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The map label for this gene is adk [H]

Identifier: 123969278

GI number: 123969278

Start: 1487958

End: 1488506

Strand: Reverse

Name: adk [H]

Synonym: A9601_17461

Alternate gene names: 123969278

Gene position: 1488506-1487958 (Counterclockwise)

Preceding gene: 123969279

Following gene: 123969277

Centisome position: 89.14

GC content: 31.51

Gene sequence:

>549_bases
ATGAAGAAGCATCTACTATTTTTAGGAGCTCCTGGAGCAGGGAAAGGGACTCAAGCGGAATTGTTGAGTCAAACTACTTC
TTACTTACATCTTTCTACTGGTGAATTATTAAGAAAAGAAATCGAAATGAATACTAACCTTGGTATCCAGGTAAAAGATA
TTATGAATCGCGGGGAACTAGTTAGTGATGAGCTCGTATTAAAGATAGTAAGACAAAATTTAGTTAAGGATAATATCGGT
TGGATTCTAGATGGTTACCCAAGAAATTTATCTCAAGCAGATTCATTGAATGAAGTCTTATCTGAAATAAATCAACCTTT
AGAAGTAGTCTTTTATTTAGATATTCCAGAAGAAGTGCTAATTGAACGTTTGCTTTTAAGGGGGAGAAAAGATGATACAG
AAGAAACAATTAGAACAAGAGTTGATATTTATAAAAAAACTACTGAACCATTGATTCAATATTTTAAAGATCTTTCATTG
TTAGAATATATTAATGCTGATAGAGATTTAAAAACCATTTCCTCTGATATCAAACAAAAAATGGCTTGA

Upstream 100 bases:

>100_bases
CAACTTCTTTGCTAATTCTTGTGGGTGTCGCTATAGATACTGCTAAGCAAATTCAAACTTATGTTATTTCACAAAGGTAT
GAGGGACTAATTAACAATTA

Downstream 100 bases:

>100_bases
TGATGATGTAGAATATAGTATTAACGTTTTAATTGTTAAACCCCTATGAAGGTCAGATCTTCAGTCAAAAAAATTAGTCC
TGACGATCAGATCGTGAGGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKKHLLFLGAPGAGKGTQAELLSQTTSYLHLSTGELLRKEIEMNTNLGIQVKDIMNRGELVSDELVLKIVRQNLVKDNIG
WILDGYPRNLSQADSLNEVLSEINQPLEVVFYLDIPEEVLIERLLLRGRKDDTEETIRTRVDIYKKTTEPLIQYFKDLSL
LEYINADRDLKTISSDIKQKMA

Sequences:

>Translated_182_residues
MKKHLLFLGAPGAGKGTQAELLSQTTSYLHLSTGELLRKEIEMNTNLGIQVKDIMNRGELVSDELVLKIVRQNLVKDNIG
WILDGYPRNLSQADSLNEVLSEINQPLEVVFYLDIPEEVLIERLLLRGRKDDTEETIRTRVDIYKKTTEPLIQYFKDLSL
LEYINADRDLKTISSDIKQKMA
>Mature_182_residues
MKKHLLFLGAPGAGKGTQAELLSQTTSYLHLSTGELLRKEIEMNTNLGIQVKDIMNRGELVSDELVLKIVRQNLVKDNIG
WILDGYPRNLSQADSLNEVLSEINQPLEVVFYLDIPEEVLIERLLLRGRKDDTEETIRTRVDIYKKTTEPLIQYFKDLSL
LEYINADRDLKTISSDIKQKMA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502011, Length=182, Percent_Identity=37.3626373626374, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI28144897, Length=172, Percent_Identity=36.6279069767442, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI28144899, Length=172, Percent_Identity=36.6279069767442, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=30.2439024390244, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=30.2439024390244, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI7706497, Length=191, Percent_Identity=28.2722513089005, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI19923437, Length=193, Percent_Identity=26.9430051813472, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI310110345, Length=193, Percent_Identity=27.979274611399, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI53832003, Length=193, Percent_Identity=27.979274611399, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI8051579, Length=193, Percent_Identity=27.979274611399, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI53832001, Length=193, Percent_Identity=27.979274611399, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI22749187, Length=199, Percent_Identity=27.1356783919598, Blast_Score=77, Evalue=7e-15,
Organism=Escherichia coli, GI1786680, Length=184, Percent_Identity=35.3260869565217, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17552384, Length=210, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=177, Percent_Identity=35.5932203389831, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550688, Length=188, Percent_Identity=30.3191489361702, Blast_Score=106, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=29.3478260869565, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17537943, Length=186, Percent_Identity=27.4193548387097, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25147457, Length=185, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322828, Length=184, Percent_Identity=34.7826086956522, Blast_Score=121, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6320432, Length=212, Percent_Identity=30.188679245283, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=31.1224489795918, Blast_Score=102, Evalue=3e-23,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=33.879781420765, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24663208, Length=186, Percent_Identity=30.1075268817204, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17647141, Length=186, Percent_Identity=30.1075268817204, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17737899, Length=188, Percent_Identity=29.2553191489362, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24645822, Length=188, Percent_Identity=29.2553191489362, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=28.2608695652174, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=28.2608695652174, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 20830; Mature: 20830

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHLLFLGAPGAGKGTQAELLSQTTSYLHLSTGELLRKEIEMNTNLGIQVKDIMNRGEL
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEHHHHHCCCCC
VSDELVLKIVRQNLVKDNIGWILDGYPRNLSQADSLNEVLSEINQPLEVVFYLDIPEEVL
HHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
IERLLLRGRKDDTEETIRTRVDIYKKTTEPLIQYFKDLSLLEYINADRDLKTISSDIKQK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MA
CC
>Mature Secondary Structure
MKKHLLFLGAPGAGKGTQAELLSQTTSYLHLSTGELLRKEIEMNTNLGIQVKDIMNRGEL
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEHHHHHCCCCC
VSDELVLKIVRQNLVKDNIGWILDGYPRNLSQADSLNEVLSEINQPLEVVFYLDIPEEVL
HHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
IERLLLRGRKDDTEETIRTRVDIYKKTTEPLIQYFKDLSLLEYINADRDLKTISSDIKQK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA