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The map label for this gene is msrA2 [H]

Identifier: 123969065

GI number: 123969065

Start: 1313099

End: 1313701

Strand: Reverse

Name: msrA2 [H]

Synonym: A9601_15331

Alternate gene names: 123969065

Gene position: 1313701-1313099 (Counterclockwise)

Preceding gene: 123969066

Following gene: 123969062

Centisome position: 78.67

GC content: 34.99

Gene sequence:

>603_bases
ATGAAATATTTGTTACCTCTAATAGTCGCTTTTTCACTATTTATGACCCCTGTCAACGCTTTTGCAGATGAATTGATTCT
TGCAGGAGGTTGTTTTTGGTGCTTAGAACATGATTTAGAGTCTTTAAAGGGGATAAATTTTGTTCAAAGTGGCTATTCAG
GTGGAGATTTGCAAAATCCTACTTACGAAAATCATGAAGGATATCAAGAAGTGGTTTTGATCGACTATGACTCCAATTTG
GTAACTTTACCCGAGATACTTAGGCTCTATTTCAGAAATATTGATCCTCTGGACGGCAAAGGTCAATTTTGTGATCGTGG
AGATTCATATAGGCCAGTAATCTTTTTCAAAGATGCAACTGAGAAAAGTGATGCAATAAATGCAATTGTTTCGGCCTCCA
ATGAGTTGAGAGTGCCAATAGAAAAAATATCTGTAGAGTTAAAATCAAAAGGTCAATTTTGGTTGGCTGAAGAATATCAT
CAGGATTTTGCTGAGAGAAATGAATTAAAATACAAATTCTATAGATTCTCATGTGGTAGAGATCAAAGGTTGGATAAATT
ATGGGGTGATAACGCTAGATCGATAAATATTTGGAATGAATGA

Upstream 100 bases:

>100_bases
GGTTATGCTTTTTTAAAAAAAGAATTAGGTGAAGAAGGTGTAGTCCAAAGAACTGCAAAAGAGATTATTAATTCTATTAT
TTGAACTTTATAATAAAAAA

Downstream 100 bases:

>100_bases
TTTAAATATAGTTATTTATTTTTAATCCATTGAACAAGAGTTTTAACTCCAAAACCGGTTGCACCTGATGGATTAATTCC
TTTATTCTTATCAGTCCAAC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MKYLLPLIVAFSLFMTPVNAFADELILAGGCFWCLEHDLESLKGINFVQSGYSGGDLQNPTYENHEGYQEVVLIDYDSNL
VTLPEILRLYFRNIDPLDGKGQFCDRGDSYRPVIFFKDATEKSDAINAIVSASNELRVPIEKISVELKSKGQFWLAEEYH
QDFAERNELKYKFYRFSCGRDQRLDKLWGDNARSINIWNE

Sequences:

>Translated_200_residues
MKYLLPLIVAFSLFMTPVNAFADELILAGGCFWCLEHDLESLKGINFVQSGYSGGDLQNPTYENHEGYQEVVLIDYDSNL
VTLPEILRLYFRNIDPLDGKGQFCDRGDSYRPVIFFKDATEKSDAINAIVSASNELRVPIEKISVELKSKGQFWLAEEYH
QDFAERNELKYKFYRFSCGRDQRLDKLWGDNARSINIWNE
>Mature_200_residues
MKYLLPLIVAFSLFMTPVNAFADELILAGGCFWCLEHDLESLKGINFVQSGYSGGDLQNPTYENHEGYQEVVLIDYDSNL
VTLPEILRLYFRNIDPLDGKGQFCDRGDSYRPVIFFKDATEKSDAINAIVSASNELRVPIEKISVELKSKGQFWLAEEYH
QDFAERNELKYKFYRFSCGRDQRLDKLWGDNARSINIWNE

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=154, Percent_Identity=31.1688311688312, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI208609995, Length=154, Percent_Identity=31.1688311688312, Blast_Score=81, Evalue=6e-16,
Organism=Escherichia coli, GI1790665, Length=163, Percent_Identity=30.6748466257669, Blast_Score=78, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24664627, Length=146, Percent_Identity=31.5068493150685, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45553131, Length=134, Percent_Identity=32.8358208955224, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23116; Mature: 23116

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLLPLIVAFSLFMTPVNAFADELILAGGCFWCLEHDLESLKGINFVQSGYSGGDLQNP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
TYENHEGYQEVVLIDYDSNLVTLPEILRLYFRNIDPLDGKGQFCDRGDSYRPVIFFKDAT
CCCCCCCCEEEEEEECCCCEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCC
EKSDAINAIVSASNELRVPIEKISVELKSKGQFWLAEEYHQDFAERNELKYKFYRFSCGR
CCHHHHHHHHHCCCCCCCCHHHHEEEECCCCCEEEHHHHHHHHHHHCCCEEEEEEECCCC
DQRLDKLWGDNARSINIWNE
CHHHHHHHCCCCCEEECCCC
>Mature Secondary Structure
MKYLLPLIVAFSLFMTPVNAFADELILAGGCFWCLEHDLESLKGINFVQSGYSGGDLQNP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
TYENHEGYQEVVLIDYDSNLVTLPEILRLYFRNIDPLDGKGQFCDRGDSYRPVIFFKDAT
CCCCCCCCEEEEEEECCCCEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCC
EKSDAINAIVSASNELRVPIEKISVELKSKGQFWLAEEYHQDFAERNELKYKFYRFSCGR
CCHHHHHHHHHCCCCCCCCHHHHEEEECCCCCEEEHHHHHHHHHHHCCCEEEEEEECCCC
DQRLDKLWGDNARSINIWNE
CHHHHHHHCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]