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The map label for this gene is lon [H]

Identifier: 123969241

GI number: 123969241

Start: 1452823

End: 1453479

Strand: Reverse

Name: lon [H]

Synonym: A9601_17091

Alternate gene names: 123969241

Gene position: 1453479-1452823 (Counterclockwise)

Preceding gene: 123969242

Following gene: 123969240

Centisome position: 87.04

GC content: 35.01

Gene sequence:

>657_bases
ATGGGAGAACTCTCAGTAAGGGAATTACCTTTATTTCCTTTGCCAGAGGTAGTCCTTTTTCCTCAAGAAGTATTGCCTTT
ACATATTTTTGAATCTAGATATAGGATTATGCTCCAAACTGTTCTTGAGAGCGATTCTATGTTTGGAGTTATTAAGTGGG
ATCCAACTTCTAAAAGTATGGCTAACGTTGGATGTTGCGCTCAAATTATAAAACACCAAACTGCTGAAGATGGTAGAAGT
AACATTATCACTCTAGGCCAACAGAGATTTCAAATCTTAGAAATTACCCGTTCGACGCCATTTTGTTCTGCGATGGTTAG
TTGGATTAGTGATGAGAATATTGATGACCTTCAAAAATTAGATTCTTTAAGAGATTCAGTAAAAGAAGCACTTGGTGATG
TTATTACATTAACAAGTAAATTGACTAATACTAAAAAAAATCTACCTGATAAATTACCTAACAACCCAATGGATTTATCA
TTTTGGATAGGAGCTCATTTGGGCGGTCCTGTTGCGGAGGAACAGCAAAGACTTTTAGAGGAAAGAAATACTTTTACCCG
TTTACAGAGAGAATATGAAATGCTTGATCATACAAGAAAACAACTTGCAGCAAGAACGGCATTGAAAGAAAGTTTTCCTG
ATATAAAAGAAAATTAA

Upstream 100 bases:

>100_bases
AACTTGATCTCCCTAGTGGTGTAGATATAGAAGTTAAACTTTAAAAAATCCCGAAATCGTCCTAAATTTACTAGTATAAA
AATAATGAAATGAGGTTTAA

Downstream 100 bases:

>100_bases
ATGATTGATTTATTATTCCCTTTTTTTATACTTTTTTTACTCTTTCTAGTCCTTGCAATAATTTGGAGAAATAATGCTAG
AAAATACATTTCTTCCGGTA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MGELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRIMLQTVLESDSMFGVIKWDPTSKSMANVGCCAQIIKHQTAEDGRS
NIITLGQQRFQILEITRSTPFCSAMVSWISDENIDDLQKLDSLRDSVKEALGDVITLTSKLTNTKKNLPDKLPNNPMDLS
FWIGAHLGGPVAEEQQRLLEERNTFTRLQREYEMLDHTRKQLAARTALKESFPDIKEN

Sequences:

>Translated_218_residues
MGELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRIMLQTVLESDSMFGVIKWDPTSKSMANVGCCAQIIKHQTAEDGRS
NIITLGQQRFQILEITRSTPFCSAMVSWISDENIDDLQKLDSLRDSVKEALGDVITLTSKLTNTKKNLPDKLPNNPMDLS
FWIGAHLGGPVAEEQQRLLEERNTFTRLQREYEMLDHTRKQLAARTALKESFPDIKEN
>Mature_217_residues
GELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRIMLQTVLESDSMFGVIKWDPTSKSMANVGCCAQIIKHQTAEDGRSN
IITLGQQRFQILEITRSTPFCSAMVSWISDENIDDLQKLDSLRDSVKEALGDVITLTSKLTNTKKNLPDKLPNNPMDLSF
WIGAHLGGPVAEEQQRLLEERNTFTRLQREYEMLDHTRKQLAARTALKESFPDIKEN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG2802

COG function: function code R; Uncharacterized protein, similar to the N-terminal domain of Lon protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI87080813, Length=126, Percent_Identity=32.5396825396825, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 24886; Mature: 24755

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRIMLQTVLESDSMFGVIKWDPTSKSM
CCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHH
ANVGCCAQIIKHQTAEDGRSNIITLGQQRFQILEITRSTPFCSAMVSWISDENIDDLQKL
HHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
DSLRDSVKEALGDVITLTSKLTNTKKNLPDKLPNNPMDLSFWIGAHLGGPVAEEQQRLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHEEHHHCCCCCHHHHHHHHH
ERNTFTRLQREYEMLDHTRKQLAARTALKESFPDIKEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRIMLQTVLESDSMFGVIKWDPTSKSM
CCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHH
ANVGCCAQIIKHQTAEDGRSNIITLGQQRFQILEITRSTPFCSAMVSWISDENIDDLQKL
HHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
DSLRDSVKEALGDVITLTSKLTNTKKNLPDKLPNNPMDLSFWIGAHLGGPVAEEQQRLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHEEHHHCCCCCHHHHHHHHH
ERNTFTRLQREYEMLDHTRKQLAARTALKESFPDIKEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA