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The map label for this gene is gyrA [H]

Identifier: 123968701

GI number: 123968701

Start: 979934

End: 982531

Strand: Direct

Name: gyrA [H]

Synonym: A9601_11681

Alternate gene names: 123968701

Gene position: 979934-982531 (Clockwise)

Preceding gene: 123968696

Following gene: 123968702

Centisome position: 58.68

GC content: 35.76

Gene sequence:

>2598_bases
ATGTCTGATATTTTAGATTCTGATAACTCAGGTTTAAGCGAAGATAACGACCGAATTATTCAGACTGACCTAAGAAATGA
GATGTCTCGCTCATACCTTGAGTATGCAATGAGCGTAATAGTTGGTCGTGCTCTTCCAGATGCAAGAGATGGATTAAAAC
CTGTTCATAGAAGGATTCTTTATGCAATGTATGAACTTGGTTTAACTAGCGGAAGACCATATAGAAAATGTGCAAGAGTT
GTAGGAGAAGTACTAGGTAAGTACCACCCTCATGGCGATACTGCTGTTTATGATGCTTTGGTTAGGATGGCTCAGGATTT
CTCGATGAGGATGCCACTCATAGATGGCCATGGAAACTTTGGTTCTGTTGATAACGACCCTCCAGCAGCAATGAGATATA
CAGAATCTCGTTTGCAGTCTCTTACAGATGAAAGTTTATTAGAGGATATTGAATCTGAAACTGTAGATTTCGCCGATAAT
TTTGATGGCTCTCAGCAAGAGCCAACAGTTTTGCCTGCTAGGATTCCTCAACTACTTCTAAATGGATCATCTGGAATAGC
AGTAGGAATGGCAACTAATATCCCACCTCATAACTTAGGGGAATTAATTAATGGTCTTAAATCAATAATCAAAAACCCTT
CACTTGAAGATAGAGAACTTTTTGAAATAATTAAGGGTCCTGATTTTCCTACAGGTGGTCAAATCTTAGGCAGAGACGGT
ATCAAAGAAACTTTCAAAACAGGAAGGGGTTCAATAACTATGAGAGGTGTAGCAAATATTGAGCAAATTAAATCTACTAG
TAGAGCAGAAAAAGATGCAGTAATAATTACAGAGCTTCCATTTCAAACAAATAAAGCAGCATTGATAGAAAGAATTGCTG
ATTTGGTTAATGAAAAAAAATTAGAAGGTATTTCTGATATTAGAGATGAAAGTGATCGAGACGGAATGAGGATTGTTATT
GAACTAAAAAGAGATGCCTACCCACAAGTAGTTTTAAATAATCTATTTAAGTTAACACCTCTACAGAATAACTTTAGTGC
AAATATACTTGCTTTAGTAAAAGGAGAGCCCACAACACTTTCTCTCAGGAAAATGTTAGATGTATTTCTAGACTTTAGAG
TAGAGACAATAAGGCGAAGAACAGGATTTTTATTGAAAAAGGCTGAAGAGAGGGATCATATAGTAAACGGTCTTTTATTA
GCATTGGGTGCTATGGATGAGATAATTAATCTAATAAGATCAGCAAAAGATACAGTTTCAGCCAGAGAAAATTTACAAGC
TGATCATGAGTTATCTGCCACACAGGCAGAAGCTATTTTACAAATGCAATTAAGAAGATTAACAGCACTAGAAGCAGATA
AAATCAAAGGAGAACATGATGAGTTAACCAGAAAAATCAACTTATATAAGCAAATATTGAATAGTAAAGAAAGAATATTT
GAAATTATTCTAGAAGAACTTAATAAAATCGATGAAAGATTTTCCTCTCCAAGAAAAACAGAAATACTTGATTTGGGCGG
TGGTCTAGATGATATTGATCTTATTGCTAATGACAGATCTGTAGTTTTATTGACTGAAGCGGGTTATTTAAAAAGAATGC
CTGTTAATGAATTCGAATCTACAAGTCGTGGGTCTAGAGGTAAAGCTGGAACAAAGACACAAGAAGATGATGAAGTAAAA
CTATTTATAAGTTGTAATGATCATGATACTCTTTTGCTTTTCAGTGATAGAGGTGTATCTTATGCTTTACCAGCATATAG
AGTTCCCATGAGTAGCAGAACAGCTAAAGGTACTCCATCAGTTCAACTTCTCCCAATACCAAGAGAAGAAAAGATAACCT
CGCTAGTTGCAGTAGATTCTTTTGATAACGATTGTTATCTGTTAATGCTAACCAAGGCTGGATTTATAAAAAGAACTTCA
CTTTCTGCTTTCTCAAAAATTCGATCTAATGGATTAATAGCAATAAATCTTGAGGATGGAGATGCTTTAACTTGGGTTAG
GTTATCCAGAGAAGGTGACAGTGTTTTAATTGGATCAAGAACAGGAATGGCGATCCATTTCAGACTAGATATTAACGAAT
TAAGGCCACTTGGCAGGACGGCAAGGGGGGTTAAATCAATGAACCTTAGGAAAGGCGATAATCTAGTATCTATGGATGTT
TTAACATCTGATTTAGTTGATCAATTAGCTAAAAGTGAAGATATTACGAAAGAGTCTGATGAAAATCTTGAAGTCAACTC
TTCAGAGGGTCCTTGGGTTCTAATAGCCAGTGCATTTGGACTAGGTAAAAGAGTACCTGTAACTCAGTTTAGATTACAAA
AAAGAGCTGGCATGGGATTGAGAGCAATAAAATTCAGAATTAAAGACGATGTATTAGTTTGTTTGAAGGTTCTTGGAGAA
GGGGAAGAATTACTTTTTGTGACCGAAAAAGGTGTTATTGTTAGAACAAACGCAGATAAAATATCCCAGCAATCCAGAGC
CGCTACTGGAGTAAAATTACAAAGATTAGATATGGGCGATCATTTATCAGAAGTTGTATTGGTTCCTCATGAACAAACAG
AAGAAGCAGACCAATCCAACTCAGACAAAGAAAATTAA

Upstream 100 bases:

>100_bases
TTTTGATTTGTGTGTAAATGTAAGTATTTGGGAATTAAATAAATATTTTTTTTTATTCATTATGACAATCAGCGATTATT
ATTAAAAAAAGGATTTTTAT

Downstream 100 bases:

>100_bases
AAGAGATTGGCTTATTAGATCATATGGAAATACTTGATATTTTAATTTTAGGTTCCGGGCCTGCAGCACTGTGCTTAGCT
TCAGAATTAGCCAAGCAAGA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 865; Mature: 864

Protein sequence:

>865_residues
MSDILDSDNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARV
VGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFADN
FDGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIIKNPSLEDRELFEIIKGPDFPTGGQILGRDG
IKETFKTGRGSITMRGVANIEQIKSTSRAEKDAVIITELPFQTNKAALIERIADLVNEKKLEGISDIRDESDRDGMRIVI
ELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTLSLRKMLDVFLDFRVETIRRRTGFLLKKAEERDHIVNGLLL
ALGAMDEIINLIRSAKDTVSARENLQADHELSATQAEAILQMQLRRLTALEADKIKGEHDELTRKINLYKQILNSKERIF
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANDRSVVLLTEAGYLKRMPVNEFESTSRGSRGKAGTKTQEDDEVK
LFISCNDHDTLLLFSDRGVSYALPAYRVPMSSRTAKGTPSVQLLPIPREEKITSLVAVDSFDNDCYLLMLTKAGFIKRTS
LSAFSKIRSNGLIAINLEDGDALTWVRLSREGDSVLIGSRTGMAIHFRLDINELRPLGRTARGVKSMNLRKGDNLVSMDV
LTSDLVDQLAKSEDITKESDENLEVNSSEGPWVLIASAFGLGKRVPVTQFRLQKRAGMGLRAIKFRIKDDVLVCLKVLGE
GEELLFVTEKGVIVRTNADKISQQSRAATGVKLQRLDMGDHLSEVVLVPHEQTEEADQSNSDKEN

Sequences:

>Translated_865_residues
MSDILDSDNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARV
VGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFADN
FDGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIIKNPSLEDRELFEIIKGPDFPTGGQILGRDG
IKETFKTGRGSITMRGVANIEQIKSTSRAEKDAVIITELPFQTNKAALIERIADLVNEKKLEGISDIRDESDRDGMRIVI
ELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTLSLRKMLDVFLDFRVETIRRRTGFLLKKAEERDHIVNGLLL
ALGAMDEIINLIRSAKDTVSARENLQADHELSATQAEAILQMQLRRLTALEADKIKGEHDELTRKINLYKQILNSKERIF
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANDRSVVLLTEAGYLKRMPVNEFESTSRGSRGKAGTKTQEDDEVK
LFISCNDHDTLLLFSDRGVSYALPAYRVPMSSRTAKGTPSVQLLPIPREEKITSLVAVDSFDNDCYLLMLTKAGFIKRTS
LSAFSKIRSNGLIAINLEDGDALTWVRLSREGDSVLIGSRTGMAIHFRLDINELRPLGRTARGVKSMNLRKGDNLVSMDV
LTSDLVDQLAKSEDITKESDENLEVNSSEGPWVLIASAFGLGKRVPVTQFRLQKRAGMGLRAIKFRIKDDVLVCLKVLGE
GEELLFVTEKGVIVRTNADKISQQSRAATGVKLQRLDMGDHLSEVVLVPHEQTEEADQSNSDKEN
>Mature_864_residues
SDILDSDNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARVV
GEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFADNF
DGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIIKNPSLEDRELFEIIKGPDFPTGGQILGRDGI
KETFKTGRGSITMRGVANIEQIKSTSRAEKDAVIITELPFQTNKAALIERIADLVNEKKLEGISDIRDESDRDGMRIVIE
LKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTLSLRKMLDVFLDFRVETIRRRTGFLLKKAEERDHIVNGLLLA
LGAMDEIINLIRSAKDTVSARENLQADHELSATQAEAILQMQLRRLTALEADKIKGEHDELTRKINLYKQILNSKERIFE
IILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANDRSVVLLTEAGYLKRMPVNEFESTSRGSRGKAGTKTQEDDEVKL
FISCNDHDTLLLFSDRGVSYALPAYRVPMSSRTAKGTPSVQLLPIPREEKITSLVAVDSFDNDCYLLMLTKAGFIKRTSL
SAFSKIRSNGLIAINLEDGDALTWVRLSREGDSVLIGSRTGMAIHFRLDINELRPLGRTARGVKSMNLRKGDNLVSMDVL
TSDLVDQLAKSEDITKESDENLEVNSSEGPWVLIASAFGLGKRVPVTQFRLQKRAGMGLRAIKFRIKDDVLVCLKVLGEG
EELLFVTEKGVIVRTNADKISQQSRAATGVKLQRLDMGDHLSEVVLVPHEQTEEADQSNSDKEN

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=500, Percent_Identity=22.8, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1788562, Length=851, Percent_Identity=42.3031727379554, Blast_Score=662, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=613, Percent_Identity=38.0097879282219, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17535065, Length=357, Percent_Identity=24.0896358543417, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=227, Percent_Identity=28.1938325991189, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=293, Percent_Identity=27.6450511945392, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96259; Mature: 96128

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILDSDNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRIL
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHH
YAMYELGLTSGRPYRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNF
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
GSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFADNFDGSQQEPTVLPARIPQLLL
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHH
NGSSGIAVGMATNIPPHNLGELINGLKSIIKNPSLEDRELFEIIKGPDFPTGGQILGRDG
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCCH
IKETFKTGRGSITMRGVANIEQIKSTSRAEKDAVIITELPFQTNKAALIERIADLVNEKK
HHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
LEGISDIRDESDRDGMRIVIELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTL
HCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCCCHH
SLRKMLDVFLDFRVETIRRRTGFLLKKAEERDHIVNGLLLALGAMDEIINLIRSAKDTVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARENLQADHELSATQAEAILQMQLRRLTALEADKIKGEHDELTRKINLYKQILNSKERIF
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHH
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANDRSVVLLTEAGYLKRMPVNEFES
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHEEECCCEEEEEECCCCCCCCCCCHHHH
TSRGSRGKAGTKTQEDDEVKLFISCNDHDTLLLFSDRGVSYALPAYRVPMSSRTAKGTPS
CCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEECCCEECCCCCCCCCCCCC
VQLLPIPREEKITSLVAVDSFDNDCYLLMLTKAGFIKRTSLSAFSKIRSNGLIAINLEDG
EEEEECCCHHHHHEEEEEECCCCCEEEEEEECCCCEEHHHHHHHHHHHCCCEEEEEECCC
DALTWVRLSREGDSVLIGSRTGMAIHFRLDINELRPLGRTARGVKSMNLRKGDNLVSMDV
CEEEEEEEECCCCEEEEECCCCEEEEEEEEHHHCCCCCHHHHHHHHCCCCCCCCEEEHHH
LTSDLVDQLAKSEDITKESDENLEVNSSEGPWVLIASAFGLGKRVPVTQFRLQKRAGMGL
HHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCE
RAIKFRIKDDVLVCLKVLGEGEELLFVTEKGVIVRTNADKISQQSRAATGVKLQRLDMGD
EEEEEEECHHHHHHHHHHCCCCEEEEEECCCEEEEECHHHHHHHHHHHCCCEEEEECCCC
HLSEVVLVPHEQTEEADQSNSDKEN
CCCCEEECCCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
SDILDSDNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRIL
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHH
YAMYELGLTSGRPYRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNF
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
GSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFADNFDGSQQEPTVLPARIPQLLL
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHH
NGSSGIAVGMATNIPPHNLGELINGLKSIIKNPSLEDRELFEIIKGPDFPTGGQILGRDG
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCCH
IKETFKTGRGSITMRGVANIEQIKSTSRAEKDAVIITELPFQTNKAALIERIADLVNEKK
HHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
LEGISDIRDESDRDGMRIVIELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTL
HCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCCCHH
SLRKMLDVFLDFRVETIRRRTGFLLKKAEERDHIVNGLLLALGAMDEIINLIRSAKDTVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARENLQADHELSATQAEAILQMQLRRLTALEADKIKGEHDELTRKINLYKQILNSKERIF
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHH
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANDRSVVLLTEAGYLKRMPVNEFES
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHEEECCCEEEEEECCCCCCCCCCCHHHH
TSRGSRGKAGTKTQEDDEVKLFISCNDHDTLLLFSDRGVSYALPAYRVPMSSRTAKGTPS
CCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEECCCEECCCCCCCCCCCCC
VQLLPIPREEKITSLVAVDSFDNDCYLLMLTKAGFIKRTSLSAFSKIRSNGLIAINLEDG
EEEEECCCHHHHHEEEEEECCCCCEEEEEEECCCCEEHHHHHHHHHHHCCCEEEEEECCC
DALTWVRLSREGDSVLIGSRTGMAIHFRLDINELRPLGRTARGVKSMNLRKGDNLVSMDV
CEEEEEEEECCCCEEEEECCCCEEEEEEEEHHHCCCCCHHHHHHHHCCCCCCCCEEEHHH
LTSDLVDQLAKSEDITKESDENLEVNSSEGPWVLIASAFGLGKRVPVTQFRLQKRAGMGL
HHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCE
RAIKFRIKDDVLVCLKVLGEGEELLFVTEKGVIVRTNADKISQQSRAATGVKLQRLDMGD
EEEEEEECHHHHHHHHHHCCCCEEEEEECCCEEEEECHHHHHHHHHHHCCCEEEEECCCC
HLSEVVLVPHEQTEEADQSNSDKEN
CCCCEEECCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]