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The map label for this gene is trpC [H]

Identifier: 123969028

GI number: 123969028

Start: 1277266

End: 1278153

Strand: Reverse

Name: trpC [H]

Synonym: A9601_14961

Alternate gene names: 123969028

Gene position: 1278153-1277266 (Counterclockwise)

Preceding gene: 123969029

Following gene: 123969027

Centisome position: 76.54

GC content: 29.17

Gene sequence:

>888_bases
ATGGAGATAAGACGCAGGCCACCAAATCCAACAGTGAGGGTAGAAAACTTAGAATATGCTGTACCTCATAGAGAAGCACA
AGCAAAAAACATTCTGGAAGAAATTGTATGGCACAAGGATATTGAAATTAAGAATTTTAAAAAAATAGTCTCTTTAGAAG
ATCTCATCAAAAAAATTGAAAATCTTCCTACTCCCAAAGATTTTTATAAAAATATCTTGGAGTCAAAAATAAAACCAGGA
GTTATTGCTGAAATAAAAAAAGCTAGTCCGAGTAAAGGAGTTATTAGAAAAGATTTTAACCCTGAAAACATAGCAATTTG
TTATGAAGGATTAGGTGCATCATGTATCTCAGTACTTACCGATAAAAAGTTTTTTCAAGGTAGTTATGAAATACTCGAAA
CTGTAAGGAAATCTACTAATCTCCCTCTACTCTGCAAAGATTTTATTATTTCTGCTTATCAGATTTATAAAGCAAGGGTA
TCTGGTGCTGATGCAATATTATTAATCGCTGCGATTTTAAGTGATGATGATTTAATTTATTTAAAGAAAATAGCTGATAA
TTTAAAGATGAGTGTTCTTGTTGAAGTCCATAACTCTTATGAATTAGAAAGGATTCTAAAGTTAAAATCTTTTAATTTGA
TTGGAATAAATAATAGGGACTTAAAGACTTTTAAAACGGATTTAAAAACATCAAAAGAATTGATGAATACATATGCAGAT
ATATTTTTAAAACAAAATATTATTCCCATAAGTGAATCTGGAATTAATTGTGCCGAAGATTTAGAATCGCTTAGATCTAT
TGGAATCATGGGAGTATTAATTGGTGAAACTTTTATGAGAGAAACTGATATTGAACAATCGTTCAAGAAATTATTTAACT
CAATTTAA

Upstream 100 bases:

>100_bases
TGAACTATCTAAAGAAGTTCATACTCATCCTACTCTTAGTGAAGTAGTGGAGGTCGCATATAAACAGGCGGCTTCTCAAA
TAAAATAATACCTAAAATTA

Downstream 100 bases:

>100_bases
AATTGACTTCAAATCGTGCTATAAAATTGGATAAACAGAGTTGTCCTGAATATATATGCAGGCTGTAATTTTAACAGGTA
TAGTCTCAGGATTTGTGCAT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MEIRRRPPNPTVRVENLEYAVPHREAQAKNILEEIVWHKDIEIKNFKKIVSLEDLIKKIENLPTPKDFYKNILESKIKPG
VIAEIKKASPSKGVIRKDFNPENIAICYEGLGASCISVLTDKKFFQGSYEILETVRKSTNLPLLCKDFIISAYQIYKARV
SGADAILLIAAILSDDDLIYLKKIADNLKMSVLVEVHNSYELERILKLKSFNLIGINNRDLKTFKTDLKTSKELMNTYAD
IFLKQNIIPISESGINCAEDLESLRSIGIMGVLIGETFMRETDIEQSFKKLFNSI

Sequences:

>Translated_295_residues
MEIRRRPPNPTVRVENLEYAVPHREAQAKNILEEIVWHKDIEIKNFKKIVSLEDLIKKIENLPTPKDFYKNILESKIKPG
VIAEIKKASPSKGVIRKDFNPENIAICYEGLGASCISVLTDKKFFQGSYEILETVRKSTNLPLLCKDFIISAYQIYKARV
SGADAILLIAAILSDDDLIYLKKIADNLKMSVLVEVHNSYELERILKLKSFNLIGINNRDLKTFKTDLKTSKELMNTYAD
IFLKQNIIPISESGINCAEDLESLRSIGIMGVLIGETFMRETDIEQSFKKLFNSI
>Mature_295_residues
MEIRRRPPNPTVRVENLEYAVPHREAQAKNILEEIVWHKDIEIKNFKKIVSLEDLIKKIENLPTPKDFYKNILESKIKPG
VIAEIKKASPSKGVIRKDFNPENIAICYEGLGASCISVLTDKKFFQGSYEILETVRKSTNLPLLCKDFIISAYQIYKARV
SGADAILLIAAILSDDDLIYLKKIADNLKMSVLVEVHNSYELERILKLKSFNLIGINNRDLKTFKTDLKTSKELMNTYAD
IFLKQNIIPISESGINCAEDLESLRSIGIMGVLIGETFMRETDIEQSFKKLFNSI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=264, Percent_Identity=40.1515151515151, Blast_Score=173, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322638, Length=280, Percent_Identity=35.3571428571429, Blast_Score=146, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 33629; Mature: 33629

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRRRPPNPTVRVENLEYAVPHREAQAKNILEEIVWHKDIEIKNFKKIVSLEDLIKKIE
CCCCCCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NLPTPKDFYKNILESKIKPGVIAEIKKASPSKGVIRKDFNPENIAICYEGLGASCISVLT
CCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEECCCCCCCEEEEECCCCHHHHHHHH
DKKFFQGSYEILETVRKSTNLPLLCKDFIISAYQIYKARVSGADAILLIAAILSDDDLIY
HHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEH
LKKIADNLKMSVLVEVHNSYELERILKLKSFNLIGINNRDLKTFKTDLKTSKELMNTYAD
HHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
IFLKQNIIPISESGINCAEDLESLRSIGIMGVLIGETFMRETDIEQSFKKLFNSI
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MEIRRRPPNPTVRVENLEYAVPHREAQAKNILEEIVWHKDIEIKNFKKIVSLEDLIKKIE
CCCCCCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NLPTPKDFYKNILESKIKPGVIAEIKKASPSKGVIRKDFNPENIAICYEGLGASCISVLT
CCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEECCCCCCCEEEEECCCCHHHHHHHH
DKKFFQGSYEILETVRKSTNLPLLCKDFIISAYQIYKARVSGADAILLIAAILSDDDLIY
HHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEH
LKKIADNLKMSVLVEVHNSYELERILKLKSFNLIGINNRDLKTFKTDLKTSKELMNTYAD
HHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
IFLKQNIIPISESGINCAEDLESLRSIGIMGVLIGETFMRETDIEQSFKKLFNSI
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA