Click here to switch to the map view.

The map label for this gene is thrA [H]

Identifier: 123968689

GI number: 123968689

Start: 971451

End: 972752

Strand: Reverse

Name: thrA [H]

Synonym: A9601_11561

Alternate gene names: 123968689

Gene position: 972752-971451 (Counterclockwise)

Preceding gene: 123968690

Following gene: 123968688

Centisome position: 58.25

GC content: 32.33

Gene sequence:

>1302_bases
ATGAGAAAATGCAAAATTGGTATTGTAGGTTTTGGAACTGTAGGTTCAGGGATTTATAAAATATTAACTTCTGAACTCGA
TTCACATCCAATTCTAGAAGAAATAGAAATTTCAAAAATAGCAGTTAAAGATCTTGATAAAAAAAGAGATATTGAGCTAG
ATAATAATTTATTAACTGATGATCCATTTAAATTAATTAATGACCCATCTATAGATGTTATTGTTGAAGTAATGGGTGGG
GTTGATTTAGCGAAAGAAATTATTCTGCAATCATTAAAATTAGGTAAATCTGTAGTTACCGCAAACAAAGCAGTTATTGC
AAGATATGGAGAAGAAATATATAAAACTGCATCTAAAGAAGGTGTCTATATATTGTCAGAAGCAGCTGTTTGCGGGGGGA
TTCCAATAATTGAACCCTTAAAAAGATCATTAAAAAGTAACAGTATAAAAAAAATGGTTGGGATAATAAATGGCACAACA
AATTTTATTCTTTCAAAGATGGCAAATGAAAAAGCTGATTATAAGGAAACTTTAAAATTGGCCCAAAGCCTTGGTTACGC
AGAATTTGATCCAACTGCAGATGTTGAGGGGCATGATGCTGCTGATAAGATTTCAATCCTTAGTGAACTCGCATTTGGAG
GGAAAATCAAAAGAGAGGAGATACATTCTGAGGGTATCAGTAAAATTAATCTCAAGGATATCGAATATGCCAATAAATTA
GGATTTGAAATAAAACTTTTAGCGCTCTCTGAAAGGGGACAAATTAATAGTAATGATTCACTCGCTTTAAATATTTGGGT
AGGACCTTCTTTGATTCCAAAATCTCATCCATTGTCAACAGTTAAGGGAGTTAACAATGCCTTGTTGATTGAGGCTGATC
CTCTTGGAGAAATAATGTTATATGGTCCAGGTGCAGGGAGTGGTCCAACTGCAGCATCAGTAGTATCAGATATATTAAAT
CTGCATGCCGCCTCAGTAAAAAATAATAATTCAATCGATCCATTATTATCTTTTGATTTCTGGAGAAACTGCCATATCAT
AGGATCTTCGCAAATAAACAAAAAAAATTACCTTAGAATTATTTGTCTTGATAGTCCAGGTGTAATAGGAAAGATTGGAG
ATATTTTTGGAAAGAATAATGTATCAATCGAATCAATTGTTCAACTTGATGCGAGTGAGGACAAAGCTGAAATTGTCGTT
ATTACTCATGAGGTGAATAATGGAGATTTTGAGAGATCGAAAAATGAAATAAATTCGTTAAATGAAGTAAAAATTATTGC
AAGTCAATTAAGTTGTATTTAA

Upstream 100 bases:

>100_bases
TGGGTTTTTAAACATATTATTGAAAATGCAGTCTCAAGCAAATGAATTTTTGTAGGTCTAATAATATAAAATTAAATTCA
AAGTAAAAAGAAATAAAACA

Downstream 100 bases:

>100_bases
AAAAATAGTTTGCAAATTTCTTTATAGCTTGGTAAACCGAAGAAAGTAAGTGTTTGGATTTAGCACCTTAATGATTCATT
CAAAATTATTAGACAGTGAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRKCKIGIVGFGTVGSGIYKILTSELDSHPILEEIEISKIAVKDLDKKRDIELDNNLLTDDPFKLINDPSIDVIVEVMGG
VDLAKEIILQSLKLGKSVVTANKAVIARYGEEIYKTASKEGVYILSEAAVCGGIPIIEPLKRSLKSNSIKKMVGIINGTT
NFILSKMANEKADYKETLKLAQSLGYAEFDPTADVEGHDAADKISILSELAFGGKIKREEIHSEGISKINLKDIEYANKL
GFEIKLLALSERGQINSNDSLALNIWVGPSLIPKSHPLSTVKGVNNALLIEADPLGEIMLYGPGAGSGPTAASVVSDILN
LHAASVKNNNSIDPLLSFDFWRNCHIIGSSQINKKNYLRIICLDSPGVIGKIGDIFGKNNVSIESIVQLDASEDKAEIVV
ITHEVNNGDFERSKNEINSLNEVKIIASQLSCI

Sequences:

>Translated_433_residues
MRKCKIGIVGFGTVGSGIYKILTSELDSHPILEEIEISKIAVKDLDKKRDIELDNNLLTDDPFKLINDPSIDVIVEVMGG
VDLAKEIILQSLKLGKSVVTANKAVIARYGEEIYKTASKEGVYILSEAAVCGGIPIIEPLKRSLKSNSIKKMVGIINGTT
NFILSKMANEKADYKETLKLAQSLGYAEFDPTADVEGHDAADKISILSELAFGGKIKREEIHSEGISKINLKDIEYANKL
GFEIKLLALSERGQINSNDSLALNIWVGPSLIPKSHPLSTVKGVNNALLIEADPLGEIMLYGPGAGSGPTAASVVSDILN
LHAASVKNNNSIDPLLSFDFWRNCHIIGSSQINKKNYLRIICLDSPGVIGKIGDIFGKNNVSIESIVQLDASEDKAEIVV
ITHEVNNGDFERSKNEINSLNEVKIIASQLSCI
>Mature_433_residues
MRKCKIGIVGFGTVGSGIYKILTSELDSHPILEEIEISKIAVKDLDKKRDIELDNNLLTDDPFKLINDPSIDVIVEVMGG
VDLAKEIILQSLKLGKSVVTANKAVIARYGEEIYKTASKEGVYILSEAAVCGGIPIIEPLKRSLKSNSIKKMVGIINGTT
NFILSKMANEKADYKETLKLAQSLGYAEFDPTADVEGHDAADKISILSELAFGGKIKREEIHSEGISKINLKDIEYANKL
GFEIKLLALSERGQINSNDSLALNIWVGPSLIPKSHPLSTVKGVNNALLIEADPLGEIMLYGPGAGSGPTAASVVSDILN
LHAASVKNNNSIDPLLSFDFWRNCHIIGSSQINKKNYLRIICLDSPGVIGKIGDIFGKNNVSIESIVQLDASEDKAEIVV
ITHEVNNGDFERSKNEINSLNEVKIIASQLSCI

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=250, Percent_Identity=27.6, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790376, Length=361, Percent_Identity=22.9916897506925, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46893; Mature: 46893

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKCKIGIVGFGTVGSGIYKILTSELDSHPILEEIEISKIAVKDLDKKRDIELDNNLLTD
CCEEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DPFKLINDPSIDVIVEVMGGVDLAKEIILQSLKLGKSVVTANKAVIARYGEEIYKTASKE
CCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHCCCC
GVYILSEAAVCGGIPIIEPLKRSLKSNSIKKMVGIINGTTNFILSKMANEKADYKETLKL
CEEEEECCHHHCCCCCHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
AQSLGYAEFDPTADVEGHDAADKISILSELAFGGKIKREEIHSEGISKINLKDIEYANKL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCEECCHHHHHHHHC
GFEIKLLALSERGQINSNDSLALNIWVGPSLIPKSHPLSTVKGVNNALLIEADPLGEIML
CCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCHHHCCCCCEEEEEECCCCCEEE
YGPGAGSGPTAASVVSDILNLHAASVKNNNSIDPLLSFDFWRNCHIIGSSQINKKNYLRI
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHCCCCEEEECCCCCCCCCCEEE
ICLDSPGVIGKIGDIFGKNNVSIESIVQLDASEDKAEIVVITHEVNNGDFERSKNEINSL
EEECCCCCEEHHHHHCCCCCCCHHHHEEECCCCCCCEEEEEEEECCCCCHHHHHHHHCCH
NEVKIIASQLSCI
HHHHHHHHHHCCC
>Mature Secondary Structure
MRKCKIGIVGFGTVGSGIYKILTSELDSHPILEEIEISKIAVKDLDKKRDIELDNNLLTD
CCEEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DPFKLINDPSIDVIVEVMGGVDLAKEIILQSLKLGKSVVTANKAVIARYGEEIYKTASKE
CCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHCCCC
GVYILSEAAVCGGIPIIEPLKRSLKSNSIKKMVGIINGTTNFILSKMANEKADYKETLKL
CEEEEECCHHHCCCCCHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
AQSLGYAEFDPTADVEGHDAADKISILSELAFGGKIKREEIHSEGISKINLKDIEYANKL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCEECCHHHHHHHHC
GFEIKLLALSERGQINSNDSLALNIWVGPSLIPKSHPLSTVKGVNNALLIEADPLGEIML
CCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCHHHCCCCCEEEEEECCCCCEEE
YGPGAGSGPTAASVVSDILNLHAASVKNNNSIDPLLSFDFWRNCHIIGSSQINKKNYLRI
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHCCCCEEEECCCCCCCCCCEEE
ICLDSPGVIGKIGDIFGKNNVSIESIVQLDASEDKAEIVVITHEVNNGDFERSKNEINSL
EEECCCCCEEHHHHHCCCCCCCHHHHEEECCCCCCCEEEEEEEECCCCCHHHHHHHHCCH
NEVKIIASQLSCI
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]