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The map label for this gene is hisD [H]

Identifier: 123969224

GI number: 123969224

Start: 1434952

End: 1436238

Strand: Direct

Name: hisD [H]

Synonym: A9601_16921

Alternate gene names: 123969224

Gene position: 1434952-1436238 (Clockwise)

Preceding gene: 123969216

Following gene: 123969227

Centisome position: 85.93

GC content: 33.18

Gene sequence:

>1287_bases
ATGAAGATCATAAATAATAAAGAAGATGCTATCCAAGAATTAAAAAGGATTTCCACTCGAACTAACTCAGAAAACAACCA
CAAAATAAATGCAATAGTCGAAGAAATTCTTCAAGAAGTAAAAAATTATGGAGATACAGCAGTAAAAAAATATACCAAAA
AATTTGATGGTTTCAACCCTGAACCTATGCAAGTAAGTTCGAACCAAATAAAAAATGCATGGAATGAAATTGATAACAAT
TTGAAGCGCTCTCTTGAGGTAGCTCATAAAAGAATACAAAAATTCCATGAAAAAGAAATTCCTAAATCTTTTACAATAAA
AGGTGAATATGGTGATACAGTCCAAAGAAGATGGCGACCAGTTAAAAATGCAGGTATTTATATTCCTGGAGGCAGAGCTG
CTTATCCAAGCACTGTATTAATGAATGCAATACCTGCGAAAGTAGCAGGAGTTAAGGAAACTATAATGGTATCTCCTGGG
AATAAAGAAGGAGAAATAAACAAAACTGTTTTAGCAGCAGCTCACTTATCAGGAATCAATAAAGTATTTAGAATTGGAGG
AGCTCAAGCAATTGGTGCTTTAGCCTTTGGCACAAATCAAATCAATAAAGTTGATGTTATTTCAGGTCCAGGGAATATTT
ATGTTACAACTGCGAAAAAACTTATTTATGGTTCTACAGGGATTGATTCTTTAGCTGGTCCAAGTGAAATATTAATCATT
GCAGATGAAACAGCTCAAAGCACTTATATAGCGTCTGATCTACTAGCCCAAGCAGAACATGATCCTTTAGCTTCATCAAT
CCTTCTAACTACATCAAAAAATCAGGCACAAGAAGTTTTAGAAGAACTTTATAAAAAAATAGATGATCATCCAAGAAAAG
AAATTTGCATGCAATCAATTAAAAATTGGGGGTTAATTGTGATTTGTGAGAATTATGAATCATGTGTTGAACTAAGTAAT
AACTTTGCCCCTGAACACCTAGAAATTCTTACTATAAATTCAAAAAAAATTCTTGCAGATATAGATAATGCAGGAGCGAT
ATTTTTGGGGAAATGGACACCAGAAGCTGTTGGAGATTATCTTGCTGGACCAAATCATACTTTACCCACATCAGGAAATT
CTAGATTCAGCGGTTCTTTGGGGGTTGAAACTTTTATGAAAAATACTTCAATAATAGAATTTAATGAAGAAAGTTTAAAA
ATCAATAGCCCGGATATTATAAATCTTGCTAATAGTGAGGGCTTACACAGCCACGCTAACTCAGTACAAATAAGATTTGA
AGATTAG

Upstream 100 bases:

>100_bases
GATACTTATCATAACAAATAAATCGACTACTAATCAATCATATATAATTTAGAAAGTTATTAATTTGGGTTTGAGCCTTT
CAATTTGAAAAATTAAGAAT

Downstream 100 bases:

>100_bases
CTAACTCTTGAGGGTGAGTAAACCACTGGAGTATTATTTTCAATTTTACCCACTAGAACTTTGTCTGTAAGATCGACGAA
TAATCCATTTTCTAAAACTC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKIINNKEDAIQELKRISTRTNSENNHKINAIVEEILQEVKNYGDTAVKKYTKKFDGFNPEPMQVSSNQIKNAWNEIDNN
LKRSLEVAHKRIQKFHEKEIPKSFTIKGEYGDTVQRRWRPVKNAGIYIPGGRAAYPSTVLMNAIPAKVAGVKETIMVSPG
NKEGEINKTVLAAAHLSGINKVFRIGGAQAIGALAFGTNQINKVDVISGPGNIYVTTAKKLIYGSTGIDSLAGPSEILII
ADETAQSTYIASDLLAQAEHDPLASSILLTTSKNQAQEVLEELYKKIDDHPRKEICMQSIKNWGLIVICENYESCVELSN
NFAPEHLEILTINSKKILADIDNAGAIFLGKWTPEAVGDYLAGPNHTLPTSGNSRFSGSLGVETFMKNTSIIEFNEESLK
INSPDIINLANSEGLHSHANSVQIRFED

Sequences:

>Translated_428_residues
MKIINNKEDAIQELKRISTRTNSENNHKINAIVEEILQEVKNYGDTAVKKYTKKFDGFNPEPMQVSSNQIKNAWNEIDNN
LKRSLEVAHKRIQKFHEKEIPKSFTIKGEYGDTVQRRWRPVKNAGIYIPGGRAAYPSTVLMNAIPAKVAGVKETIMVSPG
NKEGEINKTVLAAAHLSGINKVFRIGGAQAIGALAFGTNQINKVDVISGPGNIYVTTAKKLIYGSTGIDSLAGPSEILII
ADETAQSTYIASDLLAQAEHDPLASSILLTTSKNQAQEVLEELYKKIDDHPRKEICMQSIKNWGLIVICENYESCVELSN
NFAPEHLEILTINSKKILADIDNAGAIFLGKWTPEAVGDYLAGPNHTLPTSGNSRFSGSLGVETFMKNTSIIEFNEESLK
INSPDIINLANSEGLHSHANSVQIRFED
>Mature_428_residues
MKIINNKEDAIQELKRISTRTNSENNHKINAIVEEILQEVKNYGDTAVKKYTKKFDGFNPEPMQVSSNQIKNAWNEIDNN
LKRSLEVAHKRIQKFHEKEIPKSFTIKGEYGDTVQRRWRPVKNAGIYIPGGRAAYPSTVLMNAIPAKVAGVKETIMVSPG
NKEGEINKTVLAAAHLSGINKVFRIGGAQAIGALAFGTNQINKVDVISGPGNIYVTTAKKLIYGSTGIDSLAGPSEILII
ADETAQSTYIASDLLAQAEHDPLASSILLTTSKNQAQEVLEELYKKIDDHPRKEICMQSIKNWGLIVICENYESCVELSN
NFAPEHLEILTINSKKILADIDNAGAIFLGKWTPEAVGDYLAGPNHTLPTSGNSRFSGSLGVETFMKNTSIIEFNEESLK
INSPDIINLANSEGLHSHANSVQIRFED

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=426, Percent_Identity=39.2018779342723, Blast_Score=313, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6319819, Length=430, Percent_Identity=37.2093023255814, Blast_Score=276, Evalue=7e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47087; Mature: 47087

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIINNKEDAIQELKRISTRTNSENNHKINAIVEEILQEVKNYGDTAVKKYTKKFDGFNP
CCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
EPMQVSSNQIKNAWNEIDNNLKRSLEVAHKRIQKFHEKEIPKSFTIKGEYGDTVQRRWRP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCC
VKNAGIYIPGGRAAYPSTVLMNAIPAKVAGVKETIMVSPGNKEGEINKTVLAAAHLSGIN
CCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHH
KVFRIGGAQAIGALAFGTNQINKVDVISGPGNIYVTTAKKLIYGSTGIDSLAGPSEILII
HHHHCCCHHHHHHHEECCCCCCEEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCEEEEE
ADETAQSTYIASDLLAQAEHDPLASSILLTTSKNQAQEVLEELYKKIDDHPRKEICMQSI
ECCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
KNWGLIVICENYESCVELSNNFAPEHLEILTINSKKILADIDNAGAIFLGKWTPEAVGDY
HCCCEEEEECCHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCCEEEEECCCHHHHHHH
LAGPNHTLPTSGNSRFSGSLGVETFMKNTSIIEFNEESLKINSPDIINLANSEGLHSHAN
HCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCEEECCCCEEEECCCCCCCCCCC
SVQIRFED
EEEEEECC
>Mature Secondary Structure
MKIINNKEDAIQELKRISTRTNSENNHKINAIVEEILQEVKNYGDTAVKKYTKKFDGFNP
CCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
EPMQVSSNQIKNAWNEIDNNLKRSLEVAHKRIQKFHEKEIPKSFTIKGEYGDTVQRRWRP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCC
VKNAGIYIPGGRAAYPSTVLMNAIPAKVAGVKETIMVSPGNKEGEINKTVLAAAHLSGIN
CCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHH
KVFRIGGAQAIGALAFGTNQINKVDVISGPGNIYVTTAKKLIYGSTGIDSLAGPSEILII
HHHHCCCHHHHHHHEECCCCCCEEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCEEEEE
ADETAQSTYIASDLLAQAEHDPLASSILLTTSKNQAQEVLEELYKKIDDHPRKEICMQSI
ECCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
KNWGLIVICENYESCVELSNNFAPEHLEILTINSKKILADIDNAGAIFLGKWTPEAVGDY
HCCCEEEEECCHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCCEEEEECCCHHHHHHH
LAGPNHTLPTSGNSRFSGSLGVETFMKNTSIIEFNEESLKINSPDIINLANSEGLHSHAN
HCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCEEECCCCEEEECCCCCCCCCCC
SVQIRFED
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA