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The map label for this gene is neuA [H]

Identifier: 123968875

GI number: 123968875

Start: 1117970

End: 1118692

Strand: Direct

Name: neuA [H]

Synonym: A9601_13421

Alternate gene names: 123968875

Gene position: 1117970-1118692 (Clockwise)

Preceding gene: 123968874

Following gene: 123968876

Centisome position: 66.95

GC content: 31.26

Gene sequence:

>723_bases
ATGAAAAAATACTATTGCTTAATACCTGCCAGGGGAGGCTCAAAAGGAATTAAAGGGAAAAATATTAAACTTTTAGAAGG
GAAACCTCTTATTGCCTACACAATTGAATGTGCAAAAGAATCAAGAATTTTTGAAAAGATTTTTGTGAGCACCGACGATT
CTCAAATAGCAAAAGTTGCGAAAGATTATGGAGCTCAAATACCTTTTATGAGAGATGCCTCTCTTGGAGGAGATAGAACA
CATATGTTTAAGGTTTATAAAGAATTTGCAAAAAAATTAACTGCAATCAAAGATGAAGATATCCTAATGATTCTATTGCC
TACTAATCCCTTAAGGAATATAGAAGATATTCATTTAGTTAAAAATGCATATGAAAATGATAAAGATTTAGAATGGGTTT
TTACTTGTAACGAATGTGAGCATCACCCATATAGAGCAGTAAGGGTCTGTGAAAAAACAAACATTATGCAGCCTTTTTTT
CCTATAGAAAATAAAGTAATGTGGTCAAATAGACAAGAATTACCTAAAGCTTATCGTTTTAATGGTGCAATAATATCTGG
CAAAACTGGTTTAATTAGAAATAATGAAGAATACCCTATAGATAGTTTTAACTATATGGACGCCAAAGTAAAAGGTGTGG
TCTCATCTGAGTATTCAAGGCTAGATATTGATACAATGCTTGACTTTAGATTTATCGAAAGCTTATTAAAAATAGTCAAA
TAG

Upstream 100 bases:

>100_bases
CACCTGGAATATCAAAATTGGCTGATGCTTTAAGGACTTTAGAATTATGCCATAGGATAATAAATGAACAAAACATTTCT
TACAGTCAATTTATAAACTT

Downstream 100 bases:

>100_bases
AATTTAATGACAATAGTTTTAATAACGGGGACTCAAAATAGACACCTAAGTATAGCTTCAAAACTTATAGATAATTTTGA
AGTTATTTGGATTAGATATA

Product: CMP-N-acetylneuraminic acid synthetase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MKKYYCLIPARGGSKGIKGKNIKLLEGKPLIAYTIECAKESRIFEKIFVSTDDSQIAKVAKDYGAQIPFMRDASLGGDRT
HMFKVYKEFAKKLTAIKDEDILMILLPTNPLRNIEDIHLVKNAYENDKDLEWVFTCNECEHHPYRAVRVCEKTNIMQPFF
PIENKVMWSNRQELPKAYRFNGAIISGKTGLIRNNEEYPIDSFNYMDAKVKGVVSSEYSRLDIDTMLDFRFIESLLKIVK

Sequences:

>Translated_240_residues
MKKYYCLIPARGGSKGIKGKNIKLLEGKPLIAYTIECAKESRIFEKIFVSTDDSQIAKVAKDYGAQIPFMRDASLGGDRT
HMFKVYKEFAKKLTAIKDEDILMILLPTNPLRNIEDIHLVKNAYENDKDLEWVFTCNECEHHPYRAVRVCEKTNIMQPFF
PIENKVMWSNRQELPKAYRFNGAIISGKTGLIRNNEEYPIDSFNYMDAKVKGVVSSEYSRLDIDTMLDFRFIESLLKIVK
>Mature_240_residues
MKKYYCLIPARGGSKGIKGKNIKLLEGKPLIAYTIECAKESRIFEKIFVSTDDSQIAKVAKDYGAQIPFMRDASLGGDRT
HMFKVYKEFAKKLTAIKDEDILMILLPTNPLRNIEDIHLVKNAYENDKDLEWVFTCNECEHHPYRAVRVCEKTNIMQPFF
PIENKVMWSNRQELPKAYRFNGAIISGKTGLIRNNEEYPIDSFNYMDAKVKGVVSSEYSRLDIDTMLDFRFIESLLKIVK

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=114, Percent_Identity=38.5964912280702, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 27754; Mature: 27754

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYYCLIPARGGSKGIKGKNIKLLEGKPLIAYTIECAKESRIFEKIFVSTDDSQIAKVA
CCCEEEEEECCCCCCCCCCCCEEEECCCCEEEEEEEHHHHHHHHHHHEECCCHHHHHHHH
KDYGAQIPFMRDASLGGDRTHMFKVYKEFAKKLTAIKDEDILMILLPTNPLRNIEDIHLV
HHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHH
KNAYENDKDLEWVFTCNECEHHPYRAVRVCEKTNIMQPFFPIENKVMWSNRQELPKAYRF
HHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCHHHCCHHHCC
NGAIISGKTGLIRNNEEYPIDSFNYMDAKVKGVVSSEYSRLDIDTMLDFRFIESLLKIVK
CCEEEECCCCEEECCCCCCCCCCCCCCHHEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKKYYCLIPARGGSKGIKGKNIKLLEGKPLIAYTIECAKESRIFEKIFVSTDDSQIAKVA
CCCEEEEEECCCCCCCCCCCCEEEECCCCEEEEEEEHHHHHHHHHHHEECCCHHHHHHHH
KDYGAQIPFMRDASLGGDRTHMFKVYKEFAKKLTAIKDEDILMILLPTNPLRNIEDIHLV
HHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHH
KNAYENDKDLEWVFTCNECEHHPYRAVRVCEKTNIMQPFFPIENKVMWSNRQELPKAYRF
HHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCHHHCCHHHCC
NGAIISGKTGLIRNNEEYPIDSFNYMDAKVKGVVSSEYSRLDIDTMLDFRFIESLLKIVK
CCEEEECCCCEEECCCCCCCCCCCCCCHHEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]