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The map label for this gene is acrA [H]

Identifier: 123968847

GI number: 123968847

Start: 1090296

End: 1091357

Strand: Direct

Name: acrA [H]

Synonym: A9601_13141

Alternate gene names: 123968847

Gene position: 1090296-1091357 (Clockwise)

Preceding gene: 123968845

Following gene: 123968848

Centisome position: 65.29

GC content: 30.32

Gene sequence:

>1062_bases
ATGTTTGATTTAATAAAAAAAAATATAAACCTAAGAAGTGGAATTATATTGCTTTCTCTAGCTATATTTTTCGTTTTTAT
AAGCAATTCCTTCAAGAAAAATAAGTCAAAAGATATTTCTGATTTTGTAGTTCAAGTTGAAAAAGGAATCCTCTCAGATT
CAATTAATACTAGTGGTGAAGTAAAAGCAATAAGGACAAGCAATATTGGGCCTCGGAAGCAAGGCGTAATAAAAGAAATC
ATAGTAGATGAAGGCGATCTTGTAAAAAAAGATCAGGTTTTAGCTTCTCTTGATGATGAAGACTTTATCTATAAAATTGA
AGAACTTGAATTAAATGTAGAAAAACAAAAATCTGAATTTTTAAGAAGGGAATATTTATATCAAGAAGGTGCGGTAAGTA
AAGAAGACTATGAAAGTTATAAAAATAACTTCAACATTAGTAGCGCAAAACTTAATGATGCAAAAGCTGAAAAAAGTTTC
TACCTAATTAAAGCGCCTTATGGAGGAAAGATAACTGCAAAATATGCTGAGATAGGATCTTATGTCACACCAAGTACAAA
CTTAAGTTCAGACCCTAAAACCAAAAACTTTATTTTTGAACTATCAGAGGGCCTAGAAATTGTTGCTAAAGTACCTGAGA
GTGACATTGGCAGAATAAAAATAGGTCAAGAAGCCTCAGTAAGAATTGAGGCTTATCCCTCAAAAAAATATAGTGCCATA
GTTAAAAAAATAGCTACAAGAGCTGTAAAAGATAATAATGTAACCTCATTCGAAGTAACTTTAAATTTTAAAGATATTTC
TGAAGAAATTAAAATTGGAATGACTGCAGATCTTGAATTTAGAGTCGAAGGTAATGAAGAAAAAATCTTAGTACCAACAG
TTTCTATTGTCACGGAAAAAGGTGAAAAAGGAATTTTGAAAGTTGATAAAAACAATTCTCCCAAATTTGAAAAAATCGAA
ATTGGTATTAGTAGTGGAAATAAAACTTCAGTAATTGATGGATTAGAACCTGGAGAGCAAATCTTTATTGATATTCCACC
TTGGGCTAAGAAGAGAAAATGA

Upstream 100 bases:

>100_bases
AATATAGTATTTACTTAACCAATCTTGGATAAGTTAATTATAATCGTCTTGATTATTTATTTAGTTCCTAAATATTCTCT
ACTTCTGCTTTTAAAAAGAA

Downstream 100 bases:

>100_bases
GTTTAAAATCTGAAAACTCTAAAAAACCAATTTTACTTTTAGTCGATGGCCACTCACTTGCTTTTAGAAGCTTCTATGCA
TTTAGCAAAGGGATTGATGG

Product: membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MFDLIKKNINLRSGIILLSLAIFFVFISNSFKKNKSKDISDFVVQVEKGILSDSINTSGEVKAIRTSNIGPRKQGVIKEI
IVDEGDLVKKDQVLASLDDEDFIYKIEELELNVEKQKSEFLRREYLYQEGAVSKEDYESYKNNFNISSAKLNDAKAEKSF
YLIKAPYGGKITAKYAEIGSYVTPSTNLSSDPKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYSAI
VKKIATRAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEKGEKGILKVDKNNSPKFEKIE
IGISSGNKTSVIDGLEPGEQIFIDIPPWAKKRK

Sequences:

>Translated_353_residues
MFDLIKKNINLRSGIILLSLAIFFVFISNSFKKNKSKDISDFVVQVEKGILSDSINTSGEVKAIRTSNIGPRKQGVIKEI
IVDEGDLVKKDQVLASLDDEDFIYKIEELELNVEKQKSEFLRREYLYQEGAVSKEDYESYKNNFNISSAKLNDAKAEKSF
YLIKAPYGGKITAKYAEIGSYVTPSTNLSSDPKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYSAI
VKKIATRAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEKGEKGILKVDKNNSPKFEKIE
IGISSGNKTSVIDGLEPGEQIFIDIPPWAKKRK
>Mature_353_residues
MFDLIKKNINLRSGIILLSLAIFFVFISNSFKKNKSKDISDFVVQVEKGILSDSINTSGEVKAIRTSNIGPRKQGVIKEI
IVDEGDLVKKDQVLASLDDEDFIYKIEELELNVEKQKSEFLRREYLYQEGAVSKEDYESYKNNFNISSAKLNDAKAEKSF
YLIKAPYGGKITAKYAEIGSYVTPSTNLSSDPKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYSAI
VKKIATRAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEKGEKGILKVDKNNSPKFEKIE
IGISSGNKTSVIDGLEPGEQIFIDIPPWAKKRK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=329, Percent_Identity=22.4924012158055, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39548; Mature: 39548

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLIKKNINLRSGIILLSLAIFFVFISNSFKKNKSKDISDFVVQVEKGILSDSINTSGE
CCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
VKAIRTSNIGPRKQGVIKEIIVDEGDLVKKDQVLASLDDEDFIYKIEELELNVEKQKSEF
EEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHEEEEEEEEECCHHHHHHH
LRREYLYQEGAVSKEDYESYKNNFNISSAKLNDAKAEKSFYLIKAPYGGKITAKYAEIGS
HHHHHHHHCCCCCHHHHHHHHCCCCCEECCCCCCCCCCCEEEEECCCCCEEEEEHHHHCC
YVTPSTNLSSDPKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYSAI
EECCCCCCCCCCCCCHHEEEHHCCCEEEEECCCCCCCEEEECCCCEEEEEECCCHHHHHH
VKKIATRAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEK
HHHHHHHHHCCCCCEEEEEEEEHHHCCCHHEECEEEEEEEEEECCCCEEEEEEEEEEECC
GEKGILKVDKNNSPKFEKIEIGISSGNKTSVIDGLEPGEQIFIDIPPWAKKRK
CCCCEEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MFDLIKKNINLRSGIILLSLAIFFVFISNSFKKNKSKDISDFVVQVEKGILSDSINTSGE
CCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
VKAIRTSNIGPRKQGVIKEIIVDEGDLVKKDQVLASLDDEDFIYKIEELELNVEKQKSEF
EEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHEEEEEEEEECCHHHHHHH
LRREYLYQEGAVSKEDYESYKNNFNISSAKLNDAKAEKSFYLIKAPYGGKITAKYAEIGS
HHHHHHHHCCCCCHHHHHHHHCCCCCEECCCCCCCCCCCEEEEECCCCCEEEEEHHHHCC
YVTPSTNLSSDPKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYSAI
EECCCCCCCCCCCCCHHEEEHHCCCEEEEECCCCCCCEEEECCCCEEEEEECCCHHHHHH
VKKIATRAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEK
HHHHHHHHHCCCCCEEEEEEEEHHHCCCHHEECEEEEEEEEEECCCCEEEEEEEEEEECC
GEKGILKVDKNNSPKFEKIEIGISSGNKTSVIDGLEPGEQIFIDIPPWAKKRK
CCCCEEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]