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The map label for this gene is dxs [H]

Identifier: 123968487

GI number: 123968487

Start: 821829

End: 823718

Strand: Direct

Name: dxs [H]

Synonym: A9601_09541

Alternate gene names: 123968487

Gene position: 821829-823718 (Clockwise)

Preceding gene: 123968483

Following gene: 123968497

Centisome position: 49.21

GC content: 35.66

Gene sequence:

>1890_bases
ATGCTTTTAAGTGAGTTAAGTCATCCAAATCAACTTCATGGCTTAACAGTTTCACAATTAGAGGAAATTGCTTGTCAAAT
TAGAGAAAGACATCTTCAGGTAGTATCTACTAGTGGTGGACATCTTGGTCCTGGATTAGGTGTGGTTGAGTTGACATTGG
CTCTATATCAAACTCTCGATCTTGATTTTGACAAAGTTGTTTGGGATGTAGGACATCAAGGTTACCCTCATAAATTAATT
ACAGGACGTTTCAGTCAATTTGATTCTCTAAGGCAACAAAATGGAGTCGCTGGATATTTAAAAAGAAGTGAAAGTAAATT
TGATCATTTTGGTGCTGGACATGCAAGTACATCTATTTCTGCTGCTTTAGGAATGGCAATAGCGAGAGATAGAAAAGGTG
AAAATTATAAATGTGTTGCTGTTATTGGAGATGGAGCACTAACTGGAGGAATGGCATTAGAAGCTATAAATCATGCAGGT
CACTTACCAAATACTCCTTTAGTTGTAGTATTGAACGATAATGACATGTCTATTTCACCTCCTGTTGGAGCCCTTTCATC
GTACTTAAATAAGGTAAGAGTTAGTCCACCATTGCAATTTTTGTCCGATAGTGTTCAAGAAAGTGTAAAAAATATACCCT
TAATTGGTAAGGATATCCCAGAAGAACTCAAAAATATTAAAGGAAGTGTTAGACGACTATCTGTGCCTAAGGTTGGAGCT
GTTTTTGAAGAACTTGGATTTACATATATGGGTCCAATTGAAGGTCATGATATTGCTAATTTAATTAAGACCTTTAACGC
AGCCCATAAACTTAAAAGACCTGTACTTGTTCATGTTGTCACAACAAAAGGGAAGGGATACCCATATGCAGAAGCCGATC
AGGTTGGATATCATGCACAGTCTGCATTTGATCTTACAACTGGGAAATCTATTCCATCAAAGAAACCTAAACCTGTTAGT
TATAGTAAAATTTTTGGTCAAACCTTATTAAAAATATGTGAGCAAGATAGCAAAGTCATTGGTATCACAGCTGCAATGGC
TACAGGTACTGGTTTAGATATATTGCAAAAAAACATCCCTGATCAATATATTGATGTAGGAATAGCAGAACAACATGCAG
TTACTCTTGCGGCAGGAATGTCTTGCGATGGTCTTAAACCTGTTGTAGCTATTTATAGTACTTTTCTTCAACGTGCCTTT
GATCAATTAATTCATGATGTAGGGATACAAAATTTACCTGTATCATTCGTACTTGATAGAGCTGGGATAGTTGGAGCTGA
CGGTCCTACTCACCAAGGTCAGTACGATATCAGTTATATGAGATCTATACCTAATTTTGTATTGATGGCTCCAAAGGATG
AGTCTGAATTACAGAGAATGTTAATAACTTCAATAAACCATAATGGTCCTACAGCTCTAAGAATACCAAGAGGCTCTGGA
TTAGGAGTAGCTGTAATGGATGAGGGTTGGGAACCTATGAATATAGGCGAAGCTGAAATACTTGAAGAAGGAGAAGATAT
TTTAATTATTGCTTATGGTTCAATGGTCGCATCAGCAATCGAAACAGCAAAGATATTAAAAAATATGAACATTAATGCAT
GCATTGTTAATGCGAGATTTGTTAAACCTCTTGATAAAAATCTTATTATGCCTCTAGCAAGTAGGATTCAAAAAGTTGTA
ACTATGGAAGAAGGAACTTTAATAGGTGGTTTTGGTTCCGCGATAGTTGAACTATTTAACGATAATGAAATAAACATTCC
TGTATACAGAATAGGTATTCCTGATGTTTTAGTTGATCATGCTTCACCTGATCAGAGTAAAGAAAAATTAGGGCTTTTGC
CTGATCAGATGGCAGATAAAATTATTAAGAAATTTAAGTTAGTTATTTAA

Upstream 100 bases:

>100_bases
TTAATTATTAATCTAATAAAACATTACATGATCTATTTCAAAAAAAATACTCATTTTGCACCTCGGCGTTTTAGATTATA
TAGATGCCAATTTTTGTTAA

Downstream 100 bases:

>100_bases
AATTTTATAAATAAATATTTATAAAACACCTCGTGAGGCTAATCCTAAGATTGCTCCAATTCCGAAAATATGACCTAGGC
AATTAGCACCTACAACTGAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDFDKVVWDVGHQGYPHKLI
TGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSISAALGMAIARDRKGENYKCVAVIGDGALTGGMALEAINHAG
HLPNTPLVVVLNDNDMSISPPVGALSSYLNKVRVSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLSVPKVGA
VFEELGFTYMGPIEGHDIANLIKTFNAAHKLKRPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLTTGKSIPSKKPKPVS
YSKIFGQTLLKICEQDSKVIGITAAMATGTGLDILQKNIPDQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHNGPTALRIPRGSG
LGVAVMDEGWEPMNIGEAEILEEGEDILIIAYGSMVASAIETAKILKNMNINACIVNARFVKPLDKNLIMPLASRIQKVV
TMEEGTLIGGFGSAIVELFNDNEINIPVYRIGIPDVLVDHASPDQSKEKLGLLPDQMADKIIKKFKLVI

Sequences:

>Translated_629_residues
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDFDKVVWDVGHQGYPHKLI
TGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSISAALGMAIARDRKGENYKCVAVIGDGALTGGMALEAINHAG
HLPNTPLVVVLNDNDMSISPPVGALSSYLNKVRVSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLSVPKVGA
VFEELGFTYMGPIEGHDIANLIKTFNAAHKLKRPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLTTGKSIPSKKPKPVS
YSKIFGQTLLKICEQDSKVIGITAAMATGTGLDILQKNIPDQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHNGPTALRIPRGSG
LGVAVMDEGWEPMNIGEAEILEEGEDILIIAYGSMVASAIETAKILKNMNINACIVNARFVKPLDKNLIMPLASRIQKVV
TMEEGTLIGGFGSAIVELFNDNEINIPVYRIGIPDVLVDHASPDQSKEKLGLLPDQMADKIIKKFKLVI
>Mature_629_residues
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDFDKVVWDVGHQGYPHKLI
TGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSISAALGMAIARDRKGENYKCVAVIGDGALTGGMALEAINHAG
HLPNTPLVVVLNDNDMSISPPVGALSSYLNKVRVSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLSVPKVGA
VFEELGFTYMGPIEGHDIANLIKTFNAAHKLKRPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLTTGKSIPSKKPKPVS
YSKIFGQTLLKICEQDSKVIGITAAMATGTGLDILQKNIPDQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHNGPTALRIPRGSG
LGVAVMDEGWEPMNIGEAEILEEGEDILIIAYGSMVASAIETAKILKNMNINACIVNARFVKPLDKNLIMPLASRIQKVV
TMEEGTLIGGFGSAIVELFNDNEINIPVYRIGIPDVLVDHASPDQSKEKLGLLPDQMADKIIKKFKLVI

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=485, Percent_Identity=24.5360824742268, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI4507521, Length=485, Percent_Identity=24.5360824742268, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI133778974, Length=640, Percent_Identity=21.71875, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI225637461, Length=377, Percent_Identity=24.4031830238727, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI225637459, Length=377, Percent_Identity=24.4031830238727, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI225637463, Length=377, Percent_Identity=24.4031830238727, Blast_Score=93, Evalue=9e-19,
Organism=Escherichia coli, GI1786622, Length=613, Percent_Identity=43.3931484502447, Blast_Score=515, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17539652, Length=408, Percent_Identity=27.2058823529412, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319698, Length=317, Percent_Identity=24.9211356466877, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45551847, Length=651, Percent_Identity=23.1950844854071, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45550715, Length=651, Percent_Identity=23.1950844854071, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24645119, Length=607, Percent_Identity=23.5584843492586, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24666278, Length=654, Percent_Identity=24.0061162079511, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21358145, Length=332, Percent_Identity=24.0963855421687, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650940, Length=332, Percent_Identity=24.0963855421687, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68067; Mature: 68067

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHC
LDFDKVVWDVGHQGYPHKLITGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSIS
CCHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHCCCCHHHCCCCCCCHHHH
AALGMAIARDRKGENYKCVAVIGDGALTGGMALEAINHAGHLPNTPLVVVLNDNDMSISP
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSSYLNKVRVSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLSVPKVGA
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCCHHHH
VFEELGFTYMGPIEGHDIANLIKTFNAAHKLKRPVLVHVVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SAFDLTTGKSIPSKKPKPVSYSKIFGQTLLKICEQDSKVIGITAAMATGTGLDILQKNIP
CCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCHHHHHHCCC
DQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAFDQLIHDVGIQNLPVSFVLDR
HHHHHCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEC
AGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHNGPTALRIPRGSG
CCEECCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCC
LGVAVMDEGWEPMNIGEAEILEEGEDILIIAYGSMVASAIETAKILKNMNINACIVNARF
CEEEEECCCCCCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEHH
VKPLDKNLIMPLASRIQKVVTMEEGTLIGGFGSAIVELFNDNEINIPVYRIGIPDVLVDH
HCCCCHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCEEEEEECCCHHHHCC
ASPDQSKEKLGLLPDQMADKIIKKFKLVI
CCCCCCHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHC
LDFDKVVWDVGHQGYPHKLITGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSIS
CCHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHCCCCHHHCCCCCCCHHHH
AALGMAIARDRKGENYKCVAVIGDGALTGGMALEAINHAGHLPNTPLVVVLNDNDMSISP
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSSYLNKVRVSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLSVPKVGA
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCCHHHH
VFEELGFTYMGPIEGHDIANLIKTFNAAHKLKRPVLVHVVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SAFDLTTGKSIPSKKPKPVSYSKIFGQTLLKICEQDSKVIGITAAMATGTGLDILQKNIP
CCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCHHHHHHCCC
DQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAFDQLIHDVGIQNLPVSFVLDR
HHHHHCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEC
AGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHNGPTALRIPRGSG
CCEECCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCC
LGVAVMDEGWEPMNIGEAEILEEGEDILIIAYGSMVASAIETAKILKNMNINACIVNARF
CEEEEECCCCCCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEHH
VKPLDKNLIMPLASRIQKVVTMEEGTLIGGFGSAIVELFNDNEINIPVYRIGIPDVLVDH
HCCCCHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCEEEEEECCCHHHHCC
ASPDQSKEKLGLLPDQMADKIIKKFKLVI
CCCCCCHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA