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The map label for this gene is serS [H]

Identifier: 123968914

GI number: 123968914

Start: 1148068

End: 1149345

Strand: Direct

Name: serS [H]

Synonym: A9601_13811

Alternate gene names: 123968914

Gene position: 1148068-1149345 (Clockwise)

Preceding gene: 123968913

Following gene: 123968915

Centisome position: 68.75

GC content: 32.24

Gene sequence:

>1278_bases
GTGTTAGATCAAAAATTAATAAGAGAAAACCCAACATCTGTTGAAGAGAATTTATCCTTAAGAGGAAAAGTTTATAAGAT
ATCTCATATACACGAATTAACTGTTAAGAAAAAAGAAATTGACATAGAAATATCCAGTCTCCAATCTGAGAGTAAAAAAT
TAAGCAAATTAATCAGTCAAGTTATTGGAAAGTCCCAAGATAATAATTCACAAGAATTAAATGATTTAAAGAAAAAAGGA
AACGAATACAGAATTAAAATTTCTGAACTCGAAGAGAAACAAAGAATATTAAACAAAAAAGTAGATGATGAAATTTATAA
TTTGCCAAATTTCCCTAGCAAAGATGCACCTATTGGGAAAGATGAAAGTGAAAATTTACAAATTAAAACTTGGGGGGATC
CTCTAATAAAAGAGAATATAAAATCACACTGGGAAATCGGAGAAAGTCTTAATATTTTTGACTCTATAAAATCAACAAAA
ATATCAAAAAGTCGTTTTATCACTCTTATAGGCAATGGTGCCAGATTAGAGAGGGCATTAATTAATTTTATGCTCGATAT
GCATACTAAGAATGGTTACTTGGAGTTAATGCCGCCAGCTTTAGTAAATTCAGAAAGTCTTACCGGATCTGGTCAATTGC
CTAAATTTTCAAATGAAAGTTTCAAGTGTTCCAATGACGATTTATGGCTTTCTCCAACAGCTGAAGTTCCACTAACTGCT
TTACATAGAAACGAGCTTATTGATCCCAAGCACTTACCCCTTAAATACGTTGCATATAGCCCATGTTTTAGGAGAGAAGC
TGGAAGTTATGGAAGGGATACTAAAGGTTTAATAAGACTTCATCAATTTAATAAGGTTGAACTTTATTGGTTTTGTGATC
CAAGTAAATCTTTAGAAGCTCATAAAGAGATTACTACTGATGCAGAAAGCATTTTAAAAAAGCTCAACTTACCCTACAGA
TTAGTAGATATTTGTACTGGAGACTTAGGCTTTTCTTCTAGTAGAACTTTTGATCTTGAAGTTTGGCTTCCCAGTAGTAA
ATGTTATAGAGAAATTTCAAGTTGCAGTAATTGCCTTGACTTTCAAGCACGAAGATCATCAATAAGATCAAAAATTGATA
AAAAAAATACATATATCCACACCTTAAATGGCAGTGGTCTTGCTATTGGAAGAACAATGGCAGCGATTCTTGAGAATGGC
CAACAAACAGATGGTAGCGTTAAGATTCCAGATGCTCTGGTTCCATATTTTGGATCAAATCTATTAAAAACTGCTTAA

Upstream 100 bases:

>100_bases
TTCCATAAGTTAGGAATCATTAATTTAGTTAATTTTTAATCAAAAAACCCAAATAATGAATTGAGATTAACTATCTTAAT
TAATGTAATAAAAAAAAAGA

Downstream 100 bases:

>100_bases
TATAAAAAAATGAATGTTTTAACCTCCATAACAGTACTTGGATTCCTTATATTTTTTCATGAGATGGGACATTTTCTTGC
GGCCATTTTACAAGGAATTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDQKLIRENPTSVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLISQVIGKSQDNNSQELNDLKKKG
NEYRIKISELEEKQRILNKKVDDEIYNLPNFPSKDAPIGKDESENLQIKTWGDPLIKENIKSHWEIGESLNIFDSIKSTK
ISKSRFITLIGNGARLERALINFMLDMHTKNGYLELMPPALVNSESLTGSGQLPKFSNESFKCSNDDLWLSPTAEVPLTA
LHRNELIDPKHLPLKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEAHKEITTDAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLDFQARRSSIRSKIDKKNTYIHTLNGSGLAIGRTMAAILENG
QQTDGSVKIPDALVPYFGSNLLKTA

Sequences:

>Translated_425_residues
MLDQKLIRENPTSVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLISQVIGKSQDNNSQELNDLKKKG
NEYRIKISELEEKQRILNKKVDDEIYNLPNFPSKDAPIGKDESENLQIKTWGDPLIKENIKSHWEIGESLNIFDSIKSTK
ISKSRFITLIGNGARLERALINFMLDMHTKNGYLELMPPALVNSESLTGSGQLPKFSNESFKCSNDDLWLSPTAEVPLTA
LHRNELIDPKHLPLKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEAHKEITTDAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLDFQARRSSIRSKIDKKNTYIHTLNGSGLAIGRTMAAILENG
QQTDGSVKIPDALVPYFGSNLLKTA
>Mature_425_residues
MLDQKLIRENPTSVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLISQVIGKSQDNNSQELNDLKKKG
NEYRIKISELEEKQRILNKKVDDEIYNLPNFPSKDAPIGKDESENLQIKTWGDPLIKENIKSHWEIGESLNIFDSIKSTK
ISKSRFITLIGNGARLERALINFMLDMHTKNGYLELMPPALVNSESLTGSGQLPKFSNESFKCSNDDLWLSPTAEVPLTA
LHRNELIDPKHLPLKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEAHKEITTDAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLDFQARRSSIRSKIDKKNTYIHTLNGSGLAIGRTMAAILENG
QQTDGSVKIPDALVPYFGSNLLKTA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=361, Percent_Identity=36.2880886426593, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI8923421, Length=395, Percent_Identity=30.6329113924051, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI225579074, Length=397, Percent_Identity=29.7229219143577, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=43.9252336448598, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17539260, Length=335, Percent_Identity=34.9253731343284, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=333, Percent_Identity=28.8288288288288, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=347, Percent_Identity=35.1585014409222, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=412, Percent_Identity=30.8252427184466, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24581334, Length=384, Percent_Identity=33.0729166666667, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17737985, Length=391, Percent_Identity=28.9002557544757, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48157; Mature: 48157

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDQKLIRENPTSVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLISQ
CCCCHHHHCCCCCHHHCCCCCCEEEEEECHHHHHEEHHHEEEEHHHHHHHHHHHHHHHHH
VIGKSQDNNSQELNDLKKKGNEYRIKISELEEKQRILNKKVDDEIYNLPNFPSKDAPIGK
HHCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DESENLQIKTWGDPLIKENIKSHWEIGESLNIFDSIKSTKISKSRFITLIGNGARLERAL
CCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEECCHHHHHHH
INFMLDMHTKNGYLELMPPALVNSESLTGSGQLPKFSNESFKCSNDDLWLSPTAEVPLTA
HHHHHHHCCCCCEEEECCCHHCCCCCCCCCCCCCCCCCCCCEECCCCEEECCCCCCCHHH
LHRNELIDPKHLPLKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEA
HHHHCCCCCCCCCEEEEECCCHHHHHCCCCCCCCHHHEEEEECCEEEEEEEECCCCCHHH
HKEITTDAESILKKLNLPYRLVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLD
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FQARRSSIRSKIDKKNTYIHTLNGSGLAIGRTMAAILENGQQTDGSVKIPDALVPYFGSN
HHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCEECCHHHHHHHCCH
LLKTA
HHCCC
>Mature Secondary Structure
MLDQKLIRENPTSVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLISQ
CCCCHHHHCCCCCHHHCCCCCCEEEEEECHHHHHEEHHHEEEEHHHHHHHHHHHHHHHHH
VIGKSQDNNSQELNDLKKKGNEYRIKISELEEKQRILNKKVDDEIYNLPNFPSKDAPIGK
HHCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DESENLQIKTWGDPLIKENIKSHWEIGESLNIFDSIKSTKISKSRFITLIGNGARLERAL
CCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEECCHHHHHHH
INFMLDMHTKNGYLELMPPALVNSESLTGSGQLPKFSNESFKCSNDDLWLSPTAEVPLTA
HHHHHHHCCCCCEEEECCCHHCCCCCCCCCCCCCCCCCCCCEECCCCEEECCCCCCCHHH
LHRNELIDPKHLPLKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEA
HHHHCCCCCCCCCEEEEECCCHHHHHCCCCCCCCHHHEEEEECCEEEEEEEECCCCCHHH
HKEITTDAESILKKLNLPYRLVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLD
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FQARRSSIRSKIDKKNTYIHTLNGSGLAIGRTMAAILENGQQTDGSVKIPDALVPYFGSN
HHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCEECCHHHHHHHCCH
LLKTA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA