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The map label for this gene is panB [H]

Identifier: 123969041

GI number: 123969041

Start: 1293026

End: 1293799

Strand: Direct

Name: panB [H]

Synonym: A9601_15091

Alternate gene names: 123969041

Gene position: 1293026-1293799 (Clockwise)

Preceding gene: 123969040

Following gene: 123969043

Centisome position: 77.43

GC content: 34.37

Gene sequence:

>774_bases
ATGTTACCTTCAGACCTAGTTAACTATAAAAAAAAATCTCGCAAAATCATTGCTCTAACAGCATGGGACTCCATATCAGG
ATCTATTGCAGAACAAGCAAATGTTGATCTTGTACTAGTAGGAGATTCATTAGCAATGGTCTGTTTAGGATACAAATCGA
CATTGCCATTAACTTTGGAAAATATAATTTACCATACTAATGCTGTTTCTAGAGGATTCAAGAAGAAAATTGAGGAACAA
CCTTTAGTAGTTTCAGATATGCCTTTTCTAACTTACCAATGTGGTGAGGATAAGGCTGTTGAGTATGCAGGGAAAATCAT
TCAGAGCACTTATGCAAAAGCTGTAAAAGTGGAAGGGGCAGAACCAGAAATACAAAAAGTTATCTCTAGATTAATAAGGA
TGGGAATCCCTGTTATGGGTCATATAGGTCTTACACCACAAAGCTACCTAAATATTGGATTAAGAAAACAAGGAGAAAGC
TTAGCAAGCCAAGAAAAAATTAAGAAAGAGGCTTCAATTCTTGAAGAATTAGGATGTTTTTCAATAGTTCTTGAACATAT
TCCTGATTTGCTTGCTAAAGAAATAAAAAATTCTTTAACAATTCCCATAATAGGTATTGGTGCAGGCAATTATTGCGATG
GGCAAGTAAGAGTTACTGCAGATTTGTTAGGCCTAAATGATGATCAACCACCATTTTGCCAACCAATTATCCAGGGAAAG
AAATTATTTAAGGATAAATTAAAAGAATGGGTAGACTCTGAAAGACTTAATTAA

Upstream 100 bases:

>100_bases
CTACCTTCCGGTCCTGACCAGGTTTAGGCGTTAAAACCGCGAAAGGCCGAGTCAAGATCATATTAGCAATTCTTGTTTAA
AAAAGATACATAAATTTATT

Downstream 100 bases:

>100_bases
TCTCATCCCACCACTTAAACATAGAAACAAGAACTTGATTGCTTAGTTCCATGCCATTAGGCTCACTTAAAAAGAATCTA
TAACCCTTTCTTACTAAAAG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MLPSDLVNYKKKSRKIIALTAWDSISGSIAEQANVDLVLVGDSLAMVCLGYKSTLPLTLENIIYHTNAVSRGFKKKIEEQ
PLVVSDMPFLTYQCGEDKAVEYAGKIIQSTYAKAVKVEGAEPEIQKVISRLIRMGIPVMGHIGLTPQSYLNIGLRKQGES
LASQEKIKKEASILEELGCFSIVLEHIPDLLAKEIKNSLTIPIIGIGAGNYCDGQVRVTADLLGLNDDQPPFCQPIIQGK
KLFKDKLKEWVDSERLN

Sequences:

>Translated_257_residues
MLPSDLVNYKKKSRKIIALTAWDSISGSIAEQANVDLVLVGDSLAMVCLGYKSTLPLTLENIIYHTNAVSRGFKKKIEEQ
PLVVSDMPFLTYQCGEDKAVEYAGKIIQSTYAKAVKVEGAEPEIQKVISRLIRMGIPVMGHIGLTPQSYLNIGLRKQGES
LASQEKIKKEASILEELGCFSIVLEHIPDLLAKEIKNSLTIPIIGIGAGNYCDGQVRVTADLLGLNDDQPPFCQPIIQGK
KLFKDKLKEWVDSERLN
>Mature_257_residues
MLPSDLVNYKKKSRKIIALTAWDSISGSIAEQANVDLVLVGDSLAMVCLGYKSTLPLTLENIIYHTNAVSRGFKKKIEEQ
PLVVSDMPFLTYQCGEDKAVEYAGKIIQSTYAKAVKVEGAEPEIQKVISRLIRMGIPVMGHIGLTPQSYLNIGLRKQGES
LASQEKIKKEASILEELGCFSIVLEHIPDLLAKEIKNSLTIPIIGIGAGNYCDGQVRVTADLLGLNDDQPPFCQPIIQGK
KLFKDKLKEWVDSERLN

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=230, Percent_Identity=38.695652173913, Blast_Score=144, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319653, Length=242, Percent_Identity=40.0826446280992, Blast_Score=156, Evalue=3e-39,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28342; Mature: 28342

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPSDLVNYKKKSRKIIALTAWDSISGSIAEQANVDLVLVGDSLAMVCLGYKSTLPLTLE
CCCHHHHHHHHHCCEEEEEEECCCCCCCHHHHCCCCEEEECCCCEEHHHCCCCCCCHHHH
NIIYHTNAVSRGFKKKIEEQPLVVSDMPFLTYQCGEDKAVEYAGKIIQSTYAKAVKVEGA
HHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHEEECCC
EPEIQKVISRLIRMGIPVMGHIGLTPQSYLNIGLRKQGESLASQEKIKKEASILEELGCF
CHHHHHHHHHHHHHCCCCEECCCCCHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHH
SIVLEHIPDLLAKEIKNSLTIPIIGIGAGNYCDGQVRVTADLLGLNDDQPPFCQPIIQGK
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHH
KLFKDKLKEWVDSERLN
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLPSDLVNYKKKSRKIIALTAWDSISGSIAEQANVDLVLVGDSLAMVCLGYKSTLPLTLE
CCCHHHHHHHHHCCEEEEEEECCCCCCCHHHHCCCCEEEECCCCEEHHHCCCCCCCHHHH
NIIYHTNAVSRGFKKKIEEQPLVVSDMPFLTYQCGEDKAVEYAGKIIQSTYAKAVKVEGA
HHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHEEECCC
EPEIQKVISRLIRMGIPVMGHIGLTPQSYLNIGLRKQGESLASQEKIKKEASILEELGCF
CHHHHHHHHHHHHHCCCCEECCCCCHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHH
SIVLEHIPDLLAKEIKNSLTIPIIGIGAGNYCDGQVRVTADLLGLNDDQPPFCQPIIQGK
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHH
KLFKDKLKEWVDSERLN
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA