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The map label for this gene is hisG [H]

Identifier: 123968151

GI number: 123968151

Start: 537293

End: 537931

Strand: Direct

Name: hisG [H]

Synonym: A9601_06161

Alternate gene names: 123968151

Gene position: 537293-537931 (Clockwise)

Preceding gene: 123968147

Following gene: 123968152

Centisome position: 32.18

GC content: 33.02

Gene sequence:

>639_bases
ATGATTACTATAGCTTTACCAAAAGGAGCTCTGTTAAAAGATTCAATTTCAACTTTTAAAAAAGCTGGGTTAGATTTCTC
TAATGCGTTGGAAGAAAATAATAGATCATTAACCTTTGAATCAAATTGCAAACGGGCAAAAGCTCTATTAGTAAGAAATG
GAGATGTTCCTGTTTATGTAAGTTATGGTCAGGCTGATTTGGGTATTGTTGGGTATGACGTTTTACGAGAATCTGAATTA
AAAGTCGCAAAATTATTAGATTTAGGATTTGGGGGTTGTCATATGTCGTTGGCGGTTAAGAAAAATAGCAATTATTTAAA
ACCAACCGATCTTCCAGCGAATTGTAAAGTAGCAAGTAAATTTATAAAAACAGCAAGATCTTATTTTGAAGAATTAAATA
TTCCTGTAGAAATAGTACATTTGACGGGATCAGTAGAGCTTGGTCCTATTACAGGTATGGCAGAGGCAATAGTTGATTTG
GTGGCAACCGGAAAGACTCTCAAAGAGAATGGTTTAATTAAAATAGATGATCTTTATTACTCGACTGCAAGACTAATTGG
AAATCCTTTATCGATGAGGTTAGATGATAATCATCTCAGAGATACAATTTTATCAATAGAATCAACTAATGCTTTATAG

Upstream 100 bases:

>100_bases
TATGACGTTATCACTTAAAACTCTAAGTCCGATTATATTTCGAGCTTTATTAAATTCCATTGTTAAATTAGAATGAAGAA
TCCTTGGAAGAAATTGATCT

Downstream 100 bases:

>100_bases
AAGATTAGCTAAATGTTTTTTAAAGATTTTAGAAGGATTAAAAAGTTAGGTAAATATTTAACAAAAGATAAAAAAACAAT
CTATCTAATCTTGATAGTTT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MITIALPKGALLKDSISTFKKAGLDFSNALEENNRSLTFESNCKRAKALLVRNGDVPVYVSYGQADLGIVGYDVLRESEL
KVAKLLDLGFGGCHMSLAVKKNSNYLKPTDLPANCKVASKFIKTARSYFEELNIPVEIVHLTGSVELGPITGMAEAIVDL
VATGKTLKENGLIKIDDLYYSTARLIGNPLSMRLDDNHLRDTILSIESTNAL

Sequences:

>Translated_212_residues
MITIALPKGALLKDSISTFKKAGLDFSNALEENNRSLTFESNCKRAKALLVRNGDVPVYVSYGQADLGIVGYDVLRESEL
KVAKLLDLGFGGCHMSLAVKKNSNYLKPTDLPANCKVASKFIKTARSYFEELNIPVEIVHLTGSVELGPITGMAEAIVDL
VATGKTLKENGLIKIDDLYYSTARLIGNPLSMRLDDNHLRDTILSIESTNAL
>Mature_212_residues
MITIALPKGALLKDSISTFKKAGLDFSNALEENNRSLTFESNCKRAKALLVRNGDVPVYVSYGQADLGIVGYDVLRESEL
KVAKLLDLGFGGCHMSLAVKKNSNYLKPTDLPANCKVASKFIKTARSYFEELNIPVEIVHLTGSVELGPITGMAEAIVDL
VATGKTLKENGLIKIDDLYYSTARLIGNPLSMRLDDNHLRDTILSIESTNAL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=166, Percent_Identity=35.5421686746988, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=196, Percent_Identity=34.1836734693878, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23092; Mature: 23092

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIALPKGALLKDSISTFKKAGLDFSNALEENNRSLTFESNCKRAKALLVRNGDVPVYV
CEEEECCCCCHHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCCCCEEEEEEECCCEEEEE
SYGQADLGIVGYDVLRESELKVAKLLDLGFGGCHMSLAVKKNSNYLKPTDLPANCKVASK
ECCCCCCCEEEHHHHCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHH
FIKTARSYFEELNIPVEIVHLTGSVELGPITGMAEAIVDLVATGKTLKENGLIKIDDLYY
HHHHHHHHHHHCCCCEEEEEEECCEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEHHHH
STARLIGNPLSMRLDDNHLRDTILSIESTNAL
HHHHHHCCCEEEEECCHHHHHHHEEEECCCCC
>Mature Secondary Structure
MITIALPKGALLKDSISTFKKAGLDFSNALEENNRSLTFESNCKRAKALLVRNGDVPVYV
CEEEECCCCCHHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCCCCEEEEEEECCCEEEEE
SYGQADLGIVGYDVLRESELKVAKLLDLGFGGCHMSLAVKKNSNYLKPTDLPANCKVASK
ECCCCCCCEEEHHHHCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHH
FIKTARSYFEELNIPVEIVHLTGSVELGPITGMAEAIVDLVATGKTLKENGLIKIDDLYY
HHHHHHHHHHHCCCCEEEEEEECCEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEHHHH
STARLIGNPLSMRLDDNHLRDTILSIESTNAL
HHHHHHCCCEEEEECCHHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA