTVGAGMAFKVGTAGK
EEEECCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEECCHHH
IFRALADQNINIEMIATSEIRTSCIVLEKDCDKAVNAIHNHFELEK
HHHHHHCCCCCEEEEEECCCCEEEEEEECHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALLVKKFGGTSIGDIKKIKNIASSICQSKEAGNEIVVVVSAMGQTTDDLNCLAESISKN
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHCC
PNRRELDMLLSTGEQVTIALLSMALNECGIPAISMTGSQVGIITESIHGKARILDIKTER
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCEEEEEEEHHH
IQNYLNQGFVVVVAGFQGTTLSHTGSMEITTLGRGGSDTSAVALSTALGAETCEIYTDVP
HHHHHCCCEEEEEECCCCCEEECCCCEEEEEECCCCCCCHHEEEHHHCCCCEEEEEECCC
GVLTTDPRIVPNAKLLDEISCEEMLELASVGASVLHPRAVEIARNYGIKLCVKSSQSDSS
CCEECCCCCCCCHHHHHHCCHHHHHHHHHCCHHHCCCHHHHHHHCCCEEEEEECCCCCCC
GTLLESQIQPLPLKRGSLELTKTVNSLEVLENQAVFSLSNIPDRPGIAAQIFEKLSEASI
CCEEHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCC
NVDLIIQATNDGNKNDITFTVGELEVQKTAEQCELITSQLGGEFNLKTNMTKLSIQGAGI
CEEEEEEECCCCCCCEEEEEEECEEHHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCC
MGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIEVNNIPKAIRFVAEKFKLSETQIFV
CCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEE
NPINEKQDQPEVRGIALDRNQVQVSFRKLPDRPGVAASICLALAENNLLIDTIVQSERIS
ECCCCCCCCCCCCEEEECCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHC
TLKTKDISLTMNKQDRDKANLVFEALTKKLPGSYVEDGPAIAKVSTVGAGMAFKVGTAGK
EEEECCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEECCHHH
IFRALADQNINIEMIATSEIRTSCIVLEKDCDKAVNAIHNHFELEK
HHHHHHCCCCCEEEEEECCCCEEEEEEECHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10074061 [H]