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The map label for this gene is hemB [H]

Identifier: 123967772

GI number: 123967772

Start: 218928

End: 219929

Strand: Direct

Name: hemB [H]

Synonym: A9601_02351

Alternate gene names: 123967772

Gene position: 218928-219929 (Clockwise)

Preceding gene: 123967769

Following gene: 123967773

Centisome position: 13.11

GC content: 35.33

Gene sequence:

>1002_bases
ATGAATTCGATTATTCGTCCAAGAAGATTAAGAAGAACTGAGTCAATAAGAGAAATGGTTAGAGAAAACCATTTGGCGGC
ATCGGACTTTATCTATCCATTATTTATTCATGAGAAAGATTTTAAAGAGGAAATTTCCGCAATGCCCGGAACTTATAGAT
GGGATATTGATGGTTTACTAAAGGAGGTTACTAGGGCATGGGAATTGGGAATTAGATGTGTGGTTCTTTTCCCAAAAATT
AATGATAGCTTAAAGACTGAAGATGGAGCAGAATGTTTTAATGAGGACGGTTTAATACCTAAAGCTATTCGAATATTAAA
AAAAGAGATTCCAGAAATGGCAATAATGACAGATGTTGCCTTGGACCCTTACTCCTGTGATGGACATGATGGCTTAGTTG
ATGAAACTGGAAAAATATTGAATGATGAAACGATTGAAATTTTAAAAAAACAAGCTTTAACTCAAGCTAGAGCTGGAGCA
GATTTTATTGGCCCTAGTGACATGATGGATGGGAGAGTTGGAGCAATTAGGACTGCTCTTGATAGTGAAGGATTTAGTGA
TGTAGGTATTATTAGTTATACAGCTAAATATTCATCTGCTTATTATGGTCCGTTTAGAACTGCTTTAGATTCGGCTCCTA
GAGAAAATAGTAAGAAAGTAATTCCAGACAATAAGTCTACATATCAAATGGACCCTGCCAATTCAAAAGAGGCTTTAATT
GAATCTGCATTGGATCAGTATGAAGGAGCTGATATTTTGATGGTAAAACCAGGAATTTCATATTTGGATATTGTTTATAG
AATAAGCACATTTTCAAATAAGCCCATAGCTGCATACAACGTTAGTGGGGAGTATTCCATGGTAAAGTCTGCTGCTATGA
AGAACTGGATTAACGAAAAAGATATTGTTTTAGAGACATTGCTTAGTTTTAAAAGAGCAGGAGCAAAATTAATACTCACT
TATCATGCTTGTGATGCATCTCAATGGTTGCAGGATACTTAA

Upstream 100 bases:

>100_bases
TAGTTACTTTTCCTGAACAAAAGTAGTCTCTGATTGATTTATATGCGAGGCAAGCGATTAATGTATTAGATAAATATTTT
TCAATTTTAATAATATTCAA

Downstream 100 bases:

>100_bases
AAACTCATTATTAACAAAAATTTGGTTTATTCTTAGATAAGTAATAAATTAATTGCTTTGTTTTGAAGTTTTCACAAGGA
GTAAATAGGATTGGTCACAT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MNSIIRPRRLRRTESIREMVRENHLAASDFIYPLFIHEKDFKEEISAMPGTYRWDIDGLLKEVTRAWELGIRCVVLFPKI
NDSLKTEDGAECFNEDGLIPKAIRILKKEIPEMAIMTDVALDPYSCDGHDGLVDETGKILNDETIEILKKQALTQARAGA
DFIGPSDMMDGRVGAIRTALDSEGFSDVGIISYTAKYSSAYYGPFRTALDSAPRENSKKVIPDNKSTYQMDPANSKEALI
ESALDQYEGADILMVKPGISYLDIVYRISTFSNKPIAAYNVSGEYSMVKSAAMKNWINEKDIVLETLLSFKRAGAKLILT
YHACDASQWLQDT

Sequences:

>Translated_333_residues
MNSIIRPRRLRRTESIREMVRENHLAASDFIYPLFIHEKDFKEEISAMPGTYRWDIDGLLKEVTRAWELGIRCVVLFPKI
NDSLKTEDGAECFNEDGLIPKAIRILKKEIPEMAIMTDVALDPYSCDGHDGLVDETGKILNDETIEILKKQALTQARAGA
DFIGPSDMMDGRVGAIRTALDSEGFSDVGIISYTAKYSSAYYGPFRTALDSAPRENSKKVIPDNKSTYQMDPANSKEALI
ESALDQYEGADILMVKPGISYLDIVYRISTFSNKPIAAYNVSGEYSMVKSAAMKNWINEKDIVLETLLSFKRAGAKLILT
YHACDASQWLQDT
>Mature_333_residues
MNSIIRPRRLRRTESIREMVRENHLAASDFIYPLFIHEKDFKEEISAMPGTYRWDIDGLLKEVTRAWELGIRCVVLFPKI
NDSLKTEDGAECFNEDGLIPKAIRILKKEIPEMAIMTDVALDPYSCDGHDGLVDETGKILNDETIEILKKQALTQARAGA
DFIGPSDMMDGRVGAIRTALDSEGFSDVGIISYTAKYSSAYYGPFRTALDSAPRENSKKVIPDNKSTYQMDPANSKEALI
ESALDQYEGADILMVKPGISYLDIVYRISTFSNKPIAAYNVSGEYSMVKSAAMKNWINEKDIVLETLLSFKRAGAKLILT
YHACDASQWLQDT

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=311, Percent_Identity=38.2636655948553, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI87081728, Length=327, Percent_Identity=44.954128440367, Blast_Score=264, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6321398, Length=323, Percent_Identity=35.2941176470588, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21358291, Length=300, Percent_Identity=35.3333333333333, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37349; Mature: 37349

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIIRPRRLRRTESIREMVRENHLAASDFIYPLFIHEKDFKEEISAMPGTYRWDIDGLL
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHCEEEEEEECHHHHHHHHCCCCCEEECHHHHH
KEVTRAWELGIRCVVLFPKINDSLKTEDGAECFNEDGLIPKAIRILKKEIPEMAIMTDVA
HHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHC
LDPYSCDGHDGLVDETGKILNDETIEILKKQALTQARAGADFIGPSDMMDGRVGAIRTAL
CCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHH
DSEGFSDVGIISYTAKYSSAYYGPFRTALDSAPRENSKKVIPDNKSTYQMDPANSKEALI
CCCCCCCCEEEEEEHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHH
ESALDQYEGADILMVKPGISYLDIVYRISTFSNKPIAAYNVSGEYSMVKSAAMKNWINEK
HHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCHH
DIVLETLLSFKRAGAKLILTYHACDASQWLQDT
HHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCC
>Mature Secondary Structure
MNSIIRPRRLRRTESIREMVRENHLAASDFIYPLFIHEKDFKEEISAMPGTYRWDIDGLL
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHCEEEEEEECHHHHHHHHCCCCCEEECHHHHH
KEVTRAWELGIRCVVLFPKINDSLKTEDGAECFNEDGLIPKAIRILKKEIPEMAIMTDVA
HHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHC
LDPYSCDGHDGLVDETGKILNDETIEILKKQALTQARAGADFIGPSDMMDGRVGAIRTAL
CCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHH
DSEGFSDVGIISYTAKYSSAYYGPFRTALDSAPRENSKKVIPDNKSTYQMDPANSKEALI
CCCCCCCCEEEEEEHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHH
ESALDQYEGADILMVKPGISYLDIVYRISTFSNKPIAAYNVSGEYSMVKSAAMKNWINEK
HHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCHH
DIVLETLLSFKRAGAKLILTYHACDASQWLQDT
HHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]