BacMap

Definition	Prochlorococcus marinus str. AS9601, complete genome.
Accession	NC_008816
Length	1,669,886

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The map label for this gene is rot [H]

Identifier: 123968500

GI number: 123968500

Start: 833646

End: 834083

Strand: Direct

Name: rot [H]

Synonym: A9601_09671

Alternate gene names: 123968500

Gene position: 833646-834083 (Clockwise)

Preceding gene: 123968499

Following gene: 123968502

Centisome position: 49.92

GC content: 36.76

Gene sequence:

>438_bases
ATGACAGCTGCATTATTTGAAACAGAAGTTGGGAACATTAATATTGAATTTTTCTCTGACGATGCACCTAATACAGTTAA
AAACTTCACGAGCCTAATTAGTGATGGTTTTTATGATGGTCTAGCATTTCACAGAGTTATTCCTGGATTTATGGCTCAGG
GTGGATGTCCAAATACTCGTAATGGAGCATCAGGTATGCCTGGAACTGGTGGGCCTGGATATAATATAAAATGTGAAATT
AATTCCAATAAACATCTAAAAGGCTCACTTTCTATGGCTCATGCAGGAAAGGATACAGGTGGAAGTCAGTTTTTCATAGT
TTATGAACCACAACCCCATCTCGATGGAGTTCATACAGTTTTTGGTAAGACTGATGATATGGATGTAGTGCTAAAGCTTA
CTAATGGGTCAAAAATTTTAAAGGCAACTTTAAAATAG

Upstream 100 bases:

>100_bases
AACAGTAATAAAGATAGCATTGATATAAACACTATTAAGGAAAACCTTGAAAAGTTGCTTTAGCTACTAAAATATTTATT
AATTACTAAACAAATAAAAC

Downstream 100 bases:

>100_bases
TTTTTAGCTCTCAAAAACAATACTAAATGTCTCTTTATCTAGATTAAATTTTCTTGTAGATGAATACAAGATTTCATTAT
TTATTGAAAATTTAGTATTG

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MTAALFETEVGNINIEFFSDDAPNTVKNFTSLISDGFYDGLAFHRVIPGFMAQGGCPNTRNGASGMPGTGGPGYNIKCEI
NSNKHLKGSLSMAHAGKDTGGSQFFIVYEPQPHLDGVHTVFGKTDDMDVVLKLTNGSKILKATLK

Sequences:

>Translated_145_residues
MTAALFETEVGNINIEFFSDDAPNTVKNFTSLISDGFYDGLAFHRVIPGFMAQGGCPNTRNGASGMPGTGGPGYNIKCEI
NSNKHLKGSLSMAHAGKDTGGSQFFIVYEPQPHLDGVHTVFGKTDDMDVVLKLTNGSKILKATLK
>Mature_144_residues
TAALFETEVGNINIEFFSDDAPNTVKNFTSLISDGFYDGLAFHRVIPGFMAQGGCPNTRNGASGMPGTGGPGYNIKCEIN
SNKHLKGSLSMAHAGKDTGGSQFFIVYEPQPHLDGVHTVFGKTDDMDVVLKLTNGSKILKATLK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=136, Percent_Identity=41.9117647058824, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI19557636, Length=150, Percent_Identity=40.6666666666667, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI7706339, Length=121, Percent_Identity=41.3223140495868, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI64276486, Length=121, Percent_Identity=40.495867768595, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI6631100, Length=125, Percent_Identity=46.4, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI42560244, Length=144, Percent_Identity=38.1944444444444, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI4826932, Length=132, Percent_Identity=42.4242424242424, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI10863927, Length=130, Percent_Identity=45.3846153846154, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI256017253, Length=129, Percent_Identity=41.8604651162791, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI221139811, Length=129, Percent_Identity=41.8604651162791, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI256017251, Length=129, Percent_Identity=41.8604651162791, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI5031987, Length=137, Percent_Identity=43.0656934306569, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI209417936, Length=121, Percent_Identity=42.9752066115703, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI30102944, Length=121, Percent_Identity=42.9752066115703, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI219842199, Length=121, Percent_Identity=42.9752066115703, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4505991, Length=141, Percent_Identity=43.9716312056738, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI178057341, Length=121, Percent_Identity=43.801652892562, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI4758950, Length=136, Percent_Identity=41.9117647058824, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI310129267, Length=126, Percent_Identity=42.0634920634921, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI310120620, Length=126, Percent_Identity=42.0634920634921, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI310110104, Length=129, Percent_Identity=41.8604651162791, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI310127646, Length=129, Percent_Identity=39.5348837209302, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI310114371, Length=129, Percent_Identity=39.5348837209302, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI310119221, Length=129, Percent_Identity=39.5348837209302, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI150418007, Length=130, Percent_Identity=38.4615384615385, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI5174637, Length=138, Percent_Identity=40.5797101449275, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI45439316, Length=132, Percent_Identity=40.1515151515151, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI303305009, Length=132, Percent_Identity=40.1515151515151, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI169164185, Length=129, Percent_Identity=40.3100775193798, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI169163623, Length=129, Percent_Identity=40.3100775193798, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI5454154, Length=136, Percent_Identity=38.9705882352941, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI169163387, Length=129, Percent_Identity=40.3100775193798, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI20911035, Length=147, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI22547212, Length=116, Percent_Identity=35.3448275862069, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI7657473, Length=116, Percent_Identity=35.3448275862069, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI310132444, Length=124, Percent_Identity=37.9032258064516, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI310113152, Length=124, Percent_Identity=37.9032258064516, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI22547215, Length=131, Percent_Identity=32.824427480916, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI169214050, Length=129, Percent_Identity=39.5348837209302, Blast_Score=64, Evalue=6e-11,
Organism=Homo sapiens, GI239751853, Length=129, Percent_Identity=39.5348837209302, Blast_Score=63, Evalue=7e-11,
Organism=Homo sapiens, GI113428306, Length=129, Percent_Identity=39.5348837209302, Blast_Score=63, Evalue=7e-11,
Organism=Escherichia coli, GI1789763, Length=139, Percent_Identity=38.1294964028777, Blast_Score=74, Evalue=3e-15,
Organism=Escherichia coli, GI1786736, Length=105, Percent_Identity=41.9047619047619, Blast_Score=67, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=122, Percent_Identity=42.6229508196721, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71980590, Length=125, Percent_Identity=41.6, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=125, Percent_Identity=41.6, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17532641, Length=123, Percent_Identity=38.2113821138211, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71997782, Length=122, Percent_Identity=38.5245901639344, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=141, Percent_Identity=41.1347517730496, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17565860, Length=142, Percent_Identity=41.5492957746479, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=134, Percent_Identity=44.0298507462687, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17506307, Length=141, Percent_Identity=41.8439716312057, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551282, Length=123, Percent_Identity=41.4634146341463, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17551284, Length=123, Percent_Identity=41.4634146341463, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539498, Length=132, Percent_Identity=40.1515151515151, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17566266, Length=142, Percent_Identity=38.7323943661972, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=136, Percent_Identity=38.2352941176471, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=143, Percent_Identity=39.1608391608392, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17552782, Length=135, Percent_Identity=39.2592592592593, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17552784, Length=136, Percent_Identity=32.3529411764706, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=128, Percent_Identity=44.53125, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320359, Length=146, Percent_Identity=41.0958904109589, Blast_Score=85, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320510, Length=136, Percent_Identity=44.8529411764706, Blast_Score=80, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321848, Length=133, Percent_Identity=44.3609022556391, Blast_Score=77, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323246, Length=144, Percent_Identity=36.8055555555556, Blast_Score=68, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19922376, Length=131, Percent_Identity=38.1679389312977, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17986117, Length=131, Percent_Identity=40.4580152671756, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357249, Length=139, Percent_Identity=38.8489208633094, Blast_Score=92, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24650807, Length=126, Percent_Identity=42.0634920634921, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19922912, Length=136, Percent_Identity=40.4411764705882, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI45549139, Length=131, Percent_Identity=43.5114503816794, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24664125, Length=132, Percent_Identity=43.1818181818182, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357783, Length=132, Percent_Identity=43.1818181818182, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24652460, Length=132, Percent_Identity=35.6060606060606, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20130249, Length=137, Percent_Identity=43.0656934306569, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17647301, Length=139, Percent_Identity=39.568345323741, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24586038, Length=139, Percent_Identity=35.9712230215827, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17136360, Length=133, Percent_Identity=34.5864661654135, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15458; Mature: 15326

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAALFETEVGNINIEFFSDDAPNTVKNFTSLISDGFYDGLAFHRVIPGFMAQGGCPNTR
CCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
NGASGMPGTGGPGYNIKCEINSNKHLKGSLSMAHAGKDTGGSQFFIVYEPQPHLDGVHTV
CCCCCCCCCCCCCCEEEEEECCCCCEECCEEEEECCCCCCCCEEEEEECCCCCCCCEEEE
FGKTDDMDVVLKLTNGSKILKATLK
CCCCCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure 
TAALFETEVGNINIEFFSDDAPNTVKNFTSLISDGFYDGLAFHRVIPGFMAQGGCPNTR
CCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
NGASGMPGTGGPGYNIKCEINSNKHLKGSLSMAHAGKDTGGSQFFIVYEPQPHLDGVHTV
CCCCCCCCCCCCCCEEEEEECCCCCEECCEEEEECCCCCCCCEEEEEECCCCCCCCEEEE
FGKTDDMDVVLKLTNGSKILKATLK
CCCCCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA