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The map label for this gene is cmk [H]

Identifier: 123969331

GI number: 123969331

Start: 1531756

End: 1533285

Strand: Direct

Name: cmk [H]

Synonym: A9601_17991

Alternate gene names: 123969331

Gene position: 1531756-1533285 (Clockwise)

Preceding gene: 123969324

Following gene: 123969337

Centisome position: 91.73

GC content: 28.69

Gene sequence:

>1530_bases
GTGAAGAAGTTAATCATAAGGAAAACTGAAGAAATAGAAAATTGGAGGAAAGATATAGATAGTGAAATTAACTTCATTCC
AACAATGGGTAATCTTCATGATGGACATATAAAACTAATATCAACAGCAAAAAATGACAATTCTAATATTAATTTGGTAA
GTATTTTTATTAATCCACTTCAATTTGATAACAAGTTGGATTTAGAGAATTACCCTAAAACAATTGATAATGATATAAAT
ATCTCCTTTTCAAATGGTGCAGATGCCATCTTCATCCCAAGTAATGAAGATATATATCCACCGAATAATAATATTAGCTT
CCTAAAAGCTCCAATAGAATTATCTTCTGCATTATGTGGATTAAATCGAATTGGACATTTTGATGGCGTTTGCACAGTAG
TTTATAGATTACTTAATCTCATCAAGCCAAAAAATCTTTACTTAGGAGAAAAAGATTGGCAACAACTTTTAATTTTAAAA
AATCTTGTCCTAAGAAAGAAATTAAATATTGCTATAAAATCTATTCCTACACAAAGAGATTTTGATGGGATTCCTTTAAG
TTCTCGTAATGTACATTTATCAAAAAACGAAAGAAAATTGATTAGTTTTTTTTCAAGGGAGTTATTAGAAGCAAAAAAAA
ATTTTCAAAAAGAAAAAAAGATCAATTTAAAAGAAATAATTAAAAAGCTATCAGAAAAAAAAATTTCAATTGAATATTTA
GAACATTTGCACCCTTATACACTCCAAAAAGCAAAAATTGAGGATAATATTTCGTTACTGGCTGGTGCGATAAGATGTGG
AGAGACAAGATTAATTGATCACGTTTTTCTTATGAAAAGAAGGCCAATTATTGCAATTGATGGTCCTGCAGGGTCTGGTA
AGAGTACTGTAACAAAGTTAATAGCAAAGAAACTTAAACTTTTATATTTAGATACTGGAGCAATGTATAGGGCATTGAGT
TGGCTCATCATAAAAGAAAATATTGATTTTAAAAAAGAAAATAAATTACAGAACATTCTTAAAGATATATCTATTGTTTT
CAAATCGAATACAAGTTCACATCAGGATGTTTATGTTAACAACTACTGTGTTACTGAAGAAATTAGGTCGCAAAAGATAA
GTTCCATCGTTTCTAAAATTTCTTCTATAAAAGAAGTACGAGAATTCTTAGTAGAAGAACAAAGAAAAATTGGAGAATCA
GGCGGACTTGTAGCTGAGGGAAGAGATATAGGAACTACTGTTTTTCCTCATGCAGAACTTAAAATATTTTTAACTGCTAG
CATCGATGAAAGAGCAAAAAGAAGAAAATCTGATAAAAATAGTAAAGACTTACAAGAAATAGACCTTCATAAATTAAAAG
AACTTATAAAGCAAAGAGATTCTGAAGATTCCAATAGGAAAATTTCACCTCTAATAAAAGCGAATGACGCAATAGAAATT
ATTACGGATGGATATTCAATTAATGAGGTAGTGGATAAAATTATCGATCTTTATAATGACAAGATTCCTAAAGAGAGTGA
GATCAAATAA

Upstream 100 bases:

>100_bases
ATGAAATAAAAATGATAGACTTTCTCTATATAGATCTTCCTCCTAAGATTGATTTTGTCCAGTAATTATTTATCAAATAG
ATTTATTTTTTAAAAACAAA

Downstream 100 bases:

>100_bases
ATTCAAGAAATACTTTCCAAAAAACCGCTTACAGAGTCTTCTAAAATATCAAGGACATAATCGAAGCCCTCATCACCTCC
AAAATATGGGTCAGGAACTT

Product: bifunctional pantoate ligase/cytidylate kinase

Products: NA

Alternate protein names: Pantothenate synthetase; PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme; Cytidylate kinase; CK; Cytidine monophosphate kinase; CMP kinase [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MKKLIIRKTEEIENWRKDIDSEINFIPTMGNLHDGHIKLISTAKNDNSNINLVSIFINPLQFDNKLDLENYPKTIDNDIN
ISFSNGADAIFIPSNEDIYPPNNNISFLKAPIELSSALCGLNRIGHFDGVCTVVYRLLNLIKPKNLYLGEKDWQQLLILK
NLVLRKKLNIAIKSIPTQRDFDGIPLSSRNVHLSKNERKLISFFSRELLEAKKNFQKEKKINLKEIIKKLSEKKISIEYL
EHLHPYTLQKAKIEDNISLLAGAIRCGETRLIDHVFLMKRRPIIAIDGPAGSGKSTVTKLIAKKLKLLYLDTGAMYRALS
WLIIKENIDFKKENKLQNILKDISIVFKSNTSSHQDVYVNNYCVTEEIRSQKISSIVSKISSIKEVREFLVEEQRKIGES
GGLVAEGRDIGTTVFPHAELKIFLTASIDERAKRRKSDKNSKDLQEIDLHKLKELIKQRDSEDSNRKISPLIKANDAIEI
ITDGYSINEVVDKIIDLYNDKIPKESEIK

Sequences:

>Translated_509_residues
MKKLIIRKTEEIENWRKDIDSEINFIPTMGNLHDGHIKLISTAKNDNSNINLVSIFINPLQFDNKLDLENYPKTIDNDIN
ISFSNGADAIFIPSNEDIYPPNNNISFLKAPIELSSALCGLNRIGHFDGVCTVVYRLLNLIKPKNLYLGEKDWQQLLILK
NLVLRKKLNIAIKSIPTQRDFDGIPLSSRNVHLSKNERKLISFFSRELLEAKKNFQKEKKINLKEIIKKLSEKKISIEYL
EHLHPYTLQKAKIEDNISLLAGAIRCGETRLIDHVFLMKRRPIIAIDGPAGSGKSTVTKLIAKKLKLLYLDTGAMYRALS
WLIIKENIDFKKENKLQNILKDISIVFKSNTSSHQDVYVNNYCVTEEIRSQKISSIVSKISSIKEVREFLVEEQRKIGES
GGLVAEGRDIGTTVFPHAELKIFLTASIDERAKRRKSDKNSKDLQEIDLHKLKELIKQRDSEDSNRKISPLIKANDAIEI
ITDGYSINEVVDKIIDLYNDKIPKESEIK
>Mature_509_residues
MKKLIIRKTEEIENWRKDIDSEINFIPTMGNLHDGHIKLISTAKNDNSNINLVSIFINPLQFDNKLDLENYPKTIDNDIN
ISFSNGADAIFIPSNEDIYPPNNNISFLKAPIELSSALCGLNRIGHFDGVCTVVYRLLNLIKPKNLYLGEKDWQQLLILK
NLVLRKKLNIAIKSIPTQRDFDGIPLSSRNVHLSKNERKLISFFSRELLEAKKNFQKEKKINLKEIIKKLSEKKISIEYL
EHLHPYTLQKAKIEDNISLLAGAIRCGETRLIDHVFLMKRRPIIAIDGPAGSGKSTVTKLIAKKLKLLYLDTGAMYRALS
WLIIKENIDFKKENKLQNILKDISIVFKSNTSSHQDVYVNNYCVTEEIRSQKISSIVSKISSIKEVREFLVEEQRKIGES
GGLVAEGRDIGTTVFPHAELKIFLTASIDERAKRRKSDKNSKDLQEIDLHKLKELIKQRDSEDSNRKISPLIKANDAIEI
ITDGYSINEVVDKIIDLYNDKIPKESEIK

Specific function: Displays a CMP kinase activity [H]

COG id: COG0283

COG function: function code F; Cytidylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786325, Length=257, Percent_Identity=35.7976653696498, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1787139, Length=221, Percent_Identity=37.10407239819, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322046, Length=243, Percent_Identity=33.7448559670782, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003136
- InterPro:   IPR011994
- InterPro:   IPR003721
- InterPro:   IPR014729 [H]

Pfam domain/function: PF02224 Cytidylate_kin; PF02569 Pantoate_ligase [H]

EC number: =6.3.2.1; =2.7.4.14 [H]

Molecular weight: Translated: 58243; Mature: 58243

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLIIRKTEEIENWRKDIDSEINFIPTMGNLHDGHIKLISTAKNDNSNINLVSIFINPL
CCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECC
QFDNKLDLENYPKTIDNDINISFSNGADAIFIPSNEDIYPPNNNISFLKAPIELSSALCG
CCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCEEEECCHHHHHHHHH
LNRIGHFDGVCTVVYRLLNLIKPKNLYLGEKDWQQLLILKNLVLRKKLNIAIKSIPTQRD
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FDGIPLSSRNVHLSKNERKLISFFSRELLEAKKNFQKEKKINLKEIIKKLSEKKISIEYL
CCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHH
EHLHPYTLQKAKIEDNISLLAGAIRCGETRLIDHVFLMKRRPIIAIDGPAGSGKSTVTKL
HHCCCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
IAKKLKLLYLDTGAMYRALSWLIIKENIDFKKENKLQNILKDISIVFKSNTSSHQDVYVN
HHHHHHEEEECCCHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHEECCCCCCCCEEEE
NYCVTEEIRSQKISSIVSKISSIKEVREFLVEEQRKIGESGGLVAEGRDIGTTVFPHAEL
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCEE
KIFLTASIDERAKRRKSDKNSKDLQEIDLHKLKELIKQRDSEDSNRKISPLIKANDAIEI
EEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEE
ITDGYSINEVVDKIIDLYNDKIPKESEIK
EECCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKKLIIRKTEEIENWRKDIDSEINFIPTMGNLHDGHIKLISTAKNDNSNINLVSIFINPL
CCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECC
QFDNKLDLENYPKTIDNDINISFSNGADAIFIPSNEDIYPPNNNISFLKAPIELSSALCG
CCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCEEEECCHHHHHHHHH
LNRIGHFDGVCTVVYRLLNLIKPKNLYLGEKDWQQLLILKNLVLRKKLNIAIKSIPTQRD
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FDGIPLSSRNVHLSKNERKLISFFSRELLEAKKNFQKEKKINLKEIIKKLSEKKISIEYL
CCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHH
EHLHPYTLQKAKIEDNISLLAGAIRCGETRLIDHVFLMKRRPIIAIDGPAGSGKSTVTKL
HHCCCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
IAKKLKLLYLDTGAMYRALSWLIIKENIDFKKENKLQNILKDISIVFKSNTSSHQDVYVN
HHHHHHEEEECCCHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHEECCCCCCCCEEEE
NYCVTEEIRSQKISSIVSKISSIKEVREFLVEEQRKIGESGGLVAEGRDIGTTVFPHAEL
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCEE
KIFLTASIDERAKRRKSDKNSKDLQEIDLHKLKELIKQRDSEDSNRKISPLIKANDAIEI
EEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEE
ITDGYSINEVVDKIIDLYNDKIPKESEIK
EECCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA