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The map label for this gene is uvrC [H]

Identifier: 123968512

GI number: 123968512

Start: 846959

End: 848917

Strand: Direct

Name: uvrC [H]

Synonym: A9601_09791

Alternate gene names: 123968512

Gene position: 846959-848917 (Clockwise)

Preceding gene: 123968511

Following gene: 123968513

Centisome position: 50.72

GC content: 27.31

Gene sequence:

>1959_bases
ATGAGTAATTCCTCTATCGAAAAAATAAATAACAAATATAATTTTAAAATTGAATATAAATTAATTAATAATAAGGAGTT
ATTAAAATCAAGATTATCCGAAATTCCAAAGTCATCTGGTTGTTATCTTTTTAAAGATATTGATAATAACTTACTTTATA
TCGGTAAATCTAAAAAACTACGTAGTAGAGTAAGTAGTTATTTCAATAATTATTCAGATTTAACTCCCCGATTAAGTTTG
ATGGTTCGTCAAATAACTGAAATAGAAATAATAGTCACAGATAGCGAATATGAAGCATTAAATTTAGAGTCAAATTTAAT
TAAAACAAACAAACCATATTTTAATATTCTTTTAAAGGATGATAAGAAATATCCATATCTTTGTATAACTTGGAGTGAAA
AATATCCTCGAATATTTATTACAAGAAGAAGAAGAAATAGAAATAATTTAGATAGATATTATGGACCTTATGTTGATGTC
GGACTATTAAGGAGAACATTATTTACGATAAAAAAAATATTTCCACTTAGACAAAGACCAAGGCCAGTCTATAAGGATAG
AACTTGTTTGAATTATTCAATAGGAAGATGTCCAGGTGTTTGCCAAGAAGTAATATCATCTGACGATTATAAAAAAATAA
TGAAACAAGTATCTATGATATTTCAGGGAAGAAATGATGACTTAGAAATATTTTTACAAAAAAAAATGCTGCAATTTTCA
AATGATTTAGATTATGAGAATGCAGCAAAAATAAGGGACCAAATTTCAGGTTTAAAATTATTAACTGAATCACAAAAAAT
ATCAATACCAGATTCTTCAATTAATAGAGATATCTTTGGAATAGTTTCAGAAAAAAATTTAGCTAGTATACAAATTTTCC
AAATGAGATCTGGTAAGCTCATTGGGAGAATTGGCTATAGTCAAAAATTAAATAATGAAGATGAAAATCTTATTTTACAA
AAGATATTAGAAGAGCATTATATGAATGTTGAACCTGTAGAAATACCATCAGAAATTCTTATTCAATATAACCTTCCAAA
ACAAGCAACCATAGAGGATTGGTTAACGGAGCTAAGAAAAAATAAAGTAAAAATCTTAATCCCAAAAAGAAATAAAAAAC
ATGAAACTGTAGAAATGGTTTTAAAAAATGCGAAATTGGAATTAGATAGAATATTAAATGGGATACAAGATAATGAATCA
TCAATTGAGGATCTTGCCCAAATACTTGAATTAAGCGAACAACCTAAAAGAATTGAAGGTTATGATATAAGCCATATTCA
AGGTAGTGACCCTGTAGCATCACAAGTCGTTTTTATTGATGGGATTCCTTCTAAACAGGATTATAGGAAATATAAAATTA
AAGATCCAAACGTTTTTGTAGGACATAGTGATGATTTTGCTTCGATATATGAAGTAATACATAGAAGGTTTAAGAAATGG
TCAAGATTTAAAAAAAACGGAGGAGATTTTTCAATATTAAATGATAAAACGAATAGTAAATTAGACAATGAACTTCTATC
AGATTGGCCTGATTTAATAATGATTGATGGAGGGAAAGGACAGTTAAATGCAGCTATTAAAGCATTAAAAGAATTAAGTC
TTGAGGAAGAAGTAACTATATGTTCATTGGCAAAAAAAAATGAAGAAATATTTATTCCAGGATTTACTAAGTCTCTTGAT
ACTGATGAAAATCAAAAAGGAGTTCTTCTATTAAGAAGGGTAAGAGATGAAGCACATAGATTTGCATTATCTTTTCATAG
AGACAAAAGATCTAAAAGAATGAATAGATCTCAATTGTCCCAAATCAGTGGATTAGGACCATCAAGAATAAGAGAATTGC
TTGAGCATTTTAAATCAATAGACGCGATAAGAATAGCTAGTAAAGAGGAATTATCAAAAGTTAAAGGACTTGGAAAAAAT
TCAGTAAATGATATATATGAATATTTTAACGAGTTATAA

Upstream 100 bases:

>100_bases
CGTTTTTGTAGGAGAGGTTCAATCTGCTTATCTGAATAATGATGTTGACTCACTAAATTTATCTTCAACTGGCTGGAATT
ATGGAGGTTAGTCATTATAA

Downstream 100 bases:

>100_bases
ATATTAATTAATTTTTGAAAAATAGATTTCTTGATATTGTTAAATATAACTATATTAAAAATATATATTTTTATATTAAT
CTAGTAATTTGGCAGCTGAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MSNSSIEKINNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKLRSRVSSYFNNYSDLTPRLSL
MVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDV
GLLRRTLFTIKKIFPLRQRPRPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMKQVSMIFQGRNDDLEIFLQKKMLQFS
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNLASIQIFQMRSGKLIGRIGYSQKLNNEDENLILQ
KILEEHYMNVEPVEIPSEILIQYNLPKQATIEDWLTELRKNKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNES
SIEDLAQILELSEQPKRIEGYDISHIQGSDPVASQVVFIDGIPSKQDYRKYKIKDPNVFVGHSDDFASIYEVIHRRFKKW
SRFKKNGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALKELSLEEEVTICSLAKKNEEIFIPGFTKSLD
TDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLSQISGLGPSRIRELLEHFKSIDAIRIASKEELSKVKGLGKN
SVNDIYEYFNEL

Sequences:

>Translated_652_residues
MSNSSIEKINNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKLRSRVSSYFNNYSDLTPRLSL
MVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDV
GLLRRTLFTIKKIFPLRQRPRPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMKQVSMIFQGRNDDLEIFLQKKMLQFS
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNLASIQIFQMRSGKLIGRIGYSQKLNNEDENLILQ
KILEEHYMNVEPVEIPSEILIQYNLPKQATIEDWLTELRKNKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNES
SIEDLAQILELSEQPKRIEGYDISHIQGSDPVASQVVFIDGIPSKQDYRKYKIKDPNVFVGHSDDFASIYEVIHRRFKKW
SRFKKNGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALKELSLEEEVTICSLAKKNEEIFIPGFTKSLD
TDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLSQISGLGPSRIRELLEHFKSIDAIRIASKEELSKVKGLGKN
SVNDIYEYFNEL
>Mature_651_residues
SNSSIEKINNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKLRSRVSSYFNNYSDLTPRLSLM
VRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDVG
LLRRTLFTIKKIFPLRQRPRPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMKQVSMIFQGRNDDLEIFLQKKMLQFSN
DLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNLASIQIFQMRSGKLIGRIGYSQKLNNEDENLILQK
ILEEHYMNVEPVEIPSEILIQYNLPKQATIEDWLTELRKNKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNESS
IEDLAQILELSEQPKRIEGYDISHIQGSDPVASQVVFIDGIPSKQDYRKYKIKDPNVFVGHSDDFASIYEVIHRRFKKWS
RFKKNGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALKELSLEEEVTICSLAKKNEEIFIPGFTKSLDT
DENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLSQISGLGPSRIRELLEHFKSIDAIRIASKEELSKVKGLGKNS
VNDIYEYFNEL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=633, Percent_Identity=31.2796208530806, Blast_Score=312, Evalue=4e-86,
Organism=Escherichia coli, GI1788037, Length=208, Percent_Identity=29.8076923076923, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 75979; Mature: 75848

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSSIEKINNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKL
CCCCHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCHHH
RSRVSSYFNNYSDLTPRLSLMVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKD
HHHHHHHHCCHHCCCHHHHHHHHHHCEEEEEEECCCCCEECCCCCCEECCCCEEEEEEEC
DKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDVGLLRRTLFTIKKIFPLRQRP
CCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
RPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMKQVSMIFQGRNDDLEIFLQKKMLQFS
CCCCCCCCEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNLASIQIFQMRSGKL
CCCCCHHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCEEEECCCCCCEEEEEEECCCCE
IGRIGYSQKLNNEDENLILQKILEEHYMNVEPVEIPSEILIQYNLPKQATIEDWLTELRK
EEECCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHC
NKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNESSIEDLAQILELSEQPKRIEG
CCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
YDISHIQGSDPVASQVVFIDGIPSKQDYRKYKIKDPNVFVGHSDDFASIYEVIHRRFKKW
CCCCCCCCCCCHHCEEEEEECCCCCCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHH
SRFKKNGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALKELSLEEEVTI
HHHHCCCCCEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHH
CSLAKKNEEIFIPGFTKSLDTDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLS
HHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
QISGLGPSRIRELLEHFKSIDAIRIASKEELSKVKGLGKNSVNDIYEYFNEL
HHHCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SNSSIEKINNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKL
CCCHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCHHH
RSRVSSYFNNYSDLTPRLSLMVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKD
HHHHHHHHCCHHCCCHHHHHHHHHHCEEEEEEECCCCCEECCCCCCEECCCCEEEEEEEC
DKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDVGLLRRTLFTIKKIFPLRQRP
CCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
RPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMKQVSMIFQGRNDDLEIFLQKKMLQFS
CCCCCCCCEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNLASIQIFQMRSGKL
CCCCCHHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCEEEECCCCCCEEEEEEECCCCE
IGRIGYSQKLNNEDENLILQKILEEHYMNVEPVEIPSEILIQYNLPKQATIEDWLTELRK
EEECCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHC
NKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNESSIEDLAQILELSEQPKRIEG
CCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
YDISHIQGSDPVASQVVFIDGIPSKQDYRKYKIKDPNVFVGHSDDFASIYEVIHRRFKKW
CCCCCCCCCCCHHCEEEEEECCCCCCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHH
SRFKKNGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALKELSLEEEVTI
HHHHCCCCCEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHH
CSLAKKNEEIFIPGFTKSLDTDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLS
HHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
QISGLGPSRIRELLEHFKSIDAIRIASKEELSKVKGLGKNSVNDIYEYFNEL
HHHCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA