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The map label for this gene is parC [H]

Identifier: 123967541

GI number: 123967541

Start: 5882

End: 8323

Strand: Reverse

Name: parC [H]

Synonym: A9601_00041

Alternate gene names: 123967541

Gene position: 8323-5882 (Counterclockwise)

Preceding gene: 123967542

Following gene: NA

Centisome position: 0.5

GC content: 26.74

Gene sequence:

>2442_bases
ATGGATAAGAAAAATTTCACTTCCATATCACTTCAAGAAGAAATGCAACGTTCTTATTTGGAGTATGCAATGAGCGTAAT
AGTTGGACGTGCTTTGCCTGATGCAAGAGACGGTCTTAAACCTGTACAAAGAAGAATCATATTTGCAATGTACGAATTAG
GTTTAACTCCTGATAAACCATTTAGGAAGTGTGCAAGAGTTGTTGGAGATGTACTTGGAAAGTACCATCCTCACGGAGAT
CAAGCGGTATATGATGCATTAGTAAAACTAGTACAAAATTTTTCAACTAAGTATCCTACTCTTGACGGTCATGGAAATTT
TGGATCTATCGATAATGATCCGCCGGCAGCAATGAGATATACTGAGACCAGATTAGCTCCAATAGCTCATAAAGGATTTC
TTGAAGAAATTGGATCAGAAACAGTAAACTTTTCAAATAACTTTGACGGTTCTCAAAAAGAACCAGATGTTCTTCCAGCC
CAACTTCCATTTTTATTATTGAACGGCTCAACAGGTATTGCTGTTGGCATGGCAACAAATATTCCGCCTCACAACCTAGG
TGAAATTGTTGATGGCTTAGTTACCTTAGTTAAAAATAAAGATATTAGTGATAAAAAACTTTTTAACATTATCAAAGGAC
CTGATTTTCCTACAGGAGGAGAATTAATTTATAGTCGTGCAATAGAAGAACTTTATCAAACTGGAAAAGGATCCATAACG
ATAAGAGGGGTTATAAATACGGAAGAGGTAAATTTGGGCAAAGGGAAACATAAAAAGAATGCAATAATCATTAAGGAACT
TCCTTACCAAATTAATAAAGCAGGTTGGATTGAAAAACTCGCAGAACTTGTAAATGCAGGCAAAATTATTGGAATTTCTG
ATATTAGGGATGAAAGCGACAGAGATGGAATGAGAATTGTAATAGAACTAAAAAAAGATTCTAATTCTGAACTTGTTATT
TCTAATTTATATAAAAAAACAACTCTACAAACAAACTTTGGCGCAATATTCTTAGCTTTAATTAAAGGGAAGCCTGTACA
ACTAAATCTTAAAAAATATCTTAACTATTTTCTTGAATTTAGAGAAGAAACAATTAGAAAAAGAACTTTTTATTTTCTAA
AAAACACCCTTGATAAACTAGAAATATCAGAAGGTTTATCTAAAGCTACAAAAGACATAAAAAAAGTTATCGCAATTATT
GAAGAATCAGAAAATTCTGTGCAGGCTAGATCAAAATTAGTAGAAAAATTTTTTTTAAGTGAAAAACAGGCAAATTCAGT
TTTAGATATGCCACTAAAAAAATTAACAAATCTAGAAAAAAATCAAATTGATAATGAAATAAAAAATTTAGCAGAAAAAA
AGAATTATTTTCAAAAATTATTGAACGAAAGAGAATTATTACTTAAATTACTCATAGAAGAATTATTAATATTAAAGAAA
AAATATAATGTTATACGTAAAACAAAAATAATTAAAAATTTAAATCAAAATGAAGAATTAGAAACTCTTAATAATCAGAT
ATTAGAAGACTTTATAAATAAAAAAACAAAATTATACATAGACAATAGACTTTATTTAAAAAGGATGATTTTAAGTAATT
ACAAGAAATCATTTGAGGGTGTAAATAAAATTATAGATAATAAAAATATTCAAAAATTTATATGTAATATTGAAAAAAAT
ACAAAATTAATAGGAATCACAAATACGGGAAGAGTATTTAACATTGATTGGGAATCAAGTATTAATAAAGACTATAAATT
AGATAATAAAATTCTTGGAAATATTCATCCAAGTGAAATAATAAATTTTCATTCAATTAAAAAAGAAACTAGAAATTATT
TATGCATATTAAATTCGGATGGAAGATTTAAAAAAGTTTTATTTGATAAAGATATGATTAAAAGCAATAGATCTTTCACT
ATTACAAAATTAAAAAATAATTTAAAAACAGTTGATTCTTTTATTTCTAATGAAAGCAAAAATTTAATAATATTAACCTC
AATAGGAAGAATTTTTAAATTTAATTTATCAAATAAATTTCTAACGGCAACTTCTAAACAATCCAAAGGATTAATAATTG
CAAAGCTTTTACCAACTGAAAAAATCGTTTCCTGTTGTACATTTCATGATGGAGAAAATATTTTTTTAATTTCTAAACAA
GGAAAAATCTTCTGCATAAATAGTAATGAAATTTACTGCTCAAATGAATACAGTTTGGGATATTTGAACGAAAAAACCCA
ACTTAAAAACGATTACTTCCTAAAAATAATGGCAAGCAACCATTACCTTGATATTGAAACTAATAAAAATAAATCTGCAA
GATTAGACTTAAATAAAATAAATTTCAAATCCAATAAATCAAACTTTTTAATTGATTTTTTAAAAATAGATAATGATGAA
TACCTTGAAAATTGTTTCCGACTTGAAAACTTTCTCAACTAA

Upstream 100 bases:

>100_bases
TCCAAAATAAATCAATCATCTTAATGTTCAATACTGGTAATTATTGTTTTACCTATTAGTCTTAATTTAGTTAGTTCATA
ATTTTAAATTTTGCGCTCTA

Downstream 100 bases:

>100_bases
GATTTATATTCATTTTCAACCCAATTTAAGTATTCTTGATTTACTGTTCCAGTTACATAATCACCAGTGAAACAACTCAT
CTCTAAACCTTTAATAGGAG

Product: DNA gyrase/topoisomerase IV, subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MDKKNFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRIIFAMYELGLTPDKPFRKCARVVGDVLGKYHPHGD
QAVYDALVKLVQNFSTKYPTLDGHGNFGSIDNDPPAAMRYTETRLAPIAHKGFLEEIGSETVNFSNNFDGSQKEPDVLPA
QLPFLLLNGSTGIAVGMATNIPPHNLGEIVDGLVTLVKNKDISDKKLFNIIKGPDFPTGGELIYSRAIEELYQTGKGSIT
IRGVINTEEVNLGKGKHKKNAIIIKELPYQINKAGWIEKLAELVNAGKIIGISDIRDESDRDGMRIVIELKKDSNSELVI
SNLYKKTTLQTNFGAIFLALIKGKPVQLNLKKYLNYFLEFREETIRKRTFYFLKNTLDKLEISEGLSKATKDIKKVIAII
EESENSVQARSKLVEKFFLSEKQANSVLDMPLKKLTNLEKNQIDNEIKNLAEKKNYFQKLLNERELLLKLLIEELLILKK
KYNVIRKTKIIKNLNQNEELETLNNQILEDFINKKTKLYIDNRLYLKRMILSNYKKSFEGVNKIIDNKNIQKFICNIEKN
TKLIGITNTGRVFNIDWESSINKDYKLDNKILGNIHPSEIINFHSIKKETRNYLCILNSDGRFKKVLFDKDMIKSNRSFT
ITKLKNNLKTVDSFISNESKNLIILTSIGRIFKFNLSNKFLTATSKQSKGLIIAKLLPTEKIVSCCTFHDGENIFLISKQ
GKIFCINSNEIYCSNEYSLGYLNEKTQLKNDYFLKIMASNHYLDIETNKNKSARLDLNKINFKSNKSNFLIDFLKIDNDE
YLENCFRLENFLN

Sequences:

>Translated_813_residues
MDKKNFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRIIFAMYELGLTPDKPFRKCARVVGDVLGKYHPHGD
QAVYDALVKLVQNFSTKYPTLDGHGNFGSIDNDPPAAMRYTETRLAPIAHKGFLEEIGSETVNFSNNFDGSQKEPDVLPA
QLPFLLLNGSTGIAVGMATNIPPHNLGEIVDGLVTLVKNKDISDKKLFNIIKGPDFPTGGELIYSRAIEELYQTGKGSIT
IRGVINTEEVNLGKGKHKKNAIIIKELPYQINKAGWIEKLAELVNAGKIIGISDIRDESDRDGMRIVIELKKDSNSELVI
SNLYKKTTLQTNFGAIFLALIKGKPVQLNLKKYLNYFLEFREETIRKRTFYFLKNTLDKLEISEGLSKATKDIKKVIAII
EESENSVQARSKLVEKFFLSEKQANSVLDMPLKKLTNLEKNQIDNEIKNLAEKKNYFQKLLNERELLLKLLIEELLILKK
KYNVIRKTKIIKNLNQNEELETLNNQILEDFINKKTKLYIDNRLYLKRMILSNYKKSFEGVNKIIDNKNIQKFICNIEKN
TKLIGITNTGRVFNIDWESSINKDYKLDNKILGNIHPSEIINFHSIKKETRNYLCILNSDGRFKKVLFDKDMIKSNRSFT
ITKLKNNLKTVDSFISNESKNLIILTSIGRIFKFNLSNKFLTATSKQSKGLIIAKLLPTEKIVSCCTFHDGENIFLISKQ
GKIFCINSNEIYCSNEYSLGYLNEKTQLKNDYFLKIMASNHYLDIETNKNKSARLDLNKINFKSNKSNFLIDFLKIDNDE
YLENCFRLENFLN
>Mature_813_residues
MDKKNFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRIIFAMYELGLTPDKPFRKCARVVGDVLGKYHPHGD
QAVYDALVKLVQNFSTKYPTLDGHGNFGSIDNDPPAAMRYTETRLAPIAHKGFLEEIGSETVNFSNNFDGSQKEPDVLPA
QLPFLLLNGSTGIAVGMATNIPPHNLGEIVDGLVTLVKNKDISDKKLFNIIKGPDFPTGGELIYSRAIEELYQTGKGSIT
IRGVINTEEVNLGKGKHKKNAIIIKELPYQINKAGWIEKLAELVNAGKIIGISDIRDESDRDGMRIVIELKKDSNSELVI
SNLYKKTTLQTNFGAIFLALIKGKPVQLNLKKYLNYFLEFREETIRKRTFYFLKNTLDKLEISEGLSKATKDIKKVIAII
EESENSVQARSKLVEKFFLSEKQANSVLDMPLKKLTNLEKNQIDNEIKNLAEKKNYFQKLLNERELLLKLLIEELLILKK
KYNVIRKTKIIKNLNQNEELETLNNQILEDFINKKTKLYIDNRLYLKRMILSNYKKSFEGVNKIIDNKNIQKFICNIEKN
TKLIGITNTGRVFNIDWESSINKDYKLDNKILGNIHPSEIINFHSIKKETRNYLCILNSDGRFKKVLFDKDMIKSNRSFT
ITKLKNNLKTVDSFISNESKNLIILTSIGRIFKFNLSNKFLTATSKQSKGLIIAKLLPTEKIVSCCTFHDGENIFLISKQ
GKIFCINSNEIYCSNEYSLGYLNEKTQLKNDYFLKIMASNHYLDIETNKNKSARLDLNKINFKSNKSNFLIDFLKIDNDE
YLENCFRLENFLN

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=352, Percent_Identity=25.8522727272727, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI19913406, Length=175, Percent_Identity=31.4285714285714, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1788562, Length=773, Percent_Identity=35.8344113842173, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1789396, Length=731, Percent_Identity=33.9261285909713, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI212645845, Length=483, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17535065, Length=175, Percent_Identity=31.4285714285714, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=177, Percent_Identity=29.3785310734463, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.3

Molecular weight: Translated: 93184; Mature: 93184

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKNFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRIIFAMYELGLTPDKP
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHH
FRKCARVVGDVLGKYHPHGDQAVYDALVKLVQNFSTKYPTLDGHGNFGSIDNDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEE
TETRLAPIAHKGFLEEIGSETVNFSNNFDGSQKEPDVLPAQLPFLLLNGSTGIAVGMATN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECC
IPPHNLGEIVDGLVTLVKNKDISDKKLFNIIKGPDFPTGGELIYSRAIEELYQTGKGSIT
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
IRGVINTEEVNLGKGKHKKNAIIIKELPYQINKAGWIEKLAELVNAGKIIGISDIRDESD
EEEEEECCEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCC
RDGMRIVIELKKDSNSELVISNLYKKTTLQTNFGAIFLALIKGKPVQLNLKKYLNYFLEF
CCCCEEEEEEECCCCCCEEHHHHHHHHCCCCCHHHHEEHHHCCCCEEEEHHHHHHHHHHH
REETIRKRTFYFLKNTLDKLEISEGLSKATKDIKKVIAIIEESENSVQARSKLVEKFFLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
EKQANSVLDMPLKKLTNLEKNQIDNEIKNLAEKKNYFQKLLNERELLLKLLIEELLILKK
HHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYNVIRKTKIIKNLNQNEELETLNNQILEDFINKKTKLYIDNRLYLKRMILSNYKKSFEG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHH
VNKIIDNKNIQKFICNIEKNTKLIGITNTGRVFNIDWESSINKDYKLDNKILGNIHPSEI
HHHHHCCCCHHHHHHCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCHHCCCCCHHHH
INFHSIKKETRNYLCILNSDGRFKKVLFDKDMIKSNRSFTITKLKNNLKTVDSFISNESK
HHHHHHHHCCCCEEEEECCCCCEEHHHHCHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCC
NLIILTSIGRIFKFNLSNKFLTATSKQSKGLIIAKLLPTEKIVSCCTFHDGENIFLISKQ
CEEEEEECCCEEEEECCCCEEEECCCCCCCEEEEEECCHHHHHHHHEEECCCEEEEEECC
GKIFCINSNEIYCSNEYSLGYLNEKTQLKNDYFLKIMASNHYLDIETNKNKSARLDLNKI
CEEEEEECCEEEECCCCCEEECCCHHHCCCCEEEEEEECCEEEEEEECCCCCEEEEEEEE
NFKSNKSNFLIDFLKIDNDEYLENCFRLENFLN
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDKKNFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRIIFAMYELGLTPDKP
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHH
FRKCARVVGDVLGKYHPHGDQAVYDALVKLVQNFSTKYPTLDGHGNFGSIDNDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEE
TETRLAPIAHKGFLEEIGSETVNFSNNFDGSQKEPDVLPAQLPFLLLNGSTGIAVGMATN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECC
IPPHNLGEIVDGLVTLVKNKDISDKKLFNIIKGPDFPTGGELIYSRAIEELYQTGKGSIT
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
IRGVINTEEVNLGKGKHKKNAIIIKELPYQINKAGWIEKLAELVNAGKIIGISDIRDESD
EEEEEECCEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCC
RDGMRIVIELKKDSNSELVISNLYKKTTLQTNFGAIFLALIKGKPVQLNLKKYLNYFLEF
CCCCEEEEEEECCCCCCEEHHHHHHHHCCCCCHHHHEEHHHCCCCEEEEHHHHHHHHHHH
REETIRKRTFYFLKNTLDKLEISEGLSKATKDIKKVIAIIEESENSVQARSKLVEKFFLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
EKQANSVLDMPLKKLTNLEKNQIDNEIKNLAEKKNYFQKLLNERELLLKLLIEELLILKK
HHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYNVIRKTKIIKNLNQNEELETLNNQILEDFINKKTKLYIDNRLYLKRMILSNYKKSFEG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHH
VNKIIDNKNIQKFICNIEKNTKLIGITNTGRVFNIDWESSINKDYKLDNKILGNIHPSEI
HHHHHCCCCHHHHHHCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCHHCCCCCHHHH
INFHSIKKETRNYLCILNSDGRFKKVLFDKDMIKSNRSFTITKLKNNLKTVDSFISNESK
HHHHHHHHCCCCEEEEECCCCCEEHHHHCHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCC
NLIILTSIGRIFKFNLSNKFLTATSKQSKGLIIAKLLPTEKIVSCCTFHDGENIFLISKQ
CEEEEEECCCEEEEECCCCEEEECCCCCCCEEEEEECCHHHHHHHHEEECCCEEEEEECC
GKIFCINSNEIYCSNEYSLGYLNEKTQLKNDYFLKIMASNHYLDIETNKNKSARLDLNKI
CEEEEEECCEEEECCCCCEEECCCHHHCCCCEEEEEEECCEEEEEEECCCCCEEEEEEEE
NFKSNKSNFLIDFLKIDNDEYLENCFRLENFLN
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Isomerization [C]

Inhibitor: CJ-12, 371; CJ-12, 372; Coumermycin; Doxorubicin; Sitafloxacin [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]