Click here to switch to the map view.

The map label for this gene is guaA [H]

Identifier: 123967573

GI number: 123967573

Start: 34778

End: 36364

Strand: Direct

Name: guaA [H]

Synonym: A9601_00361

Alternate gene names: 123967573

Gene position: 34778-36364 (Clockwise)

Preceding gene: 123967572

Following gene: 123967575

Centisome position: 2.08

GC content: 32.39

Gene sequence:

>1587_bases
ATGAGTCAAACATCTTTAAAAAAAGAACGAGATCCTTCAATATTAATTTTAGATTTTGGATCTCAATATTCTGAATTGAT
TGCAAGAAGAATTAGAGAAACTAATGTTTTCTCTCTTGTAGTGAGTAATTTTATTTCAATTGAGGATATTAATAGAATTA
ATCCTAAAGGGATCATATTGAGTGGAGGCCCAAATTCTGTATATGAACAAAATGCTCCCAGATGTGATGAAAAAATTTTT
AATTTAGGAATTCCTATTCTTGGCATATGCTATGGAATGCAATTAATGGTCAAGGAACTTGGAGGAACTGTTATTTCAGC
AACCAAAAAAGCTGAATATGGTAGAGCACCACTAAATATAGATCAAGAATCTGACCTTCTTTTTGATGTAGAAGATAAAT
CTATAATGTGGATGAGTCATGGCGATTCAATTAATTGTTTGCCTGATGGATTTAATAAGATTGCTCATACCGAGAACACA
CTCCATGCAGCAATTTCAAATGATGTAAAGAAATTATTTGGCGTACAATTTCATCCTGAAGTTGTTCATTCAGAATTTGG
AATGAGGGTAATTAAAAATTTTGTTTATAAAATTTCTTGTTGTACGGCTGATTGGACAACCGAAACATATATAGAAGAAA
CTATTCCAAGAATAAGAGAGCAAGTTGGCAACAAAAAAGTATTGCTTGCTTTATCAGGGGGAGTTGATTCCTCAACTCTT
GCCTTTCTTCTTAATAAAGCAATTGGAAATCAGCTTACTTGCATGTTTATAGATCAAGGTTTCATGAGAAAAGGTGAACC
AGAATTTTTAATGAATTTTTTTGATAAGAAATTTCACATTAAAGTTGAATACATTAATGCAAGAGAAAGGTTTATTGCCA
AATTAAAAGGAATTACTGATCCAGAACAAAAAAGAAAAATTATTGGTGAAGAATTTATTAGAGTATTTGAAGAGGAAAGT
AATAGATTGGGACCTTTTCAGTATTTAGCTCAAGGTACTCTATATCCTGATGTTATTGAAAGTGCTGGTACTAATATTGA
TCCTAAGACAGGTGAGAGGATAGCTGTAAAAATAAAGAGTCATCATAATGTAGGTGGATTGCCAAAAGATTTACAATTTA
AATTAGTTGAGCCATTAAGAAAACTTTTTAAGGATGAAGTTCGAAAAGTCGGCGCTGCTTTAGGTTTGCCAGATGAAATT
ATAAAAAGGCATCCATTCCCAGGACCTGGATTAGCTATAAGAATTTTGGGAGAGGTGAATAATGAAAAACTTGATTGTTT
AAGAGATGCAGACTGGATAGTAAGAGACGAAATTAAAAAAGCAGGTCTTTACAACGATATTTGGCAAGCTTTTGCAGTAT
TGTTACCTGTAAAAACTGTAGGAGTTATGGGTGATAAAAGGACTTATTCATGGCCAATAGTTTTACGTTGTGTATCAAGT
GAAGATGGCATGACAGCTGATTGGTCAAAAATTCCTTTTCAGATTTTGGAGAGGATTGCTAATAGAATAGTAAATGAAGT
AATTTCAGTTAATAGAGTTGTTTATGATATTACAAGCAAACCTCCTGGAACTATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
GGTGGGCTGGAATTAACGGTAATAAGTATATTTCTTATTTTCAATGAGATTAACTTTGATTCATTATGCTTTTGTAAATA
AATTGAGCTAACTTTTATAC

Downstream 100 bases:

>100_bases
GTTATAGGGTCAGATTGTAGTGATATCCCTATTTTTGCGGTTTGTCACGTATGATATGGTAACGGAATTACTGAGATTCC
AGCCCTTCGTTGTCGTGGAT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MSQTSLKKERDPSILILDFGSQYSELIARRIRETNVFSLVVSNFISIEDINRINPKGIILSGGPNSVYEQNAPRCDEKIF
NLGIPILGICYGMQLMVKELGGTVISATKKAEYGRAPLNIDQESDLLFDVEDKSIMWMSHGDSINCLPDGFNKIAHTENT
LHAAISNDVKKLFGVQFHPEVVHSEFGMRVIKNFVYKISCCTADWTTETYIEETIPRIREQVGNKKVLLALSGGVDSSTL
AFLLNKAIGNQLTCMFIDQGFMRKGEPEFLMNFFDKKFHIKVEYINARERFIAKLKGITDPEQKRKIIGEEFIRVFEEES
NRLGPFQYLAQGTLYPDVIESAGTNIDPKTGERIAVKIKSHHNVGGLPKDLQFKLVEPLRKLFKDEVRKVGAALGLPDEI
IKRHPFPGPGLAIRILGEVNNEKLDCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYSWPIVLRCVSS
EDGMTADWSKIPFQILERIANRIVNEVISVNRVVYDITSKPPGTIEWE

Sequences:

>Translated_528_residues
MSQTSLKKERDPSILILDFGSQYSELIARRIRETNVFSLVVSNFISIEDINRINPKGIILSGGPNSVYEQNAPRCDEKIF
NLGIPILGICYGMQLMVKELGGTVISATKKAEYGRAPLNIDQESDLLFDVEDKSIMWMSHGDSINCLPDGFNKIAHTENT
LHAAISNDVKKLFGVQFHPEVVHSEFGMRVIKNFVYKISCCTADWTTETYIEETIPRIREQVGNKKVLLALSGGVDSSTL
AFLLNKAIGNQLTCMFIDQGFMRKGEPEFLMNFFDKKFHIKVEYINARERFIAKLKGITDPEQKRKIIGEEFIRVFEEES
NRLGPFQYLAQGTLYPDVIESAGTNIDPKTGERIAVKIKSHHNVGGLPKDLQFKLVEPLRKLFKDEVRKVGAALGLPDEI
IKRHPFPGPGLAIRILGEVNNEKLDCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYSWPIVLRCVSS
EDGMTADWSKIPFQILERIANRIVNEVISVNRVVYDITSKPPGTIEWE
>Mature_527_residues
SQTSLKKERDPSILILDFGSQYSELIARRIRETNVFSLVVSNFISIEDINRINPKGIILSGGPNSVYEQNAPRCDEKIFN
LGIPILGICYGMQLMVKELGGTVISATKKAEYGRAPLNIDQESDLLFDVEDKSIMWMSHGDSINCLPDGFNKIAHTENTL
HAAISNDVKKLFGVQFHPEVVHSEFGMRVIKNFVYKISCCTADWTTETYIEETIPRIREQVGNKKVLLALSGGVDSSTLA
FLLNKAIGNQLTCMFIDQGFMRKGEPEFLMNFFDKKFHIKVEYINARERFIAKLKGITDPEQKRKIIGEEFIRVFEEESN
RLGPFQYLAQGTLYPDVIESAGTNIDPKTGERIAVKIKSHHNVGGLPKDLQFKLVEPLRKLFKDEVRKVGAALGLPDEII
KRHPFPGPGLAIRILGEVNNEKLDCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYSWPIVLRCVSSE
DGMTADWSKIPFQILERIANRIVNEVISVNRVVYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=558, Percent_Identity=38.8888888888889, Blast_Score=324, Evalue=1e-88,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=50.2868068833652, Blast_Score=541, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI71992717, Length=579, Percent_Identity=36.7875647668394, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI133901714, Length=579, Percent_Identity=36.7875647668394, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71992710, Length=579, Percent_Identity=36.7875647668394, Blast_Score=300, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=522, Percent_Identity=48.8505747126437, Blast_Score=503, Evalue=1e-143,
Organism=Drosophila melanogaster, GI281365319, Length=557, Percent_Identity=37.1633752244165, Blast_Score=293, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59655; Mature: 59523

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTSLKKERDPSILILDFGSQYSELIARRIRETNVFSLVVSNFISIEDINRINPKGIIL
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEE
SGGPNSVYEQNAPRCDEKIFNLGIPILGICYGMQLMVKELGGTVISATKKAEYGRAPLNI
ECCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCCC
DQESDLLFDVEDKSIMWMSHGDSINCLPDGFNKIAHTENTLHAAISNDVKKLFGVQFHPE
CCCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHH
VVHSEFGMRVIKNFVYKISCCTADWTTETYIEETIPRIREQVGNKKVLLALSGGVDSSTL
HHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHH
AFLLNKAIGNQLTCMFIDQGFMRKGEPEFLMNFFDKKFHIKVEYINARERFIAKLKGITD
HHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHCCCEEEEEEEEECHHHHHHHHHCCCCC
PEQKRKIIGEEFIRVFEEESNRLGPFQYLAQGTLYPDVIESAGTNIDPKTGERIAVKIKS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEEEEC
HHNVGGLPKDLQFKLVEPLRKLFKDEVRKVGAALGLPDEIIKRHPFPGPGLAIRILGEVN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEEECCC
NEKLDCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYSWPIVLRCVSS
CCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECC
EDGMTADWSKIPFQILERIANRIVNEVISVNRVVYDITSKPPGTIEWE
CCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SQTSLKKERDPSILILDFGSQYSELIARRIRETNVFSLVVSNFISIEDINRINPKGIIL
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEE
SGGPNSVYEQNAPRCDEKIFNLGIPILGICYGMQLMVKELGGTVISATKKAEYGRAPLNI
ECCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCCC
DQESDLLFDVEDKSIMWMSHGDSINCLPDGFNKIAHTENTLHAAISNDVKKLFGVQFHPE
CCCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHH
VVHSEFGMRVIKNFVYKISCCTADWTTETYIEETIPRIREQVGNKKVLLALSGGVDSSTL
HHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHH
AFLLNKAIGNQLTCMFIDQGFMRKGEPEFLMNFFDKKFHIKVEYINARERFIAKLKGITD
HHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHCCCEEEEEEEEECHHHHHHHHHCCCCC
PEQKRKIIGEEFIRVFEEESNRLGPFQYLAQGTLYPDVIESAGTNIDPKTGERIAVKIKS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEEEEC
HHNVGGLPKDLQFKLVEPLRKLFKDEVRKVGAALGLPDEIIKRHPFPGPGLAIRILGEVN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEEECCC
NEKLDCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYSWPIVLRCVSS
CCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECC
EDGMTADWSKIPFQILERIANRIVNEVISVNRVVYDITSKPPGTIEWE
CCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA