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The map label for this gene is bioA [H]

Identifier: 123969206

GI number: 123969206

Start: 1416711

End: 1418012

Strand: Direct

Name: bioA [H]

Synonym: A9601_16741

Alternate gene names: 123969206

Gene position: 1416711-1418012 (Clockwise)

Preceding gene: 123969205

Following gene: 123969209

Centisome position: 84.84

GC content: 34.79

Gene sequence:

>1302_bases
ATGAAATCTTTGGATTCAAAAACTCCAAATCAAGATTGGCACCCAAATATTTGGCCACCTTTTACGCAAATCAATAACAG
CAAACCTCAGATTGAAGTAACTCATGGTAAAGATGCCCTCCTATTTACTAAAGATCCTAAAAAAGAACTAATAGATGCAA
TTAGTAGTTGGTGGGTAACTCTTCATGGTCATAGTAACGAATATATTGCGGATGCCATTTTTGATCAATCAAAAAAACTT
GAGCAAGTTATATTTGCTGATTTCTTACATCCACAGGCAAAAAAATTAGCGGAAAGGCTTAGTGAATTAACAAAACTAGA
AAGATTATTCTTTTCTGATAACGGTTCTACTGCAGTGGAAGTTGCTTTAAAAATTGCCTTCCAATCATGGCAAAATAGAG
GAGAGACAAGAACTCAAATAGTAGCTTTTGATGGCGCCTATCATGGTGATACATTTGGCGCGATGGCTTTAGGTGAAAGA
AATATTTTTAATGAGAATTTCGATAATCTTATGTTCCCAGTTAGAAGAGTCCCATGGCCTTCAACTTGGATGAACGATGA
AGAAGTAGAAAAGAAAGAAAATAAGGCGATCCAAAAATTAGAAACCCTACTTAAAACTCCCACAGTTGCAGTTATCCTTG
AGCCACTTGTACAAGGAGCAGGAGGGATGAATATGGTTAGGCCTCAGTTTATCAAAAAAGTTTCAGAAATTATAAAGAAA
AGTAATTCTTTGTTAATTGCCGATGAAGTATTGACTGGGTTTGGAAGATGTGGGACCCTTTTTGCTTTTCAAAAGGCAAA
AATCGTTCCTGATTTAATAAGTATTTCAAAAGGTTTAACTGGTGGATTTTTACCGATGGGAATAACTTTATGTAAAGAAA
AAATTTTTCAATCCTTTATTGATGATTCCCCAAGAAAAACTTTTTGGCATGGACATAGTTTTACTGCTAATCCTTTAGGT
TGTGCGGCAGCAAACGCTAGCCTTGATTTATTAGAAAAAGAACCACAAAAATACCTTTCATTTGAAGAAAAACATTTATC
TCATCTAATTAAATTTAAAAACTTACCCTATATAAAGAAGGTAAGGGTATCCGGCACAATTGCAGCCTTCGATTTAGATA
TTGGGAACAAAAAAGGTTATTTCAATAATATTGGGAAAGAAATAAAGAGTCTTGCAATGGAGCAAGGTTTATTCATTAGG
CCCCTCGGGAATGTTATTTACCTCTTGCCGCCTCTCTGTATAACAGATGATCAATTGGGGAAAAGTTACTGGATAATAAG
GCAAATCTTAGAAAATCTTTAG

Upstream 100 bases:

>100_bases
TTACATCAAAAAAATGGACTCAAATAATTTAGATATACTATGGAAAGAACTAGACATCAAAAATAAGTTGATCTCACTAT
TAAACTCAAAAATAAGTTAA

Downstream 100 bases:

>100_bases
ATAGAAATTTAAGGTCCCTGCAGTATTGCATTTTCCACATCTTCTCTATTAATGCAGTAGGAAAATAGTCTTTTAGTTTC
TTGTCCTTCACTTTCCCATA

Product: putative diaminopelargonic acid synthase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKSLDSKTPNQDWHPNIWPPFTQINNSKPQIEVTHGKDALLFTKDPKKELIDAISSWWVTLHGHSNEYIADAIFDQSKKL
EQVIFADFLHPQAKKLAERLSELTKLERLFFSDNGSTAVEVALKIAFQSWQNRGETRTQIVAFDGAYHGDTFGAMALGER
NIFNENFDNLMFPVRRVPWPSTWMNDEEVEKKENKAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRPQFIKKVSEIIKK
SNSLLIADEVLTGFGRCGTLFAFQKAKIVPDLISISKGLTGGFLPMGITLCKEKIFQSFIDDSPRKTFWHGHSFTANPLG
CAAANASLDLLEKEPQKYLSFEEKHLSHLIKFKNLPYIKKVRVSGTIAAFDLDIGNKKGYFNNIGKEIKSLAMEQGLFIR
PLGNVIYLLPPLCITDDQLGKSYWIIRQILENL

Sequences:

>Translated_433_residues
MKSLDSKTPNQDWHPNIWPPFTQINNSKPQIEVTHGKDALLFTKDPKKELIDAISSWWVTLHGHSNEYIADAIFDQSKKL
EQVIFADFLHPQAKKLAERLSELTKLERLFFSDNGSTAVEVALKIAFQSWQNRGETRTQIVAFDGAYHGDTFGAMALGER
NIFNENFDNLMFPVRRVPWPSTWMNDEEVEKKENKAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRPQFIKKVSEIIKK
SNSLLIADEVLTGFGRCGTLFAFQKAKIVPDLISISKGLTGGFLPMGITLCKEKIFQSFIDDSPRKTFWHGHSFTANPLG
CAAANASLDLLEKEPQKYLSFEEKHLSHLIKFKNLPYIKKVRVSGTIAAFDLDIGNKKGYFNNIGKEIKSLAMEQGLFIR
PLGNVIYLLPPLCITDDQLGKSYWIIRQILENL
>Mature_433_residues
MKSLDSKTPNQDWHPNIWPPFTQINNSKPQIEVTHGKDALLFTKDPKKELIDAISSWWVTLHGHSNEYIADAIFDQSKKL
EQVIFADFLHPQAKKLAERLSELTKLERLFFSDNGSTAVEVALKIAFQSWQNRGETRTQIVAFDGAYHGDTFGAMALGER
NIFNENFDNLMFPVRRVPWPSTWMNDEEVEKKENKAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRPQFIKKVSEIIKK
SNSLLIADEVLTGFGRCGTLFAFQKAKIVPDLISISKGLTGGFLPMGITLCKEKIFQSFIDDSPRKTFWHGHSFTANPLG
CAAANASLDLLEKEPQKYLSFEEKHLSHLIKFKNLPYIKKVRVSGTIAAFDLDIGNKKGYFNNIGKEIKSLAMEQGLFIR
PLGNVIYLLPPLCITDDQLGKSYWIIRQILENL

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=415, Percent_Identity=26.2650602409639, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI13994255, Length=379, Percent_Identity=25.3298153034301, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI284507298, Length=333, Percent_Identity=27.3273273273273, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI24119277, Length=434, Percent_Identity=24.4239631336406, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI37574042, Length=441, Percent_Identity=24.2630385487528, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=24.6192893401015, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI226442705, Length=369, Percent_Identity=24.9322493224932, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786991, Length=411, Percent_Identity=35.2798053527981, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI145693181, Length=380, Percent_Identity=30.5263157894737, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788044, Length=378, Percent_Identity=27.5132275132275, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1789759, Length=375, Percent_Identity=27.7333333333333, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1789016, Length=400, Percent_Identity=28.5, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=28.5, Blast_Score=119, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=25.0608272506083, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=445, Percent_Identity=26.7415730337079, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=235, Percent_Identity=31.4893617021277, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=466, Percent_Identity=31.3304721030043, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6323470, Length=405, Percent_Identity=28.1481481481481, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=413, Percent_Identity=27.6029055690073, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6321456, Length=306, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=25.9708737864078, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI21356575, Length=424, Percent_Identity=23.8207547169811, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574759, Length=393, Percent_Identity=24.4274809160305, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI161085790, Length=397, Percent_Identity=23.9294710327456, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281366494, Length=188, Percent_Identity=29.2553191489362, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667139, Length=188, Percent_Identity=29.2553191489362, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667143, Length=188, Percent_Identity=29.2553191489362, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48955; Mature: 48955

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLDSKTPNQDWHPNIWPPFTQINNSKPQIEVTHGKDALLFTKDPKKELIDAISSWWVT
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCEEE
LHGHSNEYIADAIFDQSKKLEQVIFADFLHPQAKKLAERLSELTKLERLFFSDNGSTAVE
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VALKIAFQSWQNRGETRTQIVAFDGAYHGDTFGAMALGERNIFNENFDNLMFPVRRVPWP
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCC
STWMNDEEVEKKENKAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRPQFIKKVSEIIKK
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
SNSLLIADEVLTGFGRCGTLFAFQKAKIVPDLISISKGLTGGFLPMGITLCKEKIFQSFI
CCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DDSPRKTFWHGHSFTANPLGCAAANASLDLLEKEPQKYLSFEEKHLSHLIKFKNLPYIKK
CCCCCCEEECCCCCCCCCCCHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEE
VRVSGTIAAFDLDIGNKKGYFNNIGKEIKSLAMEQGLFIRPLGNVIYLLPPLCITDDQLG
EEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCCEECCHHHC
KSYWIIRQILENL
HHHHHHHHHHHHC
>Mature Secondary Structure
MKSLDSKTPNQDWHPNIWPPFTQINNSKPQIEVTHGKDALLFTKDPKKELIDAISSWWVT
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCEEE
LHGHSNEYIADAIFDQSKKLEQVIFADFLHPQAKKLAERLSELTKLERLFFSDNGSTAVE
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VALKIAFQSWQNRGETRTQIVAFDGAYHGDTFGAMALGERNIFNENFDNLMFPVRRVPWP
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCC
STWMNDEEVEKKENKAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRPQFIKKVSEIIKK
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
SNSLLIADEVLTGFGRCGTLFAFQKAKIVPDLISISKGLTGGFLPMGITLCKEKIFQSFI
CCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DDSPRKTFWHGHSFTANPLGCAAANASLDLLEKEPQKYLSFEEKHLSHLIKFKNLPYIKK
CCCCCCEEECCCCCCCCCCCHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEE
VRVSGTIAAFDLDIGNKKGYFNNIGKEIKSLAMEQGLFIRPLGNVIYLLPPLCITDDQLG
EEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCCEECCHHHC
KSYWIIRQILENL
HHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]