Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 123967984

GI number: 123967984

Start: 387419

End: 388231

Strand: Direct

Name: proC [H]

Synonym: A9601_04471

Alternate gene names: 123967984

Gene position: 387419-388231 (Clockwise)

Preceding gene: 123967983

Following gene: 123967989

Centisome position: 23.2

GC content: 29.27

Gene sequence:

>813_bases
GTGACAGATAAAATTGCGATTATTGGTTTTGGAAATATTGCAAGCGCTATAGTTACCCCTTTATTAGATAACAAATTAAT
TCAGCCAGAGAATGTTTTTTGTGTTGTTAATTCAGAAAAAAGTTTAGAAAACATAAAAAAAAATTATAAATATAAAATAA
ACGTTTATAAATCAGGTTCTAAAGAGTCAAAAATAATTTGGGATTGTCAATATAAACTTCTTTCGATAAAACCCCAACAA
TTAAAAGATATAAGTGAGGCCCATCAGATAAAAAATAAGGGCAATTTAATAGTTTCAATTCTTGCGGGGGTTTCAATAAA
TAAACTCACTCAAAAGTTTCCTAATCATAAATGTGTGAGAGTGGTTACAAATATTCCAATAACTATTGGAAAAGGTTTAA
CAGGAATTTCTTGGGGTGAAGAAATTACAGAAGATCAGAAACAATTTACAAAAAAATTATTTGAAAATACTAGTAAGATT
TATGAATTTACTGAAGATTACCTTGATATATTTTTAGCTTTAACCTCATCTGGTCCTGCAATTATTGCTTTGATTATAGA
AGCATTAAGTGATGGAGGATTAAGTGGGGGATTACCAAAAATAATTTCAGAGGAACTTGTTATGGAAATGATACTAGGGA
CTATTTGTTTAATAAAGGAAAATAAACTTACTACTTCTGAGCTCAAAAATTTAGTAACCTCTCCAGGTGGAACAACTATC
TCTGCTTTAAGGGTTTTAGAAAAAAAGAGTGTAAGGTCAGCATTAATTGAATCAATAGTTTCAGCTAGTAATCGAAGTAA
AGAGTTTCGTTAG

Upstream 100 bases:

>100_bases
GTGTCTACAGAAAACACACCACAATATAGTTTGGGCAAAAATACTACTCCTGAACCAGCATGGGGTAATTCTAAATTAAG
TGCTTATTCATGATTAATCT

Downstream 100 bases:

>100_bases
TTTTTTCAATTATCTTTTAAGTTCATATAAACTTTTTCAAGTGAATTTATATTTTTAGTAATTGTGTATCTCTCAAGTAC
ACGTTCTCTAGCTTTTTCGC

Product: Delta 1-pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTDKIAIIGFGNIASAIVTPLLDNKLIQPENVFCVVNSEKSLENIKKNYKYKINVYKSGSKESKIIWDCQYKLLSIKPQQ
LKDISEAHQIKNKGNLIVSILAGVSINKLTQKFPNHKCVRVVTNIPITIGKGLTGISWGEEITEDQKQFTKKLFENTSKI
YEFTEDYLDIFLALTSSGPAIIALIIEALSDGGLSGGLPKIISEELVMEMILGTICLIKENKLTTSELKNLVTSPGGTTI
SALRVLEKKSVRSALIESIVSASNRSKEFR

Sequences:

>Translated_270_residues
MTDKIAIIGFGNIASAIVTPLLDNKLIQPENVFCVVNSEKSLENIKKNYKYKINVYKSGSKESKIIWDCQYKLLSIKPQQ
LKDISEAHQIKNKGNLIVSILAGVSINKLTQKFPNHKCVRVVTNIPITIGKGLTGISWGEEITEDQKQFTKKLFENTSKI
YEFTEDYLDIFLALTSSGPAIIALIIEALSDGGLSGGLPKIISEELVMEMILGTICLIKENKLTTSELKNLVTSPGGTTI
SALRVLEKKSVRSALIESIVSASNRSKEFR
>Mature_269_residues
TDKIAIIGFGNIASAIVTPLLDNKLIQPENVFCVVNSEKSLENIKKNYKYKINVYKSGSKESKIIWDCQYKLLSIKPQQL
KDISEAHQIKNKGNLIVSILAGVSINKLTQKFPNHKCVRVVTNIPITIGKGLTGISWGEEITEDQKQFTKKLFENTSKIY
EFTEDYLDIFLALTSSGPAIIALIIEALSDGGLSGGLPKIISEELVMEMILGTICLIKENKLTTSELKNLVTSPGGTTIS
ALRVLEKKSVRSALIESIVSASNRSKEFR

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=23.8805970149254, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI21361454, Length=274, Percent_Identity=27.7372262773723, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI24797097, Length=204, Percent_Identity=29.9019607843137, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI24797095, Length=204, Percent_Identity=29.9019607843137, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=27.6752767527675, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=26.2172284644195, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=26.8817204301075, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=231, Percent_Identity=31.1688311688312, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=26.3157894736842, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24647700, Length=156, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24648116, Length=278, Percent_Identity=26.2589928057554, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29806; Mature: 29675

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKIAIIGFGNIASAIVTPLLDNKLIQPENVFCVVNSEKSLENIKKNYKYKINVYKSGS
CCCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHCCEEEEEEEECCC
KESKIIWDCQYKLLSIKPQQLKDISEAHQIKNKGNLIVSILAGVSINKLTQKFPNHKCVR
CCCCEEEEECEEEECCCHHHHHHHHHHHHHHCCCCEEEEHHHCCCHHHHHHHCCCCCEEE
VVTNIPITIGKGLTGISWGEEITEDQKQFTKKLFENTSKIYEFTEDYLDIFLALTSSGPA
EEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IIALIIEALSDGGLSGGLPKIISEELVMEMILGTICLIKENKLTTSELKNLVTSPGGTTI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCHH
SALRVLEKKSVRSALIESIVSASNRSKEFR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDKIAIIGFGNIASAIVTPLLDNKLIQPENVFCVVNSEKSLENIKKNYKYKINVYKSGS
CCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHCCEEEEEEEECCC
KESKIIWDCQYKLLSIKPQQLKDISEAHQIKNKGNLIVSILAGVSINKLTQKFPNHKCVR
CCCCEEEEECEEEECCCHHHHHHHHHHHHHHCCCCEEEEHHHCCCHHHHHHHCCCCCEEE
VVTNIPITIGKGLTGISWGEEITEDQKQFTKKLFENTSKIYEFTEDYLDIFLALTSSGPA
EEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IIALIIEALSDGGLSGGLPKIISEELVMEMILGTICLIKENKLTTSELKNLVTSPGGTTI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCHH
SALRVLEKKSVRSALIESIVSASNRSKEFR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]