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The map label for this gene is hemF [H]

Identifier: 123969321

GI number: 123969321

Start: 1523724

End: 1524752

Strand: Direct

Name: hemF [H]

Synonym: A9601_17891

Alternate gene names: 123969321

Gene position: 1523724-1524752 (Clockwise)

Preceding gene: 123969310

Following gene: 123969323

Centisome position: 91.25

GC content: 34.31

Gene sequence:

>1029_bases
ATGTTGAAAGAACCTCCTAAAAACTCGAGAGAAAAAACTAAAAATCTCTTATTAACTCTACAAGACAAAATTTGTTCAGG
ACTTGAAAATGTAGATGGAAAAGGAAAATTTACAGAGGAATCCTGGCTAAGAGACGAAGGTGGCGGTGGAAGATCTAGAG
TATTGAAAAATGGTTCTATTTTTGAGCAAGCAGGCGTAAATTTCTCGGAAGTACAAGGAAAAGAATTACCTCAATCTATA
ATCTCTCAAAGGCCCGAAGCAAAAGGTCATGAATGGTTTGCTACGGGAACTTCTATGGTTTTGCATCCTAAGAATCCCTA
TATTCCCACAGTTCATCTGAATTATCGATATTTCGAAGCTGGTCCTGTTTGGTGGTTTGGAGGAGGTGCAGACTTAACCC
CTTTTTATCCTTATCTTTCTGATGTAAGGAATTTTCATAATGAGCATAAAAAAGCTTGTGAGAAAGTTGATCAAGATTTG
CATAAAGTTTTCAAACCATGGTGTGATGAATATTTCTTCTTGAAACATAGAAATGAATCTAGAGGTATAGGAGGTATTTT
TTATGATTATCAAGATGGTTCAGGAAATATTTATAGAGGAAATAATAAAAATGGAGAAGCATCAAAAGCTTCACAAAATG
TTGGCAGATCTAATTTAAATTGGGATAATTTATTTTCTTTAGCAGAAAACTGTGGGCAGGCATTCCTACCTTCATATTTG
CCCATTATTGAAAAAAGAGCTTCTCAAAAATATTCACCGAAAGAAAGAGAATTCCAGCTATATCGAAGAGGTAGATATGT
CGAATTCAATTTAGTTTGGGATAGAGGGACGATTTTTGGGCTACAAACAAATGGCAGAACTGAATCTATATTAATGTCCT
TACCGCCTTTAGCTAGATGGGAATATGGATATAAAGCTAAAAATGGCTCTCGAGAGGAATTTCTCACATCAATTTTTACA
AAACCCCAAGATTGGTTTAATGATAAAGAGTTAGAAAAATTCTGTATGGAGAATAATATTTTTGATTAA

Upstream 100 bases:

>100_bases
AACTATCAAATAATAGGCAATAAGGTCCCCCTAAGAGAAATTATAAAGAGAAACTTATAATTAACCAAAAAATTTTTTTT
CTTCAAGATTTACTAAATAC

Downstream 100 bases:

>100_bases
AAATTATCAAATAAAATTTTCAAGTATCTTAAATAGGTGTTTTAAATAAAGAACCGTCACTTTTCAATTGAAGTTTTTCT
CCGAGTTCATTTTCTAAAGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MLKEPPKNSREKTKNLLLTLQDKICSGLENVDGKGKFTEESWLRDEGGGGRSRVLKNGSIFEQAGVNFSEVQGKELPQSI
ISQRPEAKGHEWFATGTSMVLHPKNPYIPTVHLNYRYFEAGPVWWFGGGADLTPFYPYLSDVRNFHNEHKKACEKVDQDL
HKVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGNIYRGNNKNGEASKASQNVGRSNLNWDNLFSLAENCGQAFLPSYL
PIIEKRASQKYSPKEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKNGSREEFLTSIFT
KPQDWFNDKELEKFCMENNIFD

Sequences:

>Translated_342_residues
MLKEPPKNSREKTKNLLLTLQDKICSGLENVDGKGKFTEESWLRDEGGGGRSRVLKNGSIFEQAGVNFSEVQGKELPQSI
ISQRPEAKGHEWFATGTSMVLHPKNPYIPTVHLNYRYFEAGPVWWFGGGADLTPFYPYLSDVRNFHNEHKKACEKVDQDL
HKVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGNIYRGNNKNGEASKASQNVGRSNLNWDNLFSLAENCGQAFLPSYL
PIIEKRASQKYSPKEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKNGSREEFLTSIFT
KPQDWFNDKELEKFCMENNIFD
>Mature_342_residues
MLKEPPKNSREKTKNLLLTLQDKICSGLENVDGKGKFTEESWLRDEGGGGRSRVLKNGSIFEQAGVNFSEVQGKELPQSI
ISQRPEAKGHEWFATGTSMVLHPKNPYIPTVHLNYRYFEAGPVWWFGGGADLTPFYPYLSDVRNFHNEHKKACEKVDQDL
HKVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGNIYRGNNKNGEASKASQNVGRSNLNWDNLFSLAENCGQAFLPSYL
PIIEKRASQKYSPKEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKNGSREEFLTSIFT
KPQDWFNDKELEKFCMENNIFD

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=338, Percent_Identity=41.1242603550296, Blast_Score=267, Evalue=1e-71,
Organism=Escherichia coli, GI1788777, Length=324, Percent_Identity=50.3086419753086, Blast_Score=330, Evalue=8e-92,
Organism=Saccharomyces cerevisiae, GI6320249, Length=340, Percent_Identity=42.9411764705882, Blast_Score=266, Evalue=4e-72,
Organism=Drosophila melanogaster, GI17864388, Length=332, Percent_Identity=43.9759036144578, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 39555; Mature: 39555

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKEPPKNSREKTKNLLLTLQDKICSGLENVDGKGKFTEESWLRDEGGGGRSRVLKNGSI
CCCCCCCCHHHHHHHHHEEEHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHEECCCCC
FEQAGVNFSEVQGKELPQSIISQRPEAKGHEWFATGTSMVLHPKNPYIPTVHLNYRYFEA
HHHHCCCHHHHCCHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEEEEEC
GPVWWFGGGADLTPFYPYLSDVRNFHNEHKKACEKVDQDLHKVFKPWCDEYFFLKHRNES
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
RGIGGIFYDYQDGSGNIYRGNNKNGEASKASQNVGRSNLNWDNLFSLAENCGQAFLPSYL
CCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
PIIEKRASQKYSPKEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARW
HHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCHHHEEECCCHHHC
EYGYKAKNGSREEFLTSIFTKPQDWFNDKELEKFCMENNIFD
CCCCCCCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLKEPPKNSREKTKNLLLTLQDKICSGLENVDGKGKFTEESWLRDEGGGGRSRVLKNGSI
CCCCCCCCHHHHHHHHHEEEHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHEECCCCC
FEQAGVNFSEVQGKELPQSIISQRPEAKGHEWFATGTSMVLHPKNPYIPTVHLNYRYFEA
HHHHCCCHHHHCCHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEEEEEC
GPVWWFGGGADLTPFYPYLSDVRNFHNEHKKACEKVDQDLHKVFKPWCDEYFFLKHRNES
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
RGIGGIFYDYQDGSGNIYRGNNKNGEASKASQNVGRSNLNWDNLFSLAENCGQAFLPSYL
CCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
PIIEKRASQKYSPKEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARW
HHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCHHHEEECCCHHHC
EYGYKAKNGSREEFLTSIFTKPQDWFNDKELEKFCMENNIFD
CCCCCCCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA