Click here to switch to the map view.

The map label for this gene is gltA [H]

Identifier: 123967716

GI number: 123967716

Start: 166130

End: 167275

Strand: Reverse

Name: gltA [H]

Synonym: A9601_01791

Alternate gene names: 123967716

Gene position: 167275-166130 (Counterclockwise)

Preceding gene: 123967717

Following gene: 123967715

Centisome position: 10.02

GC content: 37.61

Gene sequence:

>1146_bases
TTGGACAGTAACAAACTAATTTTAAAACCAGGATTAGAGGGTGTCCCAGTTACTAATTCATCTATCTGTGATATTGACGG
CAACAAAGGTAAATTATTGTACAGAGGGTTCTCCATTGAGGAACTATCCAAAAAAAGCAGTTTTTTAGAAACTGCTTACC
TTTTGATTTGGGGTGAATTGCCCACGGCTATTCAACTTAGAGATTTTGAACAAGAAGTCCAGATGCATCGAAGGTTAAGT
TTTAGAGTCAGAGATATGATGAAATGTTTTCCTGCTACCGGTCATCCTATGGATGCTCTTCAATCTAGTGCAGCTTCTTT
GGGGTTATTCTATTCACGTAGAGCAATAGATGATCCTAATTACATTTACAACGCAGTGATAAGACTAATAGCAAAAATTC
CAACAATGATTGCTGCGTTTCAACTTATTAGAAAAGGACAAGACCCAATTCAACCAAGAGATGATTTAACTTACTCATCA
AATTTTCTTTACATGCTGACTGAAAAAGAACAAGATCCTATAGCTGCAAAAGTTTTTGACAGGTGTTTAATCCTACATGC
CGAACATAGTTTAAACGCAAGTACATTTAGCGCTAGAGTTACTGCAAGTACTCTTACAGACCCATATGCTGTCATCGCCT
CTGCAGTAGGAACCCTTGCTGGCCCACTGCATGGAGGAGCAAATGAGGACGTAATTGCAATGTTAGAAGAGATTAAAACT
CCAGAAAATGCTGGGTCTTTTTTAGATAATGCAATTAAAAATAAAAGTAAGATAATGGGCTTCGGCCACAGAGAATATAA
AGTTAAAGATCCAAGAGCAATAATTCTACAAAAACTGGCAGAAGAGCTTTTTATTAGATTTGGAGCAGATGAAATGTATG
AAGTTGCTAAATCACTTGAGGCAGAGGCAATACCAAGACTTGGACCTAAAGGTATATTCCCTAACGTGGATTTTTATTCT
GGTCTTGTTTATAGAAAACTTGGTATTCCTCGTGATTTATTTACTCCAATTTTTGCCATATCTAGAGTGGCTGGTTGGTT
AGCTCATTGGAGAGAGCAACTTGGAGCAAACAGAATTTTCAGGCCATCGCAAATCTATACGGGTTCAGCACCAAGAGATT
GGATCAGCCTAGAAAATAGAGAATAA

Upstream 100 bases:

>100_bases
GACAATCATTTGAAATTTTTGTGAAGTTAATAACTTGTGGTTAATTAAAAAATATTTGACTATCTTTAATCTATAAGTAT
TTGATATTGAAATTAAGCAA

Downstream 100 bases:

>100_bases
TATTTGCAGCTTTTCATAAAAAACACACATATTGTTTGTGAAGAGTTAATCTATTAAGTAAATAACATAAAAATTTTGGA
ATACGGATTAGATCTCGAAT

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGFSIEELSKKSSFLETAYLLIWGELPTAIQLRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPNYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
PENAGSFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLEAEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPRDWISLENRE

Sequences:

>Translated_381_residues
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGFSIEELSKKSSFLETAYLLIWGELPTAIQLRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPNYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
PENAGSFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLEAEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPRDWISLENRE
>Mature_381_residues
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGFSIEELSKKSSFLETAYLLIWGELPTAIQLRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPNYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
PENAGSFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLEAEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPRDWISLENRE

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=380, Percent_Identity=27.8947368421053, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786939, Length=383, Percent_Identity=39.4255874673629, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1786527, Length=386, Percent_Identity=33.6787564766839, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17555174, Length=376, Percent_Identity=27.6595744680851, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=374, Percent_Identity=26.2032085561497, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325257, Length=374, Percent_Identity=25.668449197861, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324328, Length=319, Percent_Identity=24.1379310344828, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24640126, Length=395, Percent_Identity=27.5949367088608, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640124, Length=395, Percent_Identity=27.5949367088608, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21356863, Length=389, Percent_Identity=26.4781491002571, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 42738; Mature: 42738

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGFSIEELSKKSSFLETAYLLIWGEL
CCCCCEEECCCCCCCCCCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHEEEECCC
PTAIQLRDFEQEVQMHRRLSFRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPN
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
YIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSSNFLYMLTEKEQDPIAAKVFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEEECCCCCCHHHHHHH
RCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
HHHHEECCCCCCCCHHEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
PENAGSFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLE
CCHHHHHHHHHHHCHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AEAIPRLGPKGIFPNVDFYSGLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIF
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPSQIYTGSAPRDWISLENRE
CCCCEEECCCCCHHCCCCCCC
>Mature Secondary Structure
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGFSIEELSKKSSFLETAYLLIWGEL
CCCCCEEECCCCCCCCCCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHEEEECCC
PTAIQLRDFEQEVQMHRRLSFRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPN
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
YIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSSNFLYMLTEKEQDPIAAKVFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEEECCCCCCHHHHHHH
RCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
HHHHEECCCCCCCCHHEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
PENAGSFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLE
CCHHHHHHHHHHHCHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AEAIPRLGPKGIFPNVDFYSGLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIF
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPSQIYTGSAPRDWISLENRE
CCCCEEECCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]