Click here to switch to the map view.

The map label for this gene is ksgA [H]

Identifier: 123968460

GI number: 123968460

Start: 797422

End: 798246

Strand: Direct

Name: ksgA [H]

Synonym: A9601_09271

Alternate gene names: 123968460

Gene position: 797422-798246 (Clockwise)

Preceding gene: 123968454

Following gene: 123968461

Centisome position: 47.75

GC content: 25.45

Gene sequence:

>825_bases
ATGAATTCTAAAAACCATCATCAAAAAAAAAGATTTGGACAACACTGGTTGGTAAATAAAAAAATATTAGAAAAAATCAA
AGAAATTGCTGTTCTTAATCAAAATGACTTTATTTTAGAAATTGGCCCAGGTAAAGGAGCTTTAACATCTAAGTTATTAG
ATTCAGAAATTAAAAAATTACATGCGATTGAATTAGATAAAGATTTAATAAATTTATTGAATGATAAATTCAATAATAAT
GATAAGTTTTCACTTCAGCAGGGAGATATTCTTACCGTAAATTTAGATTCAATTAATAAAAAGATTACAAAAGTGATTGC
AAATATTCCTTACAATATAACTGGCCCAATATTGGATATTTTCATAGGGAGATTGGGTATTACAAGAAACTATAATTACG
AAAAAATAATTTTTTTAATGCAGAAAGACGTTGTAGATAGGATTTTGTCTAAAGAAGGAAGTCCCAATGCTGGTGCGCTT
AGTGTAAGAATGCAACTCTTATCAAAAATAAAAAAAATTTGTGATGTACCGCCTTCATCTTTTAGTCCACCTCCAAAAGT
TTTTTCTTCTTTAGTAGTTTTCGAACCAATTAAAAATCATTTAAGATTAGATATTAGTATAGAAAAAAATATAGATAAAC
TTCTTCGAATTTCATTTAATTCAAGAAGAAAAATGCTTAGAAATACACTTAATTCAATACTTTCAAATGAAGAGATAAAT
GAATTATCTGAATCTTCAAAAGTTTGTTTTAATTTAAGACCACAAGATATTTCTATTGAACAATGGATTAAGCTTGCAGA
AAATTGTATTAAAATTAAAAAATAA

Upstream 100 bases:

>100_bases
TTAAATTTATTGAGTTTATCTAAATTTTTTTTTGATAAGCTCATGATATAAAGTATTAAATAAATTCATATTTAATTTAA
ACATATTATTTATCTTTTAG

Downstream 100 bases:

>100_bases
AAATTTAAGTATATGCAAGATTTTGCTAAAAAGAAAATTAATATAAAATCTCCTGCCAAAATAAATTTGCACCTTGAAGT
GATTGGTAAAAGAGAGGATG

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MNSKNHHQKKRFGQHWLVNKKILEKIKEIAVLNQNDFILEIGPGKGALTSKLLDSEIKKLHAIELDKDLINLLNDKFNNN
DKFSLQQGDILTVNLDSINKKITKVIANIPYNITGPILDIFIGRLGITRNYNYEKIIFLMQKDVVDRILSKEGSPNAGAL
SVRMQLLSKIKKICDVPPSSFSPPPKVFSSLVVFEPIKNHLRLDISIEKNIDKLLRISFNSRRKMLRNTLNSILSNEEIN
ELSESSKVCFNLRPQDISIEQWIKLAENCIKIKK

Sequences:

>Translated_274_residues
MNSKNHHQKKRFGQHWLVNKKILEKIKEIAVLNQNDFILEIGPGKGALTSKLLDSEIKKLHAIELDKDLINLLNDKFNNN
DKFSLQQGDILTVNLDSINKKITKVIANIPYNITGPILDIFIGRLGITRNYNYEKIIFLMQKDVVDRILSKEGSPNAGAL
SVRMQLLSKIKKICDVPPSSFSPPPKVFSSLVVFEPIKNHLRLDISIEKNIDKLLRISFNSRRKMLRNTLNSILSNEEIN
ELSESSKVCFNLRPQDISIEQWIKLAENCIKIKK
>Mature_274_residues
MNSKNHHQKKRFGQHWLVNKKILEKIKEIAVLNQNDFILEIGPGKGALTSKLLDSEIKKLHAIELDKDLINLLNDKFNNN
DKFSLQQGDILTVNLDSINKKITKVIANIPYNITGPILDIFIGRLGITRNYNYEKIIFLMQKDVVDRILSKEGSPNAGAL
SVRMQLLSKIKKICDVPPSSFSPPPKVFSSLVVFEPIKNHLRLDISIEKNIDKLLRISFNSRRKMLRNTLNSILSNEEIN
ELSESSKVCFNLRPQDISIEQWIKLAENCIKIKK

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=235, Percent_Identity=31.4893617021277, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI156415992, Length=282, Percent_Identity=24.468085106383, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1786236, Length=273, Percent_Identity=30.7692307692308, Blast_Score=127, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI25146882, Length=243, Percent_Identity=31.2757201646091, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25141369, Length=291, Percent_Identity=26.1168384879725, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324989, Length=212, Percent_Identity=29.7169811320755, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21358017, Length=236, Percent_Identity=31.7796610169492, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357273, Length=277, Percent_Identity=25.9927797833935, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 31380; Mature: 31380

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKNHHQKKRFGQHWLVNKKILEKIKEIAVLNQNDFILEIGPGKGALTSKLLDSEIKKL
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
HAIELDKDLINLLNDKFNNNDKFSLQQGDILTVNLDSINKKITKVIANIPYNITGPILDI
HHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHH
FIGRLGITRNYNYEKIIFLMQKDVVDRILSKEGSPNAGALSVRMQLLSKIKKICDVPPSS
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
FSPPPKVFSSLVVFEPIKNHLRLDISIEKNIDKLLRISFNSRRKMLRNTLNSILSNEEIN
CCCCHHHHHHHHHHHHHHCCEEEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ELSESSKVCFNLRPQDISIEQWIKLAENCIKIKK
HHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSKNHHQKKRFGQHWLVNKKILEKIKEIAVLNQNDFILEIGPGKGALTSKLLDSEIKKL
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
HAIELDKDLINLLNDKFNNNDKFSLQQGDILTVNLDSINKKITKVIANIPYNITGPILDI
HHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHH
FIGRLGITRNYNYEKIIFLMQKDVVDRILSKEGSPNAGALSVRMQLLSKIKKICDVPPSS
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
FSPPPKVFSSLVVFEPIKNHLRLDISIEKNIDKLLRISFNSRRKMLRNTLNSILSNEEIN
CCCCHHHHHHHHHHHHHHCCEEEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ELSESSKVCFNLRPQDISIEQWIKLAENCIKIKK
HHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA